| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erica Staurenghi, Gabriella Testa, Valerio Leoni, Rebecca Cecci, Lucrezia Floro, Serena Giannelli, Eugenio Barone, Marzia Perluigi, Gabriella Leonarduzzi, Barbara Sottero, Paola Gamb. Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671883. |
down syndrome (ds) is a complex chromosomal disorder considered as a genetically determined form of alzheimer's disease (ad). |
2024-04-27 |
2024-04-29 |
mouse |
| Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ance. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631766. |
comparison of tau spread in people with down syndrome versus autosomal-dominant alzheimer's disease: a cross-sectional study. |
2024-04-17 |
2024-04-20 |
Not clear |
| Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ance. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631766. |
in people with genetic forms of alzheimer's disease, such as in down syndrome and autosomal-dominant alzheimer's disease, pathological changes specific to alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. |
2024-04-17 |
2024-04-20 |
Not clear |
| Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ance. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631766. |
we compared the magnitude, spatial extent, and temporal ordering of tau spread in people with down syndrome and autosomal-dominant alzheimer's disease. |
2024-04-17 |
2024-04-20 |
Not clear |
| Emily K Schworer, Benjamin L Handen, Melissa Petersen, Sid O'Bryant, Jamie C Peven, Dana L Tudorascu, Laisze Lee, Sharon J Krinsky-McHale, Christy L Hom, Isabel C H Clare, Bradley T Christian, Nicole Schupf, Joseph H Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M Ances, Shahid Zaman, Adam M Brickman, Florence Lai, H Diana Rosas, Sigan L Hartle. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-04-16. PMID:38623384. |
people with down syndrome (ds) have a 75% to 90% lifetime risk of alzheimer's disease (ad). |
2024-04-16 |
2024-04-18 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
cryo-em structures reveal tau filaments from down syndrome adopt alzheimer's disease fold. |
2024-04-15 |
2024-04-17 |
Not clear |
| Ann-Charlotte Granholm, Eric D Hamlet. The Role of Tau Pathology in Alzheimer's Disease and Down Syndrome. Journal of clinical medicine. vol 13. issue 5. 2024-04-09. PMID:38592182. |
the role of tau pathology in alzheimer's disease and down syndrome. |
2024-04-09 |
2024-04-11 |
Not clear |
| Anllely Fernandez, Md Rejaul Hoq, Grace I Hallinan, Daoyi Li, Sakshibeedu R Bharath, Frank S Vago, Xiaoqi Zhang, Kadir A Ozcan, Kathy L Newell, Holly J Garringer, Wen Jiang, Bernardino Ghetti, Ruben Vida. Cryo-EM structures of amyloid-β and tau filaments in Down syndrome. Nature structural & molecular biology. 2024-03-30. PMID:38553642. |
adult individuals with down syndrome (ds) develop alzheimer disease (ad). |
2024-03-30 |
2024-04-01 |
Not clear |
| Debomoy K Lahiri, Deborah K Soko. Alzheimer's Drugs APPlication for Down syndrome? Ageing research reviews. 2024-03-21. PMID:38513771. |
accumulation of the amyloid β (aβ) peptide, derived from aβ precursor protein (app), is a trait of down syndrome (ds), as is early development of dementia like alzheimer's disease (ad). |
2024-03-21 |
2024-03-24 |
human |
| Frode Kibsgaard Larsen, R Asaad Baksh, Eimear McGlinchey, Ellen Melbye Langballe, Bessy Benejam, Jessica Beresford-Webb, Mary McCarron, Antonia Coppus, Segolene Falquero, Juan Fortea, Johannes Levin, Sandra V Loosli, Ruth Mark, Anne-Sophie Rebillat, Shahid Zaman, Andre Strydo. Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-20. PMID:38506627. |
people with down syndrome (ds) have high risk of developing alzheimer's disease (ad). |
2024-03-20 |
2024-03-23 |
Not clear |
| Natalie DiProspero, Mithra Sathishkumar, John Janecek, Anna Smith, Liv McMillan, Melissa Petersen, Nicholas Tustison, David B Keator, Eric Doran, Christy L Hom, Dana Nguyen, Howard Andrews, Sharon Krinsky-McHale, Adam M Brickman, H Diana Rosas, Florence Lai, Elizabeth Head, Mark Mapstone, Wayne Silverman, Ira T Lott, Sid O'Bryant, Michael A Yass. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 1. 2024-02-13. PMID:38348178. |
virtually all people with down syndrome (ds) develop neuropathology associated with alzheimer's disease (ad). |
2024-02-13 |
2024-02-15 |
Not clear |
| Iban Aldecoa, Isabel Barroeta, Steven L Carroll, Juan Fortea, Anah Gilmore, Stephen D Ginsberg, Samuel J Guzman, Eric D Hamlett, Elizabeth Head, Sylvia E Perez, Huntington Potter, Laura Molina-Porcel, Ruma Raha-Chowdhury, Thomas Wisniewski, William H Yong, Shahid Zaman, Sujay Ghosh, Elliott J Mufson, Ann-Charlotte Granhol. Down Syndrome Biobank Consortium: A perspective. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-25. PMID:38270275. |
individuals with down syndrome (ds) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset alzheimer's disease (ad)-type dementia by early midlife. |
2024-01-25 |
2024-01-27 |
Not clear |
| Eri Shimizu, Keiko Goto-Hirano, Yumiko Motoi, Masami Arai, Nobutaka Hattor. Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-01-16. PMID:38228941. |
the diagnostic criteria for adult-onset alzheimer's disease (ad) in patients with down syndrome (ds) have not been standardised. |
2024-01-16 |
2024-01-19 |
Not clear |
| Yi-Wen Wu, Wei-Chun HuangFu, Tony Eight Lin, Chao-Hiang Peng, Huang-Ju Tu, Ting-Yi Sung, Tzu-Ying Sung, Shih-Chung Yen, Shiow-Lin Pan, Kai-Cheng Hs. Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule. International journal of biological macromolecules. 2024-01-01. PMID:38163507. |
the overexpression of dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a), commonly observed in neurodegenerative diseases like alzheimer's disease (ad) and down syndrome (ds), can induce the formation of neurofibrillary tangles (nfts) and amyloid plaques. |
2024-01-01 |
2024-01-05 |
Not clear |
| Beatriz Sánchez-Moreno, Linda Zhang, Gloria Mateo, Fernando Moldenhauer, Mikael Brudfors, John Ashburner, Parashkev Nachev, Diego Real de Asúa, Bryan A Strang. Voxel-based dysconnectomic brain morphometry with computed tomography in Down syndrome. Annals of clinical and translational neurology. 2023-12-30. PMID:38158639. |
alzheimer's disease (ad) is a major health concern for aging adults with down syndrome (ds), but conventional diagnostic techniques are less reliable in those with severe baseline disability. |
2023-12-30 |
2024-01-05 |
Not clear |
| Shannon D R Ringenbach, Nathaniel E Arnold, Kori Tucker, Miya K Rand, Breanna E Studenka, Stockton B Ringenbach, Chih-Chia Che. Assisted Cycle Therapy (ACT) Improved Self-Efficacy and Exercise Perception in Middle-Age Adults with Down Syndrome. Brain sciences. vol 13. issue 12. 2023-12-23. PMID:38137167. |
alzheimer's disease is prevalent in persons with down syndrome (ds) as early as their 30s and presents as decreased social interaction, coordination, and physical activity. |
2023-12-23 |
2023-12-25 |
human |
| Natalie C Edwards, Patrick J Lao, Mohamad J Alshikho, Olivia M Ericsson, Batool Rizvi, Melissa E Petersen, Sid O'Bryant, Lisi Flores-Aguilar, Sabrina Simoes, Mark Mapstone, Dana L Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L Handen, Bradley T Christian, Joseph H Lee, Florence Lai, H Diana Rosas, Shahid Zaman, Ira T Lott, Michael A Yassa, José Gutierrez, Donna M Wilcock, Elizabeth Head, Adam M Brickma. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-12-11. PMID:38076904. |
by age 40 years over 90% of adults with down syndrome (ds) have alzheimer's disease (ad) pathology and most progress to dementia. |
2023-12-11 |
2023-12-17 |
Not clear |
| Mattias F Lindberg, Emmanuel Deau, Frédéric Miege, Marie Greverie, Didier Roche, Nicolas George, Pascal George, Laura Merlet, Julie Gavard, Sander J T Brugman, Edwin Aret, Paul Tinnemans, René de Gelder, Jan Sadownik, Eva Verhofstad, Dennis Sleegers, Sara Santangelo, Julien Dairou, Álvaro Fernandez-Blanco, Mara Dierssen, Andreas Krämer, Stefan Knapp, Laurent Meije. Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate. Journal of medicinal chemistry. 2023-12-05. PMID:38051674. |
leucettinibs are substituted 2-aminoimidazolin-4-ones (inspired by the marine sponge natural product leucettamine b) developed as pharmacological inhibitors of dyrk1a (dual-specificity, tyrosine phosphorylation-regulated kinase 1a), a therapeutic target for indications such as down syndrome and alzheimer's disease. |
2023-12-05 |
2023-12-10 |
mouse |
| Batool Rizvi, Patrick J Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan, Natalie Edwards, David B Keator, Eric Doran, Christy Hom, Dana Nguyen, H Diana Rosas, Florence Lai, Nicole Schupf, Jose Gutierrez, Wayne Silverman, Ira T Lott, Mark Mapstone, Donna M Wilcock, Elizabeth Head, Michael A Yassa, Adam M Brickma. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961444. |
participants with ds from the biomarkers of alzheimer's disease in adults with down syndrome study (adds; n=195, age=50.6±7.2 years, 44% women, 18% diagnosed with dementia) were included. |
2023-11-14 |
2023-11-20 |
human |
| Megan K Gautier, Christy M Kelley, Sang Han Lee, Melissa J Alldred, John McDaid, Elliott J Mufson, Grace E Stutzmann, Stephen D Ginsber. Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Neurobiology of disease. vol 188. 2023-11-04. PMID:37890559. |
maternal choline supplementation protects against age-associated cholinergic and gabaergic basal forebrain neuron degeneration in the ts65dn mouse model of down syndrome and alzheimer's disease. |
2023-11-04 |
2023-11-08 |
mouse |