| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elif Korkusuz, Yusuf Sert, Seher Arslan, Hava Aydın, İsmail Yıldırım, Yeliz Demir, İlhami Gülçin, İrfan Koc. Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes. Archiv der Pharmazie. 2024-05-21. PMID:38772694. |
novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes i and ii (hca i and ii), acetylcholinesterase (ache), butyrylcholinesterase (bche), α-glycosidase, and aldose reductase (ar) enzymes associated with some common diseases such as epilepsy, glaucoma, alzheimer's disease, diabetes, and neuropathy. |
2024-05-21 |
2024-05-27 |
Not clear |
| Prema V, Prema A, Prema . A Computational Study of Phenothiazine Derivatives as Acetylcholinesterase Inhibitors Targeting Alzheimer's Disease. Central nervous system agents in medicinal chemistry. 2024-05-17. PMID:38757327. |
a computational study of phenothiazine derivatives as acetylcholinesterase inhibitors targeting alzheimer's disease. |
2024-05-17 |
2024-05-27 |
Not clear |
| Eman E Nasr, Samar S Tawfik, Mohammed A M Massoud, Amany S Mostaf. Unveiling new thiazole-clubbed piperazine derivatives as multitarget anti-AD: Design, synthesis, and in silico studies. Archiv der Pharmazie. 2024-05-16. PMID:38754070. |
new thiazole-clubbed piperazine derivatives were designed, synthesized, evaluated for their inhibitory capabilities against human acetylcholinesterase and butyrylcholinesterase (hache and/or hbuche) and β-amyloid (aβ) aggregation, and investigated for their metal chelating potential as multitarget agents for the treatment of alzheimer's disease. |
2024-05-16 |
2024-05-27 |
human |
| b' Re\\xc5\\x9fit \\xc3\\x87akmak, Ey\\xc3\\xbcp Ba\\xc5\\x9faran, Kader Sahin, Murat \\xc5\\x9eent\\xc3\\xbcrk, Serdar Durda\\xc4\\x9f\\xc4\\xb. Synthesis of Novel Hydrazide-Hydrazone Compounds and ACS omega. vol 9. issue 18. 2024-05-13. PMID:38737075.' |
synthesis of novel hydrazide-hydrazone compounds and the abnormal levels of the human carbonic anhydrase isoenzymes i and ii (hca i and ii) and cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are linked with various disorders including alzheimer's disease. |
2024-05-13 |
2024-05-27 |
human |
| Hind Al Khashali, Ravel Ray, Ban Darweesh, Caroline Wozniak, Ben Haddad, Stuti Goel, Issah Seidu, Jeneen Khalil, Brooke Lopo, Nayrooz Murshed, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732252. |
we previously reported that the levels of amyloid beta (aβ), at the center of alzheimer's disease pathophysiology, are regulated by acetylcholinesterase (ache) in non-small cell lung cancer (nsclc). |
2024-05-11 |
2024-05-27 |
Not clear |
| Guang Yang, Jiawen Wu, Hang Lei, Yining Hu. Letter to the editor: Limitations of acetylcholinesterase inhibitor (AChEI) therapy for Alzheimer's disease. International journal of surgery (London, England). 2024-05-10. PMID:38728857. |
letter to the editor: limitations of acetylcholinesterase inhibitor (achei) therapy for alzheimer's disease. |
2024-05-10 |
2024-05-27 |
Not clear |
| Joseph Magagnoli, S Scott Sutton, Jayakrishna Ambat. Acetylcholinesterase Inhibitors, AMD, and Alzheimer Disease-Reply. JAMA ophthalmology. 2024-05-09. PMID:38722622. |
acetylcholinesterase inhibitors, amd, and alzheimer disease-reply. |
2024-05-09 |
2024-05-27 |
Not clear |
| Yu-Hung Chen, Chen Wang, Tobias Kurt. Acetylcholinesterase Inhibitors, AMD, and Alzheimer Disease. JAMA ophthalmology. 2024-05-09. PMID:38722653. |
acetylcholinesterase inhibitors, amd, and alzheimer disease. |
2024-05-09 |
2024-05-27 |
Not clear |
| Hatice Esra Duran, Şükrü Beydemi. Naphthoquinones and anthraquinones: Exploring their impact on acetylcholinesterase enzyme activity. Biotechnology and applied biochemistry. 2024-05-08. PMID:38715453. |
the identification of novel acetylcholinesterase inhibitors holds significant relevance in the treatment of alzheimer's disease (ad), the prevailing form of dementia. |
2024-05-08 |
2024-05-27 |
Not clear |
| Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. |
identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2024-05-06 |
2024-05-08 |
Not clear |
| Rosa Martha Pérez Gutiérrez, Luis Miguel Rodríguez-Serrano, José Fidel Laguna-Chimal, Mónica de la Luz Corea, Silvia Patricia Paredes Carrera, Julio Téllez Gome. Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673848. |
alzheimer's disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. |
2024-04-27 |
2024-04-29 |
Not clear |
| G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. |
2024-04-22 |
2024-04-26 |
mouse |
| Thana Sutthibutpong, Kewalin Posansee, Monrudee Liangruksa, Teerasit Termsaithong, Supanida Piyayotai, Paripok Phitsuwan, Patchreenart Saparpakorn, Supa Hannongbua, Teeraphan Laomettachi. Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from ACS omega. vol 9. issue 14. 2024-04-15. PMID:38617639. |
combining deep learning and structural modeling to identify potential acetylcholinesterase inhibitors from alzheimer's disease (ad) is the most common type of dementia, affecting over 50 million people worldwide. |
2024-04-15 |
2024-04-17 |
Not clear |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
amino-7,8-dihydro-4h-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for alzheimer's disease management; in vitro and in silico study. |
2024-04-10 |
2024-04-13 |
Not clear |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
Not clear |
| Francesco Samarelli, Rosa Purgatorio, Gianfranco Lopopolo, Caterina Deruvo, Marco Catto, Michael Andresini, Antonio Carrieri, Orazio Nicolotti, Annalisa De Palma, Daniela Valeria Miniero, Modesto de Candia, Cosimo D Altomar. Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults. European journal of medicinal chemistry. vol 270. 2024-04-05. PMID:38579622. |
due to the putative role of butyrylcholinesterase (bche) in regulation of acetylcholine levels and functions in the late stages of the alzheimer's disease (ad), the potential of selective inhibitors (bcheis) has been envisaged as an alternative to administration of acetylcholinesterase inhibitors (acheis). |
2024-04-05 |
2024-04-10 |
Not clear |
| Deepali Shukla, Anjali Suryavanshi, Sanjay Kumar Bharti, Vivek Asati, Debarshi Kar Mahapatr. Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective. Current topics in medicinal chemistry. 2024-04-03. PMID:38566385. |
dolopezil, rivastigmine, galantamine, and other acetylcholinesterase inhibitors are among the medications now used to treat alzheimer's disease. |
2024-04-03 |
2024-04-05 |
human |
| A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. |
potential acetylcholinesterase inhibitors to treat alzheimer's disease. |
2024-04-03 |
2024-04-05 |
Not clear |
| Paraskevi Papakyriakopoulou, Georgia Valsami, Kumlesh K De. The Effect of Donepezil Hydrochloride in the Twitcher Mouse Model of Krabbe Disease. Molecular neurobiology. 2024-04-01. PMID:38558359. |
acetylcholinesterase inhibitors (achei) are commonly used for symptomatic management of alzheimer's disease and are suggested to have potential disease-modifying effects, including regulating myelin state. |
2024-04-01 |
2024-04-04 |
mouse |
| Arturo Coaviche-Yoval, Ricardo Tovar-Miranda, Jessica E Rodríguez, Jesus A Lagos-Cruz, Héctor Luna, Erik Andrade-Jorge, José Guadalupe Trujillo-Ferrar. Benzofurans as acetylcholinesterase inhibitors for treating Alzheimer's disease: synthesis, in vitro testing, and in silico analysis. ChemMedChem. 2024-03-30. PMID:38554286. |
benzofurans as acetylcholinesterase inhibitors for treating alzheimer's disease: synthesis, in vitro testing, and in silico analysis. |
2024-03-30 |
2024-04-02 |
Not clear |