| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erica Staurenghi, Gabriella Testa, Valerio Leoni, Rebecca Cecci, Lucrezia Floro, Serena Giannelli, Eugenio Barone, Marzia Perluigi, Gabriella Leonarduzzi, Barbara Sottero, Paola Gamb. Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671883. |
down syndrome (ds) is a complex chromosomal disorder considered as a genetically determined form of alzheimer's disease (ad). |
2024-04-27 |
2024-04-29 |
mouse |
| Emily K Schworer, Benjamin L Handen, Melissa Petersen, Sid O'Bryant, Jamie C Peven, Dana L Tudorascu, Laisze Lee, Sharon J Krinsky-McHale, Christy L Hom, Isabel C H Clare, Bradley T Christian, Nicole Schupf, Joseph H Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M Ances, Shahid Zaman, Adam M Brickman, Florence Lai, H Diana Rosas, Sigan L Hartle. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-04-16. PMID:38623384. |
people with down syndrome (ds) have a 75% to 90% lifetime risk of alzheimer's disease (ad). |
2024-04-16 |
2024-04-18 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, individuals with ds develop progressive dementia and early onset alzheimer's disease (ad). |
2024-04-15 |
2024-04-17 |
Not clear |
| Margherita Grasso, Annamaria Fidilio, Francesca L'Episcopo, Marilena Recupero, Concetta Barone, Maria Giulia Bacalini, Cristina Benatti, Maria Concetta Giambirtone, Giuseppe Caruso, Donatella Greco, Santo Di Nuovo, Corrado Romano, Raffaele Ferri, Serafino Buono, A Claudio Cuello, Johanna M C Blom, Fabio Tascedda, Pier Vincenzo Piazza, Rafael De La Torre, Filippo Carac. Low TGF-β1 plasma levels are associated with cognitive decline in Down syndrome. Frontiers in pharmacology. vol 15. 2024-04-05. PMID:38576478. |
almost all individuals with down's syndrome (ds) show the characteristic neuropathological features of alzheimer's disease (ad) by the age of 40, yet not every individual with ds experiences symptoms of ad later in life. |
2024-04-05 |
2024-04-07 |
human |
| Theodora Panagaki, Lucia Janickova, Dunja Petrovic, Karim Zuhra, Tamás Ditrói, Eszter P Jurányi, Olivier Bremer, Kelly Ascenção, Thilo M Philipp, Péter Nagy, Milos R Filipovic, Csaba Szab. Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H GeroScience. 2024-04-01. PMID:38558215. |
ds is associated with accelerated aging; people with ds are prone to age-related neurological conditions including an early-onset alzheimer's disease. |
2024-04-01 |
2024-04-04 |
mouse |
| Anllely Fernandez, Md Rejaul Hoq, Grace I Hallinan, Daoyi Li, Sakshibeedu R Bharath, Frank S Vago, Xiaoqi Zhang, Kadir A Ozcan, Kathy L Newell, Holly J Garringer, Wen Jiang, Bernardino Ghetti, Ruben Vida. Cryo-EM structures of amyloid-β and tau filaments in Down syndrome. Nature structural & molecular biology. 2024-03-30. PMID:38553642. |
adult individuals with down syndrome (ds) develop alzheimer disease (ad). |
2024-03-30 |
2024-04-01 |
Not clear |
| Debomoy K Lahiri, Deborah K Soko. Alzheimer's Drugs APPlication for Down syndrome? Ageing research reviews. 2024-03-21. PMID:38513771. |
accumulation of the amyloid β (aβ) peptide, derived from aβ precursor protein (app), is a trait of down syndrome (ds), as is early development of dementia like alzheimer's disease (ad). |
2024-03-21 |
2024-03-24 |
human |
| Frode Kibsgaard Larsen, R Asaad Baksh, Eimear McGlinchey, Ellen Melbye Langballe, Bessy Benejam, Jessica Beresford-Webb, Mary McCarron, Antonia Coppus, Segolene Falquero, Juan Fortea, Johannes Levin, Sandra V Loosli, Ruth Mark, Anne-Sophie Rebillat, Shahid Zaman, Andre Strydo. Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-20. PMID:38506627. |
people with down syndrome (ds) have high risk of developing alzheimer's disease (ad). |
2024-03-20 |
2024-03-23 |
Not clear |
| Srikant Sarangi, Olga Minaeva, Danielle M Ledoux, Douglas S Parsons, Juliet A Moncaster, Caitlin A Black, Jeffrey Hollander, Yorghos Tripodis, John I Clark, David G Hunter, Lee E Goldstei. In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome. Experimental eye research. vol 241. 2024-02-29. PMID:38422787. |
ds is accompanied by age-dependent accumulation of alzheimer's disease (ad) amyloid-β (aβ) peptides and amyloid pathology in the brain and comorbid early-onset aβ amyloidopathy and colocalizing cataracts in the lens. |
2024-02-29 |
2024-03-03 |
human |
| Carolina Gastelum Guerrero, Yuridia Lizet Cháidez Fernández, Dalia Magaña Ordorica, Heidi Berger, Marilyn Vazquez Landrove, Alma Guadrón Llanos, Carla Angulo Rojo, Javier Magaña Góme. A systematic review and meta-analysis of serum lipid concentrations in people with Down syndrome. Journal of intellectual disability research : JIDR. 2024-02-26. PMID:38404114. |
the increased life expectancy of individuals with ds has led to a shift in the incidence of non-communicable chronic diseases, resulting in new concerns, particularly cardiovascular disease (cvd) and alzheimer's disease. |
2024-02-26 |
2024-02-28 |
Not clear |
| Natalie DiProspero, Mithra Sathishkumar, John Janecek, Anna Smith, Liv McMillan, Melissa Petersen, Nicholas Tustison, David B Keator, Eric Doran, Christy L Hom, Dana Nguyen, Howard Andrews, Sharon Krinsky-McHale, Adam M Brickman, H Diana Rosas, Florence Lai, Elizabeth Head, Mark Mapstone, Wayne Silverman, Ira T Lott, Sid O'Bryant, Michael A Yass. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 1. 2024-02-13. PMID:38348178. |
virtually all people with down syndrome (ds) develop neuropathology associated with alzheimer's disease (ad). |
2024-02-13 |
2024-02-15 |
Not clear |
| Rodrigo M M Santiago, Vítor Lopes-Dos-Santos, Emily A Aery Jones, Yadong Huang, David Dupret, Adriano B L Tor. Waveform-based classification of dentate spikes. Scientific reports. vol 14. issue 1. 2024-02-05. PMID:38316828. |
we observed that the latter group, which is a model for alzheimer's disease, exhibited wider dss of both types from a young age, with a larger effect size for ds type 2, likely reflecting early pathophysiological alterations in the ec-dg network, such as hyperactivity. |
2024-02-05 |
2024-02-09 |
mouse |
| Iban Aldecoa, Isabel Barroeta, Steven L Carroll, Juan Fortea, Anah Gilmore, Stephen D Ginsberg, Samuel J Guzman, Eric D Hamlett, Elizabeth Head, Sylvia E Perez, Huntington Potter, Laura Molina-Porcel, Ruma Raha-Chowdhury, Thomas Wisniewski, William H Yong, Shahid Zaman, Sujay Ghosh, Elliott J Mufson, Ann-Charlotte Granhol. Down Syndrome Biobank Consortium: A perspective. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-25. PMID:38270275. |
individuals with down syndrome (ds) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset alzheimer's disease (ad)-type dementia by early midlife. |
2024-01-25 |
2024-01-27 |
Not clear |
| Eri Shimizu, Keiko Goto-Hirano, Yumiko Motoi, Masami Arai, Nobutaka Hattor. Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-01-16. PMID:38228941. |
the diagnostic criteria for adult-onset alzheimer's disease (ad) in patients with down syndrome (ds) have not been standardised. |
2024-01-16 |
2024-01-19 |
Not clear |
| Alberto Valdés, José David Sánchez-Martínez, Rocío Gallego, Elena Ibáñez, Miguel Herrero, Alejandro Cifuente. In vivo neuroprotective capacity of a Dunaliella salina extract - comprehensive transcriptomics and metabolomics study. NPJ science of food. vol 8. issue 1. 2024-01-10. PMID:38200022. |
in this study, an exhaustive chemical characterization of a dunaliella salina (ds) microalga extract obtained using supercritical fluids has been performed, and its neuroprotective capacity has been evaluated in vivo using an alzheimer's disease (ad) transgenic model of caenorhabditis elegans (strain cl4176). |
2024-01-10 |
2024-01-13 |
caenorhabditis_elegans |
| Jean M Delabar, Marco Antônio G B Gomes, Marta Fructuoso, Nadège Sarrazin, Nicolas George, Nadia Fleary-Roberts, Hua Sun, Linh Chi Bui, Fernando Rodrigues-Lima, Nathalie Janel, Julien Dairou, Edmilson J Maria, Robert H Dodd, Kevin Cariou, Marie-Claude Potie. EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model. European journal of medicinal chemistry. vol 265. 2024-01-03. PMID:38171148. |
aging neurons of specific brain regions of patients with alzheimer's disease, ds and pick's disease have increased dyrk1a immunoreactivity suggesting a possible association of dyrk1a with neurofibrillary tangle pathology. |
2024-01-03 |
2024-01-06 |
mouse |
| Yi-Wen Wu, Wei-Chun HuangFu, Tony Eight Lin, Chao-Hiang Peng, Huang-Ju Tu, Ting-Yi Sung, Tzu-Ying Sung, Shih-Chung Yen, Shiow-Lin Pan, Kai-Cheng Hs. Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule. International journal of biological macromolecules. 2024-01-01. PMID:38163507. |
the overexpression of dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a), commonly observed in neurodegenerative diseases like alzheimer's disease (ad) and down syndrome (ds), can induce the formation of neurofibrillary tangles (nfts) and amyloid plaques. |
2024-01-01 |
2024-01-05 |
Not clear |
| Beatriz Sánchez-Moreno, Linda Zhang, Gloria Mateo, Fernando Moldenhauer, Mikael Brudfors, John Ashburner, Parashkev Nachev, Diego Real de Asúa, Bryan A Strang. Voxel-based dysconnectomic brain morphometry with computed tomography in Down syndrome. Annals of clinical and translational neurology. 2023-12-30. PMID:38158639. |
alzheimer's disease (ad) is a major health concern for aging adults with down syndrome (ds), but conventional diagnostic techniques are less reliable in those with severe baseline disability. |
2023-12-30 |
2024-01-05 |
Not clear |
| Shannon D R Ringenbach, Nathaniel E Arnold, Kori Tucker, Miya K Rand, Breanna E Studenka, Stockton B Ringenbach, Chih-Chia Che. Assisted Cycle Therapy (ACT) Improved Self-Efficacy and Exercise Perception in Middle-Age Adults with Down Syndrome. Brain sciences. vol 13. issue 12. 2023-12-23. PMID:38137167. |
alzheimer's disease is prevalent in persons with down syndrome (ds) as early as their 30s and presents as decreased social interaction, coordination, and physical activity. |
2023-12-23 |
2023-12-25 |
human |
| Natalie C Edwards, Patrick J Lao, Mohamad J Alshikho, Olivia M Ericsson, Batool Rizvi, Melissa E Petersen, Sid O'Bryant, Lisi Flores-Aguilar, Sabrina Simoes, Mark Mapstone, Dana L Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L Handen, Bradley T Christian, Joseph H Lee, Florence Lai, H Diana Rosas, Shahid Zaman, Ira T Lott, Michael A Yassa, José Gutierrez, Donna M Wilcock, Elizabeth Head, Adam M Brickma. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-12-11. PMID:38076904. |
by age 40 years over 90% of adults with down syndrome (ds) have alzheimer's disease (ad) pathology and most progress to dementia. |
2023-12-11 |
2023-12-17 |
Not clear |