| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang-Shuai Shen, Cui Liu, Hui-Zhe Sun, Xin-Yi Chen, Yan Xue, Lei Che. Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS. Journal of leukocyte biology. 2024-05-03. PMID:38700080. |
in alzheimer's disease, microglia employ complement-dependent mechanisms for synapse engulfment in tauopathy and early β-amyloid pathology. |
2024-05-03 |
2024-05-05 |
Not clear |
| Bridget K Greuel, Dylan E Da Silva, Victoria N Robert-Gostlin, Andis Klegeri. Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia. Brain sciences. vol 14. issue 4. 2024-04-27. PMID:38671980. |
accumulating evidence indicates that the adverse neuroimmune activation of microglia, brain immunocytes that support neurons, contributes to a range of neuroinflammatory disorders, including alzheimer's disease. |
2024-04-27 |
2024-04-29 |
human |
| Tracy Butler, Xiuyuan Wang, Gloria Chiang, Ke Xi, Sumit Niogi, Lidia Glodzik, Yi Li, Qolamreza Ray Razlighi, Liangdong Zhou, Seyed Hani Hojjati, Ilker Ozsahin, Xiangling Mao, Thomas Maloney, Emily Tanzi, Nesrine Rahmouni, Cécile Tissot, Firoza Lussier, Sudhin Shah, Dikoma Shungu, Ajay Gupta, Mony De Leon, P David Mozley, Tharick Pascoal, Pedro Rosa-Net. Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669537. |
reduction in constitutively activated auditory brainstem microglia in aging and alzheimer's disease. |
2024-04-26 |
2024-04-29 |
Not clear |
| Tracy Butler, Xiuyuan Wang, Gloria Chiang, Ke Xi, Sumit Niogi, Lidia Glodzik, Yi Li, Qolamreza Ray Razlighi, Liangdong Zhou, Seyed Hani Hojjati, Ilker Ozsahin, Xiangling Mao, Thomas Maloney, Emily Tanzi, Nesrine Rahmouni, Cécile Tissot, Firoza Lussier, Sudhin Shah, Dikoma Shungu, Ajay Gupta, Mony De Leon, P David Mozley, Tharick Pascoal, Pedro Rosa-Net. Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669537. |
alzheimer's disease (ad) pathology is considered to begin in the brainstem, and cerebral microglia are known to play a critical role in ad pathogenesis, yet little is known about brainstem microglia in ad. |
2024-04-26 |
2024-04-29 |
Not clear |
| Radhika Joshi, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szab. IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-24. PMID:38654824. |
moreover, expression of a constitutively active irf3 (s388d/s390d:irf3-2d) in microglia induces a transcriptional program reminiscent of the activated response microglia and the expression of genes associated with alzheimer's disease, notably |
2024-04-24 |
2024-04-28 |
Not clear |
| Daniel C Shippy, Sophia F Oliai, Tyler K Ullan. Zinc utilization by microglia in Alzheimer's disease. The Journal of biological chemistry. 2024-04-22. PMID:38648940. |
zinc utilization by microglia in alzheimer's disease. |
2024-04-22 |
2024-04-26 |
Not clear |
| Sujun Jiang, Guoen Cai, Zhimin Yang, Haoyuan Shi, Huajie Zeng, Qinyong Ye, Zhiyuan Hu, Zihua Wan. Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease. ACS nano. 2024-04-22. PMID:38649866. |
the association between dysfunctional microglia and amyloid-β (aβ) is a fundamental pathological event and increases the speed of alzheimer's disease (ad). |
2024-04-22 |
2024-04-26 |
mouse |
| Stefanie Fruhwürth, Henrik Zetterberg, Søren R Paluda. Microglia and amyloid plaque formation in Alzheimer's disease - Evidence, possible mechanisms, and future challenges. Journal of neuroimmunology. vol 390. 2024-04-19. PMID:38640827. |
microglia and amyloid plaque formation in alzheimer's disease - evidence, possible mechanisms, and future challenges. |
2024-04-19 |
2024-04-22 |
Not clear |
| Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwart. Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain. Nature neuroscience. 2024-04-18. PMID:38637622. |
identification of senescent, trem2-expressing microglia in aging and alzheimer's disease model mouse brain. |
2024-04-18 |
2024-04-21 |
mouse |
| Xiqi Hu, Ya-Nan Ma, Ying Xi. Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia. Bioscience trends. 2024-04-17. PMID:38631884. |
association between abnormal lipid metabolism and alzheimer's disease: new research has revealed significant findings on the apoe4 genotype in microglia. |
2024-04-17 |
2024-04-20 |
Not clear |
| Zihao Li, Cun-Jin Zhan. Isolation and Culture of Mouse Primary Microglia and Oligodendrocyte Precursor Cells. Methods in molecular biology (Clifton, N.J.). vol 2782. 2024-04-15. PMID:38622401. |
microglia and oligodendrocyte precursor cells (opcs) are critical glia subsets in the central nervous system (cns) and are actively engaged in a body of diseases, such as stroke, alzheimer's disease, multiple sclerosis, etc. |
2024-04-15 |
2024-04-18 |
mouse |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
microglia play a pivotal role in the pathology of alzheimer's disease (ad), with the triggering receptor expressed on myeloid cells 2 (trem2) central to their neuroprotective functions. |
2024-04-13 |
2024-04-16 |
mouse |
| Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, Maria Latorre Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia Fragkopoulou, André Fisahn, Luis Enrique Arroyo-Garcí. Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression. Brain, behavior, and immunity. 2024-04-12. PMID:38608739. |
recent evidence highlights the role of neuroinflammation, particularly involving microglia, in alzheimer's disease onset and progression. |
2024-04-12 |
2024-04-15 |
Not clear |
| Imdadul Haq, Jason C Ngo, Nainika Roy, Richard L Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K Soni, Xuebing Wu, David A Bennett, Vilas Menon, Marta Olah, Falak She. An integrated toolkit for human microglia functional genomics. Stem cell research & therapy. vol 15. issue 1. 2024-04-10. PMID:38600587. |
microglia, the brain's resident immune cells, play vital roles in brain development, and disorders like alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
human |
| Carla Cuní-López, Romal Stewart, Lotta E Oikari, Tam Hong Nguyen, Tara L Roberts, Yifan Sun, Christine C Guo, Michelle K Lupton, Anthony R White, Hazel Que. Correction: Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-04-10. PMID:38600570. |
correction: advanced patient-specific microglia cell models for pre-clinical studies in alzheimer's disease. |
2024-04-10 |
2024-04-13 |
Not clear |
| Izabela Lepiarz-Raba, Taufik Hidayat, Anthony J Hannan, Ali Jawai. Potential Alzheimer's disease drug targets identified through microglial biology research. Expert opinion on drug discovery. 2024-04-09. PMID:38590098. |
microglia, the primary immune cells in the brain, play multifaceted roles in alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fu. Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation. American journal of Alzheimer's disease and other dementias. vol 39. 2024-04-09. PMID:38592304. |
triggering receptor expressed on myeloid cells 2 (trem2) is upregulated in activated microglia and may be related to cognitive decline in patients with alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Jinchao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Yiyang Zhu, Nicole D Wagner, Nolan McLaughlin, Xinyi Cynthia Kuang, Alexander D Barrow, Dian Li, Yingyue Zhou, Shoutang Wang, Susan Gilfillan, Michael L Gross, Simone Brioschi, Yongjian Liu, David M Holtzman, Marco Colonn. Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Science translational medicine. vol 16. issue 741. 2024-04-03. PMID:38569016. |
microglia help limit the progression of alzheimer's disease (ad) by constraining amyloid-β (aβ) pathology, effected through a balance of activating and inhibitory intracellular signals delivered by distinct cell surface receptors. |
2024-04-03 |
2024-04-06 |
mouse |
| Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-Aad, Huan Li, Matthew P Frosch, Markus P Kummer, Sudeshna Das, Tammy Dellovade, Eric H Karran, Xavier Langlois, Janina S Ried, Alberto Serrano-Pozo, Robert V Talanian, Knut Biber, Bradley T Hyma. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta neuropathologica. vol 147. issue 1. 2024-04-01. PMID:38557897. |
human microglia are critically involved in alzheimer's disease (ad) progression, as shown by genetic and molecular studies. |
2024-04-01 |
2024-04-04 |
human |
| Mengmeng Jin, Ziyuan Ma, Rui Dang, Haiwei Zhang, Rachael Kim, Haipeng Xue, Jesse Pascual, Steven Finkbeiner, Elizabeth Head, Ying Liu, Peng Jian. A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559257. |
a trisomy 21-linked hematopoietic gene variant in microglia confers resilience in human ipsc models of alzheimer's disease. |
2024-04-01 |
2024-04-04 |
human |