| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mara Mathe. The emotion paradox in the aging body and brain. Annals of the New York Academy of Sciences. 2024-04-27. PMID:38676452. |
in this model, failing organs, the initial phases of alzheimer's pathology, and other age-related diseases trigger noradrenergic hyperactivity. |
2024-04-27 |
2024-04-30 |
Not clear |
| Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Nicola Martini, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorg. The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation. Brain structure & function. 2024-04-16. PMID:38625557. |
the noradrenergic nucleus locus coeruleus (lc) is precociously involved in alzheimer's disease (ad) pathology, and its degeneration progresses during the course of the disease. |
2024-04-16 |
2024-04-18 |
Not clear |
| Ania Majewska, Linh Le, Alexis Feidler, Herman Li, Kallam Kara-Pabani, Cassandra Lamantia, M Kerry O'Banio. Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors. Research square. 2024-03-11. PMID:38464247. |
noradrenergic signaling controls alzheimer's disease pathology via activation of microglial β2 adrenergic receptors. |
2024-03-11 |
2024-03-14 |
mouse |
| Chen-Pei Lin, Irene Frigerio, John G J M Bol, Maud M A Bouwman, Alex J Wesseling, Martin J Dahl, Annemieke J M Rozemuller, Ysbrand D van der Werf, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration. vol 13. issue 1. 2024-02-09. PMID:38336865. |
microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in alzheimer's disease and parkinson's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Chen-Pei Lin, Irene Frigerio, John G J M Bol, Maud M A Bouwman, Alex J Wesseling, Martin J Dahl, Annemieke J M Rozemuller, Ysbrand D van der Werf, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration. vol 13. issue 1. 2024-02-09. PMID:38336865. |
degeneration of the locus coeruleus (lc) noradrenergic system contributes to clinical symptoms in alzheimer's disease (ad) and parkinson's disease (pd). |
2024-02-09 |
2024-02-12 |
Not clear |
| L Le, A M Feidler, H Li, K Kara-Pabani, C Lamantia, M K O'Banion, K A Majewsk. Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors. bioRxiv : the preprint server for biology. 2023-12-18. PMID:38106167. |
noradrenergic signaling controls alzheimer's disease pathology via activation of microglial β2 adrenergic receptors. |
2023-12-18 |
2023-12-21 |
mouse |
| Emad H M Hassanein, Hanan S Althagafy, Mohammad A Baraka, Esraa K Abd-Alhameed, Islam M Ibrahi. Pharmacological update of mirtazapine: a narrative literature review. Naunyn-Schmiedeberg's archives of pharmacology. 2023-11-09. PMID:37943296. |
mtz is hypothesized to have antidepressant effects because of the synergy between noradrenergic and serotonergic actions and is effective in treating major depressive disorder and depression associated with epilepsy, alzheimer's disease, stroke, cardiovascular disease, and respiratory disease. |
2023-11-09 |
2023-11-20 |
Not clear |
| Martin J Dahl, Agnieszka Kulesza, Markus Werkle-Bergner, Mara Mathe. Declining locus coeruleus-dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer's disease. Neuroscience and biobehavioral reviews. 2023-08-19. PMID:37597700. |
declining locus coeruleus-dopaminergic and noradrenergic modulation of long-term memory in aging and alzheimer's disease. |
2023-08-19 |
2023-09-07 |
Not clear |
| Martin J Dahl, Agnieszka Kulesza, Markus Werkle-Bergner, Mara Mathe. Declining locus coeruleus-dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer's disease. Neuroscience and biobehavioral reviews. 2023-08-19. PMID:37597700. |
new in-vivo assessments of locus coeruleus integrity reveal associations with alzheimer's markers and late-life memory impairments, which likely stem from impaired dopaminergic and noradrenergic neurotransmission. |
2023-08-19 |
2023-09-07 |
Not clear |
| F Krohn, E Lancini, M Ludwig, M Leiman, G Guruprasath, L Haag, J Panczyszyn, E Düzel, D Hämmerer, M Bett. Noradrenergic neuromodulation in ageing and disease. Neuroscience and biobehavioral reviews. 2023-07-12. PMID:37437752. |
the extent of degeneration to the lc in healthy ageing remains unclear, however, noradrenergic dysfunction may contribute to the pathogenesis of alzheimer's (ad) and parkinson's disease (pd). |
2023-07-12 |
2023-08-14 |
Not clear |
| Alexa F Iannitelli, David Weinshenke. Riddles in the Dark: Decoding the Relationship Between Neuromelanin and Neurodegeneration in Locus Coeruleus Neurons. Neuroscience and biobehavioral reviews. 2023-06-16. PMID:37327835. |
the noradrenergic locus coeruleus (lc) is among the first regions of the brain affected by pathology in both alzheimer's disease (ad) and parkinson's disease (pd), but the reasons for this selective vulnerability are not completely understood. |
2023-06-16 |
2023-08-14 |
human |
| Junko Ohishi-Fukuchi, Yoshiomi Imamura, Ryuzo Orihashi, Hiroko Kunitake, Yutaka Kunitake, Hiroshi Tateishi, Shigeto Yamada, Akira Monji, Yoshito Mizoguch. Salivary 3-methoxy-4-hydroxyphenylglycol and MRI-based volume change of the precuneus in community-dwelling elderly people. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2023-05-29. PMID:37248036. |
in addition, hypofunction of noradrenergic systems is supposed to be involved in the pathophysiology of alzheimer's disease. |
2023-05-29 |
2023-08-14 |
Not clear |
| Elisa Lancini, Lena Haag, Franziska Bartl, Maren Rühling, Nicholas J Ashton, Henrik Zetterberg, Emrah Düzel, Dorothea Hämmerer, Matthew J Bett. Cerebrospinal fluid and positron-emission tomography biomarkers for noradrenergic dysfunction in neurodegenerative diseases: a systematic review and meta-analysis. Brain communications. vol 5. issue 3. 2023-05-08. PMID:37151227. |
the noradrenergic system shows pathological modifications in aging and neurodegenerative diseases and undergoes substantial neuronal loss in alzheimer's disease and parkinson's disease. |
2023-05-08 |
2023-08-14 |
Not clear |
| Isabella F Orlando, James M Shine, Trevor W Robbins, James B Rowe, Claire O'Callagha. Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing. Neuroscience and biobehavioral reviews. 2023-04-13. PMID:37054802. |
noradrenergic and cholinergic systems are among the most vulnerable brain systems in neuropsychiatric diseases of ageing, including alzheimer's disease, parkinson's disease, lewy body dementia, and progressive supranuclear palsy. |
2023-04-13 |
2023-08-14 |
Not clear |
| Jungwon Min, Jeremy Rouanet, Alessandra Cadete Martini, Kaoru Nashiro, Hyun Joo Yoo, Shai Porat, Christine Cho, Junxiang Wan, Steve W Cole, Elizabeth Head, Daniel A Nation, Julian F Thayer, Mara Mathe. Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Scientific reports. vol 13. issue 1. 2023-03-09. PMID:36894565. |
slow paced breathing via heart rate variability (hrv) biofeedback stimulates vagus-nerve pathways that counter noradrenergic stress and arousal pathways that can influence production and clearance of alzheimer's disease (ad)-related proteins. |
2023-03-09 |
2023-08-14 |
Not clear |
| Gioacchino de Leo, Rosario Gulino, Marino Coradazzi, Giampiero Leanz. Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory. Brain communications. vol 5. issue 1. 2023-01-12. PMID:36632183. |
severe loss of cholinergic neurons in the basal forebrain nuclei and of noradrenergic neurons in the locus coeruleus are almost invariant histopathological hallmarks of alzheimer's disease. |
2023-01-12 |
2023-08-14 |
human |
| Anna B Szabo, Vanessa Cattaud, Charlotte Bezzina, Robin F Dard, Fares Sayegh, Sebastien Gauzin, Camille Lejards, Luc Valton, Claire Rampon, Laure Verret, Lionel Daha. Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease - the influence of sleep and noradrenergic transmission. Neurobiology of aging. vol 123. 2023-01-12. PMID:36634385. |
neuronal hyperexcitability in the tg2576 mouse model of alzheimer's disease - the influence of sleep and noradrenergic transmission. |
2023-01-12 |
2023-08-14 |
mouse |
| Alexa F Iannitelli, Michael A Kelberman, Daniel J Lustberg, Anu Korukonda, Katharine E McCann, Bernard Mulvey, Arielle Segal, L Cameron Liles, Steven A Sloan, Joseph D Dougherty, David Weinshenke. The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease. eNeuro. 2023-01-12. PMID:36635251. |
the noradrenergic locus coeruleus (lc) is among the earliest sites of tau and alpha-synuclein pathology in alzheimer's disease (ad) and parkinson's disease (pd), respectively. |
2023-01-12 |
2023-08-14 |
mouse |
| Masud Husai. Noradrenergic therapies for apathy in Alzheimer's disease? Journal of neurology, neurosurgery, and psychiatry. 2023-01-05. PMID:36600570. |
noradrenergic therapies for apathy in alzheimer's disease? |
2023-01-05 |
2023-08-14 |
Not clear |
| Giampiero Leanza, Robert Zore. Towards Astroglia-based Noradrenergic Hypothesis of Alzheimer's Disease. Function (Oxford, England). vol 4. issue 1. 2023-01-02. PMID:36590326. |
towards astroglia-based noradrenergic hypothesis of alzheimer's disease. |
2023-01-02 |
2023-08-14 |
Not clear |