| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Camille Noiray, Stéphane Lehericy, Romain Valabrègue, Fabien Caillé, Philippe Gervais, Martin Moussion, Michel Bottlaender, Marie Sarazi. Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer's disease, suspected-LATE and frontotemporal dementia. Alzheimer's research & therapy. vol 16. issue 1. 2024-05-04. PMID:38702802. |
combined in vivo mri assessment of locus coeruleus and nucleus basalis of meynert integrity in amnestic alzheimer's disease, suspected-late and frontotemporal dementia. |
2024-05-04 |
2024-05-06 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Camille Noiray, Stéphane Lehericy, Romain Valabrègue, Fabien Caillé, Philippe Gervais, Martin Moussion, Michel Bottlaender, Marie Sarazi. Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer's disease, suspected-LATE and frontotemporal dementia. Alzheimer's research & therapy. vol 16. issue 1. 2024-05-04. PMID:38702802. |
the locus coeruleus (lc) and the nucleus basalis of meynert (nbm) are altered in early stages of alzheimer's disease (ad). |
2024-05-04 |
2024-05-06 |
Not clear |
| Yoo Hyun Um, Sheng-Min Wang, Dong Woo Kang, Sunghwan Kim, Chang Uk Lee, Donghyeon Kim, Yeong Sim Choe, Regina E Y Kim, Soyoung Lee, Min-Kyung Lee, Hyun Kook Li. Impact of Apolipoprotein E4 on the Locus Coeruleus Functional Connectivity in Preclinical Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669549. |
impact of apolipoprotein e4 on the locus coeruleus functional connectivity in preclinical alzheimer's disease. |
2024-04-26 |
2024-04-29 |
Not clear |
| Yoo Hyun Um, Sheng-Min Wang, Dong Woo Kang, Sunghwan Kim, Chang Uk Lee, Donghyeon Kim, Yeong Sim Choe, Regina E Y Kim, Soyoung Lee, Min-Kyung Lee, Hyun Kook Li. Impact of Apolipoprotein E4 on the Locus Coeruleus Functional Connectivity in Preclinical Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669549. |
recent interest has surged in the locus coeruleus (lc) for its early involvement in alzheimer's disease (ad), notably concerning the apolipoprotein ɛ4 allele (apoe4). |
2024-04-26 |
2024-04-29 |
Not clear |
| Elisenda Bueichekú, Ibai Diez, Chan-Mi Kim, John Alex Becker, Elouise A Koops, Kenneth Kwong, Kathryn V Papp, David H Salat, David A Bennett, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Jorge Sepulcre, Heidi I L Jacob. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature aging. 2024-04-25. PMID:38664576. |
autopsy studies indicated that the locus coeruleus (lc) accumulates hyperphosphorylated tau before allocortical regions in alzheimer's disease. |
2024-04-25 |
2024-04-28 |
Not clear |
| Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Nicola Martini, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorg. The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation. Brain structure & function. 2024-04-16. PMID:38625557. |
the degeneration of locus coeruleus occurring during alzheimer's disease clinical progression: a neuroimaging follow-up investigation. |
2024-04-16 |
2024-04-18 |
Not clear |
| Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Nicola Martini, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorg. The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation. Brain structure & function. 2024-04-16. PMID:38625557. |
the noradrenergic nucleus locus coeruleus (lc) is precociously involved in alzheimer's disease (ad) pathology, and its degeneration progresses during the course of the disease. |
2024-04-16 |
2024-04-18 |
Not clear |
| Elise Beckers, Joost M Riphagen, Maxime Van Egroo, David A Bennett, Heidi I L Jacob. Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-12. PMID:38607758. |
sparse asymmetry in locus coeruleus pathology in alzheimer's disease. |
2024-04-12 |
2024-04-15 |
Not clear |
| Elise Beckers, Joost M Riphagen, Maxime Van Egroo, David A Bennett, Heidi I L Jacob. Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-12. PMID:38607758. |
tau accumulation in and neurodegeneration of locus coeruleus (lc) neurons is observed in alzheimer's disease (ad). |
2024-04-12 |
2024-04-15 |
Not clear |
| Francesca Biagioni, Michela Ferrucci, Gloria Lazzeri, Mariarosaria Scioli, Alessandro Frati, Stefano Puglisi-Allegra, Francesco Forna. Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542133. |
the present investigation was designed based on the evidence that, in neurodegenerative disorders, such as alzheimer's dementia (ad) and parkinson's disease (pd), damage to the locus coeruleus (lc) arising norepinephrine (ne) axons (lc-ne) is documented and hypothesized to foster the onset and progression of neurodegeneration within target regions. |
2024-03-28 |
2024-03-30 |
mouse |
| Maxime Van Egroo, Eus J W van Someren, Lea T Grinberg, David A Bennett, Heidi I L Jacob. Associations of 24-Hour Rest-Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease. Annals of neurology. 2024-02-26. PMID:38407546. |
associations of 24-hour rest-activity rhythm fragmentation, cognitive decline, and postmortem locus coeruleus hypopigmentation in alzheimer's disease. |
2024-02-26 |
2024-02-28 |
Not clear |
| Maxime Van Egroo, Eus J W van Someren, Lea T Grinberg, David A Bennett, Heidi I L Jacob. Associations of 24-Hour Rest-Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease. Annals of neurology. 2024-02-26. PMID:38407546. |
while studies suggested that locus coeruleus (lc) neurodegeneration contributes to sleep-wake dysregulation in alzheimer's disease (ad), the association between lc integrity and circadian rest-activity patterns remains unknown. |
2024-02-26 |
2024-02-28 |
Not clear |
| Rebecca Beardmore, Matthew Durkin, Faizan Zayee-Mellick, Laurie C Lau, James A R Nicoll, Clive Holmes, Delphine Boch. Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-20. PMID:38374720. |
changes in the locus coeruleus during the course of alzheimer's disease and their relationship to cortical pathology. |
2024-02-20 |
2024-02-22 |
human |
| Rebecca Beardmore, Matthew Durkin, Faizan Zayee-Mellick, Laurie C Lau, James A R Nicoll, Clive Holmes, Delphine Boch. Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-20. PMID:38374720. |
in alzheimer's disease (ad), the locus coeruleus (lc) undergoes early and extensive neuronal loss, preceded by abnormal intracellular tau aggregation, decades before the onset of clinical disease. |
2024-02-20 |
2024-02-22 |
human |
| L Gong, K Chen, H Zhang, S Zhang, W Luo, W Zhou, B Zhang, R Xu, C X. Higher Cognitive Reserve Is Beneficial for Cognitive Performance Via Various Locus Coeruleus Functional Pathways in the Pre-Dementia Stage of Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 2. 2024-02-20. PMID:38374755. |
higher cognitive reserve is beneficial for cognitive performance via various locus coeruleus functional pathways in the pre-dementia stage of alzheimer's disease. |
2024-02-20 |
2024-02-22 |
Not clear |
| Benjamin S Zide, Nancy J Donovan, Soyoung Lee, Sukriti Nag, David A Bennett, Heidi I L Jacob. Social activity mediates locus coeruleus tangle-related cognition in older adults. Molecular psychiatry. 2024-02-14. PMID:38355788. |
conversely, accumulation of tau tangles in the brainstem locus coeruleus nuclei is recently studied as a very early marker of alzheimer's disease (ad) pathogenesis and cognitive vulnerability, even among older adults without cognitive impairment or significant cerebral ad pathologies. |
2024-02-14 |
2024-02-17 |
Not clear |
| Chen-Pei Lin, Irene Frigerio, John G J M Bol, Maud M A Bouwman, Alex J Wesseling, Martin J Dahl, Annemieke J M Rozemuller, Ysbrand D van der Werf, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration. vol 13. issue 1. 2024-02-09. PMID:38336865. |
microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in alzheimer's disease and parkinson's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Chen-Pei Lin, Irene Frigerio, John G J M Bol, Maud M A Bouwman, Alex J Wesseling, Martin J Dahl, Annemieke J M Rozemuller, Ysbrand D van der Werf, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration. vol 13. issue 1. 2024-02-09. PMID:38336865. |
degeneration of the locus coeruleus (lc) noradrenergic system contributes to clinical symptoms in alzheimer's disease (ad) and parkinson's disease (pd). |
2024-02-09 |
2024-02-12 |
Not clear |
| Giulia Quattrini, Lorenzo Pini, Ilaria Boscolo Galazzo, Ileana O Jelescu, Jorge Jovicich, Rosa Manenti, Giovanni B Frisoni, Moira Marizzoni, Francesca B Pizzini, Michela Pievan. Microstructural alterations in the locus coeruleus-entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 1. 2024-01-12. PMID:38213948. |
we investigated in vivo the microstructural integrity of the pathway connecting the locus coeruleus to the transentorhinal cortex (lc-tec) in patients with alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2024-01-12 |
2024-01-14 |
Not clear |
| Tyler R Bell, Carol E Franz, Lisa T Eyler, Christine Fennema-Notestine, Olivia K Puckett, Stephen M Dorros, Matthew S Panizzon, Rahul C Pearce, Donald J Hagler, Michael J Lyons, Asad Beck, Jeremy A Elman, William S Kreme. Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men. The journal of pain. 2024-01-10. PMID:38199594. |
in this study, we provide one of the first assessments in humans, examining the associations of probable chronic pain with hippocampal volume, integrity of the locus coeruleus (lc)-an upstream site of tau deposition-and alzheimer's disease (ad)-related plasma biomarkers. |
2024-01-10 |
2024-01-13 |
mouse |