| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Larry Baum, Chi Chiu Lee, Rui Ye, Yuanxin Zhong, Se Fong Hung, Chun Pan Tang, Ting Pong Ho, James M Swanson, Robert K Moyzis, Pak-Chung Sham, Patrick Wing-Leung Leun. Attention-deficit/hyperactivity disorder and dopamine receptor D4 (DRD4) exon 3 variable number of tandem repeats (VNTR) 2-repeat allele. Annals of human genetics. 2024-04-16. PMID:38624263. |
to investigate the association of attention-deficit/hyperactivity disorder (adhd) with the 48-base pair (bp) variable number of tandem repeats (vntr) in exon 3 of the dopamine receptor d4 (drd4) gene, we genotyped 240 adhd patients and their parents from hong kong. |
2024-04-16 |
2024-04-18 |
Not clear |
| Margus Kanarik, Oliver Grimm, Nina Roth Mota, Andreas Reif, Jaanus Harr. ADHD co-morbidities: A review of implication of gene × environment effects with dopamine-related genes. Neuroscience and biobehavioral reviews. 2022-07-01. PMID:35777579. |
some evidence suggest that the variable number tandem repeats in drd4 and maoa may mediate gxe interactions in adhd generally, and comorbid conditions specifically. |
2022-07-01 |
2023-08-14 |
Not clear |
| Annika L Weiß, Mandy Meijer, Bettina Budeus, Marc Pauper, Marina Hakobjan, Johanne Groothuismink, Yan Shi, Kornelia Neveling, Jan K Buitelaar, Martine Hoogman, Barbara Franke, Marieke Klei. DNA methylation associated with persistent ADHD suggests TARBP1 as novel candidate. Neuropharmacology. vol 184. 2021-10-22. PMID:33137342. |
dna methylation of single sites within drd4 and kldr1 was associated with adult adhd status, and multiple dna methylation sites within tarbp1 were associated with adhd symptoms in adulthood and childhood. |
2021-10-22 |
2023-08-13 |
Not clear |
| Shuangli Chen, Andan Qian, Jiejie Tao, Ronghui Zhou, Chuqi Fu, Chuang Yang, Qingxia Lin, JieJie Zhou, Jiance Li, Xiaoqi Huang, Meihao Wan. Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls. Brain imaging and behavior. 2021-08-18. PMID:34406637. |
different effects of the drd4 genotype on intrinsic brain network connectivity strength in drug-naïve children with adhd and healthy controls. |
2021-08-18 |
2023-08-13 |
human |
| Shuangli Chen, Andan Qian, Jiejie Tao, Ronghui Zhou, Chuqi Fu, Chuang Yang, Qingxia Lin, JieJie Zhou, Jiance Li, Xiaoqi Huang, Meihao Wan. Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls. Brain imaging and behavior. 2021-08-18. PMID:34406637. |
the dopamine d4 receptor gene (drd4) has been consistently reported to be associated with attention-deficit/hyperactivity disorder (adhd). |
2021-08-18 |
2023-08-13 |
human |
| Shuangli Chen, Andan Qian, Jiejie Tao, Ronghui Zhou, Chuqi Fu, Chuang Yang, Qingxia Lin, JieJie Zhou, Jiance Li, Xiaoqi Huang, Meihao Wan. Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls. Brain imaging and behavior. 2021-08-18. PMID:34406637. |
the current study aimed to compare the effects of the drd4 genotype on functional integrity in drug-naïve adhd children and healthy children. |
2021-08-18 |
2023-08-13 |
human |
| Shuangli Chen, Andan Qian, Jiejie Tao, Ronghui Zhou, Chuqi Fu, Chuang Yang, Qingxia Lin, JieJie Zhou, Jiance Li, Xiaoqi Huang, Meihao Wan. Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls. Brain imaging and behavior. 2021-08-18. PMID:34406637. |
this genetic imaging study suggests that the drd4 genotype regulates the functional integration of brain networks in children with adhd and hcs differently. |
2021-08-18 |
2023-08-13 |
human |
| Shuangli Chen, Andan Qian, Jiejie Tao, Ronghui Zhou, Chuqi Fu, Chuang Yang, Qingxia Lin, JieJie Zhou, Jiance Li, Xiaoqi Huang, Meihao Wan. Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls. Brain imaging and behavior. 2021-08-18. PMID:34406637. |
this may have important implications for our understanding of the role of drd4 in altering functional connectivity in adhd subjects. |
2021-08-18 |
2023-08-13 |
human |
| Djûke M Brinksma, Pieter J Hoekstra, Annelies de Bildt, Jan K Buitelaar, Barbara J van den Hoofdakker, Catharina A Hartman, Andrea Dietric. Parental rejection in early adolescence predicts a persistent ADHD symptom trajectory across adolescence. European child & adolescent psychiatry. 2021-07-18. PMID:34275051. |
here, we investigated how children perceived their parents' parenting style (i.e., rejection, overprotection, and emotional warmth) at the age of 11, and their interaction with drd4, maoa, and 5-httlpr genotypes on parent-reported adhd symptoms at three time points (mean ages 11.1, 13.4, and 16.2 years) in 1730 adolescents from the tracking adolescents' individual lives survey (trails). |
2021-07-18 |
2023-08-13 |
Not clear |
| Cristian Bonvicini, Samuele Cortese, Carlo Maj, Bernhard T Baune, Stephen V Faraone, Catia Scassellat. DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32075956. |
using bioinformatics tools, based on the latest genome-wide association (gwas) meta-analysis of the psychiatry genomic consortium (pgc), we demonstrated that the 48 bp vntr is not in linkage disequilibrium with the drd4 snps (single nucleotide polymorphisms), which were not found to be associated with adhd. |
2021-06-18 |
2023-08-13 |
Not clear |
| Cristian Bonvicini, Samuele Cortese, Carlo Maj, Bernhard T Baune, Stephen V Faraone, Catia Scassellat. DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32075956. |
moreover, a drd4 expression downregulation was found in adhd specific brain regions (putamen, z score = -3.02, p = 0.00252). |
2021-06-18 |
2023-08-13 |
Not clear |
| Cristian Bonvicini, Samuele Cortese, Carlo Maj, Bernhard T Baune, Stephen V Faraone, Catia Scassellat. DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32075956. |
overall, our results suggest that drd4 48 bp vntr variants should be considered as biomarkers to support the diagnosis of adhd and to predict mph response, although the accuracy of such a biomarker remains to be further elucidated. |
2021-06-18 |
2023-08-13 |
Not clear |
| Stefania Zampatti, Michele Ragazzo, Carlo Fabrizio, Andrea Termine, Giulia Campoli, Valerio Caputo, Claudia Strafella, Raffaella Cascella, Carlo Caltagirone, Emiliano Giardin. Genetic Variants Allegedly Linked to Antisocial Behaviour Are Equally Distributed Across Different Populations. Journal of personalized medicine. vol 11. issue 3. 2021-04-13. PMID:33809805. |
in particular, allelic variants in slc6a4, maoa, drd4, and drd2 showed statistical associations with major depressive disorder, antisocial behaviour, schizophrenia, and bipolar disorder; bdnf polymorphic variants were associated with depressive, bipolar, and schizophrenia diseases, and tph2 variants were found both in people with unipolar depression and in children with attention deficit-hyperactivity disorder (adhd). |
2021-04-13 |
2023-08-13 |
human |
| Hilmi Bolat, Eyüp S Ercan, Gül Ünsel-Bolat, Akin Tahillioğlu, Kemal U Yazici, Ali Bacanli, Erhan Pariltay, Duygu Aygüneş Jafari, Buket Kosova, Semiha Özgül, Luis A Rohde, Haluk Aki. DRD4 genotyping may differentiate symptoms of attention-deficit/hyperactivity disorder and sluggish cognitive tempo. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 42. issue 6. 2020-11-27. PMID:32491038. |
the aim of this study was to investigate if the prevalence of two variable-number tandem repeats (vntrs) located within the 3'-untranslated region of the dat1 gene and in exon 3 of the dopamine d4 receptor (drd4) gene differ among four groups (31 subjects with sct but no adhd, 146 individuals with adhd but no sct, 67 subjects with sct + adhd, and 92 healthy controls). |
2020-11-27 |
2023-08-13 |
human |
| Andrieke J A M Thissen, Janita Bralten, Nanda N J Rommelse, Alejandro Arias-Vasquez, Corina U Greven, Dirk Heslenfeld, Marjolein Luman, Jaap Oosterlaan, Pieter J Hoekstra, Catharina Hartman, Barbara Franke, Jan K Buitelaa. The role of age in association analyses of ADHD and related neurocognitive functioning: A proof of concept for dopaminergic and serotonergic genes. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 6. 2020-10-01. PMID:25586935. |
associations of three genetic adhd risk factors, dat1, drd4, and 5-htt with symptoms and six neurocognitive measures were explored in two samples of the neuroimage study: 756 children, adolescents, and young adults with adhd, their siblings, and controls (m age 17 years, sd 3.2), and 393 parents with and without adhd (m age 48 years, sd 4.8). |
2020-10-01 |
2023-08-13 |
Not clear |
| Andan Qian, Jiejie Tao, Xin Wang, Huiru Liu, Lingxiao Ji, Chuang Yang, Qiong Ye, Chengchun Chen, Jiance Li, Jingliang Cheng, Meihao Wang, Ke Zha. Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD. Frontiers in human neuroscience. vol 12. 2020-10-01. PMID:30050420. |
effects of the 2-repeat allele of the drd4 gene on neural networks associated with the prefrontal cortex in children with adhd. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cristina Sánchez-Mora, Vanesa Richarte, Iris Garcia-Martínez, Mireia Pagerols, Montse Corrales, Rosa Bosch, Raquel Vidal, Laia Viladevall, Miguel Casas, Bru Cormand, Josep Antoni Ramos-Quiroga, Marta Ribasé. Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 6. 2020-09-30. PMID:26174753. |
we performed a case-control association study in persistent adhd considering eight candidate genes (drd4, dat1/slc6a3, comt, adra2a, ces1, cyp2d6, lphn3, and oprm1) and found additional evidence for the involvement of the dup 120bp and vntr 48bp functional variants within the dopamine receptor drd4 gene in the etiology of adult adhd. |
2020-09-30 |
2023-08-13 |
Not clear |
| Cristina Sánchez-Mora, Vanesa Richarte, Iris Garcia-Martínez, Mireia Pagerols, Montse Corrales, Rosa Bosch, Raquel Vidal, Laia Viladevall, Miguel Casas, Bru Cormand, Josep Antoni Ramos-Quiroga, Marta Ribasé. Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 6. 2020-09-30. PMID:26174753. |
we subsequently investigated the interaction of stressful life events with these two drd4 polymorphisms, and the impact of such events on the severity of adhd symptomatology. |
2020-09-30 |
2023-08-13 |
Not clear |
| Cristina Sánchez-Mora, Vanesa Richarte, Iris Garcia-Martínez, Mireia Pagerols, Montse Corrales, Rosa Bosch, Raquel Vidal, Laia Viladevall, Miguel Casas, Bru Cormand, Josep Antoni Ramos-Quiroga, Marta Ribasé. Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 6. 2020-09-30. PMID:26174753. |
these results are in agreement with previous works reporting a relationship between drd4 and the effect of adverse experiences, which may explain the discordant findings in previous genetic studies and strengthen the importance of gene-by-environment interactions on the severity of adhd. |
2020-09-30 |
2023-08-13 |
Not clear |
| Cempaka Thursina, Dian Kesumapramudya Nurputra, Indra Sari Kusuma Harahap, Nur Imma Fatimah Harahap, Nihayatus Sa'adah, Samekto Wibowo, Sri Sutarni, Ahmad Hamim Sadewa, Hermawan Hanjaya, Hisahide Nishi. Determining the association between polymorphisms of the Neurology international. vol 12. issue 1. 2020-09-28. PMID:32774820. |
vntr polymorphism in 3'utr exon 15 of dat1 gene and exon 3 of drd4 gene are reported to be associated in adhd. |
2020-09-28 |
2023-08-13 |
Not clear |