| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nianzhuang Qiu, Chenliang Qian, Tingting Guo, Yaling Wang, Hongwei Jin, Mingli Yao, Mei Li, Tianyang Guo, Yuli Lv, Xinxin Si, Song Wu, Hao Wang, Xuehui Zhang, Jie Xi. Discovery of a novel chemotype as DYRK1A inhibitors against Alzheimer's disease: Computational modeling and biological evaluation. International journal of biological macromolecules. 2024-05-04. PMID:38704072. |
more importantly, compound q17 significantly improved cognitive dysfunction of 3 × tg-ad mice, ameliorated pathological changes, and attenuated tau hyperphosphorylation as well as aβ deposition. |
2024-05-04 |
2024-05-07 |
mouse |
| Xiao-Hong Hu, Kai-Yue Yu, Xin-Xin Li, Jin-Nan Zhang, Juan-Juan Jiao, Zhao-Jun Wang, Hong-Yan Cai, Lei Wang, Ye-Xin He, Mei-Na W. Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-04-29. PMID:38682858. |
the results showed that ox2r blockade ameliorated cognitive dysfunction, improved ltp depression, increased the expression of psd-95, alleviated anxiety- and depression-like behaviors and circadian rhythm disturbances in 3xtg-ad mice, and reduced aβ pathology, tau phosphorylation and neuroinflammation in the brains of 3xtg-ad mice. |
2024-04-29 |
2024-05-02 |
mouse |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syringaresinol attenuates tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. |
2024-04-16 |
2024-04-18 |
rat |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr exerts neuroprotective effects on sevoflurane-induced cognitive dysfunction by modulating glial activity, apoptotic signaling, and tau phosphorylation through the sirt1 pathway. |
2024-04-16 |
2024-04-18 |
rat |
| Xu Yang, Shu Liu, Chuanling Wang, Haixia Fan, Qian Zou, Yingshuang Pu, Zhiyou Ca. Dietary salt promotes cognition impairment through GLP-1R/mTOR/p70S6K signaling pathway. Scientific reports. vol 14. issue 1. 2024-04-04. PMID:38575652. |
in summary, our study demonstrates that dietary salt inhibits the glp-1r/mtor/p70s6k pathway to inhibit autophagy and induces synaptic dysfunction and tau hyperphosphorylation, eventually impairing cognitive dysfunction. |
2024-04-04 |
2024-04-07 |
mouse |
| Guy C Brown, Michael T Henek. The endotoxin hypothesis of Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-04-02. PMID:38561809. |
the evidence supporting this hypothesis includes: i) blood and brain levels of lps are elevated in ad patients, ii) ad risk factors increase lps levels or response, iii) lps induces aβ expression, aggregation, inflammation and neurotoxicity, iv) lps induces tau phosphorylation, aggregation and spreading, v) lps induces microglial priming, activation and neurotoxicity, and vi) blood lps induces loss of synapses, neurons and memory in ad mouse models, and cognitive dysfunction in humans. |
2024-04-02 |
2024-04-04 |
mouse |
| Hoda M Moghazy, Nesreen G Abdelhaliem, Sherine Ahmed Mohammed, Asmaa Hassan, Amany Abdelrahma. Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK-3β/TTBK pathway and decreasing Tau hyperphosphorylation in high-fat diet- streptozocin rat model. Pflugers Archiv : European journal of physiology. 2024-03-27. PMID:38536493. |
the characteristic brain lesions of cognitive dysfunction are neurofibrillary tangles (nft) and senile plaques formed of amyloid-β deposition, glycogen synthase kinase 3 beta (gsk3β), and highly homologous kinase tau tubulin kinase 1 (ttbk1) can phosphorylate tau proteins at different sites, overexpression of these enzymes produces extensive phosphorylation of tau proteins making them insoluble and enhance nft formation, which impairs cognitive functions. |
2024-03-27 |
2024-03-30 |
rat |
| Elena Rodriguez-Vieitez, Amit Kumar, Mona-Lisa Malarte, Konstantinos Ioannou, Filipa M Rocha, Konstantinos Chioti. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods in molecular biology (Clifton, N.J.). vol 2785. 2024-03-01. PMID:38427196. |
alzheimer's disease (ad) - the most common neurodegenerative disorder - is characterized by a complex neuropathology involving the deposition of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, accompanied by the activation of glial cells, i.e., astrocytes and microglia, and neuroinflammatory response, leading to neurodegeneration and cognitive dysfunction. |
2024-03-01 |
2024-03-03 |
Not clear |
| Natalie A Tan, Angelica M Alvarado Carpio, H Craig Heller, Elsa C Pittara. Behavioral and Neuronal Characterizations, across Ages, of the TgSwDI Mouse Model of Alzheimer's Disease. Genes. vol 15. issue 1. 2024-01-23. PMID:38254938. |
it is neurochemically characterized by an aggregation of β-amyloid plaques and tau neurofibrillary tangles that result in neuronal dysfunction, cognitive decline, and a progressive loss of brain function. |
2024-01-23 |
2024-01-25 |
mouse |
| Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease. Cell reports. vol 43. issue 2. 2024-01-20. PMID:38244198. |
spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in alzheimer's disease. |
2024-01-20 |
2024-01-23 |
Not clear |
| Yue Zuo, Hui-Ting Liu, Lai-Biao Lin, Rui-Zhu Yue, Huan-Huan Liu, Hong-Wei Wang, Lu Wang, Ruan-Ling Hou, Wei-Zhen Liu, Chang-Zheng Li, Jian-Zhi Wang, Peng Li, Ya-Ling Yi. A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice. Experimental neurology. 2023-12-23. PMID:38141802. |
however, how tau induces cognitive dysfunction is still unknown, which leads to a lack of effective treatments for ad. |
2023-12-23 |
2023-12-25 |
mouse |
| Juan Huang, Nanqu Huang, Yu Qiu, Jingshan Sh. Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo. Journal of ethnopharmacology. 2023-12-14. PMID:38097026. |
however, the specific effects and mechanisms of action of its main active component, dnla, on cognitive dysfunction caused by tau hyperphosphorylation, are still unclear. |
2023-12-14 |
2023-12-17 |
Not clear |
| So Hoon Yoon, Han-Kyeol Kim, Jae-Hoon Lee, Joong-Hyun Chun, Young H Sohn, Phil Hyu Lee, Young Hoon Ryu, Hanna Cho, Han Soo Yoo, Chul Hyoung Lyo. Association of Sleep Disturbances With Brain Amyloid and Tau Burden, Cortical Atrophy, and Cognitive Dysfunction Across the AD Continuum. Neurology. 2023-10-12. PMID:37813585. |
association of sleep disturbances with brain amyloid and tau burden, cortical atrophy, and cognitive dysfunction across the ad continuum. |
2023-10-12 |
2023-10-15 |
Not clear |
| So Hoon Yoon, Han-Kyeol Kim, Jae-Hoon Lee, Joong-Hyun Chun, Young H Sohn, Phil Hyu Lee, Young Hoon Ryu, Hanna Cho, Han Soo Yoo, Chul Hyoung Lyo. Association of Sleep Disturbances With Brain Amyloid and Tau Burden, Cortical Atrophy, and Cognitive Dysfunction Across the AD Continuum. Neurology. 2023-10-12. PMID:37813585. |
we investigated the association of total sleep time with brain amyloid and tau burden, cortical atrophy, cognitive dysfunction, and their longitudinal changes in the ad spectrum. |
2023-10-12 |
2023-10-15 |
Not clear |
| Sagar Gaikwad, Sudipta Senapati, Md Anzarul Haque, Rakez Kaye. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-10. PMID:37814508. |
tau oligomers (tauo)-the most neurotoxic tau species-are known to induce senescence and the sasp, which subsequently promote neuropathology, inflammation, oxidative stress, synaptic dysfunction, neuronal death, and cognitive dysfunction. |
2023-10-10 |
2023-10-15 |
Not clear |
| Xiqi Hu, Jun Peng, Wei Tang, Ying Xia, Peipei Son. A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan. Bioscience trends. 2023-09-18. PMID:37722875. |
abnormal deposition of amyloid β (aβ) and tau proteins in the brain and impaired synaptic function are linked to cognitive dysfunction. |
2023-09-18 |
2023-10-07 |
Not clear |
| Ying Hu, Jixiong Xu, Jiancheng Wang, Lingyan Zhu, Jiao Wang, Qin Zhan. DPP-4 Inhibitors Suppress Tau Phosphorylation and Promote Neuron Autophagy through the AMPK/mTOR Pathway to Ameliorate Cognitive Dysfunction in Diabetic Mellitus. ACS chemical neuroscience. 2023-09-01. PMID:37655714. |
dpp-4 inhibitors suppress tau phosphorylation and promote neuron autophagy through the ampk/mtor pathway to ameliorate cognitive dysfunction in diabetic mellitus. |
2023-09-01 |
2023-09-07 |
rat |
| Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-08-30. PMID:37645867. |
spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in alzheimer's disease. |
2023-08-30 |
2023-09-07 |
human |
| Tao Zhang, Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Yingxue Mei, Quling Wang, Mi Zhang, Xiuzhi Zheng, Long Wang, Dongmei Chen, Wucheng Tao, Tae Ho Le. Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement. CNS neuroscience & therapeutics. 2023-08-29. PMID:37641913. |
activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement. |
2023-08-29 |
2023-09-07 |
Not clear |
| Yijun Chen, Yang Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. Journal of neuroinflammation. vol 20. issue 1. 2023-07-14. PMID:37452321. |
tau has received increasing attention as a potential therapeutic target, since evidence indicates that tau pathology is more associated with cognitive dysfunction. |
2023-07-14 |
2023-08-14 |
Not clear |