| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yejia Xu, Bowen Jia, Jing Li, Qianqian Li, Chengliang Lu. The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671843. |
it specifically emphasizes the core molecules within the shared pathways governing ferroptosis and neuroinflammation, including sirt1, nrf2, nf-κb, cox-2, inos/no·, and how different immune cells and structures contribute to cognitive dysfunction through these mechanisms. |
2024-04-27 |
2024-04-29 |
Not clear |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr exerts neuroprotective effects on sevoflurane-induced cognitive dysfunction by modulating glial activity, apoptotic signaling, and tau phosphorylation through the sirt1 pathway. |
2024-04-16 |
2024-04-18 |
rat |
| Yanping Liu, Qiang Liu, Haibi Wang, Yongkang Qiu, Jiatao Lin, Weifeng Wu, Ning Wang, Wei Dong, Jie Wan, Chen Chen, Shuai Li, Hui Zheng, Yuqing W. Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain-related cognitive dysfunction. CNS neuroscience & therapeutics. 2023-08-18. PMID:37592394. |
hippocampal synaptic plasticity injury mediated by sirt1 downregulation is involved in chronic pain-related cognitive dysfunction. |
2023-08-18 |
2023-09-07 |
Not clear |
| Weina Gao, Lijuan Wang, Zuoxiao L. Ubiquitin-specific protease 8 regulates cognitive dysfunction of mice with sepsis-associated encephalopathy through SIRT1 deubiquitination. Current neurovascular research. 2023-07-13. PMID:37438900. |
ubiquitin-specific protease 8 regulates cognitive dysfunction of mice with sepsis-associated encephalopathy through sirt1 deubiquitination. |
2023-07-13 |
2023-08-14 |
mouse |
| Hui-Ru Li, Qiang Liu, Cheng-Long Zhu, Xiao-Yang Sun, Chen-Yan Sun, Chang-Meng Yu, Peng Li, Xiao-Ming Deng, Jia-Feng Wan. β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice. Redox biology. vol 63. 2023-05-18. PMID:37201414. |
sirtuin 1 (sirt1) has been reported to be downregulated in the hippocampus and sirt1 agonists can attenuated the cognitive dysfunction in septic mice. |
2023-05-18 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
caloric restriction can ameliorate postoperative cognitive dysfunction by upregulating the expression of sirt1, mecp2 and bdnf in the hippocampal ca1 region of aged c57bl/6 mice. |
2023-03-29 |
2023-08-14 |
mouse |
| Yi Sun, Yuzhu Wang, Fan Ye, Victoria Cui, Dandan Lin, Hui Shi, Yan Zhang, Anshi Wu, Changwei We. SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36437988. |
sirt1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction. |
2022-11-28 |
2023-08-14 |
Not clear |
| Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Che. Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats. Cells. vol 11. issue 22. 2022-11-26. PMID:36429082. |
our findings suggest that tmao increases oxidative stress-induced neuroinflammation and apoptosis by inhibiting the sirt1 pathway, thereby exacerbating cognitive dysfunction and neuropathological changes in vad rats. |
2022-11-26 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
lin28a reduced sevoflurane-induced nerve injury and cognitive dysfunction by inhibiting tau acetylation and phosphorylation via activating sirt1 in elderly rats. |
2022-11-02 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
in conclusion, our findings demonstrated that lin28a reduced sevoflurane-induced nerve injury and cognitive dysfunction by inhibiting tau acetylation and phosphorylation via activating sirt1 in elderly rats. |
2022-11-02 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
further mechanistic analysis showed that lin28a significantly promoted sirt1 expression, which further reversed sev-induced tau acetylation at lysine 280 and 686 and tau hyperphosphorylation, thereby alleviating nerve injury and cognitive dysfunction in elderly rats. |
2022-11-02 |
2023-08-14 |
rat |
| Jun Zhang, Yang Liu, Hejian Li, Yanhui Hu, Shuchun Yu, Qin Liu, Yong Che. Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair. Neurochemical research. 2022-10-31. PMID:36315371. |
nowadays, stellate ganglion block (sgb) is considered as an effective intervention for postoperative cognitive dysfunction and sirt1 may play a role in that, but the exact mechanism remains unclear. |
2022-10-31 |
2023-08-14 |
rat |
| Jun Zhang, Yang Liu, Hejian Li, Yanhui Hu, Shuchun Yu, Qin Liu, Yong Che. Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair. Neurochemical research. 2022-10-31. PMID:36315371. |
therefore, the underlying mechanisms that sgb improves postoperative cognitive dysfunction through sirt1 in aged rats and its association with white matter lesion are yet to be elucidated. |
2022-10-31 |
2023-08-14 |
rat |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
overexpression of sirt1 attenuated propofol-induced cognitive dysfunction, excitation-inhibition imbalance, and synaptic plasticity damage. |
2022-01-16 |
2023-08-13 |
rat |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
our findings demonstrate that sirt1 plays an important role in cognitive dysfunction induced by repeated neonatal propofol exposure by suppressing synaptic plasticity and neuronal excitability. |
2022-01-16 |
2023-08-13 |
rat |
| Chao Mai, Li Qiu, Yong Zeng, Yiping H. Yunnan Black Tea Flavonoids Can Improve Cognitive Dysfunction in Septic Mice by Activating SIRT1. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-02. PMID:34721636. |
yunnan black tea flavonoids can improve cognitive dysfunction in septic mice by activating sirt1. |
2021-11-02 |
2023-08-13 |
mouse |
| Juan He, Zhuo Chen, Xuan Kang, Lin Wu, Jia-Mei Jiang, Su-Mei Liu, Hai-Jun Wei, Yong-Jun Chen, Wei Zou, Chun-Yan Wang, Ping Zhan. SIRT1 Mediates H Neurochemical research. vol 46. issue 3. 2021-09-07. PMID:33534060. |
sirt1 mediates h diabetes-associated cognitive dysfunction (dacd) characterized by hippocampal injury increases the risk of major cerebrovascular events and death. |
2021-09-07 |
2023-08-13 |
Not clear |
| Jing Shi, Xiaohua Zou, Ke Jiang, Feng Wan. SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-κB pathway. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 21. issue 10. 2021-04-27. PMID:31418620. |
sirt1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the tlr4/nf-κb pathway. |
2021-04-27 |
2023-08-13 |
Not clear |
| Ayong Tian, Wan Li, Qing Zai, Hui Li, Rong-Wei Zhan. 3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377741. |
silent information regulator 1 (sirt1) plays an important role in memory formation and cognitive performance, and its abnormal reduction is associated with cognitive dysfunction in neurodegenerative diseases. |
2021-02-16 |
2023-08-13 |
rat |
| Xiaole Tang, Yilin Zhao, Zhiqiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, Ailin Luo, Shiyong L. Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-10-19. PMID:32148659. |
sirtuin 1 (sirt1) plays an important role in synaptic plasticity and cognitive performance, and its abnormal reduction is associated with cognitive dysfunction in neurodegenerative diseases. |
2020-10-19 |
2023-08-13 |
mouse |