| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily K Schworer, Benjamin L Handen, Melissa Petersen, Sid O'Bryant, Jamie C Peven, Dana L Tudorascu, Laisze Lee, Sharon J Krinsky-McHale, Christy L Hom, Isabel C H Clare, Bradley T Christian, Nicole Schupf, Joseph H Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M Ances, Shahid Zaman, Adam M Brickman, Florence Lai, H Diana Rosas, Sigan L Hartle. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-04-16. PMID:38623384. |
ad pathology begins a decade or more prior to onset of clinical ad dementia in people with ds. |
2024-04-16 |
2024-04-18 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, individuals with ds develop progressive dementia and early onset alzheimer's disease (ad). |
2024-04-15 |
2024-04-17 |
Not clear |
| Debomoy K Lahiri, Deborah K Soko. Alzheimer's Drugs APPlication for Down syndrome? Ageing research reviews. 2024-03-21. PMID:38513771. |
accumulation of the amyloid β (aβ) peptide, derived from aβ precursor protein (app), is a trait of down syndrome (ds), as is early development of dementia like alzheimer's disease (ad). |
2024-03-21 |
2024-03-24 |
human |
| Hampus Hillerstrom, Richard Fisher, Matthew P Janicki, Brian Chicoine, Bradley T Christian, Anna Esbensen, Lucille Esralew, Juan Fortea, Sigan Hartley, Jason Hassenstab, Seth M Keller, Sharon Krinsky-McHale, Florence Lai, Johannes Levin, Mary McCarron, Eric McDade, Anne Sophie Rebillat, Herminia Diana Rosas, Wayne Silverman, Andre Strydom, Shahid H Zaman, Henrik Zetterber. Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-14. PMID:38480678. |
this overlooks adults with down syndrome (ds), who often experience dementia at a younger age and with different diagnostic assessment outcomes. |
2024-03-14 |
2024-03-16 |
Not clear |
| Iban Aldecoa, Isabel Barroeta, Steven L Carroll, Juan Fortea, Anah Gilmore, Stephen D Ginsberg, Samuel J Guzman, Eric D Hamlett, Elizabeth Head, Sylvia E Perez, Huntington Potter, Laura Molina-Porcel, Ruma Raha-Chowdhury, Thomas Wisniewski, William H Yong, Shahid Zaman, Sujay Ghosh, Elliott J Mufson, Ann-Charlotte Granhol. Down Syndrome Biobank Consortium: A perspective. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-25. PMID:38270275. |
individuals with down syndrome (ds) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset alzheimer's disease (ad)-type dementia by early midlife. |
2024-01-25 |
2024-01-27 |
Not clear |
| Eri Shimizu, Keiko Goto-Hirano, Yumiko Motoi, Masami Arai, Nobutaka Hattor. Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-01-16. PMID:38228941. |
this study investigated the specific symptoms of ad in the prodromal stage of ds, the mean age at diagnosis at each stage of dementia, and the relationship between intellectual disability (id) and dementia. |
2024-01-16 |
2024-01-19 |
Not clear |
| Eri Shimizu, Keiko Goto-Hirano, Yumiko Motoi, Masami Arai, Nobutaka Hattor. Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-01-16. PMID:38228941. |
pubmed, web of science, and embase were searched for studies on ds, ad, early-stage disease, initial symptoms, and prodromal dementia registered between january 2012 and january 2022. |
2024-01-16 |
2024-01-19 |
Not clear |
| Eri Shimizu, Keiko Goto-Hirano, Yumiko Motoi, Masami Arai, Nobutaka Hattor. Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-01-16. PMID:38228941. |
we selected 14 articles reporting the behavioural and psychological symptoms of dementia (bpsd) and memory- and language-related impairments as early symptoms of ad in patients with ds. |
2024-01-16 |
2024-01-19 |
Not clear |
| Beatriz Sánchez-Moreno, Linda Zhang, Gloria Mateo, Fernando Moldenhauer, Mikael Brudfors, John Ashburner, Parashkev Nachev, Diego Real de Asúa, Bryan A Strang. Voxel-based dysconnectomic brain morphometry with computed tomography in Down syndrome. Annals of clinical and translational neurology. 2023-12-30. PMID:38158639. |
we implemented an automated analysis of ct scans to characterize differences across dementia stages in a cross-sectional study of an adult ds cohort. |
2023-12-30 |
2024-01-05 |
Not clear |
| Natalie C Edwards, Patrick J Lao, Mohamad J Alshikho, Olivia M Ericsson, Batool Rizvi, Melissa E Petersen, Sid O'Bryant, Lisi Flores-Aguilar, Sabrina Simoes, Mark Mapstone, Dana L Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L Handen, Bradley T Christian, Joseph H Lee, Florence Lai, H Diana Rosas, Shahid Zaman, Ira T Lott, Michael A Yassa, José Gutierrez, Donna M Wilcock, Elizabeth Head, Adam M Brickma. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-12-11. PMID:38076904. |
by age 40 years over 90% of adults with down syndrome (ds) have alzheimer's disease (ad) pathology and most progress to dementia. |
2023-12-11 |
2023-12-17 |
Not clear |
| Batool Rizvi, Patrick J Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan, Natalie Edwards, David B Keator, Eric Doran, Christy Hom, Dana Nguyen, H Diana Rosas, Florence Lai, Nicole Schupf, Jose Gutierrez, Wayne Silverman, Ira T Lott, Mark Mapstone, Donna M Wilcock, Elizabeth Head, Michael A Yassa, Adam M Brickma. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961444. |
here, we assessed whether pulse pressure is associated with markers of cerebrovascular disease, entorhinal cortical atrophy, and diagnosis of dementia in adults with ds. |
2023-11-14 |
2023-11-20 |
human |
| Batool Rizvi, Patrick J Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan, Natalie Edwards, David B Keator, Eric Doran, Christy Hom, Dana Nguyen, H Diana Rosas, Florence Lai, Nicole Schupf, Jose Gutierrez, Wayne Silverman, Ira T Lott, Mark Mapstone, Donna M Wilcock, Elizabeth Head, Michael A Yassa, Adam M Brickma. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961444. |
participants with ds from the biomarkers of alzheimer's disease in adults with down syndrome study (adds; n=195, age=50.6±7.2 years, 44% women, 18% diagnosed with dementia) were included. |
2023-11-14 |
2023-11-20 |
human |
| Batool Rizvi, Patrick J Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan, Natalie Edwards, David B Keator, Eric Doran, Christy Hom, Dana Nguyen, H Diana Rosas, Florence Lai, Nicole Schupf, Jose Gutierrez, Wayne Silverman, Ira T Lott, Mark Mapstone, Donna M Wilcock, Elizabeth Head, Michael A Yassa, Adam M Brickma. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961444. |
higher pulse pressure may be a risk factor for dementia in people with ds by promoting cerebrovascular disease, which in turn affects neurodegeneration. |
2023-11-14 |
2023-11-20 |
human |
| Aline S G G Conceição, Lívea F G Sant Ana, Guilherme P Mattar, Maria de Fátima R Silva, Andressa R Ramos, Alexandra M Oliveira, Claudia L Carvalho, Octavio R Gonçalves, Bruna L R Varotto, Luana D Martinez, Vinícius Leduc, Luciana M Fonseca, Orestes V Forlenz. Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome. Alzheimer disease and associated disorders. 2023-10-03. PMID:37788381. |
the aim of this study was to determine whether gait disorders are associated with worse cognitive performance and dementia in adults with ds. |
2023-10-03 |
2023-10-07 |
Not clear |
| Shintaro Takenoshita, Seishi Terada, Tomokazu Inoue, Taku Kurozumi, Norihito Yamada, Ryozo Kuwano, Shigeru Suemits. Prevalence and modifiable risk factors for dementia in persons with intellectual disabilities. Alzheimer's research & therapy. vol 15. issue 1. 2023-07-18. PMID:37464412. |
people with intellectual disability (id) without down syndrome (ds) are presumed to be at higher risk of developing dementia due to their lower baseline cognitive reserve. |
2023-07-18 |
2023-08-14 |
Not clear |
| Shintaro Takenoshita, Seishi Terada, Tomokazu Inoue, Taku Kurozumi, Norihito Yamada, Ryozo Kuwano, Shigeru Suemits. Prevalence and modifiable risk factors for dementia in persons with intellectual disabilities. Alzheimer's research & therapy. vol 15. issue 1. 2023-07-18. PMID:37464412. |
we aimed to determine the prevalence of dementia in people with id without ds and to identify risk factors of dementia. |
2023-07-18 |
2023-08-14 |
Not clear |
| Victoria Fleming, Christy L Hom, Isabel C H Clare, Shemaya L Hurd-Thomas, Sharon Krinsky-McHale, Benjamin Handen, Sigan L Hartle. Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome. International review of research in developmental disabilities. vol 62. 2023-07-03. PMID:37396708. |
as the field of ds prepares for ad clinical intervention trials, there is a strong need to identify cognitive measures that are specific and sensitive to the transition from being cognitively stable to the prodromal (e.g., mild cognitive impairment-down syndrome) and clinical ad (e.g., dementia) stages of the disease in ds. |
2023-07-03 |
2023-08-14 |
human |
| Selena E Washington, Emily Cler, Cameron Lowery, Susan L Star. Down syndrome and Alzheimer's disease: A scoping review of functional performance and fall risk. Alzheimer's & dementia (New York, N. Y.). vol 9. issue 2. 2023-05-25. PMID:37228575. |
the aim of this scoping review was to synthesize the current state of the evidence and identify gaps in the literature regarding functional activity performance and falls and their significance to disease staging (i.e., mild, moderate, and severe defined staging criteria) in relation to alzheimer's disease and related dementias (adrd) in adults with ds. |
2023-05-25 |
2023-08-14 |
Not clear |
| M Montoya-Martinez, C Arbus, K Virecoulon Giudic. Depressive Symptoms in Older Adults via Multimodal Markers on Magnetic Resonance Imaging: A Literature Review. JAR life. vol 12. 2023-05-16. PMID:37193551. |
dementia could overlap with ds in clinical and brain abnormalities. |
2023-05-16 |
2023-08-14 |
Not clear |
| M Montoya-Martinez, C Arbus, K Virecoulon Giudic. Depressive Symptoms in Older Adults via Multimodal Markers on Magnetic Resonance Imaging: A Literature Review. JAR life. vol 12. 2023-05-16. PMID:37193551. |
to date, no review has addressed the neuro-anatomical basis of ds in older adults using magnetic resonance imaging (mri), neither has investigated the discrimination of dementia nor sex-differences. |
2023-05-16 |
2023-08-14 |
Not clear |