| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irene H Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Lura, Omnia Shadad, Erika Fernandez-Vizarra, Cèlia Painous, Alexandra Pérez-Soriano, Yaroslau Compta, Laura Molina-Porcel, Guido Alves, Ole-Bjørn Tysnes, Christian Dölle, Gonzalo S Nido, Charalampos Tzouli. Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease. Nature communications. vol 15. issue 1. 2024-04-29. PMID:38684731. |
in contrast, the non-ci deficient (nci-pd) subtype exhibits no evidence of mitochondrial impairment outside the dopaminergic substantia nigra and has a predilection for a tremor dominant phenotype. |
2024-04-29 |
2024-05-03 |
Not clear |
| Kankana Dutta, Lokesh Rav. Molecular dynamic investigation for Roco4 kinase inhibitor as treatment options for parkinsonism. Journal of molecular modeling. vol 30. issue 5. 2024-04-16. PMID:38625397. |
parkinson's disease is a neurodegenerative condition characterized by the degeneration of dopaminergic neurons, resulting in motor disabilities such as rigidity, bradykinesia, postural instability, and resting tremors. |
2024-04-16 |
2024-04-18 |
Not clear |
| Yusha Cui, Dongning Su, Junjiao Zhang, Joyce S T Lam, Shuangshuang Cao, Yaqin Yang, Yingshan Piao, Zhan Wang, Junhong Zhou, Hua Pan, Tao Fen. Dopaminergic versus anticholinergic treatment effects on physiologic complexity of hand tremor in Parkinson's disease: A randomized crossover study. CNS neuroscience & therapeutics. 2023-10-31. PMID:37905677. |
dopaminergic versus anticholinergic treatment effects on physiologic complexity of hand tremor in parkinson's disease: a randomized crossover study. |
2023-10-31 |
2023-11-08 |
Not clear |
| Jacopo Pasquini, Günther Deuschl, Alessandro Pecori, Stefano Salvadori, Roberto Ceravolo, Nicola Paves. The Clinical Profile of Tremor in Parkinson's Disease. Movement disorders clinical practice. vol 10. issue 10. 2023-10-24. PMID:37868914. |
tremor is one of the most troublesome manifestations of parkinson's disease (pd) and its response to dopaminergic medication is variable; an evidence-based framework of pd tremor is lacking yet needed to inform future investigations. |
2023-10-24 |
2023-11-08 |
Not clear |
| Do-Young Kwon, Yu-Ri Kwon, Junghyuk Ko, Ji-Won Ki. Comparison of resting tremor at the upper limb joints between patients with Parkinson's disease and scans without evidence of dopaminergic deficit. Technology and health care : official journal of the European Society for Engineering and Medicine. 2023-04-17. PMID:37066947. |
comparison of resting tremor at the upper limb joints between patients with parkinson's disease and scans without evidence of dopaminergic deficit. |
2023-04-17 |
2023-08-14 |
Not clear |
| Lin-Yi Li, Shu-Fen Liu, Jian-Long Zhuang, Mi-Mi Li, Zheng-Ping Huang, Yan-Hong Chen, Xiang-Rong Chen, Chun-Nuan Chen, Shu Lin, Li-Chao Y. Recent research progress on metabolic syndrome and risk of Parkinson's disease. Reviews in the neurosciences. 2022-11-30. PMID:36450297. |
pd is associated with progressive loss of substantia nigra dopaminergic neurons, including various motor symptoms (e.g., bradykinesia, rigidity, and resting tremor), as well as non-motor symptoms (e.g., cognitive impairment, constipation, fatigue, sleep disturbance, and depression). |
2022-11-30 |
2023-08-14 |
Not clear |
| Ali H Abusrair, Walaa Elsekaily, Saeed Bohleg. Tremor in Parkinson's Disease: From Pathophysiology to Advanced Therapies. Tremor and other hyperkinetic movements (New York, N.Y.). vol 12. 2022-10-10. PMID:36211804. |
the progression and management of tremor in pd can be challenging, as response to dopaminergic agents might be relatively poor, particularly in patients with tremor-dominant pd compared to the akinetic/rigid subtype. |
2022-10-10 |
2023-08-14 |
Not clear |
| Kevin Yen, Amanda Yaworski, Miguel Bussiere, Fang B. Pearls & Oy-sters: A Case Report of Holmes Tremor Due to Nigrostriatal Dopamine Disruption that Responded to Dopamine Replacement Therapy. Neurology. 2022-07-08. PMID:35803716. |
a trial of dopaminergic agent resulted in significant improvement of the tremor and associated symptoms. |
2022-07-08 |
2023-08-14 |
Not clear |
| Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Higor A Iha, Yukihiro Ohn. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784764. |
mechanisms underlying dopaminergic regulation of nicotine-induced kinetic tremor. |
2022-07-05 |
2023-08-14 |
Not clear |
| Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Higor A Iha, Yukihiro Ohn. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784764. |
since nicotine is known to enhance dopamine release by stimulating α4β2 and/or α6 nach receptors, we examined the effects of various dopamine receptor ligands on nicotine-induced tremor to clarify the role of the dopaminergic system in modulating nicotine tremor. |
2022-07-05 |
2023-08-14 |
Not clear |
| Emmanuel O Akano, Nikolay Novikov, Elena Brazhnik, Amy E Moritz, Alex J Mccoy, R B Free, Judith R Walters, David R Sible. Pharmacological actions of a novel and highly selective D3 dopamine receptor agonist, ML417, in a rodent model of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555958. |
since its first use in treating parkinson's disease (pd), l-dopa has remained the gold standard of therapy for this disorder, defined by the progressive degeneration of dopaminergic neurons in the cns leading to profound bradykinesia and tremor. |
2022-05-13 |
2023-08-13 |
rat |
| Aymeric Lanore, Suzanne Lesage, Louise-Laure Mariani, Poornima Jayadev Menon, Philippe Ravassard, Helene Cheval, Olga Corti, Alexis Brice, Jean-Christophe Corvo. Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson's Disease Influence Sporadic Forms? Genes. vol 13. issue 3. 2022-03-25. PMID:35328033. |
parkinson's disease (pd) is a disorder characterized by a triad of motor symptoms (akinesia, rigidity, resting tremor) related to loss of dopaminergic neurons mainly in the |
2022-03-25 |
2023-08-13 |
Not clear |
| Michiel F Dirkx, Matteo Bologn. The pathophysiology of Parkinson's disease tremor. Journal of the neurological sciences. vol 435. 2022-03-03. PMID:35240491. |
clinical and experimental observations suggest that tremor in pd cannot be interpreted merely as an expression of dopaminergic denervation of the basal ganglia. |
2022-03-03 |
2023-08-13 |
Not clear |
| Cheng-Peng Sun, Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang, Christophe Morisseau, Bruce D Hammock, Xiao-Chi M. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 9. 2022-02-26. PMID:35217618. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn), causing bradykinesia and rest tremors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Robert Fekete, Jin L. Clinical Differentiation of Essential Tremor and Parkinson's Disease. Clinical medicine insights. Case reports. vol 6. 2022-02-21. PMID:35185349. |
we present clinical features and tremor characterization in a patient with parkinson's disease (pd) as well as in two cases of essential tremor (et) with some parkinsonian features but no evidence of dopaminergic terminal loss on |
2022-02-21 |
2023-08-13 |
Not clear |
| Stephano J Chang, Ruth Mitchell, Juliette Hukin, Ash Singha. Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature. Journal of neurosurgery. Pediatrics. 2022-02-11. PMID:35148507. |
mechanistically, the combined rest and action tremor is thought to require a double lesion of both the dopaminergic nigrostriatal system and the dentatorubrothalamic pathways, often near the midbrain where both pathways converge. |
2022-02-11 |
2023-08-13 |
Not clear |
| Jingjing Wu, Cheng Zhou, Tao Guo, Xiaojun Guan, Ting Gao, Xueqin Bai, Haoting Wu, Jingwen Chen, Jiaqi Wen, Xiaocao Liu, Luyan Gu, Zhe Song, Min Xuan, Quanquan Gu, Peiyu Huang, Jiali Pu, Baorong Zhang, Xiaojun Xu, Minming Zhan. Cholinergic relevant functional reactivity is associated with dopamine responsiveness of tremor in Parkinson's disease. Brain imaging and behavior. 2022-01-01. PMID:34973120. |
through investigating the alterations of cholinergic and dopaminergic network during levodopa administration, we aimed at exploring the mechanisms of differed dopamine responsiveness of parkinsonian tremor. |
2022-01-01 |
2023-08-13 |
Not clear |
| Beatriz S Arruda, Carolina Reis, James J Sermon, Alek Pogosyan, Peter Brown, Hayriye Cagna. Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor. Journal of neuroengineering and rehabilitation. vol 18. issue 1. 2021-12-26. PMID:34953492. |
despite its high prevalence, resting tremor may not be as effectively treated with dopaminergic medication as other symptoms, and surgical treatments such as deep brain stimulation, which are effective in reducing tremor, have limited availability. |
2021-12-26 |
2023-08-13 |
Not clear |
| Rayanne Poletti Guimarães, Danilo Leandro Ribeiro, Keila Bariotto Dos Santos, Lívea Dornela Godoy, Mirella Rosine Corrêa, Fernando Eduardo Padovan-Net. The 6-hydroxydopamine Rat Model of Parkinson's Disease. Journal of visualized experiments : JoVE. issue 176. 2021-11-15. PMID:34779439. |
motor symptoms of parkinson's disease (pd)-bradykinesia, akinesia, and tremor at rest-are consequences of the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (snc) and dopaminergic striatal deficit. |
2021-11-15 |
2023-08-13 |
human |
| Jiaji Lin, Xiaopeng Kang, Yongqin Xiong, Dekang Zhang, Rui Zong, Xinguang Yu, Longsheng Pan, Xin Lo. Convergent structural network and gene signatures for MRgFUS thalamotomy in patients with Parkinson's disease. NeuroImage. vol 243. 2021-10-29. PMID:34481084. |
there was a long-term dynamic loop between structural alteration and dopaminergic signature for mrgfus thalamotomy, which may be closely related to the long-term improvements in clinical tremor. |
2021-10-29 |
2023-08-13 |
human |