| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huimin Liu, Ye Zheng, Shaoning Kan, Ming Hao, Huan Jiang, Shuangji Li, Rong Li, Yinyu Wang, Dongxu Wang, Weiwei Li. Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration. Heliyon. vol 10. issue 8. 2024-04-22. PMID:38644851. |
mt also promoted the expression of atf4, atf6, bip, bap31 and chop in crl-1623 cells leading to endoplasmic reticulum stress, and induced autophagy and apoptosis in crl-1623 cells. |
2024-04-22 |
2024-04-24 |
Not clear |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Doyoung Kwon, Hyeji Seo, Sou Hyun Kim, Ki Wung Chung, Jaewon Lee, Young-Suk Jun. Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-03-31. PMID:38556155. |
diclofenac-promoted hepatic oxidative stress (oxidized proteins, 4-hydroxynonenal, and malondialdehyde), endoplasmic reticulum (er) stress (bip, atf6, and chop), and apoptosis (cleaved caspase-3 and cleaved parp) were enhanced by fasting. |
2024-03-31 |
2024-04-03 |
mouse |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Fusen Yue, Jinsheng Xu, Linyi Meng, Qi Wang, Mingtao Tan, Aoying Zhang, Shanchun Yan, Dun Jian. A new insight into Cd exposure-induced hemocyte reduction in Lymantria dispar larvae: Involvement of the ROS-ATF6-ER stress-apoptosis pathway. Journal of hazardous materials. vol 469. 2024-03-20. PMID:38508113. |
studies using inhibitors confirmed that apoptosis mediated the decrease in hemocyte count, er stress mediated apoptosis, atf6 pathway mediated er stress, and ros or oxidative stress mediated er stress through the activation of the atf6 pathway. |
2024-03-20 |
2024-03-23 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Zhao Dai, Tian Hu, Junwen Wei, Xue Wang, Chuipu Cai, Yong Gu, Yunhui Hu, Wenjia Wang, Qihui Wu, Jiansong Fan. Network-based identification and mechanism exploration of active ingredients against Alzheimer's disease via targeting endoplasmic reticulum stress from traditional chinese medicine. Computational and structural biotechnology journal. vol 23. 2024-01-23. PMID:38261917. |
experimental results showed that echinacoside and danthron were able to effectively reduce er stress-mediated neuronal apoptosis by inhibiting the expression levels of bip, p-perk, atf6, and chop in app-sh-sy5y cells. |
2024-01-23 |
2024-01-26 |
Not clear |
| Jinuk Seo, Doyoung Kwon, Sou Hyun Kim, Mi Ran Byun, Yun-Hee Lee, Young-Suk Jun. Role of autophagy in betaine-promoted hepatoprotection against non-alcoholic fatty liver disease in mice. Current research in food science. vol 8. 2024-01-15. PMID:38222825. |
in addition, it reduced the cdahfd-induced er stress (bip, atf6, and chop) and apoptosis (bax, cleaved caspase-3, and cleaved parp); however, it induced autophagy (lc3ii/i and p62) which was downregulated by cdahfd. |
2024-01-15 |
2024-01-17 |
mouse |
| Chang Liu, Rong J. Potential Role of Endoplasmic Reticulum Stress in Modulating Protein Homeostasis in Oligodendrocytes to Improve White Matter Injury in Preterm Infants. Molecular neurobiology. 2024-01-05. PMID:38180617. |
3) ire1 and atf6 pathways enhanced various gene transcription associated with protein folding, secreting, eard, and erqc to prompt cell protein homeostasis micro-environment; however, sustained ire1 and/or atf6 activity could prompt cell survival toward apoptosis via the pro-apoptotic pathway, inflammation, and other patterns. |
2024-01-05 |
2024-01-07 |
Not clear |
| Jie-Xiang Zhang, Wei-Chen Yuan, Cheng-Gang Li, Hai-Yan Zhang, Shu-Yan Han, Xiao-Hong L. A review on the mechanisms underlying the antitumor effects of natural products by targeting the endoplasmic reticulum stress apoptosis pathway. Frontiers in pharmacology. vol 14. 2023-12-04. PMID:38044941. |
when ers is under- or overexpressed, it activates the protein kinase r (pkr)-like endoplasmic reticulum kinase (perk)-, inositol-requiring enzyme 1 (ire1)- and activating transcription factor 6 (atf6)-related apoptotic pathways to induce apoptosis. |
2023-12-04 |
2023-12-10 |
human |
| Lulu Ding, Huali Zhu, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Bianhua Zhou, Hongwei Wang, Zijun Yang, Zongping Liu, Jicang Wan. Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway. Environmental science and pollution research international. 2023-11-24. PMID:38001299. |
the mrna and protein expression levels of ers and apoptosis related factors such as grp78, ire1α, xbp1, atf6, caspase-12, caspase-3 and bax in the cells were significantly increased (p < 0.01), while the mrna and protein expression levels of bcl-2 were significantly reduced (p < 0.01). |
2023-11-24 |
2023-11-28 |
rat |
| Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Li. Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-15. PMID:37714499. |
subsequently, according to the dynamic changes of apoptosis in lung specimens, and the expression changes in sig-1r-regulated er stress pathway proteins (sig-1r, grp78, p-perk, atf6, ire1, caspase-12, atf4, chop, caspase-3 and p-jnk), it was confirmed that the sig-1r-regulated er stress signaling pathway was involved in the occurrence of hali. |
2023-09-15 |
2023-10-07 |
Not clear |
| Biswadeep Das, Sagnika Samal, Hamida Hamdi, Aditi Pal, Arpita Biswas, Jyotika Behera, Gyanraj Singh, Chinmay Kumar Behera, Debee Prasad Sahoo, Sanghamitra Pat. Role of endoplasmic reticulum stress-related unfolded protein response and its implications in dengue virus infection for biomarker development. Life sciences. 2023-07-30. PMID:37517582. |
this could be attributed to the uncontrolled activation of the key upr signaling pathways: inositol-requiring transmembrane kinase/endoribonuclease 1 (ire1), protein kinase r (pkr)-like endoplasmic reticulum kinase (perk), and activating transcription factor-6 (atf6), which promote cell autophagy under normal and diseased conditions through the downstream regulation of apoptosis promoting factors such as x-box binding protein (xbp1), gadd34, and atf-6. |
2023-07-30 |
2023-08-14 |
Not clear |
| Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, Xiang-Shun Cu. ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. Zoological research. vol 44. issue 5. 2023-07-28. PMID:37501400. |
atf6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. |
2023-07-28 |
2023-08-14 |
Not clear |
| Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, Xiang-Shun Cu. ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. Zoological research. vol 44. issue 5. 2023-07-28. PMID:37501400. |
activating transcription factor 6 (atf6), one of the three sensor proteins in the endoplasmic reticulum (er), is an important regulator of er stress-induced apoptosis. |
2023-07-28 |
2023-08-14 |
Not clear |
| Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemi. The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach. Environmental science and pollution research international. 2023-07-15. PMID:37453011. |
moreover chr down-regulated cd-induced er stress markers (perk, ire1, atf6, chop, and grp78) and apoptosis markers (caspase-3, bax) lung tissue. |
2023-07-15 |
2023-08-14 |
rat |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Xiaogang Huang, Xiongzhi He, Rongxian Qiu, Xuemei Xie, Fengfeng Zheng, Feihua Chen, Zhenting H. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333449. |
the expression levels of bmi1, kat2b, and proteins related to upr (p-eif2α, eif2α, atf4, and atf6), nf-κb (p65 and p-p65), apoptosis (cleaved caspase-3, bcl-2, and bax) and necroptosis (p-mlkl and mlkl) were determined by western blot. |
2023-06-19 |
2023-08-14 |
Not clear |
| Sung Woo Lee, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong-Seok Le. ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2023-06-01. PMID:37261864. |
atf6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes. |
2023-06-01 |
2023-08-14 |
mouse |
| Sung Woo Lee, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong-Seok Le. ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2023-06-01. PMID:37261864. |
the er stress and apoptosis response to cadmium were most strongly stimulated through the activating transcription factor 6 (atf6) pathway; in contrast, sirna-induced inhibition of protein expression could reduce apoptosis under stressful conditions. |
2023-06-01 |
2023-08-14 |
mouse |