| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Yuke Ji, Jing Li, Sha Liu, Junya Zhu, Jin Yao, Ke-Ran Li, Biao Ya. Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration. Genomics. 2024-01-01. PMID:38163571. |
cdcaf6 silencing could reduce oxidative stress-induced rgc apoptosis in vitro and alleviate retinal neurodegeneration in vivo as shown by increased neuronal nuclei antigen (neun, neuronal bodies) and beta-iii-tubulin (tubb3, neuronal filaments) staining and reduced glial fibrillary acidic protein (gfap, activated glial cells) and vimentin (activated glial cells) staining. |
2024-01-01 |
2024-01-05 |
Not clear |
| Changsheng Wang, Yi Zhu, Rongsheng Chen, Xitian Zhu, Xiaobo Zhan. microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury. Chemico-biological interactions. 2023-12-31. PMID:38161044. |
mir-143 up-regulation inhibited tgf-β stimulated-proliferation, promoted cell apoptosis, and reduced gfap, vimentin, cspg, and ctgf expression in astrocytes, which was counterweighed by sirt2 overexpression. |
2023-12-31 |
2024-01-05 |
rat |
| Changsheng Wang, Yi Zhu, Rongsheng Chen, Xitian Zhu, Xiaobo Zhan. microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury. Chemico-biological interactions. 2023-12-31. PMID:38161044. |
sirt2 silencing reduced the proliferation and gfap, vimentin, cspg, and ctgf expression while augmenting the apoptosis in tgf-β stimulated astrocytes, which was abrogated by plaur silencing. |
2023-12-31 |
2024-01-05 |
rat |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
histological analysis focused on gfap and glt-1 expression, synaptic plasticity, apoptosis and pi3k/akt/creb pathway-related proteins. |
2023-12-30 |
2024-01-05 |
rat |
| Ren Yang, Chen Zen. Protective effects of MiR-146b in cerebral infarction via targeting SIRT1/FOXO1 signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063102. |
subsequently, the levels of superoxide dismutase (sod) and reactive oxygen species (ros) in the brain tissues in each group were measured via enzyme-linked immunosorbent assay (elisa), the apoptosis of nerve cells in the brain tissues was detected by terminal deoxynucleotidyl transferase dutp nick end labeling (tunel), and glial fibrillary acidic protein (gfap), s100β gene and sirt1/foxo1 pathway-related genes and proteins in the brain tissues were determined through qrt-pcr and western blotting. |
2023-12-08 |
2023-12-17 |
rat |
| I V Arutyunyan, A G Soboleva, E A Kovtunov, A M Kosyreva, V V Kudelkina, A I Alekseeva, A V Elchaninov, E D Jumaniyazova, D V Goldshtein, G B Bolshakova, T Kh Fatkhudino. Gene Expression Profile of 3D Spheroids in Comparison with 2D Cell Cultures and Tissue Strains of Diffuse High-Grade Gliomas. Bulletin of experimental biology and medicine. 2023-09-28. PMID:37770789. |
using real time pcr, we evaluated the expression of gfap, cd44, pten, s100b, vegfa, hif1a, sox2, melk, gdnf, and mgmt genes playing an important role in the progression of gliomas and regulating tumor cell proliferation, adhesion, invasion, plasticity, apoptosis, dna repair, and recruitment of tumor-associated cells. |
2023-09-28 |
2023-10-07 |
Not clear |
| Fan Xie, Li Li, Min Peng, Huan Zhan. Overexpression of miR-199a-5p improves brain injury in newborn rats with intrauterine infection via inhibition of astrocyte activation. Brain research. 2023-08-30. PMID:37648092. |
results from cell models showed that mir-199a-5p overexpression inhibited astrocyte activation, shown by enhanced cell viability, weakened cell apoptosis, and decreased gfap, il-6, and tnf-α. |
2023-08-30 |
2023-09-07 |
rat |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
this study, using a mouse model, investigated the effects of exposure to e-vapour (± nicotine) and hfd (43% fat) consumption, on the expression of nicotinic acetylcholine receptor (nachr) subunits α3, α4, α7 and β2, apoptosis markers caspase-3 and tunel, microglial marker iba-1, and astrocyte marker gfap, in hippocampal subregions of dentate gyrus (dg) and cornu ammonis (ca) 1-3. |
2023-06-21 |
2023-08-14 |
mouse |
| Xiao-Ling Fang, Qin Zhang, Wen-Wen Xue, Jin-Hua Tao, Hai-Dong Zou, Qiu-Rong Lin, Yu-Lan Wan. Suppression of cAMP/PKA/CREB signaling ameliorates retinal injury in diabetic retinopathy. The Kaohsiung journal of medical sciences. 2023-06-20. PMID:37338034. |
as glucose concentration increases, gliosis of müller cells became apparent, as evidenced by a decline in cell activity, an increase in apoptosis, downregulation of kir4.1 level, and overexpression of gfap, aqp4, and vegf. |
2023-06-20 |
2023-08-14 |
rat |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Natalia Ziółkowska, Bogdan Lewczuk, Natalia Szyryńska, Aleksandra Rawicka, Alla Vyniarsk. Low-Intensity Blue Light Exposure Reduces Melanopsin Expression in Intrinsically Photosensitive Retinal Ganglion Cells and Damages Mitochondria in Retinal Ganglion Cells in Wistar Rats. Cells. vol 12. issue 7. 2023-04-13. PMID:37048087. |
retinal cryosections were immunolabeled for glial fibrillary acid protein (gfap) and with terminal deoxynucleotidyl transferase dutp nick-end labelling for apoptosis detection. |
2023-04-13 |
2023-08-14 |
rat |
| Xiangwu Chen, Shuqi You, Qing Xia, Xiaofen M. s7,8-Dihydroxiflavone protects retinal ganglion cells and promotes axonal regeneration through TrkB signaling pathway followed by AKT and ERK activation. Neuroscience research. 2023-02-28. PMID:36854354. |
our results revealed that 7,8-dhf significantly promoted the average density and length of regenerated neurites and suppressed the apoptosis of gcl cells in three-dimensional culture system and significantly increased the number of rbpms-positive cells and inhibited the gfap expression and apoptosis of gcl cells in onc rats. |
2023-02-28 |
2023-08-14 |
rat |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Seung-Chan Kim, Jae-Yong Park, Eun Mi Hwan. Caspase-dependent apoptosis induces reactivation and gliogenesis of astrocytes in adult mice. Frontiers in cellular neuroscience. vol 16. 2022-12-19. PMID:36531137. |
we induced apoptosis of hippocampal ca1 astrocytes in ctg mice using gfap promoter-driven adeno-associated virus (aav) containing cre recombinase. |
2022-12-19 |
2023-08-14 |
mouse |
| Svetlana Sharifulina, Andrey Khaitin, Valeria Guzenko, Yuliya Kalyuzhnaya, Valentina Dzreyan, Alexandr Logvinov, Natalia Dobaeva, Yan Li, Lei Chen, Bin He, Svetlana Demyanenk. Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289917. |
γ-secretase inhibitor dapt down-regulated glial fibrillary acidic protein (gfap) in astrocytes, prevented mouse cerebral cortex cells from pts-induced apoptosis, and reduced the infarction volume. |
2022-10-27 |
2023-08-14 |
mouse |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Sae-Bom Yoon, Geonhee Lee, Sung Bum Park, Heeyeong Cho, Jeong-O Lee, Byumseok Ko. Properties of differentiated SH-SY5Y grown on carbon-based materials. RSC advances. vol 10. issue 33. 2022-05-06. PMID:35515479. |
the data suggest that sh-sy5y cells grown on cnt surfaces show an average 20.2% increase in cell viability; 5.7% decrease in the ratio of cells undergoing apoptosis; 78.3, 43.4 and 38.1% increases in sox2, gfap and neun expression, respectively; and a 29.7% increase in mean firing rate on a multi-electrode array. |
2022-05-06 |
2023-08-13 |
Not clear |
| Junni Yan, Fuping Zhang, Le Niu, Xiaonan Wang, Xinxin Lu, Chaoyue Ma, Chencheng Zhang, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway. Brain research bulletin. 2022-03-05. PMID:35247488. |
histological analysis focused on apoptosis, expression of gfap and fgf2, and fgf2 pathway-related proteins. |
2022-03-05 |
2023-08-13 |
rat |
| Honghua Niu, Wenchao Song, Dongyang Pei, Chen Ma, Fudong Liu, Yan Li, Shuaiwei Ha. Depleted histone deacetylase 3 or restored microRNA-19b-1-5p facilitates recovery of spinal cord injury via inactivating JAK2/STAT3 signaling pathway. Genomics. 2021-12-31. PMID:34971719. |
in a rat model, the role of hdac3 and mir-19b-1-5p in sci was identified through detecting motor function, serum inflammation, pathological damage, cell apoptosis and gfap expression. |
2021-12-31 |
2023-08-13 |
rat |