| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Maria B Pazi, Daria V Belan, Elena Y Komarova, Irina V Ekimov. Intranasal Administration of GRP78 Protein (HSPA5) Confers Neuroprotection in a Lactacystin-Induced Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612761. |
grp78 overexpression can modulate the upr, block apoptosis, and promote the survival of nigral dopamine neurons in a rat model of α-synuclein pathology. |
2024-04-13 |
2024-04-15 |
rat |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. |
compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). |
2024-03-16 |
2024-03-19 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Juan Feng, Yidong Liu, Xia Tian, Chen Shen, Zhiqiang Feng, Jingxu Zhang, Xiangli Yao, Meilin Pu, Xuguang Miao, Lan Ma, Shouxin Li. Discovery of novel peptide-dehydroepiandrosterone hybrids inducing endoplasmic reticulum stress with effective in vitro and in vivo anti-melanoma activities. European journal of medicinal chemistry. vol 269. 2024-03-11. PMID:38467086. |
further mechanism studies showed that compound iid would damage the endoplasmic reticulum and upregulate the ers markers c/ebp homologous protein (chop) and glucose-regulated protein 78 (grp78), which could further regulate caspase and bcl-2 family proteins and lead to cell apoptosis. |
2024-03-11 |
2024-03-14 |
mouse |
| Libo Zhou, Fan Wu, Jing Wang, Yuqing Zhao, Gaoyi Wu, Yucheng S. Effects of endoplasmic reticulum stress on chondrocyte apoptosis via the PI3K/AKT signaling pathway. Tissue & cell. vol 87. 2024-03-06. PMID:38447334. |
protein expression of ers and apoptosis markers (grp78 and casp12) was analyzed by immunohistochemistry and western blotting. |
2024-03-06 |
2024-03-09 |
rat |
| Xiaoli Li, Xin Yu, Fei Yu, Chunli Fu, Wenqian Zhao, Xiaosong Liu, Chaochao Dai, Haiqing Gao, Mei Cheng, Baoying L. D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway. Phytotherapy research : PTR. 2024-02-08. PMID:38311336. |
our results showed that dp reduced the blood glucose and ages, and increased the expression of heart optn in diabetic mice and h9c2 cells, thereby inhibiting the endoplasmic reticulum stress (grp78, chop) and glycophagy (stbd1, gabarapl1), and alleviating the myocardial apoptosis and fibrosis of dcm. |
2024-02-08 |
2024-02-11 |
mouse |
| Min-Hua Wu, Yi-Hsien Hsieh, Chia-Liang Lin, Tsung-Ho Ying, Shih-Min Hsia, Shu-Ching Hsieh, Chien-Hsing Lee, Chu-Liang Li. Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression. Environmental toxicology. 2024-02-03. PMID:38308464. |
licochalcone a induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of grp78 expression. |
2024-02-03 |
2024-02-05 |
human |
| Min-Hua Wu, Yi-Hsien Hsieh, Chia-Liang Lin, Tsung-Ho Ying, Shih-Min Hsia, Shu-Ching Hsieh, Chien-Hsing Lee, Chu-Liang Li. Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression. Environmental toxicology. 2024-02-03. PMID:38308464. |
suppression of grp78 expression in human emc cells treated with lica significantly attenuated the effects of lica, resulting in reduced er-stress mediated cell apoptosis and decreased expression of er- and apoptosis-related proteins. |
2024-02-03 |
2024-02-05 |
human |
| Guanglang Zhu, Hongxia Gao, Yang Li, Xu Li, Xiaohu Yang, Chen Wang, Zhenyu Guo, Heyu Fan, Longhua Fa. Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression. Pathology, research and practice. vol 253. 2024-01-23. PMID:38029715. |
4-pba reduced reactive oxygen species (ros) production and attenuated apoptosis, grp78 and chop protein expression in ox-ldl-induced vsmcs via up-regulating clock expression. |
2024-01-23 |
2024-01-25 |
mouse |
| Bingyao Meng, Minna Xu, Zihan Chen, Jia You, Rui Zhou, Jian Guan, Liang Zho. SIRT7 sustains tumor development and radioresistance by repressing endoplasmic reticulum stress-induced apoptosis in cutaneous melanoma. Cellular signalling. 2024-01-20. PMID:38244711. |
loss of sirt7 enhanced eif2α acetylation and activated its phosphorylation to induce the expression of er stress proteins including ddit3, xbp1 and grp78, among which ddit3 is responsible for apoptosis induction. |
2024-01-20 |
2024-01-23 |
human |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Yue Jiang, Li-Ke Yan, Ying Wang, Jun-Feng Ding, Zhong-Hua Xu, Can Cui, Jun T. [Mechanism of Gegen Qinlian Decoction in improving glucose metabolism in vitro and in vivo by alleviating hepatic endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114149. |
the glucose oxidase method was used to measure extracellular glucose levels, flow cytometry to detect cell apoptosis, glycogen staining to measure cellular glycogen content, and immunofluorescence to detect the expression of grp78. |
2023-12-19 |
2023-12-23 |
rat |
| Simin Li, Xinquan Li, Xiliang Yang, Yumeng Lei, Mingxin He, Xiaochen Xiang, Qingming Wu, Hongyun Liu, Jiadun Wang, Qiang Wan. Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78. Scientific reports. vol 13. issue 1. 2023-12-19. PMID:38114593. |
importantly, grp78 can affect the apoptosis induced by 5-fluorouracil in crc cells. |
2023-12-19 |
2023-12-23 |
Not clear |
| Zi Yan, Yufeng Liu, Bowen Yang, Wenhui Zhao, Yan Wang, Deping Wang, Jianguo Li, Xiangying Jiao, Jimin Ca. Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78. Acta biochimica et biophysica Sinica. 2023-12-18. PMID:38105649. |
endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of grp78. |
2023-12-18 |
2023-12-21 |
rat |
| Zi Yan, Yufeng Liu, Bowen Yang, Wenhui Zhao, Yan Wang, Deping Wang, Jianguo Li, Xiangying Jiao, Jimin Ca. Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78. Acta biochimica et biophysica Sinica. 2023-12-18. PMID:38105649. |
the expression of glucose-regulating protein 78 (grp78, a molecular chaperone of the cardiomyocyte er), acetylation modification of grp78 and apoptosis of cardiomyocytes are determined. |
2023-12-18 |
2023-12-21 |
rat |
| Zi Yan, Yufeng Liu, Bowen Yang, Wenhui Zhao, Yan Wang, Deping Wang, Jianguo Li, Xiangying Jiao, Jimin Ca. Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78. Acta biochimica et biophysica Sinica. 2023-12-18. PMID:38105649. |
the results show that ers-induced grp78 elevation does not induce cardiomyocyte apoptosis in the early stage of trauma. |
2023-12-18 |
2023-12-21 |
rat |
| Zi Yan, Yufeng Liu, Bowen Yang, Wenhui Zhao, Yan Wang, Deping Wang, Jianguo Li, Xiangying Jiao, Jimin Ca. Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78. Acta biochimica et biophysica Sinica. 2023-12-18. PMID:38105649. |
however, with prolonged ers, the grp78 acetylation level is elevated, and the apoptosis of cardiomyocytes also increases significantly. |
2023-12-18 |
2023-12-21 |
rat |