| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian-Yun Nie, Gen-Meng Yang, Peng Zhang, Wen-Juan Dong, Di Jing, Zhen-Ping Hou, Yan-Xia Peng, Yang Yu, Li-Hua Li, Shi-Jun Hon. Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats. Brain research. 2024-04-30. PMID:38685372. |
in the present study, we explored the effects of ma on the expression levels of nrf2, dynamin-related protein 1 (drp1), mitofusin 1 (mfn1), cytochrome c oxidase (cyt-c), and cysteine aspartate-specific protease 3 (caspase 3), as well as the correlations between nrf2 and mitochondrial dynamics and apoptosis. |
2024-04-30 |
2024-05-03 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Yuxuan Song, Shuang Ren, Xingmei Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang, Xiangchun Shen, Yan Che. Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics. Cancer letters. 2024-04-07. PMID:38583647. |
knockdown or pharmacological inhibition of mfn1 blocked mitochondrial fusion, restored bak oligomerization and cytochrome c release, and amplified activation of caspase-3/9, thus sensitizing resistant cells to apoptosis and facilitating the therapeutic effects of tam both in vivo and in vitro. |
2024-04-07 |
2024-04-10 |
Not clear |
| Yuxuan Song, Shuang Ren, Xingmei Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang, Xiangchun Shen, Yan Che. Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics. Cancer letters. 2024-04-07. PMID:38583647. |
inhibition of mfn1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics. |
2024-04-07 |
2024-04-10 |
Not clear |
| Yuxuan Song, Shuang Ren, Xingmei Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang, Xiangchun Shen, Yan Che. Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics. Cancer letters. 2024-04-07. PMID:38583647. |
conversely, overexpression of mfn1 alleviated tam-induced mitochondrial apoptosis and promoted tam resistance in sensitive cells. |
2024-04-07 |
2024-04-10 |
Not clear |
| Adel Alghamd. A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 32. issue 4. 2024-03-11. PMID:38463181. |
mfn1, a gtpase that is located on the outer membrane of the mitochondria, is involved in the process of linking nearby mitochondria, maintaining the potential of the mitochondrial membrane, and apoptosis. |
2024-03-11 |
2024-03-14 |
Not clear |
| Xiaohan Liu, Hong Cui, Qiaoyun Bai, Hongmei Piao, Yilan Song, Guanghai Ya. miR-128-3p alleviates airway inflammation in asthma by targeting SIX1 to regulate mitochondrial fission and fusion. International immunopharmacology. vol 130. 2024-02-29. PMID:38422767. |
moreover, led to decreased production of ros/mitochondrial ros, p-drp1(616) and fis1 expression, while enhancing p-drp1(637), mfn1, caspase-3/9, and bax-mediated apoptosis. |
2024-02-29 |
2024-03-03 |
mouse |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Guoyue Liu, Cunzhi Yin, Mingjiang Qian, Xuan Xiao, Hang Wu, Fujian F. LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an European journal of histochemistry : EJH. vol 67. issue 2. 2023-05-31. PMID:37254890. |
lncrna gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type ii epithelial cells by positively regulating mfn1 in an the mortality and morbidity rates of ovarian cancer (oc) are high, but the underlying mechanisms of oc have not been characterized. |
2023-05-31 |
2023-08-14 |
Not clear |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Genhua Mu, Yijun Deng, Zhongqian Lu, Xing Li, Yanbin Che. miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2. Acta biochimica et biophysica Sinica. vol 53. issue 2. 2021-06-10. PMID:33347533. |
furthermore, both in vivo and in vitro, upregulation of mfn1 and mfn2 aggravated lung damage and cell apoptosis that were alleviated by mir-20b overexpression. |
2021-06-10 |
2023-08-13 |
Not clear |
| Genhua Mu, Yijun Deng, Zhongqian Lu, Xing Li, Yanbin Che. miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2. Acta biochimica et biophysica Sinica. vol 53. issue 2. 2021-06-10. PMID:33347533. |
mir-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting mfn1 and mfn2. |
2021-06-10 |
2023-08-13 |
Not clear |
| Juan Tur, Selma Pereira-Lopes, Tania Vico, Eros A Marín, Juan P Muñoz, Maribel Hernández-Alvarez, Pere-Joan Cardona, Antonio Zorzano, Jorge Lloberas, Antonio Celad. Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity. Cell reports. vol 32. issue 8. 2021-06-02. PMID:32846136. |
in addition, the lack of mfn2 but not mfn1 is associated with dysfunctional autophagy, apoptosis, phagocytosis, and antigen processing. |
2021-06-02 |
2023-08-13 |
mouse |
| Islam M Saadeldin, Fariba Moulavi, Ayman Abdel-Aziz Swelum, Sokhangouy Saiede Khorshid, Hossini-Fahraji Hamid, Sayyed Morteza Hossein. Vitrification of camel oocytes transiently impacts mitochondrial functions without affecting the developmental potential after intracytoplasmic sperm injection and parthenogenetic activation. Environmental science and pollution research international. vol 27. issue 35. 2020-11-25. PMID:33029771. |
at the molecular level, vitrification reduced mrna expression of many genes, including those related to mitochondrial function (tfam, mt-co1, mfn1, atp1a1, nrf1), pluripotency (sox2 and pou5f1), and apoptosis (p53 and bax). |
2020-11-25 |
2023-08-13 |
Not clear |
| Longyun Chen, Huimin Che. Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28191022. |
meanwhile, we found mggd can inhibit cell apoptosis induced by cold stress through regulating expression level of mfn1, mfn2, drp1, fis-1, and opa-1. |
2020-09-30 |
2023-08-13 |
mouse |
| Longyun Chen, Huimin Che. Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28191022. |
western blot analysis showed that these cells expressed decreased fusion-related proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy protein-1 (opa-1) and increased fission-related proteins dynamin-related protein 1 (drp1) and fission 1 (fis-1); our results also show that decreased mitochondrial fusion induces cell apoptosis during cold stress. |
2020-09-30 |
2023-08-13 |
mouse |
| Man Zhang, Muhammed Burak Bener, Zongliang Jiang, Tianren Wang, Ecem Esencan, Richard Scott Iii, Tamas Horvath, Emre Sel. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31332167. |
deletion of mfn1 in oocytes resulted in mitochondrial dysfunction and altered mitochondrial dynamics, as well as accumulation of ceramide, which contributed to increased apoptosis and a reproductive phenotype that was partially rescued by treatment with ceramide synthesis inhibitor myriocin. |
2020-08-03 |
2023-08-13 |
Not clear |
| Guoyue Liu, Hong Mei, Miao Chen, Song Qin, Kang Li, Wei Zhang, Tao Che. Protective effect of agmatine against hyperoxia-induced acute lung injury via regulating lncRNA gadd7. Biochemical and biophysical research communications. vol 516. issue 1. 2020-07-13. PMID:31196629. |
further studies suggest that agm decreased the upregulated expression of lncrna gadd7 caused by hyperoxia and due to the presence of the competitive binding of lncrna gadd7 and mfn1 to mir-125a, agm indirectly decreased mfn1 protein expression to inhibit the cells apoptosis. |
2020-07-13 |
2023-08-13 |
Not clear |
| Hongling Wang, Xiangwen Peng, Fenglin Cao, Ying Wang, Huijie Shi, Shuai Lin, Weijie Zhong, Jingxia Su. Cardiotoxicity and Mechanism of Particulate Matter 2.5 (PM2.5) Exposure in Offspring Rats During Pregnancy. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-05-07. PMID:28801545. |
the pathological changes of heart tissue, the rate of myocardial cell apoptosis, the levels of ldh, ast, and cm-kb in serum, and the difference in mitochondrial fusion genes (opa1 and mfn1) and mitochondrial genes (drp1 and fis1) were compared among groups. |
2018-05-07 |
2023-08-13 |
mouse |
| Weiping Wang, Rong Wang, Qiao Zhang, Gil Mor, Huidong Zhan. Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cell dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion. Environmental pollution (Barking, Essex : 1987). vol 233. 2018-04-11. PMID:29144987. |
furthermore, the protein expression levels of mitochondrial fusion genes (mfn1, mfn2, and opa1) were decreased and those of fission genes (fis1 and drp1) were increased with increasing concentrations of bpde and incubation time, resulting in the release of cyt c and activation of caspase 3, which irreversibly induced trophoblast cell apoptosis. |
2018-04-11 |
2023-08-13 |
human |