| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Yang Liu, Chenbei Yao, Bin Sheng, Simin Zhi, Xiangxin Chen, Pengfei Ding, Jiatong Zhang, Zhennan Tao, Wei Li, Zong Zhuang, Jiannan Mao, Zheng Peng, Huiying Yan, Wei Ji. Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH. Translational stroke research. 2023-12-26. PMID:38147294. |
in cultured neurons, inhibition of usp30 promoted ubiquitination modification of mitochondrial fusion protein 2 (mfn2) by e3 ubiquitin ligase (parkin), separating damaged mitochondria from the healthy mitochondrial network and prompting mitophagy, causing early clearance of damaged intracellular mitochondria, and reducing the onset of apoptosis. |
2023-12-26 |
2023-12-28 |
mouse |
| Alexis Martinez, Cristian M Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M Kamiński, Nibaldo C Inestrosa, Brigitte van Zundert, Gonzalo I Cancino, Andrés E Dulcey, Silvana Zanlungo, Juan J Marugan, Claudio Hetz, Douglas R Green, Alejandra R Alvare. c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration. Antioxidants (Basel, Switzerland). vol 12. issue 11. 2023-11-25. PMID:38001860. |
we found that endoplasmic reticulum stress-activated c-abl interacts with and phosphorylates the mitochondrial fusion protein mfn2, resulting in mitochondrial fragmentation and apoptosis. |
2023-11-25 |
2023-11-28 |
mouse |
| Alexis Martinez, Cristian M Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M Kamiński, Nibaldo C Inestrosa, Brigitte van Zundert, Gonzalo I Cancino, Andrés E Dulcey, Silvana Zanlungo, Juan J Marugan, Claudio Hetz, Douglas R Green, Alejandra R Alvare. c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration. Antioxidants (Basel, Switzerland). vol 12. issue 11. 2023-11-25. PMID:38001860. |
moreover, the pharmacological or genetic inhibition of c-abl prevents mfn2 phosphorylation, mitochondrial fragmentation, and apoptosis in cells under endoplasmic reticulum stress. |
2023-11-25 |
2023-11-28 |
mouse |
| Jiaxu Zhou, Yilan Song, Xingmei Wang, Xinrui Li, Chang Liu, Chenchen Tian, Chongyang Wang, Liangchang Li, Guanghai Yan, Hong Cu. JTE-013 Alleviates Pulmonary Fibrosis by Affecting the RhoA/YAP Pathway and Mitochondrial Fusion/Fission. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895915. |
in vitro, s1pr2 and yap knockdown downregulated rhoa/yap pathway protein expression, drp1 phosphorylation, and drp1 translocation, promoted yap phosphorylation and phenotypic transformation of mfn2, and inhibited the up-regulation of mitochondrial membrane potential, reactive oxygen species production, and cell apoptosis (7.13% vs. 18.14%), protecting the integrity of the mitochondrial dynamics. |
2023-10-30 |
2023-11-08 |
mouse |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Xiaofeng Deng, Haoran Xu, Xiaoxia Hao, Jiawei Liu, Xingru Shang, Ruimin Chi, Chunran Pan, Wenjie Hou, Tao X. Moderate mechanical strain and exercise reduce inflammation and excessive autophagy in osteoarthritis by downregulating mitofusin 2. Life sciences. 2023-08-14. PMID:37579836. |
mitofusin 2 (mfn2) is a crucial regulatory factor associated with inflammation, autophagy and apoptosis, and its expression is regulated by exercise. |
2023-08-14 |
2023-09-07 |
Not clear |
| Lei Qin, Wen Yang, Yao-Xin Wang, Zhen-Jun Wang, Chen-Chen Li, Man Li, Jie-Yun Li. Retraction notice to "MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury" [Biomed. Pharmacother. 105 (2018) 103-114]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023-06-23. PMID:37353380. |
retraction notice to "microrna-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of mfn2 in a mouse model of myocardial ischemia-reperfusion injury" [biomed. |
2023-06-23 |
2023-08-14 |
mouse |
| Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifanti. Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery. 2023-04-24. PMID:37088914. |
genetic or pharmacologic mfn2 targeting synergizes with bh3-mimetics by impairing mitochondrial clearance and enhancing apoptosis in aml. |
2023-04-24 |
2023-08-14 |
Not clear |
| Prakash G Kulkarni, Vaibhavi M Mohire, Pooja K Bhaisa, Mrudula M Joshi, Chitranshi M Puranik, Pranjal P Waghmare, Tanushree Banerje. Mitochondrion. 2023-02-10. PMID:36764501. |
in recent years, mitofusin-2 (mfn2), a gtpase has emerged as a multifunctional protein which not only is found to regulate the mitochondrial fusion-fission process but also known to regulate several cellular functions such as mitochondrial metabolism, cellular biogenesis, signalling, and apoptosis via maintaining the er-mitochondria contact sites. |
2023-02-10 |
2023-08-14 |
Not clear |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Hongyu Li, Joseph C K Leung, Wai Han Yiu, Loretta Y Y Chan, Bin Li, Sarah W Y Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C W Tan. Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury. Cell death & disease. vol 13. issue 12. 2022-12-20. PMID:36539406. |
in both aki models, tubular β-catenin stabilization in tubcat animals significantly reduced bun/serum creatinine, tubular damage (ngal-positive tubules), apoptosis (tunel-positive cells) and necroptosis (phosphorylation of mlkl and rip3) through activating akt phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased pgc-1α and nrf1) and restored mitochondrial mass (increased tim23) to re-establish mitochondrial homeostasis (increased fusion markers opa1, mfn2, and decreased fission protein drp1) through the foxo3/pgc-1α signaling cascade. |
2022-12-20 |
2023-08-14 |
mouse |
| Expression of concern: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury [Biomedicine & Pharmacotherapy 105 (2018) 103-114]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271530. |
expression of concern: microrna-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of mfn2 in a mouse model of myocardial ischemia-reperfusion injury [biomedicine & pharmacotherapy 105 (2018) 103-114]. |
2022-10-22 |
2023-08-14 |
mouse |
| Pushpamala Ramaiah, Indrajit Patra, Anum Abbas, Ali Abdulhussain Fadhil, Mohammad Abohassan, Zahraa Haleem Al-Qaim, Noora Mohammed Hameed, Moaed Emran Al-Gazally, Saif Sabbar Kemil Almotlaq, Yasser Fakri Mustafa, Yavar Shiravan. Mitofusin-2 in cancer: Friend or foe? Archives of biochemistry and biophysics. vol 730. 2022-09-30. PMID:36176224. |
precisely, it demonstrated that mfn2, as a tumor suppressor, induces cancer cell apoptosis and inhibits cell proliferation via ca |
2022-09-30 |
2023-08-14 |
Not clear |
| Xi Fang, Qiang Han, Shiyong Li, Ailin Lu. Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway. Heliyon. vol 8. issue 9. 2022-09-12. PMID:36091956. |
the hippocampal tissue and serum were collected to determine the levels of sirt1, mfn2, perk, and other proteins or cytokines related to er stress, apoptosis, and neuroinflammation. |
2022-09-12 |
2023-08-14 |
rat |
| Hao Wang, Yuefei Yang, Yi Wang, Yuehan Peng, Lei Xu, Yuemin Hu, Huiming J. Effect of the Porcine STC-1 Gene on Autophagy and Mitochondrial Function as Induced by Serum Starvation. Biochemical genetics. 2022-05-19. PMID:35589876. |
in addition, the increase in mfn2, opa1, drp1 and lc3b proteins was attenuated; the increase in the apoptosis rate and amount of active oxygen was attenuated; the decrease in membrane potential; the decrease in atp was reversed; the fluorescence intensity of gfp-lc3b and gfp-parkin was increased. |
2022-05-19 |
2023-08-13 |
Not clear |
| He-Yan Zhou, Yu-Ying Sun, Ping Chang, Han-Chang Huan. Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2. Neurotoxicity research. 2022-02-22. PMID:35192145. |
this study investigated the protective effect of curcumin on thapsigargin (tg)-induced ers and cell apoptosis and the role of mfn2 on mitochondrial dysfunction. |
2022-02-22 |
2023-08-13 |
Not clear |
| Yun Cao, Zhaowei Chen, Jijia Hu, Jun Feng, Zijing Zhu, Yanqin Fan, Qiaoxuan Lin, Guohua Din. Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes Frontiers in cell and developmental biology. vol 9. 2022-01-06. PMID:34988075. |
mfn2 regulates high glucose-induced mams dysfunction and apoptosis in podocytes the endoplasmic reticulum (er) stress and mitochondrial dysfunction in high glucose (hg)-induced podocyte injury have been demonstrated to the progression of diabetic kidney disease (dkd). |
2022-01-06 |
2023-08-13 |
rat |
| Elif Erdem Guzel, Nalan Kaya Tektemur, Ahmet Tektemur, Hilal Acay, Ayfer Yildiri. The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats. Andrologia. vol 53. issue 11. 2021-11-03. PMID:34431122. |
there was an increase in the apoptotic index, caspase 3 (casp3), bcl2-associated x apoptosis regulator (bax), dynamin-related protein 1 (drp1) expression and total oxidative status (tos) in the dox group, while mitofusin-2 (mfn2), total antioxidative status (tas) and serum testosterone levels of the dox group reduced when compared with the other groups. |
2021-11-03 |
2023-08-13 |
rat |