| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing Ye, Zi-Jie Lin, Guang-Hui Hong, Zhi-Min Wang, Run-Ting Dou, Jun-Yi Lin, Jian-Hui Xie, Yi-Wen She. Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia. Experimental cell research. 2024-05-01. PMID:38692345. |
concurrently, pharmacological inhibition of nlrp3 inflammasome-mediated pyroptosis with mcc950 and vx-765 effectively decreased hypoxia-induced cardiomyocytes injury, while mitigating myocardial oxidative stress, apoptosis and inflammation caused by hypoxia. |
2024-05-01 |
2024-05-04 |
mouse |
| Yixuan Huang, Chengcheng Jiang, Xiaojie Liu, Wei Tang, Hongya Gui, Tao Sun, Doudou Xu, Maozhang He, Maozhen Han, Huan Qiu, Mingwei Chen, Shenghai Huan. Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-29. PMID:38683122. |
furthermore, tlr4 activation induced autophagy and apoptosis in neuronal cells, promoted the formation of the nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome, and increased the secretion of downstream inflammatory cytokines such as interleukin-1β (il-1β), interleukin-18 (il-18) and tumour necrosis factor-α (tnf-α). |
2024-04-29 |
2024-05-02 |
human |
| Osama A Mohammed, Sameh Saber, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S Alamri, Jaber Alfaifi, Masoud I E Adam, Muffarah Hamid Alharthi, Ali M S Eleragi, Hanan B Eltahir, Mohamed Osama Abdalla, Emad Bahashwan, Elwathiq Khalid Ibrahim, Assad Ali Rezigalla, Sameh Abdel-Ghany, Amany A Alzokaky, Ahmed S Doghish, Hussein M El-Husseiny, Mushabab Alghamdi, Mahmoud E Yousse. Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives. Toxicology and applied pharmacology. 2024-04-27. PMID:38677600. |
the mechanism of action involves modulating the nf-κb signaling, inhibiting the nlrp3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. |
2024-04-27 |
2024-04-30 |
rat |
| Shimaa O Ali, Heba R Ghaiad, Ghada F Elmasry, Noha A Mehan. Sinapic Acid Mitigates Pentylenetetrazol-induced Acute Seizures By Modulating the NLRP3 Inflammasome and Regulating Calcium/calcineurin Signaling: In Vivo and In Silico Approaches. Inflammation. 2024-04-25. PMID:38662166. |
the results showed that sa alleviated oxidative stress, restored the gaba/glutamate balance and calcium/calcineurin signaling, downregulated nlrp3 and apoptosis, and improved recognition and ambulatory activity in ptz-treated mice. |
2024-04-25 |
2024-04-28 |
mouse |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Zhao Zhang, Fengming Liang, Jun Chang, Xiaoqian Shan, Zhixian Yin, Li Wang, Shujiao L. Autophagy in dry AMD: a promising therapeutic strategy for retinal pigment epithelial cell damage. Experimental eye research. 2024-04-09. PMID:38593971. |
oxidative stress and chronic inflammation are major contributors to rpe cell damage, and the nod-like receptor thermoprotein structural domain-associated protein 3 (nlrp3) inflammasome mediates the inflammatory response leading to apoptosis in rpe cells. |
2024-04-09 |
2024-04-12 |
Not clear |
| Yifeng Dai, Xijin Xu, Xia Huo, Joost H N Schuitemaker, Marijke M Faa. Cell type-dependent response to benzo(a)pyrene exposure of human placental cell lines under normoxic, hypoxic, and pro-inflammatory conditions. Ecotoxicology and environmental safety. vol 276. 2024-04-05. PMID:38579532. |
in this study, we aimed to investigate the effects of bap on mitochondrial function, pyrin domain-containing protein 3 (nlrp3) inflammasome, and apoptosis in three human trophoblast cell lines under normoxia, hypoxia, and inflammatory conditions. |
2024-04-05 |
2024-04-10 |
human |
| Yifeng Dai, Xijin Xu, Xia Huo, Joost H N Schuitemaker, Marijke M Faa. Cell type-dependent response to benzo(a)pyrene exposure of human placental cell lines under normoxic, hypoxic, and pro-inflammatory conditions. Ecotoxicology and environmental safety. vol 276. 2024-04-05. PMID:38579532. |
this increased ΔΨm may have rescued the trophoblast cells from activation of the nlrp3 inflammasome and apoptosis after bap treatment. |
2024-04-05 |
2024-04-10 |
human |
| Xiang Xiong, Caiyun Yin, Aidi Tong, Guowei Zhong, Zhou Wu, Chunyi Tong, Xiancheng Wang, Bin Li. Dermal extracellular matrix gelatin delivering Prussian blue nanoparticles to relieve skin flap ischemia. International journal of biological macromolecules. 2024-04-04. PMID:38574902. |
in vivo assays further confirmed that alp@pb-gel could effectively alleviate necrosis in the early and late stages after surgery, downregulate the levels of nlrp3 and cd68 to inhibit apoptosis and attenuate inflammation, while upregulate the levels of vegf and cd31 to promote vascular tissue regeneration. |
2024-04-04 |
2024-04-07 |
human |
| Keyvan Amirshahrokhi, Mahsa Iman. Therapeutic Effect of Levetiracetam Against Thioacetamide-Induced Hepatic Encephalopathy Through Inhibition of Oxidative Stress and Downregulation of NF-κB, NLRP3, iNOS/NO, Pro-Inflammatory Cytokines and Apoptosis. Inflammation. 2024-03-26. PMID:38530519. |
therapeutic effect of levetiracetam against thioacetamide-induced hepatic encephalopathy through inhibition of oxidative stress and downregulation of nf-κb, nlrp3, inos/no, pro-inflammatory cytokines and apoptosis. |
2024-03-26 |
2024-03-29 |
mouse |
| Ngoc Minh-Hong Hoang, Hai Duc Nguyen, Wonhee Jo, Min-Sun Ki. Role of prolactin in the protective effect of amisulpride against 1,2-Diacetylbenzene's neurotoxicity. Environmental toxicology and pharmacology. 2024-03-17. PMID:38493881. |
additionally, amisulpride inhibited dab-triggered nlrp3 inflammasome activation and apoptosis. |
2024-03-17 |
2024-03-20 |
Not clear |
| Shuaichen Liu, Lan Hong, Song Zhang, Yuxin Tian, Yuchen Wang, Duanduan Zhao, Jingheng Lv, Jingjing Zhuang, Hongyan Xu, Guangjun Xi. Sporisorium reilianum polysaccharides improve DSS-induced ulcerative colitis by regulating intestinal barrier function and metabolites. International journal of biological macromolecules. 2024-03-15. PMID:38490380. |
epithelial cell apoptosis was inhibited by increased bcl-2 and decreased bax expression nlrp3, asc, and caspase-1 protein levels decreased. |
2024-03-15 |
2024-03-18 |
mouse |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
dihydrocapsaicin suppresses the sting-mediated accumulation of ros and nlrp3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. |
2024-03-09 |
2024-03-11 |
Not clear |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
the expressions of angiogenesis, apoptosis, nlr family pyrin domain containing 3 (nlrp3) inflammasome, oxidative stress, and molecules related to cyclic guanosine monophosphate (gmp)-adenosine monophosphate synthase (cgas)-interferon gene stimulant (sting) pathway were assessed using western blotting, immunofluorescence, tunel staining, and dihydroethidium (dhe) staining. |
2024-03-09 |
2024-03-11 |
Not clear |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
our finding revealed that dhc promoted the perforator flap survival, which involves the cgas-sting pathway, oxidative stress, nlrp3 inflammasome, apoptosis, and angiogenesis. |
2024-03-09 |
2024-03-11 |
Not clear |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
dhc induced oxidative stress resistance and suppressed the nlrp3 inflammasome, preventing apoptosis in vascular endothelial cells. |
2024-03-09 |
2024-03-11 |
Not clear |
| Fatemeh Mirzaei, Ebrahim Abbasi, Amir Mirzaei, Nashmin Fayazi Hosseini, Nima Naseri, Iraj Khodadadi, Cyrus Jalili, Nesrine Majdou. Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action. Biological trace element research. 2024-03-05. PMID:38441796. |
the oxidative stress, nlrp3 inflammasome, inflammatory, and apoptosis pathways were measured. |
2024-03-05 |
2024-03-07 |
rat |
| Fatemeh Mirzaei, Ebrahim Abbasi, Amir Mirzaei, Nashmin Fayazi Hosseini, Nima Naseri, Iraj Khodadadi, Cyrus Jalili, Nesrine Majdou. Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action. Biological trace element research. 2024-03-05. PMID:38441796. |
antioxidant enzyme gene expression and activity were significantly augmented, while apoptosis, nlrp3 inflammasome, and inflammation pathways were significantly reduced by 5 mg/kg zno nps. |
2024-03-05 |
2024-03-07 |
rat |
| Li Liu, YingFeng Wei, NingSheng Xie, Hong Cai, Ye Li. Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430023. |
after tgf-β1 induction, hsc proliferation increased, apoptosis decreased, and col1a1, α-sma, and nlrp3 inflammasome protein expression increased. |
2024-03-02 |
2024-03-04 |
mouse |
| Li Liu, YingFeng Wei, NingSheng Xie, Hong Cai, Ye Li. Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430023. |
after ss-31 treatment, mitochondrial ros expression decreased, mmp recovered, atp level increased, hsc proliferation decreased, apoptosis increased, and the expressions of col1a1, α-sma, and nlrp3 inflammasome decreased. |
2024-03-02 |
2024-03-04 |
mouse |