| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei-Xuan Zhang, Hui Hong, Yun Shi, Wen-Yan Huang, Yi-Meng Xia, Lu-Lu Tan, Wei-Jiang Zhao, Chen-Meng Qiao, Jian Wu, Li-Ping Zhao, Shu-Bing Huang, Xue-Bing Jia, Yan-Qin Shen, Chun Cu. A Pilot Study on a Possible Mechanism behind Olfactory Dysfunction in Parkinson's Disease: The Association of TAAR1 Downregulation with Neuronal Loss and Inflammation along Olfactory Pathway. Brain sciences. vol 14. issue 4. 2024-04-27. PMID:38671952. |
in summary, we have identified a possible mechanism to elucidate the olfactory dysfunction in pd, positing neuronal damage and inflammation due to apoptosis and astrocyte activity along the olfactory pathway in conjunction with the downregulation of taar1. |
2024-04-27 |
2024-04-29 |
mouse |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Jianwei Lv, Hang Yu, Fangli Shan, Jianan Ye, Ao Li, Juehua Jing, Meige Zheng, Dasheng Tia. Effect of myelin debris on the phenotypic transformation of astrocytes after spinal cord injury in rats. Neuroscience. 2024-04-03. PMID:38570063. |
we emphasize that myelin debris can induce astrocyte apoptosis in vitro and promote the transformation of astrocytes into a1 astrocytes in vivo. |
2024-04-03 |
2024-04-06 |
rat |
| Cristine Marie Yde Ohki, Cecília Benazzato, Vanessa van der Linden, Julia V França, Carmen M Toledo, Rafael Rahal Guaragna Machado, Danielle Bastos Araujo, Danielle Bruna Leal Oliveira, Romulo S Neris, Iranaia Assunção-Miranda, Isis Nem de Oliveira Souza, Clara O Nogueira, Paulo Emilio Corrêa Leite, Hélio van der Linden, Claudia P Figueiredo, Edison Luiz Durigon, Julia R Clarke, Fabiele Baldino Russo, Patricia Cristina Baleeiro Beltrão-Brag. Zika virus infection impairs synaptogenesis, induces neuroinflammation, and could be an environmental risk factor for autism spectrum disorder outcome. Biochimica et biophysica acta. Molecular basis of disease. 2024-02-26. PMID:38408544. |
interestingly, zikv infection in neuroprogenitor cells compromises cell migration and causes apoptosis but does not interfere in astrocyte generation. |
2024-02-26 |
2024-03-02 |
mouse |
| Mahdiyeh Bakhtiyari-Ramezani, Mojtaba Nohekhan, Mohammad Esmaeil Akbari, Fereshteh Abbasvandi, Mahdis Bayat, Atieh Akbari, Meysam Nasir. Comparative assessment of direct and indirect cold atmospheric plasma effects, based on helium and argon, on human glioblastoma: an in vitro and in vivo study. Scientific reports. vol 14. issue 1. 2024-02-12. PMID:38347045. |
in vitro assessments on human gbm and normal astrocyte cell lines, using mtt assays, flow cytometry analysis, wound healing assays, and immunocytochemistry for caspase3 and p53 proteins, demonstrated that all studied plasma jets, especially indirect argon cap, selectively induced apoptosis, hindered tumor cell growth, and inhibited migration. |
2024-02-12 |
2024-02-15 |
human |
| Xiaodan Mi, Chengtao Ni, Jingting Zhao, Nashwa Amin, Dian Jiao, Marong Fang, Xiangming Y. P2Y12 receptor mediates apoptosis and demyelination to affect functional recovery in mice with spinal cord injury. Neurochemistry international. 2023-11-12. PMID:37952830. |
our findings demonstrated that mrs2395 significantly enhanced motor function induced by sci and that was used to alleviate apoptosis and astrocyte scarring. |
2023-11-12 |
2023-11-20 |
mouse |
| Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo, Feng Liang, Linghong Shen, Lijuan Zhu, Ben He, Hongmei Wan. Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk. Cell death discovery. vol 9. issue 1. 2023-09-06. PMID:37673878. |
our results suggested that allicin could significantly ameliorate behavioral characteristics, cerebral infarct area, cell apoptosis, inflammatory factors, and lipid metabolic-related factors (arachidonic acid, 15-hydroperoxy-eicosatetraenoic acid (15s-hpete), palmitoylcarnitine, and acylcarnitine) by recalibrating astrocyte homeostasis in mice with photothrombotic stroke (pt). |
2023-09-06 |
2023-10-07 |
mouse |
| Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo, Feng Liang, Linghong Shen, Lijuan Zhu, Ben He, Hongmei Wan. Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk. Cell death discovery. vol 9. issue 1. 2023-09-06. PMID:37673878. |
allicin was proven to inhibit hypoxia-induced astrocyte apoptosis by increasing gpx1 expression, activating proto-oncogene tyrosine-protein kinase src (src)- protein kinase b (akt)-extracellular signal-regulated kinase (erk) phosphorylation, and decreasing lipid peroxidation. |
2023-09-06 |
2023-10-07 |
mouse |
| Fan Xie, Li Li, Min Peng, Huan Zhan. Overexpression of miR-199a-5p improves brain injury in newborn rats with intrauterine infection via inhibition of astrocyte activation. Brain research. 2023-08-30. PMID:37648092. |
results from cell models showed that mir-199a-5p overexpression inhibited astrocyte activation, shown by enhanced cell viability, weakened cell apoptosis, and decreased gfap, il-6, and tnf-α. |
2023-08-30 |
2023-09-07 |
rat |
| Wan-He Li, Zheng-Ting-Yan Xiang, An-Xin Lu, Su-Su Wang, Chong-Huai Ya. Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes. Ecotoxicology and environmental safety. vol 262. 2023-08-09. PMID:37556958. |
the objectives of this study was to examine the modulation of the jnk/foxo3a signaling pathway, which is activated by ros, in mn-induced apoptosis, using a rat brain astrocyte cell line (ctx cells). |
2023-08-09 |
2023-08-16 |
rat |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
this study, using a mouse model, investigated the effects of exposure to e-vapour (± nicotine) and hfd (43% fat) consumption, on the expression of nicotinic acetylcholine receptor (nachr) subunits α3, α4, α7 and β2, apoptosis markers caspase-3 and tunel, microglial marker iba-1, and astrocyte marker gfap, in hippocampal subregions of dentate gyrus (dg) and cornu ammonis (ca) 1-3. |
2023-06-21 |
2023-08-14 |
mouse |
| Taibang Chen, Xiaoqing He, Jing Wang, Di Du, Yongqing X. NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration. Molecular biotechnology. 2023-06-15. PMID:37318740. |
nt-3 combined with tgf-β signaling pathway promotes astrocyte differentiation, reduces axon regeneration inhibitory molecules, apoptosis and glial scar formation, promotes axon regeneration, and improves spinal cord injury. |
2023-06-15 |
2023-08-14 |
mouse |
| Hongcheng Luo, Qiang Huang, Deyou Huang, Chunhong Liu, Xianke Long, Renguang Tan. HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke. ACS chemical neuroscience. 2023-06-09. PMID:37294185. |
also, an enhancement of habp2 was noted in their peripheral blood-derived exosomes, while loss of habp2 in peripheral blood-derived exosomes promoted the astrocyte autophagy and reduced the release of the inflammatory factors as well as the apoptosis of neuronal cells. |
2023-06-09 |
2023-08-14 |
mouse |
| Jing Ren, Yuan Lv, Qiuyan Tian, Li Sun, Po Miao, Xiaofeng Yang, Li-Xiao Xu, Chen-Xi Feng, Mei Li, Qin Gu, Xing Feng, Xin Din. Suppression of Microglial ERO1a Alleviates Inflammation and Enhances the Efficacy of Rehabilitative Training After Ischemic Stroke. Molecular neurobiology. 2023-04-26. PMID:37100971. |
in contrast, suppression of microglial ero1a significantly reduced activation of both microglia and astrocyte, along with cell apoptosis. |
2023-04-26 |
2023-08-14 |
Not clear |
| Parisa Zamani Esmati, Javad Baharara, Sajad Sahab-Negah, Khadijeh Nejad Shahrokhabad. Leukemia-derived Exosomes Can Induce Responses Related to Tumorigenesis on Non-tumoral Astrocytes. Applied biochemistry and biotechnology. 2023-04-17. PMID:37067679. |
to assess astrocyte responses, data were obtained by mtt, annexin/pi to indicate proliferation and apoptosis. |
2023-04-17 |
2023-08-14 |
Not clear |
| Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Ta. Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke. Journal of pharmaceutical analysis. vol 13. issue 2. 2023-03-13. PMID:36908855. |
furthermore, by inhibiting oxidative stress and astrocyte activation, celastrol effectively rescued neurons from axon damage and apoptosis. |
2023-03-13 |
2023-08-14 |
Not clear |
| Liming He, Qiang Chang, Yannan Zhang, Xiaoming Guan, Zhuo Ma, Xu Chen, Wenbo Liu, Yakun Li, Haoyu Fen. MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation. Neurochemical research. 2023-02-07. PMID:36750528. |
mir-155-5p mimic dose-dependently promoted astrocyte proliferation, and inhibited cell apoptosis. |
2023-02-07 |
2023-08-14 |
rat |
| Guang Yang, Jinxin Sh. miRNA-130a-3p targets sphingosine-1-phosphate receptor 1 to activate the microglial and astrocytes and to promote neural injury under the high glucose condition. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-12-30. PMID:36582210. |
the results revealed that mir-130a-3p deficiency alleviated apoptosis and oxidative stress of hg-stimulated neurons as well as suppressed microglial and astrocyte activation. |
2022-12-30 |
2023-08-14 |
mouse |
| Seung-Chan Kim, Jae-Yong Park, Eun Mi Hwan. Caspase-dependent apoptosis induces reactivation and gliogenesis of astrocytes in adult mice. Frontiers in cellular neuroscience. vol 16. 2022-12-19. PMID:36531137. |
overall, transient hippocampal astrocyte depletion caused by apoptosis restored cell number and function within 2 weeks and did not induce significant neurotoxicity. |
2022-12-19 |
2023-08-14 |
mouse |
| Weijie Xie, Yanqin Zeng, Yunqiu Zheng, Bin Ca. Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice. Cellular and molecular neurobiology. 2022-11-28. PMID:36441266. |
three months after bcas, we measured the ampk protein expression, spatial learning and memory, nissl bodies, cell apoptosis, astrocyte activation, and oligodendrocyte maturation. |
2022-11-28 |
2023-08-14 |
mouse |