| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beverley A Orse. Discovering the Intriguing Properties of Extrasynaptic γ-Aminobutyric Acid Type A Receptors. Anesthesiology. 2024-04-16. PMID:38624275. |
briefly, the principal inhibitory neurotransmitter in the brain, γ-aminobutyric acid (gaba), was conventionally thought to regulate cognitive processes by activating synaptic gaba type a (gabaa) receptors and generating transient inhibitory synaptic currents. |
2024-04-16 |
2024-04-18 |
mouse |
| Huiping Shang, Peijun Li, Xiangxiang Lin, Qionghui Cai, Zhihui Li, Lu Deng, Yue Song, Jiang-Fan Chen, Jianhong Zho. Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-01-24. PMID:36694040. |
several cognitive processes, including instrumental behavior and working memory, are controlled by endocannabinoids acting on cannabinoid receptor 1 (cb1r) in the brain through retrograde and presynaptic inhibition of gaba or glutamate release. |
2023-01-24 |
2023-08-14 |
human |
| Rafal Paprocki, Artem Lenski. What Does Eye-Blink Rate Variability Dynamics Tell Us About Cognitive Performance? Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:29311876. |
this surprising phenomenon could be explained by the person to person variation in concentrations of dopamine in pfc and accumulation of gaba in the visual cortex, as both neurotransmitters play a key role in cognitive processes and affect blinking. |
2020-09-30 |
2023-08-13 |
human |
| Joseph A McQuail, Cristina Bañuelos, Candi L LaSarge, Michelle M Nicolle, Jennifer L Bizo. GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22169202. |
gamma aminobutyric acid (gaba)(b) receptors (gaba(b)rs) have been linked to a wide range of physiological and cognitive processes and are of interest for treating a number of neurodegenerative and psychiatric disorders. |
2013-01-24 |
2023-08-12 |
rat |
| Erik Keimpema, Alex Straiker, Ken Mackie, Tibor Harkany, Jens Hjerling-Leffle. Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells. The Journal of physiology. vol 590. issue 4. 2012-06-26. PMID:22219340. |
certain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ-aminobutyric acid (gaba)-releasing inhibitory interneurons in the hippocampus. |
2012-06-26 |
2023-08-12 |
Not clear |
| Paul L Chazo. Therapeutic potential of histamine H3 receptor antagonists in dementias. Drug news & perspectives. vol 23. issue 2. 2010-06-14. PMID:20369074. |
selective antagonism of centrally localized histamine h(3) receptors has been shown to enhance the release of a wide spectrum of important neurotransmitters including acetylcholine, gamma-aminobutyric acid, dopamine and noradrenalin, among others, which play fundamental roles in cognitive processes, in an output-dependent manner. |
2010-06-14 |
2023-08-12 |
Not clear |
| Nicholas M Graziane, Eunice Y Yuen, Zhen Ya. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. The Journal of biological chemistry. vol 284. issue 13. 2009-05-26. PMID:19179335. |
the gaba(a) receptor-mediated inhibitory transmission in prefrontal cortex (pfc) is implicated in cognitive processes such as working memory. |
2009-05-26 |
2023-08-12 |
human |
| Laura H Jacobson, Peter H Kelly, Bernhard Bettler, Klemens Kaupmann, John F Crya. Specific roles of GABA(B(1)) receptor isoforms in cognition. Behavioural brain research. vol 181. issue 1. 2007-08-24. PMID:17498817. |
we conclude that gaba(b(1)) isoforms contribute differentially to gaba(b) receptor-mediated cognitive processes. |
2007-08-24 |
2023-08-12 |
mouse |
| Francisco Paulino Dubiela, Maria Gabriela Menezes de Oliveira, Karin Di Monteiro Moreira, José N Nobrega, Sergio Tufik, Débora Cristina Hipólid. Learning deficits induced by sleep deprivation and recovery are not associated with altered [(3)H]muscimol and [(3)H]flunitrazepam binding. Brain research. vol 1037. issue 1-2. 2005-06-16. PMID:15777764. |
other lines of evidence indicate an involvement of brain gaba systems in cognitive processes. |
2005-06-16 |
2023-08-12 |
rat |
| Neil Collinson, Frederick M Kuenzi, Wolfgang Jarolimek, Karen A Maubach, Rosa Cothliff, Cyrille Sur, Alison Smith, Franklin M Otu, Owain Howell, John R Atack, Ruth M McKernan, Guy R Seabrook, Gerry R Dawson, Paul J Whiting, Thomas W Rosah. Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 13. 2002-07-29. PMID:12097508. |
these data suggest that alpha5-containing gaba(a) receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the ca1 region of the hippocampus. |
2002-07-29 |
2023-08-12 |
mouse |
| F Nava, G Carta, M Bortolato, G L Gess. gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors. European journal of pharmacology. vol 430. issue 2-3. 2002-01-14. PMID:11711039. |
these findings indicate that ghb-induced reduction of hippocampal acetylcholine release is mediated by gaba(b) receptors and support a possible involvement of hippocampal gaba(b) receptors in the control of cognitive processes and in the claimed amnesic effect of ghb intoxication. |
2002-01-14 |
2023-08-12 |
rat |
| M Bianchi, P Ferrario, A Clavenna, A E Panera. Interleukin-6 affects scopolamine-induced amnesia, but not brain amino acid levels in mice. Neuroreport. vol 8. issue 7. 1997-07-31. PMID:9189931. |
as it is well known that brain amino acids are deeply involved in the modulation of cognitive processes we measured the levels of glutamine, aspartic acid, glutamic acid and gaba in the hippocampus and hypothalamus of mice treated with il-6. |
1997-07-31 |
2023-08-12 |
mouse |
| B Zimmerberg, P C Drucker, J M Weide. Differential behavioral effects of the neuroactive steroid allopregnanolone on neonatal rats prenatally exposed to alcohol. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667369. |
this decreased sensitivity suggests that prenatal alcohol exposure may cause a decrease in the density or affinity of the gaba receptors involved in stress response, but not cognitive processes, at this age. |
1995-10-11 |
2023-08-12 |
human |