| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maximillian N J Woodall, Ana-Maria Cujba, Kaylee B Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G H Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Batuhan Cakir, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O'Callaghan, Jie Zhou, Wendy Barclay, Paolo DeCoppi, Colin R Butler, Mario Cortina-Borja, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C Chambers, Wendy E Heywood, Kevin Mills, Robert E Hynds, Sarah A Teichmann, Kerstin B Meyer, Marko Z Nikolić, Claire M Smit. Age-specific nasal epithelial responses to SARS-CoV-2 infection. Nature microbiology. 2024-04-15. PMID:38622380. |
we show that cell tropism of sars-cov-2, and expression of ace2 and tmprss2 in nasal epithelial cell subtypes, differ between age groups. |
2024-04-15 |
2024-04-18 |
Not clear |
| Tulika Gupta, Munish Kumar, Ujjwal Jit Kaur, Asha Rao, Ranjana Bhart. Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations. Journal of neurovirology. 2024-04-10. PMID:38600308. |
the ace2 and tmprss2 gene expression was observed to be highest in hypothalamus and thalamus regions, respectively. |
2024-04-10 |
2024-04-13 |
human |
| Oluwadamilola D Ogunjinmi, Tukur Abdullahi, Riaz-Ali Somji, Charlotte L Bevan, Wendy S Barclay, Nigel Temperton, Greg N Brooke, Efstathios S Gioti. The antiviral potential of the antiandrogen enzalutamide and the viral-androgen signaling interplay in seasonal coronaviruses. Journal of medical virology. vol 96. issue 3. 2024-03-26. PMID:38529542. |
the sex disparity in covid-19 outcomes with males generally faring worse than females has been associated with the androgen-regulated expression of the protease tmprss2 and the cell receptor ace2 in the lung and fueled interest in antiandrogens as potential antivirals. |
2024-03-26 |
2024-03-28 |
human |
| Paul Feinstei. Rapid Degradation of the Human ACE2 Receptor Upon Binding and Internalization of SARS-Cov-2-Spike-RBD Protein. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496410. |
it is widely accepted that the sars-cov-2 betacoronavirus infects humans through binding the human angiotensin receptor 2 (ace2) that lines the nasal cavity and lungs, followed by import into a cell utilizing the transmembrane protease, serine 2 (tmprss2) cofactor. |
2024-03-18 |
2024-03-20 |
human |
| Arun Das, Wen Meng, Zhentao Liu, Md Musaddaqul Hasib, Hugh Galloway, Suzane Ramos da Silva, Luping Chen, Gabriel L Sica, Alberto Paniz-Mondolfi, Clare Bryce, Zachary Grimes, Emilia M Sordillo, Carlos Cordon-Cardo, Karla Paniagua Rivera, Mario Flores, Yu-Chiao Chiu, Yufei Huang, Shou-Jiang Ga. Molecular and immune signatures, and pathological trajectories of fatal COVID-19 lungs defined by in situ spatial single-cell transcriptome analysis. Journal of medical virology. vol 95. issue 8. 2023-08-11. PMID:37563850. |
the hihd regions expressed high levels of sars-cov-2 entry-related factors including ace2, furin, tmprss2 and nrp1, and co-localized with organizing pneumonia (op) and lymphocytic and immune infiltration, which exhibited increased acs and fibroblasts but decreased vascular endothelial cells and epithelial cells, mirroring the tissue damage and wound healing processes. |
2023-08-11 |
2023-08-16 |
Not clear |
| Aron Emmi, Aleksandar Tushevski, Alessandro Sinigaglia, Silvia Barbon, Michele Sandre, Elena Stocco, Veronica Macchi, Angelo Antonini, Luisa Barzon, Andrea Porzionato, Raffaele De Car. ACE2 Receptor and TMPRSS2 Protein Expression Patterns in the Human Brainstem Reveal Anatomical Regions Potentially Vulnerable to SARS-CoV-2 Infection. ACS chemical neuroscience. 2023-05-12. PMID:37172190. |
ace2 receptor and tmprss2 protein expression patterns in the human brainstem reveal anatomical regions potentially vulnerable to sars-cov-2 infection. |
2023-05-12 |
2023-08-14 |
human |
| Rattapol Phandthong, Man Wong, Ann Song, Teresa Martinez, Prue Talbo. New insights into how popular electronic cigarette aerosols and aerosol constituents affect SARS-CoV-2 infection of human bronchial epithelial cells. Scientific reports. vol 13. issue 1. 2023-04-10. PMID:37037851. |
in general, nicotine and nicotine + propylene glycol/vegetable glycerin aerosols increased ace2 (angiotensin converting enzyme 2) levels, the sars-cov-2 receptor; and increased the activity of tmprss2 (transmembrane serine protease 2), an enzyme essential for viral entry. |
2023-04-10 |
2023-08-14 |
human |
| Rhys Hamon, Miranda P Wee. E-Cigarette Vapour Increases ACE2 and TMPRSS2 Expression in a Flavour- and Nicotine-Dependent Manner. International journal of environmental research and public health. vol 19. issue 22. 2022-11-26. PMID:36429673. |
in this study, healthy donor bronchial epithelial cells (nhbe) and monocyte-derived macrophages (mdm) were exposed to cigarette smoke extract (cse) or nicotine or flavoured e-cigarette vapour extract (eve) before the assessment of sars-cov-2 recognition receptors ace2 and tmprss2 genes. |
2022-11-26 |
2023-08-14 |
Not clear |
| Rhys Hamon, Miranda P Wee. E-Cigarette Vapour Increases ACE2 and TMPRSS2 Expression in a Flavour- and Nicotine-Dependent Manner. International journal of environmental research and public health. vol 19. issue 22. 2022-11-26. PMID:36429673. |
ace2 was found to be upregulated by >2-fold in nhbe cells exposed to cse, as well as nicotine, banana, or chocolate eve, while tmprss2 was only upregulated by cse or nicotine eve exposure. |
2022-11-26 |
2023-08-14 |
Not clear |
| Rhys Hamon, Miranda P Wee. E-Cigarette Vapour Increases ACE2 and TMPRSS2 Expression in a Flavour- and Nicotine-Dependent Manner. International journal of environmental research and public health. vol 19. issue 22. 2022-11-26. PMID:36429673. |
these findings suggesting that flavourings can increase ace2 expression in multiple cell types, while tmprss2 expression increases are limited to the epithelial cells in airways and may be limited to nicotine and/or cigarette smoke exposure. |
2022-11-26 |
2023-08-14 |
Not clear |
| Ke Xu, Xingyi Shi, Christopher Husted, Rui Hong, Yichen Wang, Boting Ning, Travis B Sullivan, Kimberly M Rieger-Christ, Fenghai Duan, Helga Marques, Adam C Gower, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Grant Duclos, Michael Platt, Avrum E Spira, Sarah A Mazzilli, Ehab Billatos, Marc E Lenburg, Joshua D Campbell, Jennifer E Bean. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307504. |
the similarities and differences of ve gene expression (ace2, tmprss2, and ctsl) across nasal and bronchial compartments have not been fully characterized using matched samples from large cohorts. |
2022-10-28 |
2023-08-14 |
Not clear |
| Kotaro Sato, Koki Fujii, Noriyuki Yamamoto, Norihisa Ichimura, Satoshi Yamaguchi, Hirohisa Yamada, Hideharu Hibi, Shinya Toyokun. Association of alcohol intake and female gender with high expression of TMPRSS2 in tongue as potential risk for SARS-CoV-2 infection. Journal of clinical biochemistry and nutrition. vol 71. issue 2. 2022-10-10. PMID:36213787. |
because dysgeusia is an early symptom of covid-19, we here studied the expression of ace2 and tmprss2 in the tongue and the associated tissues of mice and humans with immunohistochemistry and immunoblot analysis. |
2022-10-10 |
2023-08-14 |
mouse |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Chin-Chu Chen, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Study on the potential of Sanghuangporus sanghuang and its components as COVID-19 spike protein receptor binding domain inhibitors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076488. |
accordingly, ace2 and tmprss2 are targets of vital importance for the avoidance of sars-cov-2 infection. |
2022-09-09 |
2023-08-14 |
mouse |
| Müge Keskin, Sefika Burcak Polat, İhsan Ates, Seval İzdes, Hatice Rahmet Güner, Oya Topaloglu, Reyhan Ersoy, Bekir Cakı. Is There Any Correlation between Baseline Serum Cortisol Levels and Disease Severity in PCR-Positive COVID-19 Patients with and without Diabetes Mellitus? Vaccines. vol 10. issue 8. 2022-08-26. PMID:36016249. |
the hypothalamus, pituitary gland, and possibly adrenal glands are the targets of sars-cov-2 because of its angiotensin-converting enzyme 2 (ace2) and transmembrane serine protease 2 (tmprss2) receptors expression. |
2022-08-26 |
2023-08-14 |
Not clear |
| Gaetano Scotto, Vincenzina Fazio, Eleonora Lo Muzio, Lorenzo Lo Muzio, Francesca Spirit. SARS-CoV-2 Infection and Taste Alteration: An Overview. Life (Basel, Switzerland). vol 12. issue 5. 2022-05-28. PMID:35629357. |
cells in the oral epithelium, taste buds, and minor and major salivary glands express cellular entry factors for the virus, such as ace2, tmprss2 and furin. |
2022-05-28 |
2023-08-13 |
Not clear |
| Aarenee Greene, Aline de Souza, Jennifer Chau, Moshe Levi, Blythe D Shepard, Kathryn Sandberg, Carolyn M Ecelbarge. Dietary Empagliflozin Regulates Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Kidney Cortex of Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556283. |
dietary empagliflozin regulates angiotensin converting enzyme 2 (ace2) and transmembrane serine protease 2 (tmprss2) in kidney cortex of mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Aarenee Greene, Aline de Souza, Jennifer Chau, Moshe Levi, Blythe D Shepard, Kathryn Sandberg, Carolyn M Ecelbarge. Dietary Empagliflozin Regulates Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Kidney Cortex of Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556283. |
our aim was to determine how chronic empa affected ace2 and tmprss2 protein levels and ace2 activity in the kidney cortex of mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Aarenee Greene, Aline de Souza, Jennifer Chau, Moshe Levi, Blythe D Shepard, Kathryn Sandberg, Carolyn M Ecelbarge. Dietary Empagliflozin Regulates Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Kidney Cortex of Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556283. |
kidney cortex protein levels of ace2 and tmprss2 were determined by conventional western blotting (to observe band size and antibody specificity) and by dot blotting (to compare all samples on the same blot). |
2022-05-13 |
2023-08-13 |
mouse |
| Nagalakshmi Balasubramanian, Thomas D James, Selvakumar Govindhasamy Pushpavathi, Catherine A Marcinkiewc. Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection. bioRxiv : the preprint server for biology. 2022-04-05. PMID:35378747. |
while ace2 and tmprss2 genes are upregulated in the cortex of alcohol-dependent individuals, information on expression in specific brain regions and neural populations implicated in sars-cov-2 neuroinvasion, particularly monoaminergic neurons, is limited. |
2022-04-05 |
2023-08-13 |
Not clear |
| Bo Wang, Dongping Li, Anna Fiselier, Igor Kovalchuk, Olga Kovalchu. New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts. Cell death discovery. vol 8. issue 1. 2022-03-12. PMID:35277472. |
here, we show akt serine/threonine kinase-dependent epigenetic control of ace2 and tmprss2 expression by high-cannabidiol (cbd) cannabis extracts and their individual components. |
2022-03-12 |
2023-08-13 |
Not clear |