| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rohan Ameratunga, Anthony Jordan, Klaus Lehnert, Euphemia Leung, Emily R Mears, Russell Snell, Richard Steele, See-Tarn Woo. SARS-CoV-2 evolution has increased resistance to monoclonal antibodies and first-generation COVID-19 vaccines: Is there a future therapeutic role for soluble ACE2 receptors for COVID-19? Antiviral research. 2024-04-27. PMID:38677595. |
nasal and inhaled treatment with soluble ace2 receptors has abrogated severe disease in animal models of covid-19. |
2024-04-27 |
2024-04-30 |
Not clear |
| Maximillian N J Woodall, Ana-Maria Cujba, Kaylee B Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G H Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Batuhan Cakir, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O'Callaghan, Jie Zhou, Wendy Barclay, Paolo DeCoppi, Colin R Butler, Mario Cortina-Borja, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C Chambers, Wendy E Heywood, Kevin Mills, Robert E Hynds, Sarah A Teichmann, Kerstin B Meyer, Marko Z Nikolić, Claire M Smit. Age-specific nasal epithelial responses to SARS-CoV-2 infection. Nature microbiology. 2024-04-15. PMID:38622380. |
we show that cell tropism of sars-cov-2, and expression of ace2 and tmprss2 in nasal epithelial cell subtypes, differ between age groups. |
2024-04-15 |
2024-04-18 |
Not clear |
| Kyungmin Lee, Yujeong Na, Minjin Kim, Dongjin Lee, Jongseo Choi, Gwanyoung Kim, Min-Soo Ki. Ursodeoxycholic acid may protect from severe acute respiratory syndrome coronavirus 2 Omicron variant by reducing angiotensin-converting enzyme 2. Pharmacology research & perspectives. vol 12. issue 2. 2024-04-04. PMID:38573021. |
furthermore, udca-treated groups had a 3-fold decrease in ace2 expression in nasal cavities, as well as reduced viral expressing genes in the respiratory tract. |
2024-04-04 |
2024-04-06 |
Not clear |
| Paul Feinstei. Rapid Degradation of the Human ACE2 Receptor Upon Binding and Internalization of SARS-Cov-2-Spike-RBD Protein. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496410. |
it is widely accepted that the sars-cov-2 betacoronavirus infects humans through binding the human angiotensin receptor 2 (ace2) that lines the nasal cavity and lungs, followed by import into a cell utilizing the transmembrane protease, serine 2 (tmprss2) cofactor. |
2024-03-18 |
2024-03-20 |
human |
| Alberto Baldelli, Chun Yuen Jerry Wong, Hale Oguzlu, Hanieh Gholizadeh, Yigong Guo, Hui Xin Ong, Anika Singh, Daniela Traini, Anubhav Pratap-Sing. Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2. International journal of pharmaceutics. 2024-03-17. PMID:38493838. |
nasal delivery of encapsulated recombinant ace2 as a prophylactic drug for sars-cov-2. |
2024-03-17 |
2024-03-20 |
human |
| Alberto Baldelli, Chun Yuen Jerry Wong, Hale Oguzlu, Hanieh Gholizadeh, Yigong Guo, Hui Xin Ong, Anika Singh, Daniela Traini, Anubhav Pratap-Sing. Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2. International journal of pharmaceutics. 2024-03-17. PMID:38493838. |
ace2 is contained in different areas of the human body, including the nasal cavity, which is considered the main entrance for different types of airborne viruses. |
2024-03-17 |
2024-03-20 |
human |
| Alberto Baldelli, Chun Yuen Jerry Wong, Hale Oguzlu, Hanieh Gholizadeh, Yigong Guo, Hui Xin Ong, Anika Singh, Daniela Traini, Anubhav Pratap-Sing. Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2. International journal of pharmaceutics. 2024-03-17. PMID:38493838. |
we took advantage of the roles of ace2 and the nasal cavity in sars-cov-2 replication and transmission to develop a nasal dry powder. |
2024-03-17 |
2024-03-20 |
human |
| Angela Lu, Brandon Ebright, Aditya Naik, Hui L Tan, Noam A Cohen, Jean-Marie C Bouteiller, Gianluca Lazzi, Stan G Louie, Mark S Humayun, Isaac Asant. Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396738. |
in situ rna mapping has revealed angiotensin-converting enzyme 2 (ace2) expression to be highest in the nose and lower in the lung, pointing to nasal susceptibility as a predominant route for infection and the cause of subsequent pulmonary effects. |
2024-02-24 |
2024-02-26 |
Not clear |
| Zechariah G Franks, Kavitha Nandakumar, Lakshmi Santhanam, Laeben Lester, Jonathan M Walsh, Nicholas M Dalesi. ACE2 and TAS2R38 receptor expression in pediatric and adult patients in the nasal and oral cavity. Laryngoscope investigative otolaryngology. vol 9. issue 1. 2024-02-16. PMID:38362187. |
ace2 and tas2r38 receptor expression in pediatric and adult patients in the nasal and oral cavity. |
2024-02-16 |
2024-02-18 |
Not clear |
| Sopisa Benjakul, Aina Karen Anthi, Anette Kolderup, Marina Vaysburd, Heidrun Elisabeth Lode, Donna Mallery, Even Fossum, Elisabeth Lea Vikse, Anna Albecka, Aleksandr Ianevski, Denis Kainov, Karine Flem Karlsen, Siri Aastedatter Sakya, Mari Nyquist-Andersen, Torleif Tollefsrud Gjølberg, Morten C Moe, Magnar Bjørås, Inger Sandlie, Leo C James, Jan Terje Anderse. A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery. PNAS nexus. vol 2. issue 12. 2023-12-11. PMID:38077689. |
specifically, a soluble truncated human dimeric ace2 variant, engineered for improved binding to the receptor-binding domain of sars-cov-2, was fused with human albumin tailored for favorable engagement of the neonatal fragment crystallizable receptor (fcrn), which resulted in enhanced plasma half-life and allowed for needle-free transmucosal delivery upon nasal administration in human fcrn-expressing transgenic mice. |
2023-12-11 |
2023-12-17 |
mouse |
| Rui Song, Xiaoyou Chen, Baoliang Li, Jun Ni, Yunao Zhou, Hongbin Zhang, Xiao Liang, Liangfeng Zou, Juan Liu, Fang Yang, Guangyu Li, Xiaodi Guo, Zhe Liu, Fengfeng Mao, Cong Lei, Jianhua Sui, Wenhui Li, Ronghua Ji. Nasal spray of an IgM-like ACE2 fusion protein HH-120 prevents SARS-CoV-2 infection: Two investigator-initiated postexposure prophylaxis trials. Journal of medical virology. vol 95. issue 12. 2023-12-06. PMID:38054556. |
nasal spray of an igm-like ace2 fusion protein hh-120 prevents sars-cov-2 infection: two investigator-initiated postexposure prophylaxis trials. |
2023-12-06 |
2023-12-10 |
human |
| Rui Song, Xiaoyou Chen, Baoliang Li, Jun Ni, Yunao Zhou, Hongbin Zhang, Xiao Liang, Liangfeng Zou, Juan Liu, Fang Yang, Guangyu Li, Xiaodi Guo, Zhe Liu, Fengfeng Mao, Cong Lei, Jianhua Sui, Wenhui Li, Ronghua Ji. Nasal spray of an IgM-like ACE2 fusion protein HH-120 prevents SARS-CoV-2 infection: Two investigator-initiated postexposure prophylaxis trials. Journal of medical virology. vol 95. issue 12. 2023-12-06. PMID:38054556. |
hh-120, an igm-like angiotensin converting enzyme 2 (ace2) fusion protein, has been developed as a nasal spray against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and is currently undergoing human trials. hh-120 nasal spray was assessed for postexposure prophylaxis (pep) in two investigator-initiated (ns01 and ns02) trials with different risk levels of sars-cov-2 exposure. |
2023-12-06 |
2023-12-10 |
human |
| Fuka Takeuchi, Aki Sugano, Azusa Yoneshige, Man Hagiyama, Takao Inoue, Akihiro Wada, Yutaka Takaoka, Akihiko It. Potential Contribution of Cell Adhesion Molecule 1 to the Binding of SARS-CoV-2 Spike Protein to Mouse Nasal Mucosa. Cells, tissues, organs. 2023-10-30. PMID:37903481. |
severe acute respiratory syndrome coronavirus 2 (sars-cov-2) first infects the host nasal mucosa, where the viral spike protein binds to angiotensin-converting enzyme 2 (ace2) on the mucosal cells. |
2023-10-30 |
2023-11-08 |
mouse |
| Rui Song, Xiaoyou Chen, Baoliang Li, Hongbin Zhang, Xiaodi Guo, Zhe Liu, Liangfeng Zou, Xiao Liang, Cong Lei, Fengfeng Mao, Jianhua Sui, Wenhui Li, Ronghua Ji. Nasal spray of an IgM-like ACE2 fusion protein HH-120 accelerates SARS-CoV-2 clearance: A single-center propensity score-matched cohort study. Journal of medical virology. vol 95. issue 5. 2023-05-25. PMID:37227062. |
nasal spray of an igm-like ace2 fusion protein hh-120 accelerates sars-cov-2 clearance: a single-center propensity score-matched cohort study. |
2023-05-25 |
2023-08-14 |
human |
| Rui Song, Xiaoyou Chen, Baoliang Li, Hongbin Zhang, Xiaodi Guo, Zhe Liu, Liangfeng Zou, Xiao Liang, Cong Lei, Fengfeng Mao, Jianhua Sui, Wenhui Li, Ronghua Ji. Nasal spray of an IgM-like ACE2 fusion protein HH-120 accelerates SARS-CoV-2 clearance: A single-center propensity score-matched cohort study. Journal of medical virology. vol 95. issue 5. 2023-05-25. PMID:37227062. |
hh-120, a recently developed igm-like ace2 fusion protein with broad-spectrum neutralizing activity against all ace2-utilizing coronaviruses, has been developed as a nasal spray for use as an early treatment agent to reduce disease progression and airborne transmission. |
2023-05-25 |
2023-08-14 |
human |
| Nikesh Tailor, Bryce M Warner, Bryan D Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P Thomas, Yanlong Pei, Stephanie A Booth, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobas. Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene. Viruses. vol 15. issue 1. 2023-01-21. PMID:36680125. |
to overcome this limitation, we transduced common laboratory accessible strains of mice of different sexes and age groups with a novel a triple aav6 mutant, termed aav6.2ff, encoding either human ace2 or luciferase via intranasal administration to promote expression in the lung and nasal turbinates. |
2023-01-21 |
2023-08-14 |
mouse |
| Chien-Ting Wu, Peter V Lidsky, Yinghong Xiao, Ran Cheng, Ivan T Lee, Tsuguhisa Nakayama, Sizun Jiang, Wei He, Janos Demeter, Miguel G Knight, Rachel E Turn, Laura S Rojas-Hernandez, Chengjin Ye, Kevin Chiem, Judy Shon, Luis Martinez-Sobrido, Carolyn R Bertozzi, Garry P Nolan, Jayakar V Nayak, Carlos Milla, Raul Andino, Peter K Jackso. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Cell. 2022-12-29. PMID:36580912. |
using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ace2 receptor. |
2022-12-29 |
2023-08-14 |
Not clear |
| Long Feng, Shihui Fu, Pei Zhang, Yujie Zhang, Yali Zhao, Yao Yao, Leiming Luo, Ping Pin. Potential use of the S-protein-Angiotensin converting enzyme 2 binding pathway in the treatment of coronavirus disease 2019. Frontiers in public health. vol 10. 2022-12-15. PMID:36518573. |
however, ace2 expression is not restricted to the lungs; altered receptors have been found in the nasal and oral mucosa, vessel, brain, pancreas, gastrointestinal tract, kidney, and heart. |
2022-12-15 |
2023-08-14 |
human |
| Ke Xu, Xingyi Shi, Christopher Husted, Rui Hong, Yichen Wang, Boting Ning, Travis B Sullivan, Kimberly M Rieger-Christ, Fenghai Duan, Helga Marques, Adam C Gower, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Grant Duclos, Michael Platt, Avrum E Spira, Sarah A Mazzilli, Ehab Billatos, Marc E Lenburg, Joshua D Campbell, Jennifer E Bean. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307504. |
the similarities and differences of ve gene expression (ace2, tmprss2, and ctsl) across nasal and bronchial compartments have not been fully characterized using matched samples from large cohorts. |
2022-10-28 |
2023-08-14 |
Not clear |
| Ke Xu, Xingyi Shi, Christopher Husted, Rui Hong, Yichen Wang, Boting Ning, Travis B Sullivan, Kimberly M Rieger-Christ, Fenghai Duan, Helga Marques, Adam C Gower, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Grant Duclos, Michael Platt, Avrum E Spira, Sarah A Mazzilli, Ehab Billatos, Marc E Lenburg, Joshua D Campbell, Jennifer E Bean. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307504. |
scrna-seq of nasal brushings indicated that ace2 co-expressed genes were highly expressed in club and c15orf48 |
2022-10-28 |
2023-08-14 |
Not clear |