| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jafar Shahraki, Kaveh Tabrizian, Ramin Rezaee, Behnam Tashakori, Zahra Dadrezaei, Vahideh Ghorani, Gholamreza Bagheri, Hosseinali Jahantigh, Mahmoud Hashemzae. Hesperidin neuroprotective effects against carbon monoxide-induced toxicity in male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-03. PMID:38700797. |
after evaluation of spatial learning and memory using a morris water maze (mwm), animals were sacrificed and oxidative stress status in blood samples, and akt, bax, bcl2, and brain-derived neurotrophic factor (bdnf) expression in brain samples were assessed. |
2024-05-03 |
2024-05-05 |
rat |
| Qiulu Li, Kaixin Ping, Yannan Xiang, YingSun, Zunhan Hu, Shujuan Liu, Xinying Guan, Mian F. Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis. Fish & shellfish immunology. 2024-04-25. PMID:38663463. |
at the same time, fa inhibited the apoptosis of renal cells induced by avm by decreasing the transcription level and protein expression level of bax, and increasing the transcription level and protein expression level of bcl2, pi3k and akt. |
2024-04-25 |
2024-04-28 |
cat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Rong Wu, Zhibin Zhang, Qingxia Xu, Fang Liu, Yu Zhan, Qiuxiao Wang, Lijuan Du, Xuegui Tan. Integration of network pharmacology and experimental verifications reveals the Bian-Se-Tong mixture can alleviate constipation in STC rats by reducing apoptosis of Cajal cells via activating PI3K-Akt signaling pathway. Heliyon. vol 10. issue 7. 2024-04-08. PMID:38586320. |
in-depth mechanistic studies have shown that bstm can significantly reduce the apoptosis of intestinal cajal cells, downregulate the expression of bax and c-caspase 3, upregulate the expression of bcl-2 and c-kit, and promote the phosphorylation of akt. |
2024-04-08 |
2024-04-10 |
rat |
| Jian-Heng Hao, Yue-Meng Zhao, Hai-Jun Wang, Yu-Xia Cao, Ying Lan, Lai-Xi J. [Mechanism of protective effect of resveratrol on poor ovarian response in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114185. |
animal experiments showed that the model group had higher rate of estrous cycle disorders, lower number and poorer morphology of normally developed follicles at all levels, more atretic follicles, higher apoptosis of ovarian granulosa cells, lower number of retrieved oocytes, lower ovarian wet weight and ovarian index, higher serum levels of fsh and lh, lower levels of amh and e_2, higher expression levels of hif-1α, foxo3a and bax, and lower expression levels of pi3k, akt, and bcl-2 in the ovarian tissue than the normal group. |
2023-12-19 |
2023-12-23 |
mouse |
| Amene Saghazade. Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond. Pharmacological research. vol 198. 2023-11-26. PMID:37995897. |
it reveals a variety of cellular and molecular targets for fcdp: cytokines (tnf-α, il-1β, il-6, il-10, il-12, il-18, ifn-γ), chemokines (ccl2), other inflammatory mediators (crp, pge2), immune receptors (tlr-2, tlr-4, fcεri), oxidative stress-related markers (sod, gsh, mda, gpx, catalase, ros, no, protein carbonyls), kinases (mapks, hexokinase, g6pase, fbpase, pepck, akt, ampk, gsk3, cdks), other enzymes (cox-2, inos, mmps, caspases), growth factors/receptors (vegf, egfr), hormones (dheas, prolactin, gnrh, fsh, lh, estradiol, dht, insulin), cell death-related markers (bcl-2, bax, bak, fasl, gasdermins, cytochrome c), glucose transporter protein (glut4), and transcription factors (nf-κb, hnf-4α, foxo, pgc-1α, ppar-γ, c/ebp-α, creb, nfatc1, stat3). |
2023-11-26 |
2023-11-28 |
Not clear |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the rats fed with copper-laden diet for 12 weeks, and the effect of chr on the copper content in liver and 24-h urine, the learning and memory ability, the morphological changes and the apoptosis level of neurons in hippocampal ca1 region, the expression level of bax, bcl-2, cleaved caspase-3, p-pi3k, pi3k, p-akt, and akt proteins were detected. |
2023-11-24 |
2023-11-29 |
human |
| Nan Nan, Xiao-Li DU, Miao Chen, Jia-Qi Lu. [Qirong Tablets inhibits apoptosis of ovarian granulosa cells via PI3K/Akt/ HIF-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 17. 2023-10-06. PMID:37802816. |
terminal deoxynucleotidyl transferase-mediated dutp nick end labeling(tunel) assay was used to detect the apoptosis of granulosa cells, and western blot to determine the expression levels of b-cell lymphoma-2(bcl-2), bcl-2-associated x protein(bax), caspase-3, pi3k, akt, and hif-1. |
2023-10-06 |
2023-10-15 |
mouse |
| Qian Zhang, Guoyang Sun, Yuna Huang, Shanshan Cui, Tingshen Li, Lianbo Zhao, Kui Lu, Peng Yu, Yongmin Zhang, Herve Galons, Nassima Oumata, Yuou Ten. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. European journal of medicinal chemistry. vol 261. 2023-09-14. PMID:37708799. |
the results in vitro indicated that compounds 3g and 3j can induce mda-mb-231 cells apoptosis, and inhibit its migration and angiogenesis through influencing protein expression such as bcl-2, bax, bcl-xl, p38, mmp2, mmp9, akt and egfr. |
2023-09-14 |
2023-10-07 |
Not clear |
| Yi-Bo Xu, Yang Sun, Lin-Yu Xiao, Guo-Qing Zhu, Xue Song, Jian-Guo Hu, Qi Q. [Effect of Shionone on Neuron Apoptosis After Spinal Cord Injury in Mice]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2023-09-07. PMID:37674468. |
results compared with the sci group,the sci+shi group showed increased bms score on days 21,28,35,and 42(p=0.003,p=0.004,p=0.023,and p=0.007,respectively),reduced area of spinal cord fibrosis(p=0.021),increased neurons survived(p=0.001),and down-regulated expression of cleaved cysteine aspastic acid-specific protease 3(cleaved caspase-3)(p=0.017).compared with the tnf-α group,the shi group presented down-regulated expression levels of cleaved caspase-3 and bax(p=0.010,p=0.001)and up-regulated expression level of bcl-2(p=0.001).the results of bioinformatics analysis showed that shi might improve the motor function of sci mice via the phosphatidylinositol 3-kinase/protein kinase b(pi3k/akt)signaling pathway.the results of in vivo and in vitro experiments showed that shi inhibited the phosphorylation of pi3k and akt in sci mice or ht22 cells exposed to tnf-α(all p<0.05).the number of apoptotic ht22 cells after treatment with insulin-like growth factor 1 was higher than that in the shi group(p=0.003). |
2023-09-07 |
2023-10-07 |
mouse |
| Chunguang Sun, Lin Lia. Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity of Shikonin. Current molecular pharmacology. 2023-09-06. PMID:37670707. |
antithyroid cancer studies of shikonin discovered that it inhibited thyroid cancer cell migration and invasion by suppressing the epithelial-mesenchymal transition; induced cell cycle arrest; induced dna damage and apoptosis by producing excessive reactive oxygen species; upregulated bax; increased the stability of p53; decreased the expression of mdm2; downregulated slug and mmp-2, mmp-9, and mmp-14; repressed the phosphorylation of erk and akt; activated the p16/retinoblastoma protein pathway, leading to apoptosis; suppressed the expression of dnmt1; reduced the pten gene methylation; increased the expression of pten, leading to the inhibition of migration; increased lc3-ii to induce autophagy and apoptosis of medullary thyroid carcinoma; and upregulated βii-tubulin in the cell to produce less resistance to cisplatin and paclitaxel, without cross-resistance to other anticancer agents. |
2023-09-06 |
2023-10-07 |
mouse |
| Jigar Pravinchandra Modi, Wen Shen, Janet Menzie-Suderam, Hongyuan Xu, Chun-Hua Lin, Rui Tao, Howard M Prentice, John Schloss, Jang-Yen W. The Role of NMDA Receptor Partial Antagonist, Carbamathione, as a Therapeutic Agent for Transient Global Ischemia. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509524. |
electrophysiological results show that carb attenuates nmda-mediated glutamate currents in the retinal ganglion cells, which results in activation of the akt signaling pathway and increased expression of pro-cell survival biomarkers, e.g., hsp 27, p-akt, and bcl2 and decreased expression of pro-cell death markers, e.g., beclin 1, bax, and cleaved caspase 3, and er stress markers, e.g., chop, ire1, xbp1, atf 4, and eif2α. |
2023-07-29 |
2023-08-14 |
mouse |
| Peng Huang, Jinliang Du, Liping Cao, Jiancao Gao, Quanjie Li, Yi Sun, Nailin Shao, Yuning Zhang, Gangchun X. Effects of prometryn on oxidative stress, immune response and apoptosis in the hepatopancreas of Eriocheir sinensis (Crustacea: Decapoda). Ecotoxicology and environmental safety. vol 262. 2023-06-25. PMID:37356403. |
histopathology showed that prometryn damaged the structure of the hepatopancreas cells and induced apoptosis, suggesting that the pi3k-akt signaling pathway may be involved in the damage process of hepatopancreas cells (pi3k, pdk and akt were downregulated whereas bax was upregulated), leading to their apoptosis. |
2023-06-25 |
2023-08-14 |
cat |
| Mohamed F Balaha, Ahmed A Alamer, Alaa A Eisa, Hashim M Aljohan. Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades. Antibiotics (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37237729. |
these potentials could be attributed to the modulation of the renal sirt1/nrf2/ho-1, tlr-4/nf-κb/mapk, and pi3k/akt cascades, which enhanced the renal antioxidant system and suppressed renal inflammation and apoptosis, as indicated by enhancements of sirt1, nrf2, ho-1, gsh, sod, tac, iκb-α, bcl-2, pi3k, and akt levels and mrna expressions, with reduction of tlr-4, nf-κb, mapk, il-1β, tnf-α, mda, inos, no, cytochrome c, caspase-3, bax levels, and bax/bcl-2 ratio. |
2023-05-27 |
2023-08-14 |
rat |
| Yanchun Wang, Yilong Dong, Wenbo Zhang, Yanmei Wang, Yang Jao, Jianjun Liu, Mingzhu Zhang, Hongbing H. AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad Apoptosis : an international journal on programmed cell death. 2023-04-04. PMID:37014579. |
subsequently, apoptosis was detected using flow cytometry, and expression and activity of bcl-2, bad, bax, pi3k, akt, ampk, mtor, and p70s6k proteins were analyzed using western blotting. |
2023-04-04 |
2023-08-14 |
human |
| Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tul. Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements. Pharmaceutics. vol 15. issue 2. 2023-02-25. PMID:36840034. |
quercetin targets apoptosis, by upregulating bax, caspase-3, and p21 while downregulating akt, plk-1, cyclin-b1, cyclin-a, cdc-2, cdk-2, and bcl-2. |
2023-02-25 |
2023-08-14 |
Not clear |
| Shuancheng Zhang, Yucong Ma, Qianqian Zuo, Mengrui Liu, Zhifang Yu, Ying Sun, Cuimiao Song, Hongyan Sun, Guimin Hao, Bulang Gao, Huilan Du, Jingwei Che. Repeated controlled ovarian stimulation-induced ovarian and uterine damage in mice through the PI3K/AKT signaling pathway. Human cell. 2022-11-28. PMID:36441500. |
the morphology of the ovary and endometrium, ovarian apoptosis, and expressions of the vascular endothelial growth factor (vegf), leukemia inhibitory factor (lif), pi3k, akt, bax, and bcl-2 in the ovarian and uterine tissues were tested by hematoxylin-eosin (he) staining, immunohistochemistry, and western blot. |
2022-11-28 |
2023-08-14 |
mouse |
| Rafael A Cazuza, Gerard Batallé, Xue Bai, Christie R A Leite-Panissi, Olga Po. Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice. Brain research bulletin. 2022-08-11. PMID:35952846. |
in c57bl/6 male mice with peripheral inflammation caused by complete freund's adjuvant (cfa), we assessed the effects of corm-2 and copp on the expression of protein kinase b (akt), the apoptotic protein bax, and the antioxidant enzymes ho-1 and nadph quinone oxidoreductase 1 (nqo1) in the periaqueductal gray matter (pag), amygdala (amg), ventral hippocampus (vhpc) and medial septal area (msa). |
2022-08-11 |
2023-08-14 |
mouse |
| Yun-Ha Lee, Hyeyoon Kim, Sorim Nam, Jae-Ryang Chu, Jung-Hwan Kim, Jong-Seok Lim, Sung-Eun Kim, Mi-Kyung Sun. Protective Effects of High-Fat Diet against Murine Colitis in Association with Leptin Signaling and Gut Microbiome. Life (Basel, Switzerland). vol 12. issue 7. 2022-07-27. PMID:35888062. |
the hfd+dss mice showed significantly increased serum leptin concentrations, colonic leptin receptor expression, enhanced anti-apoptotic akt expression, and reduced pro-apoptotic mapk and bax expression compared with the nd+dss mice, suggesting the involvement of the leptin-mediated pathway in intestinal epithelial cell apoptosis. |
2022-07-27 |
2023-08-14 |
mouse |
| Muzi Zhang, Yuwen Fan, Haibo Jiang, Jian Shao, Ming L. Establishment of hyperammonemia mode in yellow catfish and the mitigation of exogenous L-ornithine-L-aspartate. Developmental and comparative immunology. 2022-07-08. PMID:35803415. |
the results showed that ammonia poisoning could induce serum ammonia content elevated, liver damage (serum aminotransferase activity elevated and liver malondialdehyde accumulation), and up-regulation of cytokine (il 1, il 8 and tnfɑ), apoptosis (p53, bax, cytochrome c, caspase 3 and caspase 9) and autophagy (dynein, beclin 1, akt and pten) genes transcription, but lola could mitigate the adverse effect of ammonia poisoning. |
2022-07-08 |
2023-08-14 |
Not clear |