| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Hong Ye, Ying Men. Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells. Endocrine journal. vol 68. issue 8. 2021-08-30. PMID:33952780. |
finally, the viability, apoptosis, and the contents of ros, mda, and sod, as well as the expressions of chop, grp78, p-perk, p-ire1α, cleaved caspase-3, akt, p-akt, and sirt1 in the cells transfected with small interfering rna sirt1 (sisirt1) were detected by the previously mentioned methods. |
2021-08-30 |
2023-08-13 |
human |
| Patrycja Kurowska, Ewa Mlyczyńska, Monika Dawid, Małgorzata Opydo-Chanek, Joelle Dupont, Agnieszka Ra. In Vitro Effects of Vaspin on Porcine Granulosa Cell Proliferation, Cell Cycle Progression, and Apoptosis by Activation of GRP78 Receptor and Several Kinase Signaling Pathways Including MAP3/1, AKT, and STAT3. International journal of molecular sciences. vol 20. issue 22. 2020-04-07. PMID:31752432. |
in vitro effects of vaspin on porcine granulosa cell proliferation, cell cycle progression, and apoptosis by activation of grp78 receptor and several kinase signaling pathways including map3/1, akt, and stat3. |
2020-04-07 |
2023-08-13 |
Not clear |
| Wei Cui, Bin Leng, Wei Liu, GaoPin Wan. Suppression of Apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) by Klotho Protein is Associated with Reduced Endoplasmic Reticulum Oxidative Stress and Activation of the PI3K/AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-25. PMID:30471224. |
klotho protein reduced the rate of apoptosis of h₂o₂-treated huvecs and downregulated the expression of proteins associated with endoplasmic reticulum oxidative stress, grp78 and chop, and the expression of the apoptotic proteins, caspase-3, caspase-9, and caspase-12, and activated the phosphorylation of akt. |
2019-02-25 |
2023-08-13 |
human |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
we found high levels of hgf in the supernatants of caf and the caf matrix from the supernatants of activated hfl1 fibroblasts or hgf enhanced the levels of met, pi3k and akt phosphorylation and grp78 expression in a549 cells cultured in a 3d cell chamber, which was abrogated by anti-hgf. |
2016-04-06 |
2023-08-13 |
Not clear |
| Y G Lin, J Shen, E Yoo, R Liu, H-Y Yen, A Mehta, A Rajaei, W Yang, P Mhawech-Fauceglia, F J DeMayo, J Lydon, P Gill, A S Le. Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis. Oncogene. vol 34. issue 43. 2016-01-28. PMID:25684138. |
consistent with previous findings that cell surface grp78 is an upstream regulator of pi3k/akt signaling, we show here that in vivo short-term systemic treatment with a highly specific monoclonal antibody against grp78 suppressed akt activation and increased apoptosis in the cpten(f/f) tumors. |
2016-01-28 |
2023-08-13 |
mouse |
| Shaobo Tian, Weilong Chang, Hansong Du, Jie Bai, Zhenhai Sun, Qing Zhang, Hui Wang, Guangsheng Zhu, Kaixiong Tao, Yueping Lon. The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment. Anti-cancer drugs. vol 26. issue 9. 2015-11-16. PMID:26225471. |
besides, silencing the grp78 expression regulated akt activation in a time-dependent manner and increased the induction of the c/ebp homologous protein (chop) as well as considerably promoted celecoxib-induced apoptosis. |
2015-11-16 |
2023-08-13 |
human |
| Jin Muk Kang, Sujin Park, Staci Jakyong Kim, Hyojung Kim, Bona Lee, Junil Kim, Jinah Park, Shin Tae Kim, Han-Kwang Yang, Woo Ho Kim, Seong-Jin Ki. KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78. Cancer research. vol 75. issue 15. 2015-10-26. PMID:26045166. |
kiaa1324 blocked oncogenic activities of grp78 by inhibiting grp78-caspase-7 interaction and suppressing grp78-mediated akt activation, thereby inducing apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Yu-Jia Chang, Yi-Ping Huang, Zih-Ling Li, Ching-Hsein Che. GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529978. |
grp78 knockdown enhances apoptosis via the down-regulation of oxidative stress and akt pathway after epirubicin treatment in colon cancer dld-1 cells. |
2012-11-19 |
2023-08-12 |
Not clear |
| Nobuyuki Yamagishi, Takashi Ueda, Akinori Mori, Youhei Saito, Takumi Hatayam. Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22155243. |
in addition, we found that the treatment of human hepatocyte hepg2 cells with oleic acid decreased the expression of grp78, and attenuated the activation of akt by insulin stimulation. |
2012-03-22 |
2023-08-12 |
mouse |
| Nobuyuki Yamagishi, Takashi Ueda, Akinori Mori, Youhei Saito, Takumi Hatayam. Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22155243. |
these results suggest that decreased grp78 expression may induce resistance to insulin by inhibiting the akt activation, and plays an important role in the development of type 2 diabetes. |
2012-03-22 |
2023-08-12 |
mouse |
| Uma Kant Misra, Rohit Deedwania, Salvatore Vincent Pizz. Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16543232. |
silencing of grp78 gene expression by rnai suppressed activation of akt(thr-308), akt(ser-473), and ikappab kinase alpha kinase. |
2006-07-18 |
2023-08-12 |
human |