| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
further studies revealed that nerolidol decreased neuroinflammation, nlrp3 and inflammatory factor expression in hippocampal tissue while also decreasing mapk pathway expression and enhancing akt pathway expression. |
2024-04-16 |
2024-04-18 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| He Sun, Dandan Xiao, Wei Liu, Xue Li, Zhe Lin, Yong Li, Yuling Din. Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-09. PMID:37555852. |
the results showed that deer antler polypeptides (daps), by regulating egf, egfr, mapk, p38, erk, nf-κb, wnt, pi3k, akt, mmp, ampk, stir1, nlrp3, ho-1, nrf, rho, tlr, tgf-β, smad, ang ii, etc., revealed their effects on seven system-related diseases and their mechanisms, including osteoarthritis, intervertebral disc degeneration, osteoporosis, alzheimer's, parkinson's, triple-negative breast cancer, liver injury, liver fibrosis, cardiovascular disease, acute lung injury, and late-onset hypogonadism. |
2023-08-09 |
2023-08-16 |
Not clear |
| Caixia Yuan, Yucen Yao, Tao Liu, Ying Jin, Chunrong Yang, Xian Jun Loh, Zibiao L. Research Progress on Natural Compounds Exerting an Antidepressant Effect through Anti-inflammatory. Current medicinal chemistry. 2021-08-23. PMID:34420503. |
hence, this review aims to systematically sort the literature related to the mechanism of exerting an antidepressant effect through anti-inflammatory actions, and to summarize the related natural products in the past 20 years, in terms of a number of inflammatory related pathways (i.e., the protein kinase b (akt) pathway, monoamine neurotransmitters (5-hydroxytryptamine and norepinephrine) (5-ht and ne), the nod-like receptor protein-3 (nlrp3) inflammasome, proinflammatory cytokines, neurotrophins, or cytokine-signaling pathways), which might provide a useful reference for the potential treatment of depression. |
2021-08-23 |
2023-08-13 |
Not clear |
| Serena Farruggio, Grazia Cocomazzi, Patrizia Marotta, Raffaele Romito, Daniela Surico, Giuseppe Calamita, Mattia Bellan, Mario Pirisi, Elena Grossin. Genistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 54. issue 3. 2020-11-11. PMID:32330379. |
we aimed to analyze the protective effects elicited by genistein/estradiol in hepatocytes cultured in nafld-like medium on cell viability, triglycerides accumulation, mitochondrial function and oxidative stress and the role of nlrp3 inflammasome, toll like receptors 4 (tlr4), akt and 5' amp-activated protein kinase (ampk)α1/2. |
2020-11-11 |
2023-08-13 |
Not clear |
| Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qi. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015880. |
consistently, the upregulation of nlrp3 significantly increased the expression of asc, caspase‑1, il‑1β and phosphorylated-pten, promoted proliferation, migration, invasion and emt, inhibited apoptosis, and activated the akt signaling pathway. |
2018-11-26 |
2023-08-13 |
human |