All Relations between akt and opa1
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. | western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. | 2024-04-16 | 2024-04-18 | rat |
| Hongyu Li, Joseph C K Leung, Wai Han Yiu, Loretta Y Y Chan, Bin Li, Sarah W Y Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C W Tan. Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury. Cell death & disease. vol 13. issue 12. 2022-12-20. PMID:36539406. | in both aki models, tubular β-catenin stabilization in tubcat animals significantly reduced bun/serum creatinine, tubular damage (ngal-positive tubules), apoptosis (tunel-positive cells) and necroptosis (phosphorylation of mlkl and rip3) through activating akt phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased pgc-1α and nrf1) and restored mitochondrial mass (increased tim23) to re-establish mitochondrial homeostasis (increased fusion markers opa1, mfn2, and decreased fission protein drp1) through the foxo3/pgc-1α signaling cascade. | 2022-12-20 | 2023-08-14 | mouse |