| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
further studies revealed that nerolidol decreased neuroinflammation, nlrp3 and inflammatory factor expression in hippocampal tissue while also decreasing mapk pathway expression and enhancing akt pathway expression. |
2024-04-16 |
2024-04-18 |
rat |
| Wenyan Zhong, Jingjing Chen, Yumin He, Li Xiao, Chengfu Yua. The polysaccharides from Balanophora polyandra enhanced neuronal autophagy to ameliorate brain function decline in natural aging mice through the PI3K/AKT/mTOR signaling pathway. Neuroreport. 2024-04-10. PMID:38597274. |
furthermore, bpp upregulated autophagy-related proteins lc3 ii/i, parkin, and pink1 in the cortex and hippocampus of aging mice, and significantly decreased the expression of p62, pi3k, p-protein kinase b (akt), and p-mtor. |
2024-04-10 |
2024-04-12 |
mouse |
| Qian Deng, Jia-Qi Liang, Chen-Hui Gao, Xia Ge, Jin-Jin Zheng, Qing-Ping Zhan. Effects of electroacupuncture on the PI3K/Akt/CREB signaling pathway and hippocampal neuronal apoptosis in diabetic cognitive impairment rats. Zhen ci yan jiu = Acupuncture research. vol 49. issue 3. 2024-03-19. PMID:38500323. |
to observe the effects of electroacupuncture (ea) on the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/camp response element binding protein (creb) signaling pathway-related proteins and hippocampal neuron apoptosis in diabetic cognitive impairment (dci) rats, and to explore the mechanisms of ea in treating dci. |
2024-03-19 |
2024-03-21 |
rat |
| Burak Uzay, Aslıhan Bahadır-Varol, Fatma Özlem Hökelekli, Murat Yılmaz, Emre Cem Esen, Koray Başar, Yavuz Ayhan, Turgay Dalkara, Emine Eren-Koça. FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling. The Journal of physiology. 2024-03-12. PMID:38468384. |
we showed that increasing hippocampal nudt6 results in depression-like behaviour in rats without changing fgf2 levels or activating its downstream effectors, akt and erk1/2. |
2024-03-12 |
2024-03-14 |
rat |
| Hee Ra Park, Mudan Ca. Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-09. PMID:38460369. |
furthermore, the increased or decreased expression of proteins related to ectopic dgcs (reelin and dab-1), mfs (netrin-1, sema3a, and sema3f), and their downstream effectors (erk, akt, and creb) in the hippocampus of ptz kindling mice was significantly restored by welb treatment. |
2024-03-09 |
2024-03-12 |
mouse |
| Kristina Virijevic, Natasa Spasojevic, Bojana Stefanovic, Harisa Ferizovic, Milica Jankovic, Perica Vasiljevic, Sladjana Dronja. Chronic mild stress-induced dysregulation of MAPK and PI3K/AKT signaling in the hippocampus and medial prefrontal cortex of WKY female rats. Neuroscience letters. vol 825. 2024-03-03. PMID:38431038. |
the cms further suppressed p110 and the downstream akt phosphorylation in the hippocampus, but did not affect the p110 and pakt in the mpfc. |
2024-03-03 |
2024-03-06 |
rat |
| Filipe Valvassori do Nascimento, Betânia Souza de Freitas, Maiara Priscila Dos Passos, Luiza Kleverston, Cristophod de Souza Dos Santos, Luiza Wilges Kist, Maurício Reis Bogo, Elke Bromberg, Nadja Schröde. A high fat diet potentiates neonatal iron overload-induced memory impairments in rats. European journal of nutrition. 2024-02-15. PMID:38358514. |
iron overload and exposure to a hypercaloric/hyperlipidic diet, on cognition, insulin resistance, and hippocampal glut1, glut3, insr mrna expression, and akt phosporylation. |
2024-02-15 |
2024-02-17 |
rat |
| Haruhiko Tokuda, Takamitsu Hori, Daisuke Mizutani, Tomoyuki Hioki, Kumi Kojima, Takashi Onuma, Yukiko Enomoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shinji Ogura, Hiroki Iida, Toru Iwama, Takashi Sakurai, Osamu Kozaw. Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus. World journal of clinical cases. vol 12. issue 2. 2024-02-05. PMID:38313640. |
inverse relationship between platelet akt activity and hippocampal atrophy: a pilot case-control study in patients with diabetes mellitus. |
2024-02-05 |
2024-02-07 |
human |
| Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. |
finally, analyses of reelin signaling in mouse hippocampal and human cortical ko neurons show that ap4 deficiency causes no changes in reelin-dependent activation of the akt pathway and only mild changes in reelin-induced dendritic arborization, but reduces reelin-induced erk phosphorylation, creb activation, and golgi deployment. |
2024-01-28 |
2024-01-31 |
mouse |
| Yasaman Yadollahi-Farsani, Vahid Reisi Vanani, Zahra Lorigooini, Anahita Farahzad, Hossein Amini-Khoe. Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice. IBRO neuroscience reports. vol 16. 2023-12-25. PMID:38145174. |
the gene expression of the pi3k, akt and mtor assessed in the hippocampus by qrt-pcr. |
2023-12-25 |
2023-12-27 |
mouse |
| Yasaman Yadollahi-Farsani, Vahid Reisi Vanani, Zahra Lorigooini, Anahita Farahzad, Hossein Amini-Khoe. Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice. IBRO neuroscience reports. vol 16. 2023-12-25. PMID:38145174. |
also, anethole increased the gene expression of pi3k, akt and mtor in the hippocampus of ms mice. |
2023-12-25 |
2023-12-27 |
mouse |
| Bohye Kim, Joong-Sun Kim, BuHyun Youn, Changjong Moo. Dopamine depletion alters neuroplasticity-related signaling in the rat hippocampus. Animal cells and systems. vol 27. issue 1. 2023-12-21. PMID:38125760. |
interestingly, 6-ohda infusion led to increased phosphorylation of pivotal hippocampal plasticity-related proteins, including extracellular signal-regulated kinase (erk), protein kinase b (akt), glycogen synthase kinase 3β (gsk3β), and camp response element-binding protein (creb), in the ipsilateral hippocampus 7 weeks following the infusion. |
2023-12-21 |
2023-12-23 |
rat |
| Bin Wang, Yichen Zhu, Bin Wei, Hongtao Zeng, Pengjie Zhang, Lingjun Li, Hongyan Wang, Xiaohui Wu, Yufang Zheng, Miao Su. miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring. Molecular neurobiology. 2023-10-10. PMID:37817032. |
we found that zfp462 deficiency promoted pbx1 protein degradation through ubiquitination and that zfp462 het mice showed downregulation of the protein kinase b (pkb, also called akt)-glycogen synthase kinase-3β (gsk3β)-camp response element-binding protein (creb) pathway and hippocampal neurogenesis with anxiety-like behavior. |
2023-10-10 |
2023-10-15 |
mouse |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
mechanistically, insulin-stimulated hippocampal akt phosphorylation was decreased, while pten, the negative regulator of insulin signaling, was increased in the hippocampus in tail-suspended rats. |
2023-09-27 |
2023-10-07 |
rat |
| Jian Huang, Yongji Wu, Xuejun Chai, Shuai Wang, Yongkang Zhao, Yan Hou, Yue Ma, Shulin Chen, Shanting Zhao, Xiaoyan Zh. β-Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis. Stress biology. vol 2. issue 1. 2023-09-07. PMID:37676574. |
moreover, bhba inhibited the expression of cleaved caspase-3 by suppressing endoplasmic reticulum (er) stress, and increased the expression of brain-derived neurotrophic factor (bdnf) in the heat stress-treated hippocampus by activating the protein kinase b (akt)/camp response element binding protein (creb) and methyl-cpg binding protein 2 (mecp2) pathways. |
2023-09-07 |
2023-10-07 |
mouse |
| Hua Liu, Yang Du, Lian Lin Liu, Qing Shan Liu, Hehui Mao, Yong Chen. Anti-depression-like effect of Mogroside V is related to the inhibition of inflammatory and oxidative stress pathways. European journal of pharmacology. 2023-06-26. PMID:37364672. |
pathological changes in the hippocampal dentate gyrus and cortex regions were detected by immunofluorescence and western blotting was used to measure the protein expression of bdnf, trkb, tnf-α, and akt. |
2023-06-26 |
2023-08-14 |
Not clear |
| Osmar Vieira Ramires Júnior, Josiane Silva Silveira, Tiago Marcon Dos Santos, Fernanda Silva Ferreira, Adriana Fernanda K Vizuete, Carlos Alberto Gonçalves, Angela T S Wys. Homocysteine May Decrease Glucose Uptake and Alter the Akt/GSK3β/GLUT1 Signaling Pathway in Hippocampal Slices: Neuroprotective Effects of Rivastigmine and Ibuprofen. Molecular neurobiology. 2023-06-14. PMID:37314655. |
in the present study, we verified the effect of hcy on neurochemical parameters (redox homeostasis, neuronal excitability, glucose, and lactate levels) and the serine/threonine kinase b (akt), glucose synthase kinase-3β (gsk3β) and glucose transporter 1 (glut1) signaling pathway in hippocampal slices, as well as the neuroprotective effects of ibuprofen and rivastigmine alone or in combination in such effects. |
2023-06-14 |
2023-08-14 |
rat |
| Xuemei Li, Teng Teng, Wei Yan, Li Fan, Xueer Liu, Gerard Clarke, Dan Zhu, Yuanliang Jiang, Yajie Xiang, Ying Yu, Yuqing Zhang, Bangmin Yin, Lin Lu, Xinyu Zhou, Peng Xi. AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models. Translational psychiatry. vol 13. issue 1. 2023-06-12. PMID:37308476. |
akt and mapk signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models. |
2023-06-12 |
2023-08-14 |
rat |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
the hippocampal neurons were transfected with mir-10a mimics, and transcript levels of mir-10a, pi3k, akt and mtor were detected by quantitative reverse transcription-pcr, and pi3k, mtor, akt, tnf-α, il-1β, il-6 protein expression levels were detected by western blot. |
2023-06-04 |
2023-08-14 |
rat |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
in the epileptic hippocampal neurons model, the expression levels of mir-10a were significantly increased, with decreasing levels of pi3k, akt and mtor, and increasing levels of tnf-α, il-1β and il-6. |
2023-06-04 |
2023-08-14 |
rat |