| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Jinuk Seo, Doyoung Kwon, Sou Hyun Kim, Mi Ran Byun, Yun-Hee Lee, Young-Suk Jun. Role of autophagy in betaine-promoted hepatoprotection against non-alcoholic fatty liver disease in mice. Current research in food science. vol 8. 2024-01-15. PMID:38222825. |
in addition, it reduced the cdahfd-induced er stress (bip, atf6, and chop) and apoptosis (bax, cleaved caspase-3, and cleaved parp); however, it induced autophagy (lc3ii/i and p62) which was downregulated by cdahfd. |
2024-01-15 |
2024-01-17 |
mouse |
| Lulu Ding, Huali Zhu, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Bianhua Zhou, Hongwei Wang, Zijun Yang, Zongping Liu, Jicang Wan. Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway. Environmental science and pollution research international. 2023-11-24. PMID:38001299. |
the mrna and protein expression levels of ers and apoptosis related factors such as grp78, ire1α, xbp1, atf6, caspase-12, caspase-3 and bax in the cells were significantly increased (p < 0.01), while the mrna and protein expression levels of bcl-2 were significantly reduced (p < 0.01). |
2023-11-24 |
2023-11-28 |
rat |
| Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemi. The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach. Environmental science and pollution research international. 2023-07-15. PMID:37453011. |
moreover chr down-regulated cd-induced er stress markers (perk, ire1, atf6, chop, and grp78) and apoptosis markers (caspase-3, bax) lung tissue. |
2023-07-15 |
2023-08-14 |
rat |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Xiaogang Huang, Xiongzhi He, Rongxian Qiu, Xuemei Xie, Fengfeng Zheng, Feihua Chen, Zhenting H. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333449. |
the expression levels of bmi1, kat2b, and proteins related to upr (p-eif2α, eif2α, atf4, and atf6), nf-κb (p65 and p-p65), apoptosis (cleaved caspase-3, bcl-2, and bax) and necroptosis (p-mlkl and mlkl) were determined by western blot. |
2023-06-19 |
2023-08-14 |
Not clear |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Mustafa Onur Yıldız, Hamit Çelik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gür, İbrahim Bayav, Aydın Genç, Özge Kandemi. Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy. Neurotoxicology. 2022-04-12. PMID:35413380. |
moreover, hesperidin was able to down-regulate the mrna transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, bax, bcl-2, perk, ire1, atf6, and grp78 in naf-induced neurotoxicity. |
2022-04-12 |
2023-08-13 |
rat |
| Tarek Khamis, Abdelalim F Abdelalim, Ahmed A Saeed, Nagah M Edress, Alaa Nafea, Huda F Ebian, Reem Algendy, Doaa M Hendawy, Ahmed Hamed Arisha, Somia Hassan Abdalla. Breast milk MSCs upregulated β-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress /inflammatory /apoptotic signaling pathways in type 1 diabetic rats. European journal of pharmacology. vol 905. 2021-08-11. PMID:34004210. |
and, for the first time, our results revealed that intraperitoneally transplanted br-mscs homed to the diabetic islet and improved fasting blood glucose, serum insulin level, pancreatic oxidative stress, upregulated pancreatic mrna expression for: regenerative markers (pdx1, ngn3, pcna), ins, beta-cell receptors (irs1, irβ, pparγ), pancreatic growth factors (igf-1, vegfβ1, fgfβ), anti-inflammatory cytokine (il10) and anti-apoptotic marker (bcl2) too, br-mscs downregulated pancreatic mrna expression for: inflammatory markers (nfkβ, tnfα, il1β, il6, il8, mcp1), apoptotic markers for both intrinsic and extrinsic pathways (fas, fas-l, p53, p38, bax, caspase3), er stress markers (atf6, atf3, atf4, bip, chop, jnk, xbp1) and autophagy inhibitor (mtor). |
2021-08-11 |
2023-08-13 |
rat |
| Fengwu Li, Xiaokun Geng, Hangil Lee, Melissa Wills, Yuchuan Din. Neuroprotective Effects of Exercise Postconditioning After Stroke Frontiers in cellular neuroscience. vol 15. 2021-03-06. PMID:33664650. |
at 1 and 3 days thereafter, we determined infarct volumes, neurological defects, brain edema, apoptotic cell death through measuring pro- (bax and caspase-3) and anti-apoptotic (bcl-2) proteins, and er stress through the measurement of glucose-regulated protein 78 (grp78), inositol-requiring 1α (ire1α), protein kinase rna-like endoplasmic reticulum kinase (perk), activating transcription factor 6 (atf6), c/ebp homologous protein (chop), caspase-12, and sirt1. |
2021-03-06 |
2023-08-13 |
rat |
| Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Ki. Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32947930. |
endoplasmic reticulum-mediated stress and apoptosis were confirmed by upregulation of protein kinase rna-like endoplasmic reticulum kinase (perk), inositol-requiring enzyme 1 (ire1), activating transcription factor 6 (atf6), activating transcription factor 4 (atf4), p53, bax, and caspase-3 and down regulation of b-cell lymphoma 2 (bcl-2). |
2021-02-26 |
2023-08-13 |
human |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Zhi-Li Jia, Juan Cen, Jia-Bo Wang, Feng Zhang, Qing Xia, Xue Wang, Xi-Qiang Chen, Rong-Chun Wang, Chung-der Hsiao, Ke-Chun Liu, Yun Zhan. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. vol 227. 2019-07-10. PMID:31004821. |
furthermore, mrna levels of factors related to endoplasmic reticulum stress (ers) (grp78, atf6, perk, ire1, xbp1s and chop), apoptosis (bax, cyt, caspase-3, caspase-8 and caspase-9) and the nrf2 signalling pathway (nrf2, ho-1, nqo1, gclm and gclc) were significantly upregulated. |
2019-07-10 |
2023-08-13 |
cat |
| Chongshan Dai, Jichang Li, Shusheng Tang, Jian Li, Xilong Xia. Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways. Antimicrobial agents and chemotherapy. vol 58. issue 7. 2015-09-10. PMID:24798292. |
it was evident that colistin-induced apoptosis involved the mitochondrial pathway (downregulation of bcl-2 and upregulation of cytochrome c [cytc] and bax), death receptor pathway (upregulation of fas, fasl, and fas-associated death domain [fadd]), and endoplasmic reticulum pathway (upregulation of grp78/bip, atf6, gadd153/chop, and caspase-12). |
2015-09-10 |
2023-08-13 |
mouse |
| Yonju Ha, Arul K Shanmugam, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Sylvia B Smit. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and tissue research. vol 356. issue 1. 2014-11-18. PMID:24469320. |
we therefore used σr1(-/-) mice to investigate the expression of er stress genes (bip/grp78, atf6, atf4, ire1α) and proteins involved in apoptosis (bcl2, bax) and to examine the retinal transcriptome at young ages. |
2014-11-18 |
2023-08-12 |
mouse |