| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Zhe Liang, Yuan-Yi Chia, Huai-Jhih Sun, Gwo-Ching Su. Exploration of beauvericin's toxic effects and mechanisms in human astrocytes and N-acetylcysteine's protective role. Toxicon : official journal of the International Society on Toxinology. 2024-04-26. PMID:38670497. |
western blot analysis of cells treated with bea revealed altered protein levels of bax, cleaved caspase-9, and caspase-3, along with an increased bax/bcl-2 ratio, indicating the induction of apoptosis. |
2024-04-26 |
2024-04-29 |
human |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Xiaomeng Xu, Cheng Yin, Bing Dong, Yuewen Li, Shi Liu, Jun Che. LncRNA XIST Protects Against Polycystic Ovary Syndrome via the Regulation of miR-212-3p/RASA1 Axis. Biochemical genetics. 2024-04-12. PMID:38609670. |
cell viability, apoptosis, protein expression of bcl-2 and bax were assessed by mtt, flow cytometry analysis, rt-qpcr and western blot, respectively. |
2024-04-12 |
2024-04-15 |
Not clear |
| Xin Gao, Jiaqi Fu, DongHua Yu, Fang Lu, Shumin Li. Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38509878. |
western blot results showed that bct significantly regulated the protein expression levels of bax, caspase-3, lc3b, p53 and mtor and upregulated autophagy to alleviate apoptosis. |
2024-03-21 |
2024-03-23 |
mouse |
| Vinayak Sharma, Eshu Singhal Sinha, Jagtar Sing. Investigation of In Vitro Anti-cancer and Apoptotic Potential of Onion-Derived Nanovesicles Against Prostate and Cervical Cancer Cell Lines. Applied biochemistry and biotechnology. 2024-03-05. PMID:38441782. |
finally, western blot analysis indicated changes in apoptosis-related proteins including bcl-2, bax, and caspase-3, emphasizing that the anti-cancerous effect of odnvs is attributed to the induction of apoptosis and suggests the unexplored anti-cancerous potential of odnvs. |
2024-03-05 |
2024-03-07 |
Not clear |
| b' David Olivares-Berjaga, Albert Mart\\xc3\\xadnez-Pinte\\xc3\\xb1o, Natalia Rodr\\xc3\\xadguez, Santiago Madero, Lluc\\xc3\\xada Prohens, Irene Mart\\xc3\\xadnez-Serrano, Sergi Mas, Constanza Mor\\xc3\\xa9n, Eduard Parellada, Patricia Gass\\xc3\\xb. Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 131. 2024-02-10. PMID:38296154.' |
we analysed the levels of proapoptotic (caspase-3 and bax) and antiapoptotic (bcl-2) proteins by western blot in the prefrontal cortex and hippocampus of jnj-treated mice. |
2024-02-10 |
2024-02-14 |
mouse |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
then, elisa, western blot and qt-pcr tests were used to assess the expression of the key components of the nlrp3 inflammasome and its downstream inflammatory effectors (e.g., il-1β, il-18), autophagy markers (beclin-1, lc3, p62) and apoptosis markers (bax, bcl-2) in mouse brain tissues. |
2024-01-25 |
2024-01-27 |
mouse |
| Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C Lee, Bamidele Victor Owoyel. Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243560. |
using western blot, striatum was assessed for expression of dopamine metabolic enzymes: tyrosine hydroxylase (th) and monoamine oxidase-b (mao-b); cd11b, bax, p47phox, and il-1β. |
2024-01-20 |
2024-01-22 |
mouse |
| Chandramohan Kiruthiga, Devasahayam Jaya Balan, Nagaiah Hari Prasath, Muthushanmugam Manikandakrishnan, Sakthivel Jafni, Narayanasamy Marimuthu Prabhu, Shunmugiah Karutha Pandian, Kasi Pandima Dev. Synergistic induction of apoptosis in lung cancer cells through co-delivery of PLGA phytol/α-bisabolol nanoparticles. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-19. PMID:38240783. |
apoptosis was confirmed through annexin v-fitc/pi staining and western blot analysis, which also revealed changes in bax and bcl-2 protein expression. |
2024-01-19 |
2024-01-21 |
zebrafish |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Jie Mei, Jing Zuo, Jiazhuan Mei, Guiju Liu, Peng Xia. Circ-NUP98 Promotes Lung Adenocarcinoma Development Through Regulating CBX1 by miR-188-3p. Biochemical genetics. 2023-12-22. PMID:38129720. |
cyclind1, bcl-2-related x protein (bax), matrix metalloproteinase 9 (mmp9) protein, and cbx1 protein levels were determined using western blot. |
2023-12-22 |
2023-12-24 |
human |
| Ting-Ting Li, Jie Chen, En-Sheng Ji, Ya-Jing Gu. [Effect and mechanism of Danggui Buxue Decoction-containing serum in mitigating H9c2 cell injury caused by exposure to intermittent low oxygen]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114184. |
western blot was employed to determine the expression levels of the autophagy-related proteins microtubule-associated proteins light chain 3Ⅱ(lc3Ⅱ), microtubule-associated proteins light chain 3Ⅰ(lc3Ⅰ), p62, parkin and apoptosis related proteins pro caspase-3, caspase-3, b-cell lymphoma-2(bcl-2), bcl-2-associated x(bax). |
2023-12-19 |
2023-12-23 |
Not clear |
| Yiting Hou, Lihua Dong, Lihua Ca. Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063096. |
then the levels of mda, sod and gsh-px in each group were detected by elisa method; cell apoptosis was detected by flow cytometry; the protein expression levels of bax and bcl-2 were detected by western blot; the expression level of mir-483-5p was detected by rt-qpcr. |
2023-12-08 |
2023-12-17 |
Not clear |
| Pei-Qi Huang, Kai-Wen Kang, Dan-Yu Huang, Chun-Lin Zhao, Hao Zheng, Yong-Xin Luo, Yan Wen, Ming-Feng Zou, Dong-Li Li, Ri-Hui Wu, Yun-Cai Tian, Yong Tian, Wen-Huan Zhang, Jing-Wei Jin, Sheng Yin, Li-She Ga. Lignan glucosides from Gentiana macrophylla with potential anti-arthritis and hepatoprotective activities. Phytochemistry. 2023-11-11. PMID:37951561. |
flow cytometry and western blot analysis showed that compound 5 ameliorated d-galn induced aml12 cell apoptosis by upregulating the expression of anti-apoptotic bcl-2 protein and down-regulating the expression of pro-apoptotic bax protein. |
2023-11-11 |
2023-11-20 |
human |
| Łukasz Kopiasz, Katarzyna Dziendzikowska, Michał Oczkowski, Joanna Harasym, Joanna Gromadzka-Ostrowsk. Low-molar-mass oat beta-glucan impacts autophagy and apoptosis in early stages of induced colorectal carcinogenesis in rats. International journal of biological macromolecules. 2023-11-04. PMID:37924897. |
the expression of autophagy (lc3b, beclin-1) and apoptosis (caspase-3, cleaved caspase-3, bax, bcl-2 and parp-1) markers was determined by immunohistochemistry, western blot and pcr analysis. |
2023-11-04 |
2023-11-08 |
rat |
| Didem Yilmaz-Oral, Sena F Sezen, Damla Turkcan, Heba Asker, Ecem Kaya-Sezginer, Omer Faruk Kirlangic, Cagla Zubeyde Kopru, Mualla Pınar Elci, Fatma Zeynep Ozen, Petek Korkusuz, Sema Oren, Cetin Volkan Oztekin, Ilker Ates, Serap Gu. Dual Strategy with Adipose-derived Stem Cells and L-arginine Recovered Cavernosal Functions in a Rat Model of Radical Prostatectomy. Stem cells and development. 2023-10-17. PMID:37847152. |
western blot and immunohistochemistry analyses were used to determine the expression and localization of endothelial nitric oxide synthases (enos), neuronal nos (nnos), transforming growth factor-beta 1 (tgf-1), hypoxia-inducible factor-1 (hif-1), and apoptosis markers (bax and bcl-2). |
2023-10-17 |
2023-11-08 |
rat |
| Tong Li, DaJing Su, HuaWen Lu, YunQing Gao, YongGang Liu, ShaoHua Wang, YuTing Hou, KeMin Qin, XianTing Que, XiaoPing Chen, BaiLing Qin, ZiJun Wang, Yan Den. Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway. Experimental brain research. 2023-10-17. PMID:37847304. |
protein levels of antioxidant enzymes (ho-1 and nqo1) in cerebral cortex, apoptotic markers (bax, bcl-2, and cleaved caspase), and pi3k/akt pathway-associated factors in hippocampus were tested by western blot analysis. |
2023-10-17 |
2023-11-08 |
mouse |
| Nan Nan, Xiao-Li DU, Miao Chen, Jia-Qi Lu. [Qirong Tablets inhibits apoptosis of ovarian granulosa cells via PI3K/Akt/ HIF-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 17. 2023-10-06. PMID:37802816. |
terminal deoxynucleotidyl transferase-mediated dutp nick end labeling(tunel) assay was used to detect the apoptosis of granulosa cells, and western blot to determine the expression levels of b-cell lymphoma-2(bcl-2), bcl-2-associated x protein(bax), caspase-3, pi3k, akt, and hif-1. |
2023-10-06 |
2023-10-15 |
mouse |
| Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Li. Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-22. PMID:37739053. |
our subsequent validation via qpcr and western blot analyses confirmed the attenuation of grp78 and bcl-2, coupled with the upregulation of ire1, chop, jnk, p-jnk, and bax in don-induced cells, indicating the instigation of er stress-associated apoptosis by don. |
2023-09-22 |
2023-10-07 |
Not clear |
| Xiao Wu, Xiaona Zhang, Lulu Sun, Xiaoming Lu, Cunsi She. Icariin prevents depression-like behaviors in chronic unpredictable mild stress-induced rats through Bax/cytoplasm C/caspase-3 axis to alleviate neuronal apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 7. 2023-09-16. PMID:37715385. |
subsequently, expression of the glucocorticoid receptor (gr), bcl-2, cytochrome c, caspase-3 and bax in the hippocampus was tested by western blot. |
2023-09-16 |
2023-10-07 |
rat |