| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanglong Ning, Yang Chen, Jia Shao, Hui Zhu, Zepei Zhang, Jun Mia. The effects of acteoside on locomotor recovery after spinal cord injury - The role of autophagy and apoptosis signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-01. PMID:38692056. |
then, by preparing spinal cord cell homogenates, the expression levels of map1lc3a, map-2, glial fibrillary acidic protein (gfap), nrf2, keap-1, caspase 3 (casp3), bax, bcl-2, tnf-a, il-1b, reactive oxygen species (ros), and malondialdehyde (mda) were measured. |
2024-05-01 |
2024-05-04 |
rat |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Mariam F Farid, Noha A E Yasin, Asmaa K Al-Mokaddem, Marwa A Ibrahim, Yara S Abouelela, Hamdy Riz. Combined laser-activated SVF and PRP remodeled spinal sclerosis via activation of Olig-2, MBP, and neurotrophic factors and inhibition of BAX and GFAP. Scientific reports. vol 14. issue 1. 2024-02-07. PMID:38326395. |
combined laser-activated svf and prp remodeled spinal sclerosis via activation of olig-2, mbp, and neurotrophic factors and inhibition of bax and gfap. |
2024-02-07 |
2024-02-10 |
Not clear |
| Xue Wang, Xiaomei Fu, Xiurong Luo, Yiyi Lai, Chuipu Cai, Yanfang Liao, Zhao Dai, Shuhuan Fang, Jiansong Fan. Network Proximity Analysis Deciphers the Pharmacological Mechanism of Osthole against D-Galactose Induced Cognitive Disorder in Rats. Molecules (Basel, Switzerland). vol 29. issue 1. 2024-01-11. PMID:38202603. |
among them, the pro-apoptotic markers (bax), anti-apoptotic protein (bcl-2), the microgliosis (iba-1), astro-cytosis (gfap), and inflammatory cytokines (tnf-r1) were evaluated in both hippocampus and cortex. |
2024-01-11 |
2024-01-13 |
rat |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
moreover, rtms ameliorated the reduction in gfap and glt-1 expression, alleviated the decrease in bdnf, psd95 and synapsin-1 expression, also reversed the expression levels of bax and bcl2 in the hippocampus of cums-induced rats. |
2023-12-30 |
2024-01-05 |
rat |
| Samia M Sanad, Reham Farouk, Safaa E Nassar, Mohammad Y Alshahrani, Muath Suliman, Ahmed Ezzat Ahmed, Ibrahim Eid Elesaw. The neuroprotective effect of quercetin nanoparticles in the therapy of neuronal damage stimulated by acrolein. Saudi journal of biological sciences. vol 30. issue 11. 2023-09-15. PMID:37711970. |
marked differences were observed in bax, bcl-2, tnf-α, and gfap expressions in the cerebellum. |
2023-09-15 |
2023-10-07 |
mouse |
| Peijun Liu, Pan Zhou, Xinyue Zhang, Dong Zhao, Hao Chen, Ke H. Pterostilbene mediates glial and immune responses to alleviate chronic intermittent hypoxia-induced oxidative stress in nerve cells. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267263. |
pte increased the number of neuronal nissl bodies in the hippocampus of cih mice, upregulated the protein levels of bcl-2, occludin, and zo-1 as well as the mrna and protein levels of camp-response element binding protein (creb) and p-bdnf, and reduced the number of neuronal apoptotic cells, bax protein levels, iba-1, and gfap levels. |
2023-06-02 |
2023-08-14 |
mouse |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Heba M A Khalil, Dina B Mahmoud, Riham A El-Shiekh, Alaa F Bakr, Amira A Boseila, Sally Mehanna, Reham A Naggar, Hesham A Eliw. Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats. AAPS PharmSciTech. vol 23. issue 7. 2022-08-26. PMID:36028598. |
in addition, hp.snesns augmented the immunohistochemical expression of cortical and hippocampal glial fibrillary acidic protein (gfap) levels while downregulating the cortical bcl-2-associated x protein (bax) expression levels. |
2022-08-26 |
2023-08-14 |
rat |
| Shaimaa A Abdelrahman, Amal S El-Shal, Abeer A Abdelrahman, Ebtehal Zaid Hassen Saleh, Abeer A Mahmou. Neuroprotective effects of quercetin on the cerebellum of zinc oxide nanoparticles (ZnoNps)-exposed rats. Tissue barriers. 2022-08-22. PMID:35996208. |
expression levels of calbindin d28k, gfap, and bax proteins in cerebellar tissue were detected by immunohistochemistry. |
2022-08-22 |
2023-08-14 |
rat |
| Shaimaa A Abdelrahman, Amal S El-Shal, Abeer A Abdelrahman, Ebtehal Zaid Hassen Saleh, Abeer A Mahmou. Neuroprotective effects of quercetin on the cerebellum of zinc oxide nanoparticles (ZnoNps)-exposed rats. Tissue barriers. 2022-08-22. PMID:35996208. |
znonps markedly impaired cerebellar tissue structure with decreased levels of calbindin d28k, increased bax and gfap expression. |
2022-08-22 |
2023-08-14 |
rat |
| Dalia M Mabrouk, Aida I El Makawy, Kawkab A Ahmed, Mohamed Fawzy Ramadan, Faten M Ibrahi. Topiramate potential neurotoxicity and mitigating role of ginger oil in mice brain. Environmental science and pollution research international. 2022-07-08. PMID:35802336. |
in addition, topiramate exhibited various neuropathological alterations, strong bax, and gfap immune-reactivity in the cerebral cortex. |
2022-07-08 |
2023-08-14 |
mouse |
| Suzan M Hazzaa, Asmaa Gaber Abdou, Essam O Ibraheim, Esraa A Salem, Mohamad H A Hassan, Hesham A D Abdel-Raze. Effect of L-carnitine and atorvastatin on a rat model of ischemia-reperfusion injury of spinal cord. Journal of immunoassay & immunochemistry. vol 42. issue 6. 2021-12-08. PMID:33900902. |
astrogliosis was detected by gfap, and increased apoptosis was demonstrated by increasing bax and decreasing bcl-2. |
2021-12-08 |
2023-08-13 |
rat |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
the expression levels of mirnas were detected by qrt-pcr, and the expression levels of wnt2, depression-impacted proteins (gfap, bdnf, creb), brain neurotransmitters (5-ht, ne, da) and apoptosis-related proteins (bax and bcl-2) were evaluated by qrt-pcr and western blot. |
2021-11-08 |
2023-08-13 |
rat |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
in addition, mi not only increased levels of il-1β, bax, and cleaved-caspase 3, but also increased iba-1 and gfap expression in the hippocampus, as compared to those in controls, suggesting a promotion of neuro-inflammation and apoptosis in hippocampus. |
2021-10-29 |
2023-08-13 |
rat |
| Pooja Kaushik, Mubashshir Ali, Mohd Salman, Heena Tabassum, Suhel Parve. Harnessing the mitochondrial integrity for neuroprotection: Therapeutic role of piperine against experimental ischemic stroke. Neurochemistry international. vol 149. 2021-10-06. PMID:34284077. |
it also regulates pro-apoptotic, bax and anti-apoptotic, bcl-2 proteins accompanied by glial fibrillary acidic protein (gfap) positive cells in cortex region. |
2021-10-06 |
2023-08-13 |
rat |
| Cheng Huang, Yuanbing Liu, Jian Ding, Yongping Dai, Lixiang Le, Liangliang Wang, Erhu Ding, Jiandong Yan. Thermosensitive quaternized chitosan hydrogel scaffolds promote neural differentiation in bone marrow mesenchymal stem cells and functional recovery in a rat spinal cord injury model. Cell and tissue research. vol 385. issue 1. 2021-07-23. PMID:33760948. |
if staining and western blot were performed to detect the expression of neun, nf-200, gfap, cs56, and bax in the lesion sites of the injured spinal cord. |
2021-07-23 |
2023-08-13 |
rat |
| Kunchi Zhao, Ran Li, Qing Ruan, Chunyang Meng, Fei Yin, Qingsan Zh. microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury. Journal of cellular and molecular medicine. 2021-07-13. PMID:33951295. |
bbb scores were elevated, the expression of nestin, neun, gfap, nf-200 and bcl-2 protein was enhanced but that of bax protein was reduced, and cell apoptosis was inhibited in sci rats after up-regulating mir-125b or silencing atf2. |
2021-07-13 |
2023-08-13 |
rat |
| Minzhen Deng, Liping Huang, Xiaoqin Zhong, Manting Huan. Dynamic Changes of Beclin-1 in the Hippocampus of Male Mice with Vascular Dementia at Different Time Points. Journal of molecular neuroscience : MN. vol 70. issue 10. 2021-06-29. PMID:32468217. |
the expression of beclin-1, lc3b, p62, bcl-2, bax, bace1, gfap, mbp and et-1 mrna were determined by rt-pcr; the expression of beclin-1 was detected by western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (he) staining; and the correlation of beclin-1 with other vd-related proteins was analysed by pearson's correlation. |
2021-06-29 |
2023-08-13 |
mouse |