| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. |
compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). |
2024-03-16 |
2024-03-19 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Lulu Ding, Huali Zhu, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Bianhua Zhou, Hongwei Wang, Zijun Yang, Zongping Liu, Jicang Wan. Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway. Environmental science and pollution research international. 2023-11-24. PMID:38001299. |
the mrna and protein expression levels of ers and apoptosis related factors such as grp78, ire1α, xbp1, atf6, caspase-12, caspase-3 and bax in the cells were significantly increased (p < 0.01), while the mrna and protein expression levels of bcl-2 were significantly reduced (p < 0.01). |
2023-11-24 |
2023-11-28 |
rat |
| Di Li, Kaixuan Zhang, Chenchen Xu, Yangyang Jiang, Jianhua Shan, Ziwei Zhang, Jingzeng Ca. Cypermethrin induces apoptosis, autophagy and inflammation via ERS-ROS-NF-κB axis in hepatocytes of carp (Cyprinus carpio). Pesticide biochemistry and physiology. vol 196. 2023-11-09. PMID:37945258. |
we also found that cyp exposure increased the expression levels of endoplasmic reticulum-related genes (grp78, perk, ire-1, atf-6 and chop), apoptosis (bcl-2, bax, caspase-3, caspase-9 and cyt-c) and autophagy-related genes (lc3b, beclin1 and p62) also showed dose-dependent changes, and the expression levels of inflammation-related genes (nf-κb, tnf-α, il-1β, il-6) were also significantly elevated. |
2023-11-09 |
2023-11-20 |
cat |
| Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Li. Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-22. PMID:37739053. |
our subsequent validation via qpcr and western blot analyses confirmed the attenuation of grp78 and bcl-2, coupled with the upregulation of ire1, chop, jnk, p-jnk, and bax in don-induced cells, indicating the instigation of er stress-associated apoptosis by don. |
2023-09-22 |
2023-10-07 |
Not clear |
| Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Li. Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-22. PMID:37739053. |
the addition of 5 mm 4-phenylbutyric acid (4-pba), an er stress inhibitor, decreased levels of chop, ire1, jnk, p-jnk, and bax, while increasing levels of grp78 and bcl-2, suggesting that 4-pba alleviated don-induced er stress and apoptosis. |
2023-09-22 |
2023-10-07 |
Not clear |
| Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemi. The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach. Environmental science and pollution research international. 2023-07-15. PMID:37453011. |
moreover chr down-regulated cd-induced er stress markers (perk, ire1, atf6, chop, and grp78) and apoptosis markers (caspase-3, bax) lung tissue. |
2023-07-15 |
2023-08-14 |
rat |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Tao Wei, Jun-Da Li, Yu-Jing Wang, Wei Zhao, Fan Duan, Yan Wang, Ling-Ling Xia, Zhao-Bin Jiang, Xun Song, Yu-Qiong Zhu, Wen-Yi Shao, Ze Wang, Kang-Sheng Bi, Hui Li, Xiao-Chu Zhang, Dong-Liang Jia. p-Nrf2/HO-1 Pathway Involved in Methamphetamine-induced Executive Dysfunction through Endoplasmic Reticulum Stress and Apoptosis in the Dorsal Striatum. Neurotoxicity research. 2023-05-18. PMID:37199892. |
immunoblot analysis of nuclear factor-e2-related factor 2 (nrf2), phosphorylated nrf2 (p-nrf2), heme-oxygenase-1 (ho-1), glucose regulated protein 78(grp78), c/ebp homologous protein (chop), bcl-2, bax and caspase3 was performed to evaluate the levels of oxidative stress, endoplasmic reticulum (er) stress and apoptosis in the dorsal striatum (dstr). |
2023-05-18 |
2023-08-14 |
mouse |
| Huiqiong Deng, Wenying Chen, Boyang Zhang, Yiwen Zhang, Lingyun Han, Qipeng Zhang, Song Yao, Hongwei Wang, Xiao Li She. Excessive ER-phagy contributes to ochratoxin A-induced apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-04-20. PMID:37080527. |
a 24 h-treatment of 1-4 μm ota could markedly induce apoptosis via increasing the protein expressions of grp78, p-eif2α, chop, lc3b-ii, bak, and bax, and inhibiting the protein expressions of ddrgk1, uba5, lonp1, tex264, fam134b, p-mtor, p62, and bcl-2 in hk-2 cells (p < 0.05). |
2023-04-20 |
2023-08-14 |
human |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Don. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia-Reperfusion Injury via the PERK-ATF4-CHOP Pathway. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613992. |
geraniol effectively attenuated cerebral infarction and pathological injury after ciri, had a protective effect against ciri, significantly reduced the expression of the er-stress-related proteins p-perk, atf4, chop, and grp78 and the pro-apoptotic protein bax, increased the expression of the anti-apoptotic protein bcl-2, and reduced the occurrence of apoptosis. |
2023-01-08 |
2023-08-14 |
rat |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Yiwen Zhang, Yuqing Xiao, Yichen An, Lingyun Han, Huiqiong Deng, Song Yao, Hongwei Wang, Xiao Li She. Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-01-01. PMID:36587836. |
results indicated that a 24 h-treatment of 5 μm ota could significantly induce mitochondrial-mediated apoptosis via repressing lonp1 and sig-1r, thereby enhancing the protein expressions of grp78, p-perk, p-eif2α, chop, ire1α, and bax, and inhibiting the protein expression of bcl-2 in hk-2 cells, which could be remarkably relieved by a 2 h-pre-treatment of 4 μm ua (p < 0.05). |
2023-01-01 |
2023-08-14 |
human |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Mustafa Onur Yıldız, Hamit Çelik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gür, İbrahim Bayav, Aydın Genç, Özge Kandemi. Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy. Neurotoxicology. 2022-04-12. PMID:35413380. |
moreover, hesperidin was able to down-regulate the mrna transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, bax, bcl-2, perk, ire1, atf6, and grp78 in naf-induced neurotoxicity. |
2022-04-12 |
2023-08-13 |
rat |
| Abhishek Singh, Parul Gupta, Shubhangini Tiwari, Amit Mishra, Sarika Sing. Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer's disease. Cell and tissue research. 2022-02-23. PMID:35195784. |
in conjunction, guanabenz also attenuated the ad-related oxidative stress, impaired mitochondrial functionality (mmp, cytochrome-c translocation, atp level, and mitochondrial complex i activity), endoplasmic reticulum stress (grp78, gadd153, cleaved caspase-12), neuronal apoptosis (bcl-2, bax, cleaved caspase-3), and dna fragmentation. |
2022-02-23 |
2023-08-13 |
rat |