| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
results compared with ad group mice, the expression of rock2 in shrock2 group mice was significantly reduced; the cognitive function was significantly improved with the number of neurons in the hippocampal ca3 and dg areas increasing, and nissl bodies were deeply stained; the expression of c-caspase-3 and bax was decreased, while the expression of bcl2 was increased; the expression of mitochondrial division related proteins p-drp1 and fis1 were decreased, while the expression of mitochondrial fusion-related proteins opa1, mfn1 and mfn2 were increased. |
2023-07-29 |
2023-08-14 |
mouse |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Islam M Saadeldin, Fariba Moulavi, Ayman Abdel-Aziz Swelum, Sokhangouy Saiede Khorshid, Hossini-Fahraji Hamid, Sayyed Morteza Hossein. Vitrification of camel oocytes transiently impacts mitochondrial functions without affecting the developmental potential after intracytoplasmic sperm injection and parthenogenetic activation. Environmental science and pollution research international. vol 27. issue 35. 2020-11-25. PMID:33029771. |
at the molecular level, vitrification reduced mrna expression of many genes, including those related to mitochondrial function (tfam, mt-co1, mfn1, atp1a1, nrf1), pluripotency (sox2 and pou5f1), and apoptosis (p53 and bax). |
2020-11-25 |
2023-08-13 |
Not clear |
| Siwen Li, Hongjing Zhao, Yu Wang, Yizhi Shao, Juanjuan Liu, Mingwei Xin. Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens. Poultry science. vol 98. issue 2. 2019-03-06. PMID:30339249. |
further quantitative real-time pcr demonstrated that b cell lymphoma/leukemia 2 (bcl2) were significantly decreased and dynamin-related protein 1 (drp1), optic atrophy 1 (opa1), mitochondrial fission factor 1 (mfn1), mfn2, p53, caspase-8, bcl-2 associated x protein (bax), caspase-3, caspase-9 and cytochrome c were significantly increased in all as2o3 group. |
2019-03-06 |
2023-08-13 |
chicken |
| Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zha. Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells. Stem cells and development. vol 26. issue 10. 2018-02-22. PMID:28178868. |
the mechanism of the effects included proliferation rate increase mediated by increased s phase proportion; mitochondrial biogenesis and function alteration mediated by fusion (mfn1, mfn2, and opa-1) and fission (fis1, drp-1, and mtp18)-related proteins, nrf1, tfam, pgc-1a, and upregulated intracellular ros and no concentration; migration acceleration through the erk1/2 and fak pathway and upregulation of growth factors such as hgf and pdgf; and resistance to apoptosis with increased bcl-2 and decreased bax, or through tunneling nanotube formation between lll-treated mscs and 5-fluorouracil-induced apoptotic mscs. |
2018-02-22 |
2023-08-13 |
human |
| Inês O Gonçalves, Emanuel Passos, Cátia V Diogo, Sílvia Rocha-Rodrigues, Estela Santos-Alves, Paulo J Oliveira, António Ascensão, José Magalhãe. Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 41. issue 3. 2016-12-13. PMID:26905378. |
liver mptp susceptibility through osmotic swelling, mptp-related proteins (cyclophilin d, sirtuin3, cofilin-1), markers of mitochondrial biogenesis ((mitochondrial transcription factor a (tfam) and peroxisome proliferator-activated receptor gamma co-activator protein (pgc-1α)), dynamics (mitofusin 1 (mfn1), mitofusin 2 (mfn2), dynamin related protein 1, and optic atrophy 1)), auto/mitophagy (beclin-1, microtubule-associated protein 1 light chain 3, p62, pink1, and parkin), and apoptotic signaling (bax, bcl-2) and caspases-like activities were assessed. |
2016-12-13 |
2023-08-13 |
rat |
| Seung-Wook Ryu, Kyungsun Choi, Jong-Hwan Park, Yeong-Min Park, Sunchang Kim, Chulhee Cho. Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner. Cancer letters. vol 323. issue 1. 2012-08-13. PMID:22484496. |
when ectopically expressed, mfn1 inhibited the amino-terminal activation, but not the mitochondrial translocation, of bax during staurosporine-induced apoptosis; overexpression of mfn2 had no effect. |
2012-08-13 |
2023-08-12 |
Not clear |