| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ratchaniporn Kongsui, Jinatta Jittiwa. Biomedical reports. vol 20. issue 6. 2024-04-26. PMID:38665422. |
the results indicated that 6-gingerol treatment for a duration of 7 days reverses morphological alterations, enhances catalase and glutathione peroxidase activities, reduces bax, caspase-3 and mapk expression, and increases bcl-xl and mfn2 expression in the cortex and hippocampus. |
2024-04-26 |
2024-04-28 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
results compared with ad group mice, the expression of rock2 in shrock2 group mice was significantly reduced; the cognitive function was significantly improved with the number of neurons in the hippocampal ca3 and dg areas increasing, and nissl bodies were deeply stained; the expression of c-caspase-3 and bax was decreased, while the expression of bcl2 was increased; the expression of mitochondrial division related proteins p-drp1 and fis1 were decreased, while the expression of mitochondrial fusion-related proteins opa1, mfn1 and mfn2 were increased. |
2023-07-29 |
2023-08-14 |
mouse |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| Elif Erdem Guzel, Nalan Kaya Tektemur, Ahmet Tektemur, Hilal Acay, Ayfer Yildiri. The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats. Andrologia. vol 53. issue 11. 2021-11-03. PMID:34431122. |
there was an increase in the apoptotic index, caspase 3 (casp3), bcl2-associated x apoptosis regulator (bax), dynamin-related protein 1 (drp1) expression and total oxidative status (tos) in the dox group, while mitofusin-2 (mfn2), total antioxidative status (tas) and serum testosterone levels of the dox group reduced when compared with the other groups. |
2021-11-03 |
2023-08-13 |
rat |
| Zhengzhong Zeng, Jiling Liang, Liangwen Wu, Hu Zhang, Jun Lv, Ning Che. Exercise-Induced Autophagy Suppresses Sarcopenia Through Akt/mTOR and Akt/FoxO3a Signal Pathways and AMPK-Mediated Mitochondrial Quality Control. Frontiers in physiology. vol 11. 2020-11-24. PMID:33224037. |
results showed the declined mass of gastrocnemius muscle with deficient autophagy and excessive apoptosis as a result of up-regulated atrogin-1 and murf1, declined beclin1 level and lc3-ii/lc3-i ratio, accumulated p62, increased bax, and reduced bcl-2 levels, and also exhibited a defective mitochondrial quality control due to declined pgc-1α, mfn2, drp1, and pink1 levels. |
2020-11-24 |
2023-08-13 |
rat |
| Siwen Li, Hongjing Zhao, Yu Wang, Yizhi Shao, Juanjuan Liu, Mingwei Xin. Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens. Poultry science. vol 98. issue 2. 2019-03-06. PMID:30339249. |
further quantitative real-time pcr demonstrated that b cell lymphoma/leukemia 2 (bcl2) were significantly decreased and dynamin-related protein 1 (drp1), optic atrophy 1 (opa1), mitochondrial fission factor 1 (mfn1), mfn2, p53, caspase-8, bcl-2 associated x protein (bax), caspase-3, caspase-9 and cytochrome c were significantly increased in all as2o3 group. |
2019-03-06 |
2023-08-13 |
chicken |
| Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zha. Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells. Stem cells and development. vol 26. issue 10. 2018-02-22. PMID:28178868. |
the mechanism of the effects included proliferation rate increase mediated by increased s phase proportion; mitochondrial biogenesis and function alteration mediated by fusion (mfn1, mfn2, and opa-1) and fission (fis1, drp-1, and mtp18)-related proteins, nrf1, tfam, pgc-1a, and upregulated intracellular ros and no concentration; migration acceleration through the erk1/2 and fak pathway and upregulation of growth factors such as hgf and pdgf; and resistance to apoptosis with increased bcl-2 and decreased bax, or through tunneling nanotube formation between lll-treated mscs and 5-fluorouracil-induced apoptotic mscs. |
2018-02-22 |
2023-08-13 |
human |
| Inês O Gonçalves, Emanuel Passos, Cátia V Diogo, Sílvia Rocha-Rodrigues, Estela Santos-Alves, Paulo J Oliveira, António Ascensão, José Magalhãe. Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 41. issue 3. 2016-12-13. PMID:26905378. |
liver mptp susceptibility through osmotic swelling, mptp-related proteins (cyclophilin d, sirtuin3, cofilin-1), markers of mitochondrial biogenesis ((mitochondrial transcription factor a (tfam) and peroxisome proliferator-activated receptor gamma co-activator protein (pgc-1α)), dynamics (mitofusin 1 (mfn1), mitofusin 2 (mfn2), dynamin related protein 1, and optic atrophy 1)), auto/mitophagy (beclin-1, microtubule-associated protein 1 light chain 3, p62, pink1, and parkin), and apoptotic signaling (bax, bcl-2) and caspases-like activities were assessed. |
2016-12-13 |
2023-08-13 |
rat |
| Azucena Bermejo-Nogales, Marit Nederlof, Laura Benedito-Palos, Gabriel F Ballester-Lozano, Ole Folkedal, Rolf Eric Olsen, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánche. Metabolic and transcriptional responses of gilthead sea bream (Sparus aurata L.) to environmental stress: new insights in fish mitochondrial phenotyping. General and comparative endocrinology. vol 205. 2015-05-04. PMID:24792819. |
a strong down-regulation of pgc1α, nrf1, nrf2, cpt1a, cs and markers of mitochondrial dynamics and apoptosis (bax, bclx, mfn2, miro2) occurred in m-st fish in association with the greatest circulating cortisol concentration and a reduced lactate production and feed efficiency, which represents a metabolic condition with the highest allostatic load score. |
2015-05-04 |
2023-08-13 |
Not clear |
| Weilin Wang, Jianju Lu, Feng Zhu, Jianfeng Wei, Changku Jia, Yuanbiao Zhang, Lin Zhou, Haiyang Xie, Shusen Zhen. Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21190094. |
our results show that the mfn2 gene is a potential tumor suppressor target that may significantly promote apoptosis via bax and may inhibit proliferation in hcc cells. |
2012-08-23 |
2023-08-12 |
Not clear |
| Seung-Wook Ryu, Kyungsun Choi, Jong-Hwan Park, Yeong-Min Park, Sunchang Kim, Chulhee Cho. Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner. Cancer letters. vol 323. issue 1. 2012-08-13. PMID:22484496. |
when ectopically expressed, mfn1 inhibited the amino-terminal activation, but not the mitochondrial translocation, of bax during staurosporine-induced apoptosis; overexpression of mfn2 had no effect. |
2012-08-13 |
2023-08-12 |
Not clear |
| Jonathan M Gall, Zhiyong Wang, Marc Liesa, Anthony Molina, Andrea Havasi, John H Schwartz, Orian Shirihai, Steven C Borkan, Ramon G B Bonegi. Role of mitofusin 2 in the renal stress response. PloS one. vol 7. issue 1. 2012-06-04. PMID:22292091. |
despite similar stress-induced bax 6a7 epitope exposure in mfn2 deficient and control cells, mfn2 deficiency significantly increased mitochondrial bax accumulation and was associated with greater release of both apoptosis inducing factor and cytochrome c. in conclusion, mfn2 deficiency in the kidney causes mitochondrial fragmentation but does not affect kidney or tubular function during development or under non-stress conditions. |
2012-06-04 |
2023-08-12 |
mouse |
| Wei Zhang, Mary Anne Della-Fera, Diane L Hartzell, Dorothy Hausman, Clifton A Bail. Adipose tissue gene expression profiles in ob/ob mice treated with leptin. Life sciences. vol 83. issue 1-2. 2008-08-28. PMID:18547592. |
increases in mrna expression were found for hormone sensitive lipase (hsl), uncoupling protein 2 (ucp2), adrenergic receptor 3 (adr3), mitofusin 2 (mfn2), sirtuin 3 (sirt3), transcription factor sterol regulatory element binding factor 1 (srebf1), bcl-2, bax, caspase 3, tumor necrosis factor alpha (tnfalpha), adiponectin and angiopoietin 2 (ang-2). |
2008-08-28 |
2023-08-12 |
mouse |
| Mariusz Karbowski, Yang-Ja Lee, Brigitte Gaume, Seon-Yong Jeong, Stephan Frank, Amotz Nechushtan, Ansgar Santel, Margaret Fuller, Carolyn L Smith, Richard J Youl. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. The Journal of cell biology. vol 159. issue 6. 2003-02-21. PMID:12499352. |
spatial and temporal association of bax with mitochondrial fission sites, drp1, and mfn2 during apoptosis. |
2003-02-21 |
2023-08-12 |
Not clear |