| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Shuaichen Liu, Lan Hong, Song Zhang, Yuxin Tian, Yuchen Wang, Duanduan Zhao, Jingheng Lv, Jingjing Zhuang, Hongyan Xu, Guangjun Xi. Sporisorium reilianum polysaccharides improve DSS-induced ulcerative colitis by regulating intestinal barrier function and metabolites. International journal of biological macromolecules. 2024-03-15. PMID:38490380. |
epithelial cell apoptosis was inhibited by increased bcl-2 and decreased bax expression nlrp3, asc, and caspase-1 protein levels decreased. |
2024-03-15 |
2024-03-18 |
mouse |
| Xin Fang, Yaoxuan Ji, Shuang Li, Lei Wang, Bo He, Bo Li, Boshen Liang, Hongke Yin, Haotian Chen, Duojie Dingda, Bing Wu, Fabao Ga. Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments. Journal of natural medicines. 2024-03-01. PMID:38427210. |
it also attenuated apoptosis, inflammation, and fibrosis by modulating bcl-2, bax, nlrp3, and oxidative stress markers. |
2024-03-01 |
2024-03-03 |
rat |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
then, elisa, western blot and qt-pcr tests were used to assess the expression of the key components of the nlrp3 inflammasome and its downstream inflammatory effectors (e.g., il-1β, il-18), autophagy markers (beclin-1, lc3, p62) and apoptosis markers (bax, bcl-2) in mouse brain tissues. |
2024-01-25 |
2024-01-27 |
mouse |
| Changkun Hu, Zebin Liao, Liangliang Zhang, Zengchun Ma, Chengrong Xiao, Shuai Shao, Yue Ga. Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis. Radiation research. 2023-12-28. PMID:38154483. |
furthermore, the crosstalk between apoptosis signaling and nlrp3 inflammasome signaling in mediating the radio-protective activity of cb001 was clarified, in which the pro-apoptotic protein bax but not the anti-apoptotic protein bcl2 was found to be downstream of nlrp3. |
2023-12-28 |
2023-12-31 |
Not clear |
| Sen Zhou, Yang Liu, Binbin Xue, Peigen Yua. Low-dose Esketamine suppresses NLRP3-mediated apoptotic and pyroptotic cell death in microglial cells to ameliorate LPS-induced depression via ablating GSK-3β. Behavioural brain research. vol 459. 2023-11-30. PMID:38029844. |
then, the following experiments verified that low-dose esketamine treatment decreased the expression levels of il-6, tnf-α and il-18 to restrain cellular inflammation, downregulated nlrp3, cleaved caspase-1, il-1β and gsdmd-n to hamper pyroptotic cell death, and inhibited cleaved caspase-3 and bax, but upregulated bcl-2 to restrict apoptotic cell death in the lps-treated mice hippocampus tissues and mouse microglial cells, leading to the suppression of depression development. |
2023-11-30 |
2023-12-10 |
mouse |
| Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhan. Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis. Animals : an open access journal from MDPI. vol 13. issue 17. 2023-09-09. PMID:37684994. |
zea also caused apoptosis in porcine small intestine cells, resulting in a significant reduction in protein and/or mrna expression of apoptosis-related pathway factors such as p53, caspase 3, caspase 9, bax, and cyt-c, which in turn caused a significant decrease in protein and/or mrna expression of inflammatory-related factors such as il-1β, il-2, cox-2, nf-κd, nlrp3, il-6, and il -18, which in turn caused a significant increase in protein and/or mrna expression levels. |
2023-09-09 |
2023-10-07 |
cat |
| Tahmineh Mokhtari, Min Lu, Ayman El-Meghawry El-Kenaw. Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors. International immunopharmacology. vol 122. 2023-07-21. PMID:37478667. |
furthermore, the levels of mda, bcl-2-associated x protein (bax), and inflammatory markers, including nuclear factor kappa b (nf-κb), nlr family pyrin domain containing 3 (nlrp3), interleukin-1β (il-1β), il-18, il-6, and tumor necrosis factor-α (tnf-α) significantly increased in the hpc and pfc following cci induction. |
2023-07-21 |
2023-08-14 |
rat |
| Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Le. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. The Journal of biological chemistry. 2023-06-03. PMID:37269951. |
mn induced proapoptotic bax, nlrp3 inflammasome, il-1β and tnf-α in the striatum and midbrain of wt mice, and these effects were more pronounced in g2019s mice. |
2023-06-03 |
2023-08-14 |
mouse |
| Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
hpk1 inhibitor treatment increased pd-1, pd-l1, bax, p53 and nk-kb expression but decreased nlrp3 expression, indicating that the hpk1 inhibitor promoted apoptosis and blocked the nlrp3 inflammasome pathway to affect anti-pd-1-mediated t-cell cytotoxicity. |
2023-04-27 |
2023-08-14 |
zebrafish |
| Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Le. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066140. |
mn induced proapoptotic bax, nlrp3 inflammasome, il-1β and tnf-α in the striatum and midbrain of wt mice, and these effects were exacerbated in g2019s mice. |
2023-04-17 |
2023-08-14 |
mouse |
| Shilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu, Chongbin Liu, Chanyue Zhao, Lin Su. β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 111. 2022-08-08. PMID:35940076. |
compared to the control, cisplatin-treated mice exhibited high level of serum creatinine, blood urea nitrogen and severe tubular injury, which accompanied with significantly increased expression level of nlrp3, il-1β, il-18, bax, cleaved-caspase 3, as well as aggravated oxidative stress and renal tubular cell apoptosis. |
2022-08-08 |
2023-08-14 |
mouse |
| Lei Huang, Xinyu He, Wen Peng, Xueqing He, Bei Xu, Hu Xu, Yaoxing Wang, Wenjun Xu, Wentong Chen, Sheng Wang, Lanlan Zhou, Ning Liu, Youzhi Xu, Wenjie L. Hyperuricemia induces liver injury by upregulating HIF-1α and inhibiting arginine biosynthesis pathway in mouse liver and human L02 hepatocytes. Biochemical and biophysical research communications. vol 617. issue Pt 2. 2022-06-13. PMID:35696777. |
ua directly activated the hepatic nlrp3 inflammasome and bax apoptosis pathway invivo and invitro. |
2022-06-13 |
2023-08-14 |
mouse |
| Rui Li, Min Si, Hui-Yu Jia, Zheng Ma, Xin-Wei Li, Xiao-Yi Li, Xiang-Rong Dai, Peng Gong, Sheng-Yong Lu. Anfibatide alleviates inflammation and apoptosis via inhibiting NF-kappaB/NLRP3 axis in ischemic stroke. European journal of pharmacology. 2022-05-18. PMID:35584710. |
the number of tunel-positive cells, bax, cleaved-caspase-3, p-iκbα, p-p65, nlrp3, asc, cleaved caspase-1, il-β and il-18 proteins expression were significantly upregulated in the cortex of mcao/r rats and pcn exposed to ogd/r, nlrp3 and caspase-1 mrna levels were also evidently elevated. |
2022-05-18 |
2023-08-13 |
rat |
| Sandra Nikolic, Marina Gazdic-Jankovic, Gvozden Rosic, Marina Miletic-Kovacevic, Nemanja Jovicic, Natasa Nestorovic, Petra Stojkovic, Nenad Filipovic, Olivera Milosevic-Djordjevic, Dragica Selakovic, Marko Zivanovic, Dragana Seklic, Nevena Milivojević, Aleksandra Markovic, Richard Seist, Sasa Vasilijic, Konstantina M Stankovic, Miodrag Stojkovic, Biljana Ljuji. Orally administered fluorescent nanosized polystyrene particles affect cell viability, hormonal and inflammatory profile, and behavior in treated mice. Environmental pollution (Barking, Essex : 1987). 2022-04-11. PMID:35405220. |
males also showed a broad range of anxiogenic responses to ps nanoparticles while hippocampal samples from treated females showed an increased expression of bax and nlrp3 genes, indicating a pro-apoptotic/proinflammatory effect of ps treatment. |
2022-04-11 |
2023-08-13 |
mouse |
| Anil Kumar Kalvala, Arvind Bagde, Peggy Arthur, Sunil Kumar Surapaneni, Nimma Ramesh, Aakash Nathani, Mandip Sing. Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents. International immunopharmacology. vol 107. 2022-03-18. PMID:35303507. |
ptx reduced the expression of p-ampk, sirt1, nrf2, ho1, sod2, and catalase while increasing the expression of pi3k, p-akt, p-p38 map kinase, bax, tgf-β, nlrp3 inflammasome, and caspase 3 in drg homogenates of mice. |
2022-03-18 |
2023-08-13 |
mouse |
| Yanji Zhu, Min Liu, Wenlong Xun, Keliang Li, Xiangji Ni. P2X7R antagonist protects against renal injury in mice with adriamycin nephropathy. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069842. |
the expression of il-1β, il-18, p2x7r, ox-ldl, cxcl16, bax, caspase-3 and nlrp3, as well as cellular apoptosis in the renal tissues of the adr group, was significantly increased in the adr group compared with the control. |
2022-01-24 |
2023-08-13 |
mouse |
| Qian Li, Mingming Zhang, Ying Zhao, Maolong Don. Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis. Shock (Augusta, Ga.). vol 56. issue 6. 2021-11-16. PMID:34779800. |
after stimuli of lps, the function of myocardium was distinctly impaired, which was closely related to increased level of apoptosis (decreased expression of bcl-2 and elevated expression of caspase-3 and bax), pyroptosis (increased expression of caspase1, nlr family pyrin domain containing 3 (nlrp3), and gasdermin d) and inflammatory mediators (increased level of il-1β, tnf-α, and il-6). |
2021-11-16 |
2023-08-13 |
mouse |
| Jiaxuan Wu, Wenfeng Cai, Ruiming Du, Haiyang Li, Bin Wang, Yanqiong Zhou, Daifei Shen, Huimin Shen, Yang Lan, Lesi Chen, Xiaoxia Zheng, Danmei Huang, Ganggang Sh. Sevoflurane Alleviates Myocardial Ischemia Reperfusion Injury by Inhibiting P2X7-NLRP3 Mediated Pyroptosis. Frontiers in molecular biosciences. vol 8. 2021-11-13. PMID:34765646. |
the protein expression of p2x7, nlrp3, apoptosis-associated speck-like protein (asc), cysteine aspartic acid specific protease-1(caspase-1), gasdermin-d (gsdmd), bcl-2 associated x protein (bax), b-cell lymphoma-2 (bcl-2) in myocardial tissue and cells were evaluated. |
2021-11-13 |
2023-08-13 |
rat |
| Dong-Xia Li, Chang-Nan Wang, Yan Wang, Chang-Lin Ye, Lai Jiang, Xiao-Yan Zhu, Yu-Jian Li. NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32454054. |
it was found that stz treatment induced apoptotic and pyroptotic cell death in the hippocampus as evidenced by increases of cleaved caspase 3 positive hippocampal neurons, tunel-positive cells, protein levels of p53, bax, puma, and the cleaved gsdmd n-terminal fragment, all of which were decreased in nlrp3 deficient mice. |
2021-10-05 |
2023-08-13 |
mouse |