| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Par. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32827699. |
acupuncture also restored the overexpression of microglia and astrocyte as well as conversion of bax and bcl-2 expression in both the striatum and the substantia nigra, indicating that inflammatory responses and apoptosis were blocked by acupuncture. |
2021-04-27 |
2023-08-13 |
mouse |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
immunofluorescence staining of sox9 was used to analyze and compare astrocyte density in primary somatosensory cortex, motor cortex, retrosplenial cortex and hippocampus in heterozygous and homozygous bax knockout mice at age of six weeks when cortical development has finished and glia development has reached a relatively steady state. |
2021-03-08 |
2023-08-13 |
mouse |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
[absence of bax differentially affects astrocyte density in the mouse cortex and hippocampus]. |
2021-03-08 |
2023-08-13 |
mouse |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
interestingly, a significant reduction of astrocyte density was observed in the hippocampus of bax knockout mice. |
2021-03-08 |
2023-08-13 |
mouse |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
this study provided important information about the regional heterogeneity of astrocyte distribution and the potential contribution of bax gene during development. |
2021-03-08 |
2023-08-13 |
mouse |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
the aim of the present paper was to study whether bax regulates astrocyte distribution in a region-specific manner. |
2021-03-08 |
2023-08-13 |
mouse |
| Li-Fang Zhu, Xiao-Yang Wu, Xue Liu, Liang Ma, Qi Zhang, Zi Yu, Zhi-Jiao He, Yue Ying, Zhu-Tian Zhang, Xiao-Yu Pan, Yu-Qi Cai, Ling Gong, Miao H. [Absence of BAX differentially affects astrocyte density in the mouse cortex and hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665654. |
in contrast to the significant increase in gabaergic interneurons, the overall and region-specific astrocyte density remained unchanged in the cortex when bax was absent. |
2021-03-08 |
2023-08-13 |
mouse |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Ye Ji Jeong, Yeonghoon Son, Na-Kyung Han, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee, Hae-June Le. Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029554. |
in addition, levels of markers for dna damage (8-hydroxy-2'-deoxyguanosine, p53, p21, γh2ax, and bax), apoptosis (cleaved caspase-3 and cleaved poly(adp-ribose) polymerase 1 (parp-1)), astrocyte (gfap), and microglia (iba-1) were significantly elevated in the brains of aged mice. |
2018-10-29 |
2023-08-13 |
mouse |
| Maria Galuppo, Antonietta Rossi, Sabrina Giacoppo, Simona Pace, Placido Bramanti, Lidia Sautebin, Emanuela Mazzo. Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids. Pharmacological research. vol 99. 2016-06-13. PMID:26192346. |
in detail, mice sacrificed seven days after induction of sci trauma resulted not only in tissue damage, cellular infiltration, fibrosis, astrocyte activation, inos expression, extracellular signal regulated kinase 1/2 phosphorylation in injured tissue, poly (adp-ribose) polymerase 1 (parp-1) activation but also apoptosis (bax and bcl-2 expression). |
2016-06-13 |
2023-08-13 |
mouse |
| Jinghua Yang, Qiufang Liu, Ming Qi, Shuai Lu, Shengwen Wu, Qi Xi, Yuan Ca. Lanthanum chloride promotes mitochondrial apoptotic pathway in primary cultured rat astrocytes. Environmental toxicology. vol 28. issue 9. 2013-11-25. PMID:21793157. |
(3) lacl3 treatment increased the ratio of pro-apoptotic bax and antiapoptotic bcl-2 proteins, which in turn broke the balance among pro-apoptotic and antiapoptotic bcl-2 family proteins, leading to astrocyte apoptosis. |
2013-11-25 |
2023-08-12 |
rat |
| Yu Cheng, Erich Gulbins, Detlef Sieme. Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 3-4. 2011-08-10. PMID:21471707. |
using the single-channel patch-clamp method, we studied mitoplasts (vesicles of inner membrane) from rat astrocyte and liver mitochondria and intact murine glioma mitochondria to determine the action of proapoptotic bax and antiapoptotic bcl-xl on the mitochondrial ca(2+)-activated channel (mtbk) and the permeability transition pore (mtptp). |
2011-08-10 |
2023-08-12 |
rat |
| Xiaolan Fan, Guangrui Luo, Dehua Yang, Ming Ming, Hongmei Liu, Pu Pu, Weidong L. Critical role of lysosome and its associated protein cathepsin D in manganese-induced toxicity in cultured midbrain astrocyte. Neurochemistry international. vol 56. issue 2. 2010-07-08. PMID:19913584. |
furthermore, we documented that after exposed to manganese, the bax protein level in the astrocyte was increased, and its cellular distribution was significantly translocated from cytosol to mitochondria and lysosomes. |
2010-07-08 |
2023-08-12 |
Not clear |
| Bai-liu Ya, Chun-yang Li, Lan Zhang, Wen Wang, Lin L. Cornel iridoid glycoside inhibits inflammation and apoptosis in brains of rats with focal cerebral ischemia. Neurochemical research. vol 35. issue 5. 2010-07-08. PMID:20155318. |
examination of the ischemic cerebral cortex revealed microglia and astrocyte activation, increased interleukin-1beta (il-1 beta) and tumor necrosis factor-alpha (tnf-alpha) concentrations, increased dna fragmentation in the ischemia penumbra, elevated bax expression, increased caspase-3 cleavage, and decreased bcl-2 expression. |
2010-07-08 |
2023-08-12 |
rat |
| Bai-liu Ya, Chun-yang Li, Lan Zhang, Wen Wang, Lin L. Cornel iridoid glycoside inhibits inflammation and apoptosis in brains of rats with focal cerebral ischemia. Neurochemical research. vol 35. issue 5. 2010-07-08. PMID:20155318. |
pretreatment with cig decreased the infarct area, dna fragmentation, il-1beta and tnf-alpha concentrations, microglia and astrocyte activation, bax expression, and caspase-3 cleavage while increasing bcl-2 expression. |
2010-07-08 |
2023-08-12 |
rat |
| Daniela Durand, Carla Caruso, Lila Carniglia, Mercedes Lasag. Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:20085613. |
ly379268 prevented astrocyte death induced by no exposure, which correlates with a reduction in: phosphatidylserine externalization, p53 and bax activation and mitochondrial permeability. |
2010-02-05 |
2023-08-12 |
rat |
| Xi-Chun May Lu, Ren-Wu Chen, Changping Yao, Hans Wei, Xiaofang Yang, Zhilin Liao, Jitendra R Dave, Frank C Tortell. NNZ-2566, a glypromate analog, improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury. Journal of neurotrauma. vol 26. issue 1. 2009-09-25. PMID:19119917. |
the effects of nnz-2566 on injury-induced changes in bax and bcl-2 proteins, activated microgliosis, neutrophil infiltration, and astrocyte reactivity were also examined. |
2009-09-25 |
2023-08-12 |
rat |
| Carla Caruso, Daniela Durand, Helgi B Schiöth, Rodolfo Rey, Adriana Seilicovich, Mercedes Lasag. Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology. vol 148. issue 10. 2007-11-05. PMID:17595227. |
alpha-msh produced a shift in bax/bcl-2 ratio toward astrocyte survival because it increased bcl-2 expression and also prevented the effect of lps/ifn-gamma on bax and bcl-2 expression. |
2007-11-05 |
2023-08-12 |
Not clear |
| Mi-Yoon Chang, Woong Sun, Wataru Ochiai, Kinichi Nakashima, Soo-Young Kim, Chang-Hwan Park, Jin Sun Kang, Jae-Won Shim, A-Young Jo, Chun-Sik Kang, Yong-Sung Lee, Jae-Sang Kim, Sang-Hun Le. Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells. Molecular and cellular biology. vol 27. issue 12. 2007-07-09. PMID:17438128. |
specifically, in bax knockout mice, astrocyte formation was decreased in the developing cortices. |
2007-07-09 |
2023-08-12 |
mouse |