| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian-Yun Nie, Gen-Meng Yang, Peng Zhang, Wen-Juan Dong, Di Jing, Zhen-Ping Hou, Yan-Xia Peng, Yang Yu, Li-Hua Li, Shi-Jun Hon. Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats. Brain research. 2024-04-30. PMID:38685372. |
based on immunohistochemical staining and western blot analysis, the protein expression levels of nrf2 and mfn1 showed a decreasing trend, while levels of drp1, cyt-c, and caspase 3 showed an increasing trend in the cerebral prefrontal cortex of both ma abusers and ma-dependent rats. |
2024-04-30 |
2024-05-03 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Longyun Chen, Huimin Che. Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28191022. |
western blot analysis showed that these cells expressed decreased fusion-related proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy protein-1 (opa-1) and increased fission-related proteins dynamin-related protein 1 (drp1) and fission 1 (fis-1); our results also show that decreased mitochondrial fusion induces cell apoptosis during cold stress. |
2020-09-30 |
2023-08-13 |
mouse |
| Shunrong Zhang, Yue Gao, Jian'an Wan. Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966653. |
real time pcr method was used to detect the mrna expression levels of mitochondrial dynamics regulatory genes mitofusin 1 (mfn1), mitofusin 2 (mfn2), optic atrophy 1 (opa1), and dynamin-related protein 1 (drp1) of haecs, and western blot method was used to detect the protein expression levels of these regulatory genes. |
2020-01-26 |
2023-08-13 |
human |
| Hong-Wei Wang, Shi-Quan Zhu, Jing Liu, Cheng-Yi Miao, Yan Zhang, Bian-Hua Zho. Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice. Chemosphere. vol 238. 2020-01-01. PMID:31524603. |
the expression of mitochondrial fusion protein including mitofusin-1 (mfn1) and optic atrophy 1 (opa1), and mitochondrial respiratory chain complex subunits, including ndufv2, sdha, cyc1 and cox Ⅳ, were detected via real-time polymerase chain reaction, immunohistochemistry staining and western blot, respectively. |
2020-01-01 |
2023-08-13 |
mouse |
| Vivek Choudhary, Ismail Kaddour-Djebbar, Rabei Alaisami, M Vijay Kumar, Wendy B Bolla. Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: a role in apoptosis in prostate cancer cells. International journal of oncology. vol 44. issue 5. 2014-11-13. PMID:24626641. |
we used various prostate cancer cell lines and western blot analysis, qrt-pcr, sirna, m30 apoptosis assay and immunoprecipitation techniques to determine mechanisms regulating mfn1. |
2014-11-13 |
2023-08-12 |
Not clear |