| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| L I Ma, Yuan Chang, Long Yu, Wenbo He, Yueping Li. Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer cells. Oncology letters. vol 10. issue 6. 2020-10-01. PMID:26788214. |
flow cytometry, immunofluorescence and western blot analyses were used to test the effects of mfn2 on cell cycle distribution and apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Longyun Chen, Huimin Che. Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28191022. |
western blot analysis showed that these cells expressed decreased fusion-related proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy protein-1 (opa-1) and increased fission-related proteins dynamin-related protein 1 (drp1) and fission 1 (fis-1); our results also show that decreased mitochondrial fusion induces cell apoptosis during cold stress. |
2020-09-30 |
2023-08-13 |
mouse |
| Yueying Liu, Jieru Chen, Meifang Jin, Zhenhong Li, Tian Tian, Lili Li, Hong N. Relationship between changes in mitochondrial function and hippocampal neuronal apoptosis after recurrent convulsion during developmental stage. Experimental and therapeutic medicine. vol 16. issue 1. 2020-09-30. PMID:29896232. |
dynamic changes of mitochondrial fusion and division-related genes, mitochondrial fusion protein 2 (mfn2) and dynamin-related protein 1 (drp1), in the hippocampus after recurrent convulsion were observed using reverse transcription-polymerase chain reaction (rt-pcr)and western blot analysis. |
2020-09-30 |
2023-08-13 |
rat |
| Shunrong Zhang, Yue Gao, Jian'an Wan. Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966653. |
real time pcr method was used to detect the mrna expression levels of mitochondrial dynamics regulatory genes mitofusin 1 (mfn1), mitofusin 2 (mfn2), optic atrophy 1 (opa1), and dynamin-related protein 1 (drp1) of haecs, and western blot method was used to detect the protein expression levels of these regulatory genes. |
2020-01-26 |
2023-08-13 |
human |
| Rui Zhang, Huimin Zhou, Lei Jiang, Yueran Mao, Ximing Cui, Bing Xie, Dongsheng Cui, Hui Wang, Qingfu Zhang, Shunjiang X. MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice. Brain research. vol 1652. 2017-07-28. PMID:27693395. |
the results of quantitative real-time pcr and western blot revealed that mfn2 expression displayed a consistent decrease with aging in the hippocampus of samp8 than did age-matched samr1 mice. |
2017-07-28 |
2023-08-13 |
mouse |
| Baiye Jin, Guanghou Fu, Hao Pan, Xiaofei Cheng, Lin Zhou, Jia Lv, Geming Chen, Shusen Zhen. Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma. Medical oncology (Northwood, London, England). vol 28 Suppl 1. 2012-08-22. PMID:20803103. |
the effects of mfn2 on cell-cycle distribution and apoptosis were assessed by flow cytometry and western blot analyses. |
2012-08-22 |
2023-08-12 |
Not clear |