| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad S El-Wetidy, Mohamad I Rady, Islam Rady, Hamed Hela. Urolithin A affects cellular migration and modulates matrix metalloproteinase expression in colorectal cancer cells. Cell biochemistry and function. vol 42. issue 3. 2024-04-16. PMID:38622949. |
the western blot analysis investigation revealed that ua inhibits cellular metastasis by lowering the expression levels of matrix metalloproteinases 1 and 2 (mmp1 and mmp2) by more than 43% and 41% (p < .001) in ht29, 28% and 149% (p < .001) in sw480, and 90% and 74% (p < .001) in sw620, respectively, at a 100 µm dosage of ua compared to the control. |
2024-04-16 |
2024-04-18 |
Not clear |
| Mengzhe Zhang, Fenfen Xiang, Yipeng Sun, Rongrong Liu, Qian Li, Qing Gu, Xiangdong Kang, Rong W. Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression. Oncology reports. vol 51. issue 2. 2023-12-22. PMID:38131251. |
the expression levels of proteins including arl4c, matrix metallopeptidase 2 (mmp2), phosphorylated (p)‑akt and p‑mtor were measured using western blot analysis. |
2023-12-22 |
2023-12-24 |
mouse |
| Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot analysis was performed to detect key proteins involved in ventricular remodeling, including transforming growth factor-β1(tgf-β1), α-smooth muscle actin(α-sma), wingless-type mmtv integration site family member 3a(wnt3a), β-catenin, matrix metallopeptidase 2(mmp2), matrix metallopeptidase 3(mmp3), timp metallopeptidase inhibitor 1(timp1), and timp metallopeptidase inhibitor 2(timp2). |
2023-12-19 |
2023-12-23 |
mouse |
| Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot results showed that jiming powder reduced the expression of tgf-β1, α-sma, wnt3a, and β-catenin, decreased the levels of mmp2, mmp3, and timp2, and increased the level of timp1, suggesting its role in inhibiting cardiac fibroblast transformation, reducing extracellular matrix metabolism in myocardial cells, and lowering collagen Ⅰ and α-sma content, thus exerting an anti-myocardial fibrosis effect after myocardial infarction. |
2023-12-19 |
2023-12-23 |
mouse |
| Xiao-Hui Meng, Sheng Zhong, Hai-Hui Han, Qi Shi, Song-Tao Sun, Lian-Bo Xia. [Effect of Juanbi Qianggu Formula on biological behaviors of fibroblast-like synoviocytes in rheumatoid arthritis by regulating FGFR1 signaling pathway based on network pharmacology and cell function experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802828. |
the biological effect of jbqgf by inhibiting fgfr1 phosphorylation was preliminarily verified by western blot, transwell invasion assay, and pannus erosion assay, thereby inhibiting matrix metalloproteinase 2(mmp2) and receptor activator of nuclear factor-κb ligand(rankl) and suppressing the invasion of fibroblasts in rheumatoid arthritis and erosive effect of pannus bone. |
2023-10-06 |
2023-10-15 |
rat |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392658. |
western blot analysis of ss showed that it reduces inflammatory factors (tweak, inos, and cox-2), mapk (jnk, p-erk, and p-38), fibrosis-related molecules (tgf-β, smad3, fibronectin, collagen, α-sma, mmp2, and mmp9), apoptosis (p53, p21, and bax), and autophagy (beclin-1, lc3a/b-i/ii, and p62), and notably increases caspase 3, bcl-2, and antioxidant (catalase, gpx3, and sod-1) levels. |
2023-07-01 |
2023-08-14 |
mouse |
| Bin Zhang, Kuan Zeng, Rui-Cong Guan, Hui-Qi Jiang, Yong-Jia Qiang, Qing Zhang, Mo Yang, Bao-Ping Deng, Yan-Qi Yan. Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic Dissection. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830768. |
finally, immunohistochemistry, immunofluorescence, and western blot experiments confirmed the overexpression of macrophage marker genes (cd68 and cd163) and matrix metalloproteinases (mmp9 and mmp2) in ataad tissue. |
2023-02-25 |
2023-08-14 |
human |
| Cuihua Liu, Fangxin Zhao, Peng Sun, Wenjie Han, Mei Hong, Jianqiang Wu, Xuan Zhan. [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 12. 2022-12-30. PMID:36585230. |
after transfection, the real-time quantitative pcr was used to detect the relative expressions of mir-181c and reck mrna, and western blot analysis was used to detect the expression levels of reck, matrix metalloproteinase 2 (mmp2) and mmp9 proteins. |
2022-12-30 |
2023-08-14 |
human |
| Zhencheng Yu, Yun Li, Rao Fu, Yaxin Xue, Danyang Zhao, Dong Ha. Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway. Archives of dermatological research. 2022-12-16. PMID:36526799. |
finally, western blot analysis showed that pd reduced tgf-β ri expression (p < 0.05) and affected matrix metalloproteinase 2 (mmp2) protein levels (p < 0.05). |
2022-12-16 |
2023-08-14 |
human |
| Yingying Jiang, Wei Xu, Junzhen Ta. Circular RNA circVPRBP serves as a microRNA-106b-5p sponge to regulate proliferation and metastasis of cervical cancer cells via tripartite motif-containing protein 3. Anti-cancer drugs. 2022-08-10. PMID:35946546. |
protein levels of matrix metallopeptidase 2 (mmp2) and matrix mmp9, and trim3 were measured by western blot assay. |
2022-08-10 |
2023-08-14 |
human |
| Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Re. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 6. 2022-06-22. PMID:35732609. |
the proliferation ability of mgc-803 and hgc-27 cells was detected by mtt assay and edu assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of mgc-803 and hgc-27 cells; the chromatin agglutination was detected by hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin v-fitc/pi double labeling combined with flow cytometry; western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (srebf1), fatty acid synthase (fasn), and acetyl coa carboxylase 1 (acc1), epithelial-mesenchymal transition (emt)-related proteins including e-cadherin, vimentin, snail, slug, matrix metalloproteinase 2 (mmp2), mmp9, ampk, and phosphorylated ampk (p-ampk), mapk signaling pathway-related proteins including jnk, phosphorylated jnk (p-jnk), p38 mapk, and p-p38 mapk, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (adp-ribose) polymerase (c-parp). |
2022-06-22 |
2023-08-14 |
human |
| Li Chen, Wenting Luo, Peijun Ji, Zhujuan Li, Yi Yan, Qin Zho. Effects of BMI1 Gene on Regulating Apoptosis, Invasion, and Migration of HEC-1B Cells Induced by Ionizing Radiation. Journal of healthcare engineering. vol 2022. 2022-03-14. PMID:35281533. |
cell proliferation was detected by cell counting kit-8 (cck-8); cell migration and invasion were detected by transwell test; cell apoptosis was detected by flow cytometry; and the expression of mmp2, mmp7, mmp9, rock1, rhoa, p53, p21, and bax protein was detected by the western blot. |
2022-03-14 |
2023-08-13 |
human |
| Chuanbao Lin, Pengfei Qian, Yan Zhang, Zhihui Liu, Kun Dai, Dawei Su. Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway. Tissue & cell. vol 69. 2021-10-07. PMID:33418237. |
relative expressions of plac1 and proteins related to migration and invasion (e-cadherin, n-cadherin, matrix metalloproteinase2 (mmp2), and mmp9), furin/notch1 intracellular domain (nicd)/phosphate and tension homology (pten) pathway (nicd, pten, phosphorylated-akt (p-akt), akt) were quantified by quantitative real-time polymerase chain reaction (qrt-pcr) and western blot as needed. |
2021-10-07 |
2023-08-13 |
human |
| Chunhua Li, Qing L. Circular RNA circ_0111277 Serves as ceRNA, Targeting the miR-424-5p/NFAT5 Axis to Regulate the Proliferation, Migration, and Invasion of Trophoblast Cells in Preeclampsia. Reproductive sciences (Thousand Oaks, Calif.). 2021-08-31. PMID:34462874. |
protein levels of matrix metallopeptidase 2 (mmp2), vascular endothelial growth factor-a (vegf-a), nfat5, phospho-phosphatidylinositol 3 kinase (p-pi3k), pi3k, phospho-protein kinase b (p-akt), and akt were examined by western blot assay. |
2021-08-31 |
2023-08-13 |
Not clear |
| Dawei Han, Wenhui Liu, Guangshuai Li, Linbo Li. Circ_PRKDC knockdown promotes skin wound healing by enhancing keratinocyte migration via miR-31/FBN1 axis. Journal of molecular histology. vol 52. issue 4. 2021-08-02. PMID:34143322. |
the migration ability and the changes of matrix metallopeptidase 9 (mmp-9) and mmp2 levels were determined using wound healing, transwell and western blot assays. |
2021-08-02 |
2023-08-13 |
human |
| Yiheng Yang, Hongli Pan, Jie Chen, Zhonghua Zhang, Minna Liang, Xunqiang Fen. CircKIF2A contributes to cell proliferation, migration, invasion and glycolysis in human neuroblastoma by regulating miR-129-5p/PLK4 axis. Molecular and cellular biochemistry. vol 476. issue 6. 2021-07-28. PMID:33630225. |
western blot assay was performed to examine the protein levels of matrix metalloproteinase 2 (mmp2), mmp9 and plk4. |
2021-07-28 |
2023-08-13 |
human |
| Yunjuan Zhang, Zengyan Cai, Jin Liang, Erqing Chai, Anqing Lu, Yinwu Shan. CircCPA4 Promotes the Malignant Phenotypes in Glioma via miR-760/MEF2D Axis. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:33068224. |
western blot was used to detect the protein levels of matrix metallopeptidase 2 (mmp2), mmp9 and myocyte enhancer factor 2d (mef2d). |
2021-07-12 |
2023-08-13 |
Not clear |
| Yanping Yang, Wenkai Mao, Liming Wang, Lin Lu, Yunfeng Pan. Circular RNA circLMF1 regulates PDGF-BB-induced proliferation and migration of human aortic smooth muscle cells by regulating the miR-125a-3p/VEGFA or FGF1 axis. Clinical hemorheology and microcirculation. 2021-06-07. PMID:34092624. |
western blot assay determined proliferating cell nuclear antigen (pcna), cyclin d1, matrix metalloproteinase (mmp2), osteopontin (opn), vegfa, and fgf1 protein levels. |
2021-06-07 |
2023-08-13 |
human |
| Xu-E Chen, Pu Chen, Shanshan Chen, Jin Lu, Ting Ma, Guang Shi, Liang Shen. Long non-coding RNA FENDRR inhibits migration and invasion of cutaneous malignant melanoma cells. Bioscience reports. vol 40. issue 3. 2021-03-19. PMID:32134466. |
the protein expression levels of matrix metallopeptidase 2 (mmp2), mmp9, and related factors in jnk/c-jun pathway were detected using western blot. |
2021-03-19 |
2023-08-13 |
Not clear |
| Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Hossein Hosseinzade. Investigating the ameliorative effect of alpha-mangostin on development and existing pain in a rat model of neuropathic pain. Phytotherapy research : PTR. vol 34. issue 12. 2021-01-19. PMID:32592535. |
the lumbar spinal cord levels of mda, gsh, inflammatory markers (tlr-4, tnf-α, mmp2, cox2, il-1β, inos, and no), apoptotic markers (bcl-2, bax, and caspase-3) were measured by western blot on days 7 and 14. |
2021-01-19 |
2023-08-13 |
rat |