| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony D Jimenez, Margaret Gopaul, Hannah Asbell, Seyhmus Aydemir, Maysaa M Basha, Ayush Batra, Charlotte Damien, Gregory S Day, Onome Eka, Krista Eschbach, Safoora Fatima, Madeline C Fields, Brandon Foreman, Elizabeth E Gerard, Teneille E Gofton, Hiba A Haider, Stephen T Hantus, Sara Hocker, Amy Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Peter Kang, Karnig Kazazian, Marissa A Kellogg, Minjee Kim, Jong Woo Lee, Lara V Marcuse, Christopher M McGraw, Wazim Mohamed, Janet Orozco, Cederic Pimentel, Vineet Punia, Alexandra M Ramirez, Claude Steriade, Aaron F Struck, Olga Taraschenko, Andrew K Treister, Ji Yeoun Yoo, Sahar Zafar, Daniel J Zhou, Deepti Zutshi, Nicolas Gaspard, Lawrence J Hirsch, Aurelie Hani. Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection-related epilepsy syndrome) versus without prior fever: An interim analysis. Epilepsia. 2024-04-16. PMID:38625055. |
however, fires cases were more frequently cryptogenic; had higher csf interleukin 6, csf macrophage inflammatory protein-1 alpha (mip-1a), and serum chemokine ligand 2 (ccl2) levels; and received more antiseizure medications and immunotherapy. |
2024-04-16 |
2024-04-18 |
Not clear |
| Wenhua Li, Pengfei Wu, Tianrong Jin, Jialin Jia, Bo Chen, Tingting Liu, Yu Liu, Jie Mei, Bangwei Luo, Zhiren Zhan. L-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation. Frontiers in immunology. vol 15. 2024-04-10. PMID:38596683. |
a hsd led to increased peritonitis incidence in mice, as evidenced by the increased accumulation of inflammatory cells and elevated levels of inflammatory cytokines, such as tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6), and monocyte chemotactic protein-1 (mcp-1, also known as c-c motif chemokine ligand 2 or ccl2), in peritoneal lavage fluid. |
2024-04-10 |
2024-04-12 |
mouse |
| Mingyan Xu, Xuemei Lu, Feixiang Zhu, Xue Sun, Hongfa Yao, Junling Zhang, Weishi Chen, Haohao Zhu, Fan Liu, Song Lin Shi, Xiaoling Den. BRG1 mediates epigenetic regulation of TNFα-induced CCL2 expression in oral tongue squamous cell carcinoma cells. Journal of cellular biochemistry. 2024-02-13. PMID:38348687. |
however, the precise epigenetic mechanism responsible for enhanced ccl2 expression in response to the inflammatory mediator tumor necrosis factor alpha (tnf-α) in otscc remains inadequately elucidated. |
2024-02-13 |
2024-02-15 |
Not clear |
| Minhui Zhu, Yi Ma, Wei Wang, Meng Li, Shicai Chen, Fei Liu, Xiaoqiong Shi, Hongsen Bi, Chen Zhang, Fangfei Nie, Hongliang Zheng, Caiyun Zhan. SCUBE3 exerts a tumor-promoting effect in tongue squamous cell carcinoma by promoting CEBPA binding to the CCL2 promoter. Molecular cancer research : MCR. 2024-02-13. PMID:38349738. |
mechanistically, scube3 promoted the direct binding of ccaat enhancer binding protein alpha (cebpa) to c-c motif chemokine ligand 2 (ccl2) promoter in tscc cells. |
2024-02-13 |
2024-02-15 |
Not clear |
| Lao-Tzu Allan-Blitz, Jesse Goodrich, Howard Hu, Omid Akbari, Jeffrey D Klausne. Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2023-06-29. PMID:37384921. |
levels of tumor necrosis factor alpha (tnfα) were 0.76 times lower [95% confidence interval (ci) 0.62-0.94] among cases of neuro-pasc compared with controls, as were levels of c-c motif chemokine 19 (ccl19) (0.67; 95% ci 0.50-0.91), c-c motif chemokine 2 (ccl2) (0.72; 95% ci 0.55-0.95), chemokine interferon-gamma inducible protein 10 (cxcl10) (0.63; 95% ci 0.42-0.96), and chemokine interferon-gamma inducible protein 9 (cxcl9) (0.62; 95% ci 0.38-0.99). |
2023-06-29 |
2023-08-14 |
human |
| Huan Yu, Tianwen Huang, William Weijia Lu, Liping Tong, Di Che. Osteoarthritis Pain. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563035. |
we evaluate pathways associated with oa pain, such as nerve growth factor (ngf)/tropomyosin receptor kinase a (trka), calcitonin gene-related peptide (cgrp), c-c motif chemokine ligands 2 (ccl2)/chemokine receptor 2 (ccr2) and tumor necrosis factor alpha (tnf-α), interleukin-1beta (il-1β), the nod-like receptor (nlr) family, pyrin domain-containing protein 3 (nlrp3) inflammasome, and the wnt/β-catenin signaling pathway. |
2022-05-14 |
2023-08-13 |
Not clear |
| Monica L Gertz, Christopher R Chin, Delia Tomoiaga, Matthew MacKay, Christina Chang, Daniel Butler, Ebrahim Afshinnekoo, Daniela Bezdan, Michael A Schmidt, Christopher Mozsary, Ari Melnick, Francine Garrett-Bakelman, Brian Crucian, Stuart M C Lee, Sara R Zwart, Scott M Smith, Cem Meydan, Christopher E Maso. Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity. Cell reports. vol 33. issue 10. 2021-11-08. PMID:33242408. |
the unique biochemical profiles observed when landing on earth after such a long mission (e.g., spikes in interleukin-1 [il-1]/6/10, c-reactive protein [crp], c-c motif chemokine ligand 2 [ccl2], il-1 receptor antagonist [il-1ra], and tumor necrosis factor alpha [tnf-α]) opened new questions about the human body's response to gravity and how to plan for future astronauts, particularly around initiation or resolution of inflammation. |
2021-11-08 |
2023-08-13 |
human |
| Chi Sun Yun, Hironori Masaka, Daichi Nishino, Shutaro Horaku, Al-Nur Md Iftekhar Rahman, M A M Yahia Khandoker, Nobuhiko Yamauch. Analysis of novel embryonic factors of cattle and effects on endometrial cells in vitro. Animal reproduction science. vol 226. 2021-10-27. PMID:33517065. |
when endometrial cells were treated with interferon alpha (ifna) and mif, the ccl2 transcript was in a larger abundance of endometrial epithelial and polymorphonuclear neutrophil cells, and there was a larger abundance of there mrna transcripts as a result of mif treatment of peripheral blood mononuclear cells. |
2021-10-27 |
2023-08-13 |
cattle |
| Santhamani Ramasamy, Selvakumar Subbia. Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis. Clinical microbiology reviews. vol 34. issue 3. 2021-05-24. PMID:33980688. |
severe covid-19 manifests as acute respiratory distress syndrome (ards) with elevated plasma proinflammatory cytokines, including interleukin 1β (il-1β), il-6, tumor necrosis factor α (tnf-α), c-x-c motif chemokine ligand 10 (cxcl10/ip10), macrophage inflammatory protein 1 alpha (mip-1α), and chemokine (c-c motif) ligand 2 (ccl2), with low levels of interferon type i (ifn-i) in the early stage and elevated levels of ifn-i during the advanced stage of covid-19. |
2021-05-24 |
2023-08-13 |
Not clear |
| Nataliia Kalynovska, Mickael Diallo, Dita Sotakova-Kasparova, Jiri Palece. Losartan attenuates neuroinflammation and neuropathic pain in paclitaxel-induced peripheral neuropathy. Journal of cellular and molecular medicine. vol 24. issue 14. 2021-05-10. PMID:32485058. |
paclitaxel induced overexpression of c-c motif chemokine ligand 2 (ccl2), tumour necrosis alpha (tnfα) and interleukin-6 (il-6) in drgs, where the presence of macrophages was demonstrated. |
2021-05-10 |
2023-08-13 |
rat |
| Huizong Su, Qian Wang, Yue Li, Jingyi Jin, Bo Tan, Dongming Yan, Bin Zou, Guochao Song, Fengyi Weng, Furong Qi. Effect of Different Ratios of Yinchen and Gancao Decoction on ANIT-Treated Cholestatic Liver Injury in Mice and Its Potential Underlying Mechanism. Frontiers in pharmacology. vol 12. 2021-05-04. PMID:33935705. |
moreover, the expression levels of toll-like receptor 4 (tlr4), interleukin-1β (il-1β), il-6, tumor necrosis factor alpha (tnf-α), c-c ligand 2 (ccl2), and c-x-c ligand 2 (cxcl2) in the liver were significantly reduced. |
2021-05-04 |
2023-08-13 |
mouse |
| Khalid Elsaafien, Willian S Korim, Anthony Setiadi, Clive N May, Song T Ya. Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation. Frontiers in physiology. vol 10. 2020-09-29. PMID:31427987. |
chemokines such as c-c motif chemokine ligand 2 (ccl2), and pro-inflammatory cytokines such as tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β), are upregulated both peripherally and centrally in hypertension. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mitchell D Frye, Allen F Ryan, Arwa Kurab. Inflammation associated with noise-induced hearing loss. The Journal of the Acoustical Society of America. vol 146. issue 5. 2020-09-10. PMID:31795714. |
extensive evidence indicates pro-inflammatory cytokines including tnf alpha and interleukin 1 beta, and chemokines including ccl2, are induced in the cochlea after noise exposure. |
2020-09-10 |
2023-08-13 |
Not clear |
| Seok Won Ham, Hee-Young Jeon, Xiong Jin, Eun-Jung Kim, Jun-Kyum Kim, Yong Jae Shin, Yeri Lee, Se Hoon Kim, Seon Yong Lee, Sunyoung Seo, Min Gi Park, Hye-Mi Kim, Do-Hyun Nam, Hyunggee Ki. TP53 gain-of-function mutation promotes inflammation in glioblastoma. Cell death and differentiation. vol 26. issue 3. 2020-06-03. PMID:29786075. |
the tp53 gof mutant showed upregulated c-c motif chemokine ligand 2 (ccl2) and tumor necrosis factor alpha (tnfa) expression via nuclear factor kappa b (nfκb) signaling, consequently increasing microglia and monocyte-derived immune cell infiltration. |
2020-06-03 |
2023-08-13 |
Not clear |
| Michele Mondini, Pierre-Louis Loyher, Pauline Hamon, Marine Gerbé de Thoré, Marie Laviron, Kevin Berthelot, Céline Clémenson, Benoit L Salomon, Christophe Combadière, Eric Deutsch, Alexandre Boissonna. CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance. Cancer immunology research. vol 7. issue 3. 2020-05-20. PMID:30696630. |
herein, a murine model of head and neck squamous cell carcinoma was used to demonstrate that rt upregulated ccl2 chemokine production in tumor cells, leading to a ccr2-dependent accumulation of tumor necrosis factor alpha (tnfα)-producing monocytes and ccr2 |
2020-05-20 |
2023-08-13 |
Not clear |
| Stefan Jordan, Navpreet Tung, Maria Casanova-Acebes, Christie Chang, Claudia Cantoni, Dachuan Zhang, Theresa H Wirtz, Shruti Naik, Samuel A Rose, Chad N Brocker, Anastasiia Gainullina, Daniel Hornburg, Sam Horng, Barbara B Maier, Paolo Cravedi, Derek LeRoith, Frank J Gonzalez, Felix Meissner, Jordi Ochando, Adeeb Rahman, Jerry E Chipuk, Maxim N Artyomov, Paul S Frenette, Laura Piccio, Marie-Luise Berres, Emily J Gallagher, Miriam Mera. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. vol 178. issue 5. 2020-05-11. PMID:31442403. |
specifically, we found that activation of the low-energy sensor 5'-amp-activated protein kinase (ampk) in hepatocytes and suppression of systemic ccl2 production by peroxisome proliferator-activator receptor alpha (pparα) reduced monocyte mobilization from the bone marrow. |
2020-05-11 |
2023-08-13 |
Not clear |
| Indrani Ray, Sushil K Mahata, Rajat K D. Obesity: An Immunometabolic Perspective. Frontiers in endocrinology. vol 7. 2019-11-20. PMID:28018292. |
in contrast, obesity induces lipolysis and release of pro-inflammatory ffas and factors, such as chemokine (c-c motif) ligand 2 (ccl2) and tumor necrosis factor alpha (tnf-α), which recruit blood monocytes in adipose tissue, where they are converted to macrophages of the highly pro-inflammatory m1-type (atm1). |
2019-11-20 |
2023-08-13 |
Not clear |
| Edith Sierra-Mondragon, Eduardo Molina-Jijon, Carmen Namorado-Tonix, Rafael Rodríguez-Muñoz, Jose Pedraza-Chaverri, Jose L Reye. All-trans retinoic acid ameliorates inflammatory response mediated by TLR4/NF-κB during initiation of diabetic nephropathy. The Journal of nutritional biochemistry. vol 60. 2019-10-21. PMID:30193155. |
besides, diabetes induced an increase in interleukins [il-1β, il-1α, il-16, il-13, il-2; tumor necrosis factor alpha (tnf-α)] and transforming growth factor-beta 1 (tgf-β1), chemokines (ccl2, ccl20, cxcl5 and cxcl7), adhesion molecules (icam-1 and l-selectin) and growth factors (gm-csf, vegf, pdgf) in glomeruli and proximal tubules, whereas atra treatment remarkably ameliorated these alterations. |
2019-10-21 |
2023-08-13 |
rat |
| Shoichi Kageyama, Kojiro Nakamura, Takehiro Fujii, Bibo Ke, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinsk. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology (Baltimore, Md.). vol 68. issue 1. 2018-12-28. PMID:29350771. |
rhrlx-induced gr suppressed hepatocyte high-mobility group box 1 (hmgb1) translocation/release, accompanied by decreased toll-like receptor 4 (tlr4)/receptor for advanced glycation end products (rage), suppressed interleukin 1 beta (il1β), chemokine (c-c motif) ligand 2 (ccl2), c-x-c motif chemokine (cxcl)10, tumor necrosis factor alpha (tnfα), cxcl1, and cxcl2 levels, and attenuated neutrophil/macrophage accumulation in olt. |
2018-12-28 |
2023-08-13 |
human |
| Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Anna Piotrowska, Bogusława Budziszewska, Marta Kubera, Katarzyna Popiołek-Barczyk, Władysław Lasoń, Joanna Mika, Agnieszka Basta-Kai. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures. International journal of molecular sciences. vol 19. issue 7. 2018-11-05. PMID:29976873. |
tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (cd40), and major histocompatibility complex class ii (mhc ii) markers, as well as the release of pro-inflammatory factors: interleukin (il)-1β, il-18, il-6, tumor necrosis factor alpha (tnf-α), and chemokine cc motif ligand 2 (ccl2), and the production of nitric oxide and reactive oxygen species. |
2018-11-05 |
2023-08-13 |
Not clear |