| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luwei Cai, Mengxue Xia, Fang Zhan. Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671871. |
microglia, resident immune cells in the retina, are recognized as crucial drivers in the dr process. |
2024-04-27 |
2024-04-29 |
Not clear |
| Luwei Cai, Mengxue Xia, Fang Zhan. Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671871. |
emerging evidence suggests that microglia in dr not only engage specific metabolic pathways but also rearrange their oxidation-reduction (redox) system. |
2024-04-27 |
2024-04-29 |
Not clear |
| Fahad Eid Albalawi, Ifat Alsharif, Mamdoh S Moawadh, Abdulaziz Alkhoshaiban, Faez Falah Alshehri, Aishah E Albalawi, Norah A Althobaiti, Zeyad M Alharbi, Hailah M Almohaimee. Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy. International immunopharmacology. vol 133. 2024-04-16. PMID:38626549. |
diabetic retinopathy (dr) stands as a prevalent secondary complication of diabetes, notably type 1 diabetes mellitus (t1d), characterized by immune system involvement potentially impacting the retinal immune response mediated by microglia. |
2024-04-16 |
2024-04-19 |
Not clear |
| Jun Tong, Genhong Yao, Yueqin Chen, Hairong Xie, Xinyu Zheng, Lingyun Sun, Zhenping Huang, Zhenggao Xi. Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy. Inflammation. 2024-04-16. PMID:38625640. |
collectively, mscs exert beneficial effects on dr by polarizing microglia from m1 toward m2 phenotype via inhibiting the hmgb1/tlr4 signaling pathway. |
2024-04-16 |
2024-04-18 |
rat |
| Mayumi Yamato, Nao Kato, Ken-Ichi Yamada, Toyoshi Inoguch. The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium-Glucose Transporter 2 Inhibitors. Diabetes. 2024-04-12. PMID:38608284. |
furthermore, both inhibitors at this dose attenuated microglia morphological changes and these early pathogenic alterations in dr. |
2024-04-12 |
2024-04-15 |
mouse |
| Yan Wang, Xiongyi Yang, Yuxi Zhang, Libing Hong, Zhuohang Xie, Wenmin Jiang, Lin Chen, Ke Xiong, Siyu Yang, Meiping Lin, Xi Guo, Qiumo Li, Xiaoqing Deng, Yanhui Lin, Mingzhe Cao, Guoguo Yi, Min F. Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy. Diabetology & metabolic syndrome. vol 16. issue 1. 2024-02-28. PMID:38409074. |
in this study, we confirmed microglia had the most significant changes in early dr using single-cell rna sequencing. |
2024-02-28 |
2024-03-01 |
Not clear |
| Feipeng Jiang, Chunyan Lei, Yingying Chen, Nenghua Zhou, Meixia Zhan. The complement system and diabetic retinopathy. Survey of ophthalmology. 2024-02-24. PMID:38401574. |
molecules such as c3a, c5a, and membrane attacking complex, as important molecules of the complement system, are involved in the pathologenesus of dr either through direct damaging effects or by activating cells (microglia, macroglia, etc.) |
2024-02-24 |
2024-02-27 |
Not clear |
| Xingxing Wang, Changlin Xu, Cunxin Bian, Pengfei Ge, Jie Lei, Jingfan Wang, Tianhao Xiao, Yuanyuan Fan, Qinyuan Gu, Hong-Ying Li, Jingyi Xu, Zizhong Hu, Ping Xi. M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy. Journal of nanobiotechnology. vol 22. issue 1. 2024-02-09. PMID:38336783. |
the present study demonstrated that m2 microglia intensively participated in retinal microangiopathy in human diabetic proliferative membranes, mice retinas, retinas of mice with oxygen-induced retinopathy (oir) mice, and retinas of streptozotocin-induced dr mice. |
2024-02-09 |
2024-02-12 |
mouse |
| Derek Rodriguez, Kaira A Church, Alicia N Pietramale, Sandra M Cardona, Difernando Vanegas, Colin Rorex, Micah C Leary, Isabel A Muzzio, Kevin R Nash, Astrid E Cardon. Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. Journal of neuroinflammation. vol 21. issue 1. 2024-02-04. PMID:38311721. |
diabetic retinopathy (dr) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promoting neuronal and vascular damage. |
2024-02-04 |
2024-02-07 |
mouse |
| Charles W Pfeifer, James T Walsh, Andrea Santeford, Joseph B Lin, Wandy L Beatty, Ryo Terao, Yizhou A Liu, Keitaro Hase, Philip A Ruzycki, Rajendra S Apt. Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 45. 2023-10-30. PMID:37903272. |
we show that cd200-cd200r signaling between amacrine cells and microglia is dysregulated during early dr and that targeting cd200r can attenuate high glucose-induced inflammation and phagocytosis in cultured microglia. |
2023-10-30 |
2023-11-08 |
mouse |
| Charles W Pfeifer, James T Walsh, Andrea Santeford, Joseph B Lin, Wandy L Beatty, Ryo Terao, Yizhou A Liu, Keitaro Hase, Philip A Ruzycki, Rajendra S Apt. Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 45. 2023-10-30. PMID:37903272. |
these studies provide a molecular framework for the pivotal role that microglia play in early dr pathogenesis and identify a potential immunotherapeutic target for treating dr in patients. |
2023-10-30 |
2023-11-08 |
mouse |
| Yujia Yao, Jiajun Li, Yunfan Zhou, Suyu Wang, Ziran Zhang, Qin Jiang, Keran L. Macrophage/microglia polarization for the treatment of diabetic retinopathy. Frontiers in endocrinology. vol 14. 2023-10-16. PMID:37842315. |
the functional phenotypes of macrophages/microglia affect disease progression and prognosis, and thus regulate the polarization or functional phenotype of microglia at different dr stages, which may offer new concepts for individualized therapy of dr. |
2023-10-16 |
2023-11-08 |
Not clear |
| Haixiang Wu, Fangcheng Xu, Yunfang Luo, Yibao Zhang, Min Tan. 3D bioprinted endothelial cell-microglia coculture for diabetic retinopathy modeling. Biofabrication. 2023-09-19. PMID:37725996. |
microglia, essential for retinal homeostasis, remains underexplored in dr. |
2023-09-19 |
2023-10-07 |
Not clear |
| Haixiang Wu, Fangcheng Xu, Yunfang Luo, Yibao Zhang, Min Tan. 3D bioprinted endothelial cell-microglia coculture for diabetic retinopathy modeling. Biofabrication. 2023-09-19. PMID:37725996. |
in conclusion, our findings emphasize the importance of cellular interactions and microenvironmental factors in dr therapy, aiming to identify novel strategies and improve understanding of microglia's role in disease pathogenesis. |
2023-09-19 |
2023-10-07 |
Not clear |
| Marilena Bohley, Andrea E Dillinger, Barbara M Braunger, Ernst R Tamm, Achim Goepferic. Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy. Drug delivery and translational research. 2023-05-19. PMID:37208562. |
one single injection suppressed the expression of pro-inflammatory cytokines, dampened macrophage infiltration, and prevented macrophage and microglia activation in eyes with dr. |
2023-05-19 |
2023-08-14 |
mouse |
| Dolly Ann Padovani-Claudio, Carla J Ramos, Megan E Capozzi, John S Pen. Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis. Progress in retinal and eye research. vol 94. 2023-04-07. PMID:37028118. |
in vitro stimulation of glia with glucose, angiotensin ii and palmitic acid suggests that: 1) astrocytes may be more responsive than other glia to these products of systemic dyshomeostasis; 2) the effects of hyperglycemia on glia are likely to be largely osmotic; 3) fatty acid accumulation may compound dr pathophysiology by promoting predominantly proinflammatory and proangiogenic transcriptional alterations of macro and microglia; and 4) cell-targeted therapies may offer safer and more effective avenues for dr treatment as they may circumvent the complication of pleiotropism in retinal cell responses. |
2023-04-07 |
2023-08-14 |
Not clear |
| Zijing Huang, Jiajian Liang, Shaolang Chen, Tsz Kin Ng, Marten E Brelén, Qingping Liu, Rucui Yang, Biyao Xie, Shuping Ke, Weiqi Chen, Dingguo Huan. RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy. Cell death & disease. vol 14. issue 3. 2023-03-29. PMID:36991017. |
our data demonstrate the importance of microglial necroptosis in retinal neuroinflammation related to diabetes and suggest that targeting necroptosis in microglia may be a promising therapeutic strategy for the early stages of dr. |
2023-03-29 |
2023-08-14 |
mouse |
| Ying Zhu, Lipeng Guo, Jixin Zou, Liwen Wang, He Dong, Shengbo Yu, Lijun Zhang, Jun Li, Xueling Q. JQ1 inhibits high glucose-induced migration of retinal microglial cells by regulating the PI3K/AKT signaling pathway. Mathematical biosciences and engineering : MBE. vol 19. issue 12. 2023-01-19. PMID:36654036. |
jq1 suppresses the pi3k/akt cascade by targeting mmp expression, thus decreasing the viability and invasion capacity of retinal microglia, suggesting an interesting treatment target for dr. |
2023-01-19 |
2023-08-14 |
rat |
| Amy M Smith, Thomas In-Hyeup Park, Miranda Aalderink, Robyn L Oldfield, Peter S Bergin, Edward W Mee, Richard L M Faull, Mike Draguno. Distinct characteristics of microglia from neurogenic and non-neurogenic regions of the human brain in patients with Mesial Temporal Lobe Epilepsy. Frontiers in cellular neuroscience. vol 16. 2022-11-25. PMID:36425665. |
compared to microglia isolated from the cortex, ventricular/hp microglia showed increased hla-dp, dq, dr antigen presentation protein expression and a rounded morphology. |
2022-11-25 |
2023-08-14 |
human |
| Kangjia Lv, Hui Ying, Guangyi Hu, Jing Hu, Qizhi Jian, Fang Zhan. Integrated multi-omics reveals the activated retinal microglia with intracellular metabolic reprogramming contributes to inflammation in STZ-induced early diabetic retinopathy. Frontiers in immunology. vol 13. 2022-09-19. PMID:36119084. |
here, we used single-cell sequencing to identify microglia with metabolic pathway alterations that were the main source of il-1β in stz-induced dr mice. |
2022-09-19 |
2023-08-14 |
mouse |