| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasmina Curto, Héctor Carceller, Patrycja Klimczak, Marta Perez-Rando, Qing Wang, Katharina Grewe, Riki Kawaguchi, Silvio Rizzoli, Daniel Geschwind, Klaus-Armin Nave, Vicent Teruel-Marti, Manvendra Singh, Hannelore Ehrenreich, Juan Náche. Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus. Molecular psychiatry. 2024-04-15. PMID:38622200. |
effects in juvenile mice can elucidate how erythropoietin (epo) might aid in rectifying hippocampal transcriptional networks and synaptic structures of pyramidal lineages, conceivably explaining mitigation of neuropsychiatric diseases. |
2024-04-15 |
2024-04-18 |
mouse |
| William Almaguer-Melian, Daymara Mercerón-Martinez, Esteban Alberti-Amador, Laura Alacán-Ricardo, Javier Curi de Bardet, Norma Orama-Rojo, Arturo Ernesto Vergara-Piña, Idalia Herrera Estrada, Jorge A Bergad. Learning induces EPO/EPOr expression in memory relevant brain areas, whereas exogenously applied EPO promotes remote memory consolidation. Synapse (New York, N.Y.). 2023-10-05. PMID:37794768. |
data show that learning induces epo/epor expression increase linked to memory extent, exogenous epo prolongs memory up to 21 days; and prefrontal cortex bdnf expression at 24 h and in the hippocampus at 21 days, whereas arc expression increases at 21 days in the hippocampus and prefrontal cortex. |
2023-10-05 |
2023-10-07 |
Not clear |
| Tingli Guo, Ye Yu, Wenhui Yan, Meng Zhang, Xinyao Yi, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Zhuanzhuan Wang, Jia Shang, Wei Cui, Lina Che. Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis. Experimental neurology. 2023-04-19. PMID:37075971. |
to evaluate the effects of epo on diabetes-associated cognitive dysfunction, we constructed a t2dm mouse model and found that epo not only decreased fasting blood glucose but also ameliorated hippocampal damage in the brain. |
2023-04-19 |
2023-08-14 |
mouse |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
epo also significantly lowered elevated fasting blood glucose levels, improved pancreatic and hippocampal damage, and restored oxidative stress in the stz-induced diabetic mice. |
2023-02-05 |
2023-08-14 |
mouse |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
our findings revealed that epo impedes hippocampal and synaptic damage and neuronal apoptosis by regulating bdnf and psd-95 expression through nmda receptors, thereby ameliorating cognitive impairments in mice with t1dm. |
2023-02-05 |
2023-08-14 |
mouse |
| Sara Haratizadeh, Mehdi Ranjbar, Fatemeh Darvishzadeh-Mahani, Mohsen Basiri, Masoumeh Nozar. The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. Developmental psychobiology. vol 65. issue 1. 2022-12-26. PMID:36567653. |
neuroprotective effects of epo and nepo have been shown in the hippocampus. |
2022-12-26 |
2023-08-14 |
rat |
| Titikorn Chunchai, Nattayaporn Apaijai, Juthipong Benjanuwattra, Hiranya Pintana, Kodchanan Singhanat, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Erythropoietin administration exerted neuroprotective effects against cardiac ischemia/reperfusion injury. Current research in pharmacology and drug discovery. vol 3. 2022-12-26. PMID:36568264. |
we hypothesized that the administration of epo attenuates brain damage caused by cardiac i/r injury through decreasing peripheral and brain oxidative stress, preserving microglial morphology, attenuating hippocampal necroptosis, and decreasing hippocampal apoptosis, and hippocampal dysplasticity. |
2022-12-26 |
2023-08-14 |
rat |
| Titikorn Chunchai, Nattayaporn Apaijai, Juthipong Benjanuwattra, Hiranya Pintana, Kodchanan Singhanat, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Erythropoietin administration exerted neuroprotective effects against cardiac ischemia/reperfusion injury. Current research in pharmacology and drug discovery. vol 3. 2022-12-26. PMID:36568264. |
giving epo before cardiac ischemia conferred the greatest neuroprotection against cardiac i/r injury through the attenuation of lv dysfunction, decrease in peripheral and brain oxidative stress, and the attenuation of microglial activation, brain mitochondrial dysfunction, apoptosis, and necroptosis, leading to the improvement of hippocampal dysplasticity under cardiac i/r conditions. |
2022-12-26 |
2023-08-14 |
rat |
| Hannelore Ehrenreich, Laura Fernandez Garcia-Agudo, Agnes A Steixner-Kumar, Justus B H Wilke, Umer Javed But. Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance. Molecular psychiatry. 2022-04-13. PMID:35414656. |
correspondingly, rhepo treatment of young rodents or epo receptor (epor) overexpression in pyramidal neurons caused remarkable and enduring cognitive improvement, together with enhanced hippocampal long-term potentiation. |
2022-04-13 |
2023-08-13 |
human |
| Hannelore Ehrenreich, Laura Fernandez Garcia-Agudo, Agnes A Steixner-Kumar, Justus B H Wilke, Umer Javed But. Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance. Molecular psychiatry. 2022-04-13. PMID:35414656. |
the 'brain hardware upgrade', underlying these observations, includes an epo induced ~20% increase in pyramidal neurons and oligodendrocytes in cornu ammonis hippocampi in the absence of elevated dna synthesis. |
2022-04-13 |
2023-08-13 |
human |
| Robert A Jacobs, Mostafa A Aboouf, Christina Koester-Hegmann, Paola Muttathukunnel, Sofien Laouafa, Christian Arias-Reyes, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith M Schneider Gasse. Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice. Communications biology. vol 4. issue 1. 2021-11-18. PMID:34354241. |
here we show that epo promotes mitochondrial respiration in developing postnatal hippocampus by increasing mitochondrial content and enhancing cellular respiratory potential. |
2021-11-18 |
2023-08-13 |
mouse |
| Robert A Jacobs, Mostafa A Aboouf, Christina Koester-Hegmann, Paola Muttathukunnel, Sofien Laouafa, Christian Arias-Reyes, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith M Schneider Gasse. Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice. Communications biology. vol 4. issue 1. 2021-11-18. PMID:34354241. |
collectively, we identify a role for epo in the murine postnatal hippocampus by promoting mitochondrial function throughout early postnatal development, which corresponds to enhanced cognition by early adulthood. |
2021-11-18 |
2023-08-13 |
mouse |
| Kamilla W. Miskowiak, Julie L. Forman, Maj Vinberg, Hartwig R. Siebner, Lars V. Kessing, Julian Macovean. Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial Journal of psychiatry & neuroscience : JPN. vol 45. issue 3. 2021-11-08. PMID:31804779. |
erythropoietin (epo) improves verbal learning and memory in mood disorders, and this scales with an increase in left hippocampal volume. |
2021-11-08 |
2023-08-13 |
Not clear |
| Kamilla W. Miskowiak, Julie L. Forman, Maj Vinberg, Hartwig R. Siebner, Lars V. Kessing, Julian Macovean. Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial Journal of psychiatry & neuroscience : JPN. vol 45. issue 3. 2021-11-08. PMID:31804779. |
this study investigated whether pretreatment left hippocampal volume, interhemisphere hippocampal asymmetry or both influenced epo treatment response with respect to verbal learning. |
2021-11-08 |
2023-08-13 |
Not clear |
| Susan Jung, Klara Terörde, Helmuth-Günther Dörr, Regina Trollman. Recombinant Human Growth Hormone Activates Neuroprotective Growth Factors in Hypoxic Brain Injury in Neonatal Mice. Endocrinology. vol 162. issue 3. 2021-09-10. PMID:33545716. |
in the developing brain, rhgh treatment led to a notable reduction of apoptosis in the subventricular zone and hippocampus (p < .05), abolished hypoxia-induced downregulation of igf-1/igf-2 expression (p < .05), and led to a significant accumulation of endogenous epo protein and anti-inflammatory effects through modulation of interleukin-1β and tumor necrosis factor α signaling as well as upregulation of cerebral phosphorylated extracellularly regulated kinase 1/2 levels (erk1/2). |
2021-09-10 |
2023-08-13 |
mouse |
| Laura Fernandez Garcia-Agudo, Agnes A Steixner-Kumar, Yasmina Curto, Nadine Barnkothe, Imam Hassouna, Sebastian Jähne, Umer Javed Butt, Katharina Grewe, Martin S Weber, Kim Green, Silvio Rizzoli, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreic. Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell reports. vol 36. issue 8. 2021-08-25. PMID:34433021. |
in adult cornu ammonis hippocampi, erythropoietin (epo) expression drives the differentiation of new neurons, independent of dna synthesis, and increases dendritic spine density. |
2021-08-25 |
2023-08-13 |
mouse |
| Burcu Sarya Tunç, Fatih Toprak, Selin Fulya Toprak, Selcuk Soze. In vitro investigation of growth factors including MGF and IGF-1 in neural stem cell activation, proliferation, and migration. Brain research. vol 1759. 2021-08-11. PMID:33607046. |
in this study, we examined the effects of fgf-2, mgf, igf-1, epo, egf, ngf, and bdnf alone or with various combinations on rat hippocampal nsc by tracking the changes in the expression of nestin, gfap, tubb3, and dcx genes during 24 h (h), 72 h and 168 h time frame. |
2021-08-11 |
2023-08-13 |
rat |
| Kasifa Khalid, Julia Frei, Mostafa A Aboouf, Christina Koester-Hegmann, Max Gassmann, Jean-Marc Fritschy, Edith M Schneider Gasse. Erythropoietin Stimulates GABAergic Maturation in the Mouse Hippocampus. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33495244. |
here, with the use of a transgenic mouse line that constitutively overexpresses neuronal epo (tg21), we show that epo stimulates postnatal gabaergic maturation in the hippocampus. |
2021-06-18 |
2023-08-13 |
mouse |
| Chun-Yan Zhang, Juan Du, Rui Zhang, Jin Jin, Le-Yan Qia. Erythropoietin attenuates propofol-induced hippocampal neuronal cell injury in developing rats by inhibiting toll-like receptor 4 expression. Neuroscience letters. vol 716. 2020-12-14. PMID:31765729. |
this study was to investigate the neuroprotective effect of erythropoietin (epo) on hippocampal neuronal cell injury in developing rats. |
2020-12-14 |
2023-08-13 |
rat |
| Leiming Zhang, Hongsheng Wang, Tian Wang, Na Jiang, Pengfei Yu, Yating Chong, Fenghua F. Ferulic acid ameliorates nerve injury induced by cerebral ischemia in rats. Experimental and therapeutic medicine. vol 9. issue 3. 2020-10-01. PMID:25667662. |
the results showed that fa attenuated nerve injury of the hippocampus, significantly ameliorated neurological deficits, and increased epo but not g-csf expression in the hippocampus and the peripheral blood of ischemic rats. |
2020-10-01 |
2023-08-13 |
rat |