| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
immunofluorescence was used to detect gfap, iba1, and nlrp3 expression in the hippocampus. |
2024-04-16 |
2024-04-18 |
rat |
| Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Chen. CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3. Neuroreport. 2024-03-25. PMID:38526919. |
the anti-cxcl13 antibody alleviated smir-induced decreased pwt and increased expression of gfap, cxcl13, cxcr5, nlrp3, and caspase-1 p20 in spinal cord tissues. |
2024-03-25 |
2024-03-28 |
rat |
| Guido S Alvarez Quintero, Analia Lima, Paulina Roig, Maria Meyer, E Ron de Kloet, Alejandro F De Nicola, Laura I Gara. effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis. The Journal of steroid biochemistry and molecular biology. 2024-01-14. PMID:38219844. |
the mr blocker (a) significantly decreased the inflammatory parameters tlr4, myd88, il-1β, and inos mrnas; (b) attenuated hmgb1, nlrp3, tgf-β mrnas, microglia, and aquaporin4 immunoreaction without modifying gfap. |
2024-01-14 |
2024-01-17 |
mouse |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
meanwhile, ketamine reduced the level of hippocampus nlrp3 and the expression of its downstream molecules in chronic unpredictable mild stress (cums) mice model by western blot and reduced the colocalization of gfap and gsdmd by nearly 25% via immunofluorescent staining. |
2023-10-15 |
2023-11-08 |
mouse |
| He-Yu Yang, Xu Sun, Shu-Qing Zhen, Liang-Zhu Yu, Jie-Qiong Ding, Ling Liu, Min Xie, Hai-Li Zh. GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation. PloS one. vol 18. issue 4. 2023-04-14. PMID:37058473. |
in spinal cord, neuroinflammation was triggered and presented as severe infiltration of inflammatory cells and up-regulated expressions of glial fibrillary acidic protein (gfap), nuclear factor-kappab (nf-κb), pyd domains-containing protein 3 (nlrp3), cysteinyl aspartate specific proteinase (caspase-1) and interleukin-1 beta (il-1β). |
2023-04-14 |
2023-08-14 |
mouse |
| Charisse Y-J Kuo, Jack J Maran, Emma G Jamieson, Ilva D Rupenthal, Rinki Murphy, Odunayo O Mugish. Characterization of NLRP3 Inflammasome Activation in the Onset of Diabetic Retinopathy. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430950. |
the aim of this study was to characterize the role of nucleotide-binding oligomerization domain- (nod-) like receptor (nlr) protein 3 (nlrp3) inflammasome activation in the onset of diabetic retinopathy (dr) using retina and vitreous from donors without diabetes mellitus (ctl), with diabetes mellitus alone (dm), and with dr. retinal expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adapter molecule 1 (iba-1), the key markers of retinal inflammation, connexin43 (cx43) which is involved in upstream inflammasome regulation, as well as nlrp3 and cleaved caspase-1, the main markers of inflammasome activation, were evaluated using immunohistochemistry and western blotting. |
2022-11-26 |
2023-08-14 |
Not clear |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
s1 increased and/or modulated neuroimmune gene expression (iba1, cd11b, mhciiα, cd200r1, gfap, tlr2, tlr4, nlrp3, il1b, hmgb1) and protein levels (ifnγ, il-1β, tnf, cxcl1, il-2, il-10), which varied across brain regions (hypothalamus, hippocampus, and frontal cortex) and time (24h and 7d) post-s1 treatment. |
2021-12-16 |
2023-08-13 |
human |
| Hao Tang, Michael Hart. Investigating Markers of the NLRP3 Inflammasome Pathway in Alzheimer's Disease: A Human Post-Mortem Study. Genes. vol 12. issue 11. 2021-11-29. PMID:34828359. |
rna expression of genes of three glial cell markers, hla-dra, aif-1 and gfap; the components of the nlrp3 inflammasome nlrp3, asc, and caspase-1; and downstream pre-inflammatory cytokines il-1 β and il-18, were investigated in the temporal cortex of ad patients and age- and sex-matched controls. |
2021-11-29 |
2023-08-13 |
human |
| Walaa A Keshk, Marwa A Ibrahim, Shahinaz M Shalaby, Zeinab A Zalat, Walaa S Elsead. Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to high fat diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine (NAC). Archives of biochemistry and biophysics. vol 680. 2020-05-11. PMID:31838118. |
furthermore, nac improved redox and inflammatory status; decreased levels of ripk3, mlkl, nlrp3, il-18; down-regulated asc, inos, gfap and mmp-9 expression; and decreased myeloperoxidase activity in cerebral cortex. |
2020-05-11 |
2023-08-13 |
rat |
| Ying Chen, Qiu-Shuang Zhang, Qian-Hang Shao, Shuo Wang, Yu-He Yuan, Nai-Hong Chen, Hong-Bo Wan. NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP. Acta pharmacologica Sinica. vol 40. issue 8. 2019-12-23. PMID:30728466. |
furthermore, the olfactory bulbs in mptp/p-treated mice showed significantly increased levels of interleukin-1β (il-1β), caspase-1, glial fibrillary acidic protein (gfap), toll receptor 4 (tlr4), phosphorylation of p65, as well as activated molecules of nod-like receptor protein 3 (nlrp3) that were associated with neuroinflammation. |
2019-12-23 |
2023-08-13 |
mouse |