| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jit Poddar, Suresh B Rangasamy, Kalipada Paha. Therapeutic efficacy of cinnamein, a component of balsam of Tolu/Peru, in controlled cortical impact mouse model of TBI. Neurochemistry international. 2024-04-19. PMID:38641028. |
oral delivery of cinnamein through gavage brought down the activation of microglia and astrocytes to decrease the expression of inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule 1 (iba1) in hippocampus and cortex of tbi mice. |
2024-04-19 |
2024-04-22 |
mouse |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
immunofluorescence was used to detect gfap, iba1, and nlrp3 expression in the hippocampus. |
2024-04-16 |
2024-04-18 |
rat |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Zuolin Zhou, Yanhua Bi, Chunchun Zhi, Siqi Chen, Die Chen, Zhen Wei, Xiaoling Jian. Astroglial activation is exacerbated in a Down syndrome mouse model. Neuroscience. 2024-04-14. PMID:38615829. |
the expression of gfap in in vitro cultured dp16 astrocytes was not increased as it was in in vivo hippocampal tissue. |
2024-04-14 |
2024-04-17 |
mouse |
| Moses B Ekong, Anna Andrioli, Imaobong E Israel, Edemeka I Ifot, Samuel E Dickson, Ilaria Scambi, Paolo F Fabene, Giuseppe Bertini, Marina Bentivogli. Evaluation of prenatal calabash chalk geophagy on the developing brain of Wistar rats. IBRO neuroscience reports. vol 16. 2024-03-28. PMID:38544793. |
no hippocampal and somatosensory cortical cytoarchitectonic alterations and no significant signs of glial fibrillary acidic protein (gfap) activation were observed. |
2024-03-28 |
2024-03-30 |
rat |
| Miguel Farinha-Ferreira, Daniela M Magalhães, Mariana Neuparth-Sottomayor, Hugo Rafael, Catarina Miranda-Lourenço, Ana M Sebastiã. Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar-Kyoto rat model of depression. Journal of neurochemistry. 2024-03-02. PMID:38430009. |
in a separate cohort, we assessed prefrontal cortex (pfc), hippocampus and amygdala levels of markers of astrocytic (gfap, s100a10) and microglial (iba1, cd86, ym1) activation status, as well as of three key proinflammatory cytokines (il-1β, il-6, tnf-α). |
2024-03-02 |
2024-03-04 |
rat |
| Amira A Kamel, Ahmed Y Nassar, Fatma Y Meligy, Yomna A Omar, Gamal A Y Nassar, Ghada M Ezza. Acetylated oligopeptide and N-acetylcysteine protect against iron overload-induced dentate gyrus hippocampal degeneration through upregulation of Nestin and Nrf2/HO-1 and downregulation of MMP-9/TIMP-1 and GFAP. Cell biochemistry and function. vol 42. issue 2. 2024-02-24. PMID:38396357. |
acetylated oligopeptide and n-acetylcysteine protect against iron overload-induced dentate gyrus hippocampal degeneration through upregulation of nestin and nrf2/ho-1 and downregulation of mmp-9/timp-1 and gfap. |
2024-02-24 |
2024-02-26 |
rat |
| Bharti Biswas, Valsamma Eapen, Margaret J Morris, Nicole M Jone. Combined Effect of Maternal Separation and Early-Life Immune Activation on Brain and Behaviour of Rat Offspring. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397434. |
ms increased glial fibrillary acidic protein (gfap) and brain-derived neurotrophic factor expression in pfc and ionised calcium-binding adapter molecule-1 expression in male hippocampus. |
2024-02-24 |
2024-02-26 |
rat |
| Dayanne Terra Tenório Nonato, Gislei Frota Aragão, Raquel Magalhães Castelo Branco Craveiro, Maria Gonçalves Pereira, Silvânia Maria Mendes Vasconcelos, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Pedro Marcos Gomes Soares, Marcos Aurélio de Sousa Lima, Ana Maria Sampaio Assreuy, Edna Maria Camelo Chave. Polysaccharide-rich extract of Genipa americana leaves protects seizures and oxidative stress in the mice model of pentylenetetrazole-induced epilepsy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364734. |
ptz increased glial fibrillar acid proteins (gfap) and iba-1 in hippocampus, which was reversed by pre-ga (gfap: 1.9 ± 0.23 vs ptz: 3.1 ± 1.3 and iba-1: 2.2 ± 0.8 vs ptz: 3.2 ± 1.4). |
2024-02-16 |
2024-02-19 |
mouse |
| V R Varma, Y An, P R Kac, M Bilgel, A Moghekar, T Loeffler, D Amschl, J Troncoso, K Blennow, H Zetterberg, N J Ashton, S M Resnick, M Thambisett. Longitudinal progression of blood biomarkers reveals a key role of astrocyte reactivity in preclinical Alzheimer's disease. medRxiv : the preprint server for health sciences. 2024-02-12. PMID:38343809. |
in the 5xfad transgenic model of ad, we observed greater gfap levels in the cortex and hippocampus of transgenic mice relative to wild-type prior to the development of cognitive impairment. |
2024-02-12 |
2024-02-15 |
mouse |
| Grigorios Kyriatzis, Anne Bernard, Angélique Bôle, Michel Khrestchatisky, Lotfi Ferha. In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338969. |
in the hippocampus, increased expression of mrna encoding the glial proteins gfap and iba1 confirmed neuroinflammatory status. |
2024-02-10 |
2024-02-12 |
rat |
| Patrycja Kupnicka, Joanna Listos, Maciej Tarnowski, Agnieszka Kolasa, Patrycja Kapczuk, Anna Surówka, Jakub Kwiatkowski, Kamil Janawa, Dariusz Chlubek, Irena Baranowska-Bosiack. The Effect of Prenatal and Neonatal Fluoride Exposure to Morphine-Induced Neuroinflammation. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255899. |
we provide evidence that both morphine administration and fluoride exposure have an impact on the inflammatory response by altering the expression of cox-1, cox-2, ionized calcium-binding adapter molecule (iba1), and glial fibrillary acidic protein (gfap) in brain structures involved in dependence development, such as the prefrontal cortex, striatum, hippocampus, and cerebellum. |
2024-01-23 |
2024-01-25 |
rat |
| Ting Zhan, Shanshan Tang, Junpei Du, Jingshuang Liu, Bodong Yu, Yuxin Yang, Yuting Xie, Yanting Qiu, Guodong Li, Yun Ga. Implication of lncRNA MSTRG.81401 in Hippocampal Pyroptosis Induced by P2X7 Receptor in Type 2 Diabetic Rats with Neuropathic Pain Combined with Depression. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256257. |
in the dnp + mdd rats, elevated levels in hippocampal p2x7 receptor mrna and protein were observed, along with increased co-expression of p2x7 and the astrocytic marker glial fibrillary acidic protein (gfap). |
2024-01-23 |
2024-01-25 |
rat |
| Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong B. Innovative Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging and Its Utility in Whole-Brain Visualization. ACS omega. vol 9. issue 2. 2024-01-22. PMID:38250363. |
based on the assessment of glial cell responses in the hippocampus and neocortex regions using gfap and iba1 biomarkers, cy5-peg2 seems to have minimal adverse effects on brain immune response or neuronal health. |
2024-01-22 |
2024-01-24 |
Not clear |
| Jiang-Ping Wei, Zi-Xuan Zhao, Jing Zeng, Fang-Hong Shang, Lei Hua, Yong Yang, Xiao-Mei Zhan. [Yigong Powder regulates CXCL12/CXCR4 signaling to reduce glutamate release and prevent cognitive decline in mouse model of aging]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 23. 2024-01-11. PMID:38212005. |
the immunofluorescence assay was employed to detect the expression of ionized calcium-binding adapter molecule 1(iba1), glial fibrillary acidic protein(gfap), chemokine c-x-c-motif ligand 12(cxcl12), chemokine c-x-c-motif receptor 4(cxcr4) in the hippocampus and observe the positional relationship between iba1, gfap, and cxcr4. |
2024-01-11 |
2024-01-14 |
mouse |
| Xue Wang, Xiaomei Fu, Xiurong Luo, Yiyi Lai, Chuipu Cai, Yanfang Liao, Zhao Dai, Shuhuan Fang, Jiansong Fan. Network Proximity Analysis Deciphers the Pharmacological Mechanism of Osthole against D-Galactose Induced Cognitive Disorder in Rats. Molecules (Basel, Switzerland). vol 29. issue 1. 2024-01-11. PMID:38202603. |
among them, the pro-apoptotic markers (bax), anti-apoptotic protein (bcl-2), the microgliosis (iba-1), astro-cytosis (gfap), and inflammatory cytokines (tnf-r1) were evaluated in both hippocampus and cortex. |
2024-01-11 |
2024-01-13 |
rat |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
moreover, rtms ameliorated the reduction in gfap and glt-1 expression, alleviated the decrease in bdnf, psd95 and synapsin-1 expression, also reversed the expression levels of bax and bcl2 in the hippocampus of cums-induced rats. |
2023-12-30 |
2024-01-05 |
rat |
| Nan Yan, Zhengdong Wang, Zhou Li, Yang Zheng, Nan Chang, Kangjie Xu, Qian Wang, Xiaoxu Dua. Arsenic Exposure Induces Neuro-immune Toxicity in the Cerebral Cortex and the Hippocampus via Neuroglia and NLRP3 Inflammasome Activation in C57BL/6 Mice. Biological trace element research. 2023-12-26. PMID:38148432. |
in addition, immunofluorescence staining showed that 25 and 50 mg/l arsenic all increased the expression of cd11b and glial fibrillary acidic protein (gfap) in the cerebral cortex and hippocampus (p < 0.05). |
2023-12-26 |
2023-12-29 |
mouse |
| Doodipala Samba Reddy, Tanveer Singh, Sreevidhya Ramakrishnan, Madeline Huber, Xin W. The Journal of pharmacology and experimental therapeutics. 2023-12-10. PMID:38071567. |
additionally, vx-treated animals exhibited a reduced inflammatory response with decreased gfap(+) astrogliosis and iba1(+) microgliosis in the hippocampus, amygdala, and other regions. |
2023-12-10 |
2023-12-17 |
Not clear |
| Octavio Fabián Mercado-Gómez, Virginia Selene Arriaga-Ávila, Angélica Vega-García, Sandra Orozco-Suarez, Vadim Pérez-Koldenkova, Juan José Camarillo-Sánchez, Marcelino Álvarez-Herrera, Rosalinda Guevara-Guzmá. Daytime-Restricted Feeding Ameliorates Oxidative Stress by Increasing NRF2 Transcriptional Factor in the Rat Hippocampus in the Pilocarpine-Induced Acute Seizure Model. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891811. |
the cellular distribution of the nrf2 and sod2 proteins in the pyramidal cell layer of both the ca1 and ca3 hippocampal subfields and astrocytes (gfap marker) were quantified using immunofluorescence and immunohistochemistry, respectively. |
2023-10-30 |
2023-11-08 |
rat |