| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boyu Li, Limin Ye, Cheng Zhang, Ruofan Liu, Chi Wang, Xiaotian Zhang, Hong Ji, Haibo Y. Effects of glycerol monolaurate on estradiol and follicle-stimulating hormones, offspring quality, and mRNA expression of reproductive-related genes of zebrafish (Danio rerio) females. Fish physiology and biochemistry. 2024-04-16. PMID:38625478. |
these results suggest that gml may stimulate the expression of gnrh2 and gnrh3 by increasing the expression level of kiss1 and kiss2 genes in the hypothalamus, thus promoting the synthesis of fsh and e2. |
2024-04-16 |
2024-04-18 |
zebrafish |
| Ilaria Gentile, Valeria Vezzoli, Sara Martone, Maria Grazia Totaro, Marco Bonomi, Luca Persani, Federica Marell. Short-Term Exposure to Benzo(a)Pyrene Causes Disruption of GnRH Network in Zebrafish Embryos. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108076. |
we followed the entire development of gonadotropin releasing hormone (gnrh3) neurons that start to proliferate from the olfactory region at 36 hpf, migrate at 48 hpf and then reach the pre-optic area and the hypothalamus at 72 hpf. |
2023-04-28 |
2023-08-14 |
zebrafish |
| Yali Liu, Qing Wang, Xiang Wang, Zining Meng, Yun Liu, Shuisheng Li, Yong Zhang, Haoran Li. NKB/NK3 system negatively regulates the reproductive axis in sexually immature goldfish (Carassius auratus). General and comparative endocrinology. vol 281. 2019-12-12. PMID:31163181. |
intraperitoneal injections of nkb peptides significantly reduced the expression of kiss2 and gonadotropin releasing hormone 3 (gnrh3) in the hypothalamus, and the expression of luteinizing hormone beta subunit (lhb) and follicle stimulating hormone beta subunit (fshb) in the pituitary in sexually immature goldfish. |
2019-12-12 |
2023-08-13 |
Not clear |
| Shengpeng Wang, Bin Wang, Songlin Che. Spexin in the half-smooth tongue sole (Cynoglossus semilaevis): molecular cloning, expression profiles, and physiological effects. Fish physiology and biochemistry. vol 44. issue 3. 2018-10-01. PMID:29404821. |
intraperitoneal injection of spx increased gnih and gnrh3 mrna levels in the hypothalamus; however, spx inhibited the pituitary expression of gh, fshβ, and gthα mrnas. |
2018-10-01 |
2023-08-13 |
Not clear |
| Weiting Chen, Shuk-Wa Lau, Yuqin Fan, Rudolf S S Wu, Wei G. Juvenile exposure to bisphenol A promotes ovarian differentiation but suppresses its growth - Potential involvement of pituitary follicle-stimulating hormone. Aquatic toxicology (Amsterdam, Netherlands). vol 193. 2017-12-07. PMID:29055862. |
these effects did not seem to involve the hypothalamus because neither bpa nor e2 altered the expression of kiss1, kiss2, gnrh2 and gnrh3 in the hypothalamus. |
2017-12-07 |
2023-08-13 |
zebrafish |
| Yali Zhao, Chanpreet Singh, David A Prober, Nancy L Wayn. Morphological and Physiological Interactions Between GnRH3 and Hypocretin/Orexin Neuronal Systems in Zebrafish (Danio rerio). Endocrinology. vol 157. issue 10. 2017-05-29. PMID:27533887. |
our imaging data revealed close apposition and direct connection between gnrh3 and hcrt neuronal systems in the hypothalamus during larval development through adulthood. |
2017-05-29 |
2023-08-13 |
zebrafish |
| ShunLong Meng, LiPing Qiu, GengDong Hu, LiMin Fan, Chao Song, Yao Zheng, Wei Wu, JianHong Qu, DanDan Li, JiaZhang Chen, Pao X. Effects of methomyl on steroidogenic gene transcription of the hypothalamic-pituitary-gonad-liver axis in male tilapia. Chemosphere. vol 165. 2017-04-19. PMID:27643660. |
however, higher concentrations of methomyl (20 and 200 μg/l) disrupted the endocrine system and caused significant increase in the levels of gnrh2, gnrh3, erα, and erβ genes in the hypothalamus, gnrhr and fshβ genes in the pituitary, cyp19a, fshr, and erα genes in the testis, and vtg and erα genes in the liver, and significantly decreased the levels of lhr, star, 3β-hsd, and arα genes in the testis and lhβ gene in the pituitary, leading to changes in sex steroid hormone and vitellogenin levels in the serum and ultimately resulting in reproductive dysfunction in male tilapia. |
2017-04-19 |
2023-08-13 |
Not clear |
| Wenhui Qiu, Yali Zhao, Ming Yang, Matthew Farajzadeh, Chenyuan Pan, Nancy L Wayn. Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish. Endocrinology. vol 157. issue 2. 2016-06-10. PMID:26653335. |
environmentally relevant, low levels of bpa exposure during development led to advanced hatching time, increased numbers of gnrh3 neurons in both terminal nerve and hypothalamus, increased expression of reproduction-related genes (kiss1, kiss1r, gnrh3, lhβ, fshβ, and erα), and a marker for synaptic transmission (sv2). |
2016-06-10 |
2023-08-13 |
zebrafish |
| Felipe Espigares, Manuel Carrillo, Ana Gómez, Silvia Zanu. The forebrain-midbrain acts as functional endocrine signaling pathway of Kiss2/Gnrh1 system controlling the gonadotroph activity in the teleost fish European sea bass (Dicentrarchus labrax). Biology of reproduction. vol 92. issue 3. 2016-02-22. PMID:25609835. |
to establish the gene expression cascade involved in the action of kisspeptins, the expression of the two sea bass kisspeptin receptor genes (kiss1r and kiss2r) and the three sea bass gnrh genes (gnrh1, gnrh2, and gnrh3) were analyzed in the forebrain-midbrain and the hypothalamus. |
2016-02-22 |
2023-08-13 |
Not clear |
| Y Song, X Duan, J Chen, W Huang, Z Zhu, W H. The distribution of kisspeptin (Kiss)1- and Kiss2-positive neurones and their connections with gonadotrophin-releasing hormone-3 neurones in the zebrafish brain. Journal of neuroendocrinology. vol 27. issue 3. 2015-12-15. PMID:25529211. |
on the other hand, gnrh3 fibres and kiss2 fibres were adjacent but scarcely in contact with each other in the telencephalon and the hypothalamus. |
2015-12-15 |
2023-08-13 |
zebrafish |
| Y Song, X Duan, J Chen, W Huang, Z Zhu, W H. The distribution of kisspeptin (Kiss)1- and Kiss2-positive neurones and their connections with gonadotrophin-releasing hormone-3 neurones in the zebrafish brain. Journal of neuroendocrinology. vol 27. issue 3. 2015-12-15. PMID:25529211. |
the kiss2 and gnrh3 fibres in the ventral hypothalamus projected into the pituitary via the pituitary stalk. |
2015-12-15 |
2023-08-13 |
zebrafish |
| Yali Zhao, Meng-Chin A Lin, Allan Mock, Ming Yang, Nancy L Wayn. Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). PloS one. vol 9. issue 8. 2015-11-09. PMID:25093675. |
in intact brain of adult zebrafish, whole-cell patch clamp recordings of gnrh3 neurons from the preoptic area and hypothalamus revealed opposite effects of kiss1 and kiss2 on spontaneous action potential firing frequency and membrane potential. |
2015-11-09 |
2023-08-13 |
zebrafish |
| Yi Ta Shao, Yung Che Tseng, Chia-Hao Chang, Hong Young Yan, Pung Pung Hwang, Bertil Bor. GnRH mRNA levels in male three-spined sticklebacks, Gasterosteus aculeatus, under different reproductive conditions. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 180. 2015-08-21. PMID:25446939. |
moreover, higher gnrh2 mrna levels in the th and higher gnrh3 mrna levels in the t+poa and hypothalamus (hypth) were also found in long-day sham-operated males than in sham-operated fish kept under an inhibitory short day photoperiod. |
2015-08-21 |
2023-08-13 |
chicken |
| Yali Zhao, Meng-Chin A Lin, Matthew Farajzadeh, Nancy L Wayn. Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish. Frontiers in endocrinology. vol 4. 2013-09-06. PMID:24009601. |
gnrh3 neurons in the ventral telencephalon, poa, and hypothalamus control pituitary-gonadal function; in other areas (e.g., terminal nerve), they are neuromodulatory and without direct action on reproduction. |
2013-09-06 |
2023-08-12 |
zebrafish |
| Yali Zhao, Meng-Chin A Lin, Matthew Farajzadeh, Nancy L Wayn. Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish. Frontiers in endocrinology. vol 4. 2013-09-06. PMID:24009601. |
using timelapse confocal imaging to monitor the time course of gnrh3:emd expression in the live embryo, we describe the emergence and development of gnrh3 neurons in the olfactory region, hypothalamus, poa, and trigeminal ganglion. |
2013-09-06 |
2023-08-12 |
zebrafish |
| Sarah M Tuziak, Hélène Volkof. Gonadotrophin-releasing hormone in winter flounder (Pseudopleuronectes americanus): molecular characterization, distribution and effects of fasting. General and comparative endocrinology. vol 184. 2013-09-05. PMID:23298570. |
fasting reduces gnrh2 and gnrh3 mrna expression in the optic tectum/thalamus and hypothalamus, and telencephalon/preoptic area, respectively, compared with fed fish. |
2013-09-05 |
2023-08-12 |
Not clear |
| E Abraham, O Palevitch, S Ijiri, S J Du, Y Gothilf, Y Zoha. Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor. Journal of neuroendocrinology. vol 20. issue 3. 2008-05-22. PMID:18208553. |
these findings support the hypothesis that gnrh3 neurones migrate from the olfactory region to the poa and caudal hypothalamus. |
2008-05-22 |
2023-08-12 |
zebrafish |
| E Abraham, O Palevitch, S Ijiri, S J Du, Y Gothilf, Y Zoha. Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor. Journal of neuroendocrinology. vol 20. issue 3. 2008-05-22. PMID:18208553. |
gnrh3 fibres in zebrafish began to extend as early as 26 h post-fertilisation and by 4-5 days post-fertilisation had developed into an extensive network reaching the optic tract, telencephalon, hypothalamus, midbrain tegmentum and hindbrain. |
2008-05-22 |
2023-08-12 |
zebrafish |