| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Sabriye Karadenizli Ta\\xc5\\x9fkin, Deniz \\xc5\\x9eahin, Fazilet Dede, Zehra Seda \\xc3\\x9cnal Halbuto\\xc4\\x9fullari, Mehmet Sarihan, Sema Kurnaz \\xc3\\x96zbek, \\xc3\\x96zg\\xc3\\xbcr Do\\xc4\\x9fa \\xc3\\x96zsoy, Murat Kasap, Yusufhan Yazir, Nurbay Ate\\xc5\\x9. Endoplasmic reticulum stress produced by Thapsigargin affects the occurrence of spike-wave discharge by modulating unfolded protein response pathways and activating immune responses in a dose-dependent manner. European journal of pharmacology. 2024-04-26. PMID:38670446.' |
in cortex and thalamus tissues, grp78, erp57, gad153 protein changes (western blot), eif2ak3, xbp-1, atf6, cacna1h mrna expressions (rt-pcr), nf-κb and tnf-α levels (elisa) were measured. |
2024-04-26 |
2024-04-29 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Lulu Ding, Huali Zhu, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Bianhua Zhou, Hongwei Wang, Zijun Yang, Zongping Liu, Jicang Wan. Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway. Environmental science and pollution research international. 2023-11-24. PMID:38001299. |
the mrna and protein expression levels of ers and apoptosis related factors such as grp78, ire1α, xbp1, atf6, caspase-12, caspase-3 and bax in the cells were significantly increased (p < 0.01), while the mrna and protein expression levels of bcl-2 were significantly reduced (p < 0.01). |
2023-11-24 |
2023-11-28 |
rat |
| Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Li. Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-15. PMID:37714499. |
subsequently, according to the dynamic changes of apoptosis in lung specimens, and the expression changes in sig-1r-regulated er stress pathway proteins (sig-1r, grp78, p-perk, atf6, ire1, caspase-12, atf4, chop, caspase-3 and p-jnk), it was confirmed that the sig-1r-regulated er stress signaling pathway was involved in the occurrence of hali. |
2023-09-15 |
2023-10-07 |
Not clear |
| Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemi. The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach. Environmental science and pollution research international. 2023-07-15. PMID:37453011. |
moreover chr down-regulated cd-induced er stress markers (perk, ire1, atf6, chop, and grp78) and apoptosis markers (caspase-3, bax) lung tissue. |
2023-07-15 |
2023-08-14 |
rat |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Elif Ayazoglu Demir, Selim Demir, Ilke Onur Kazaz, Hatice Kucuk, Nihal Turkmen Alemdar, Ali Buyuk, Ahmet Mentese, Yuksel Aliyaziciogl. Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress. Tissue & cell. vol 82. 2023-03-15. PMID:36921493. |
the levels of dna damage [8-hydroxy-2'-deoxyguanosine (8-ohdg)], antioxidant system [superoxide dismutase (sod) and catalase (cat)], pro-inflammatory cytokines [high mobility group box 1 (hmgb1), nuclear factor kappa b protein 65 (nf-κb p65), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6) and myeloperoxidase (mpo)], er stress [78-kda glucose-regulated protein (grp78), activating transcription factor 6 (atf6) and ccaat-enhancer-binding protein homologous protein (chop)] and apoptosis (caspase-3) markers in testicular tissues were determined using commercial enzyme-linked immunosorbent assay (elisa) kits. |
2023-03-15 |
2023-08-14 |
rat |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Xiaojing Li, YiChen Bai, Wenjing Zhu, Xu Shi, Shiwen X. The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney cells. Fish & shellfish immunology. 2022-06-16. PMID:35709895. |
the results showed that imi exposure caused a higher grp78 levels, activated atf6, perk-eif2α and ire1-xbp1 pathways, led to the decline of atpase activities and atp content, induced the expression of cytokine (tnf-α, il-1β, il-6 and inf-γ), triggered bcl2/bax-mediated apoptosis and rip1/rip3/mlkl-dependent necroptosis in the cik cell line. |
2022-06-16 |
2023-08-14 |
Not clear |
| Mustafa Onur Yıldız, Hamit Çelik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gür, İbrahim Bayav, Aydın Genç, Özge Kandemi. Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy. Neurotoxicology. 2022-04-12. PMID:35413380. |
moreover, hesperidin was able to down-regulate the mrna transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, bax, bcl-2, perk, ire1, atf6, and grp78 in naf-induced neurotoxicity. |
2022-04-12 |
2023-08-13 |
rat |
| Ruyi Zhang, Wenli Liao, Ke Wu, Liangliang Hua, Mengyu Wu, Cairong Li, Fei Ca. Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway. Neurochemistry international. 2022-01-25. PMID:35074478. |
also, further investigations showed that mat treatment abated endoplasmic reticulum stress induced hippocampal ultra-structure injury as evidenced by increasing the numbers of rough endoplasmic reticulum and mitochondria, as well as down-regulating endoplasmic reticulum stress related protein levels (grp78, chop, atf6 and caspase-12). |
2022-01-25 |
2023-08-13 |
mouse |
| Xin Luo, Junjie Xu, Ran Zhao, Jiajia Qin, Xiaoyu Wang, Yu Yan, Li-Jing Wang, Guang Wang, Xuesong Yan. The role of inactivated NF-κB in the occurrence of premature ovarian failure. The American journal of pathology. 2021-12-31. PMID:34971586. |
in the successfully established nf-κb-inactivated mouse model, the results showed that the reduced expression of nuclear p65 and the increased expression of iκbα in ovarian granulosa cells; the reduced numbers of antral follicles; the reduction of ki67/pcna-labeled cell proliferation and enhanced fas/fasl-dependent apoptosis in granulosa cells; the declined level of e2 and amh; the decreased expressions of fshr and cyp19a1 in granulosa cells, which was reversed in the context of blocking nf-κb signaling with bay 11-7082; the decreased expressions of grp78, atf6, perk and ire1 in granulosa cells. |
2021-12-31 |
2023-08-13 |
mouse |
| Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tis. Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes. Scientific reports. vol 11. issue 1. 2021-11-05. PMID:34341463. |
ucn3 overexpression significantly downregulated heat shock proteins (hsp60, hsp72 and hsp90) and er stress response markers (grp78, perk, atf6, and ire1α) and attenuated inflammation (tnfα) and apoptosis (chop). |
2021-11-05 |
2023-08-13 |
Not clear |
| Mariam Markouli, Dimitrios Strepkos, Athanasios G Papavassiliou, Christina Piper. Targeting of endoplasmic reticulum (ER) stress in gliomas. Pharmacological research. vol 157. 2021-05-31. PMID:32305494. |
general upr activators or selective grp78, atf6 and perk inducers have been detected to modulate cell proliferation and induce apoptosis of glioma cells. |
2021-05-31 |
2023-08-13 |
Not clear |
| Shuangshuang Zhang, Mengke Cao, Fang Fan. The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952149. |
ers-induced apoptosis of egcg influences cell survival and death in various diseases via regulating ire1, atf6, and perk signaling pathways, and activating grp78 and caspase proteins. |
2021-05-20 |
2023-08-13 |
human |
| Guoqin Wang, Qiuwen Ye, Shujuan Ning, Zhuangqing Yang, Yunlan Chen, Lijuan Zhang, Youguang Huang, Fujia Xie, Xi Cheng, Junlin Chi, Yi Lei, Rong Guo, Jiangqiong Ha. LncRNA MEG3 promotes endoplasmic reticulum stress and suppresses proliferation and invasion of colorectal carcinoma cells through the MEG3/miR-103a-3p/PDHB ceRNA pathway. Neoplasma. vol 68. issue 2. 2021-05-14. PMID:33118833. |
restoring meg3 suppressed cell viability, colony formation ability, and invasion, arrested cell cycle, and induced apoptosis rate in sw620 and hct116 cells, as well as promoted expression of er stress-related proteins (grp78, atf6, chop, caspase-3, and caspase-9). |
2021-05-14 |
2023-08-13 |
human |
| Krista Gonzales, Victoria Feng, Priyanka Bikkina, Marie Angelica Landicho, Michael J Haas, Arshag D Mooradia. The effect of nicotine and dextrose on endoplasmic reticulum stress in human coronary artery endothelial cells. Toxicology research. vol 10. issue 2. 2021-04-24. PMID:33884179. |
nicotine (10 nm) also increased ire1α and perk phosphorylation, and atf6 and grp78 expression. |
2021-04-24 |
2023-08-13 |
human |