| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Camille Fraichard, Fidéline Bonnet-Serrano, Christelle Laguillier-Morizot, Marylise Hebert-Schuster, René Lai-Kuen, Jeanne Sibiude, Thierry Fournier, Marie Cohen, Jean Guibourdench. Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function. International journal of molecular sciences. vol 22. issue 2. 2021-04-12. PMID:33445576. |
we evaluated the expression of p4 synthesis partners (metastatic lymph node 64 (mln64), cholesterol side-chain cleavage (p450scc), hydroxy-delta-5-steroid dehydrogenase and 3 beta-and steroid delta-isomerase 1 (hsd3b1)), of mitochondrial pro-fusion factors (mitofusin 2 (mfn2), optic atrophy 1 (opa1)) and of upr factors (glucose-regulated protein 78 (grp78), activating transcription factor 4 (atf4), activating transcription factor 6 (atf6), spliced x-box binding protein 1 (sxbp1)). |
2021-04-12 |
2023-08-13 |
human |
| Shu Hou, Lili Wang, Guoping Zhan. Mitofusin-2 regulates inflammation-mediated mouse neuroblastoma N2a cells dysfunction and endoplasmic reticulum stress via the Yap-Hippo pathway. The journal of physiological sciences : JPS. vol 69. issue 5. 2020-01-06. PMID:31134519. |
our data show that mfn2 overexpression significantly ameliorated tumor necrosis factor alpha (tnfα)-induced er stress, as indicated by the downregulation of the er stress proteins perk, grp78 and chop. |
2020-01-06 |
2023-08-13 |
mouse |