All Relations between grp78 and nlrp3
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. | western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. | 2024-04-16 | 2024-04-18 | rat |
| Pingping Hong, Qing Wang, Guoping Che. Cholesterol induces inflammation and reduces glucose utilization. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-05-17. PMID:37197354. | cholesterol decreased beta-tc-6 cell glucose utilization; enhanced pancreatic tissue pathological alterations; increased glucose and insulin levels in mouse serum; increased g6pc2, grp78, grp94, and nlrp3 expression levels; and elevated casp1 and pro-il-1β cleavage. | 2023-05-17 | 2023-08-14 | mouse |
| Ling Wang, Ying-Qi Zhai, Li-Li Xu, Chen Qiao, Xiu-Lan Sun, Jian-Hua Ding, Ming Lu, Gang H. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Experimental neurology. vol 251. 2014-02-19. PMID:24220636. | notably, the expressions of monomeric and oligomeric α-synuclein as well as endoplasmic reticulum stress markers (chop and grp78) were significantly upregulated in both pancreas and midbrain of t2d mice, accompanied by the increased activation of nlrp3 inflammasomes to produce excess il-1β. | 2014-02-19 | 2023-08-12 | mouse |