| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew L Zhou, Suresh K Swaminathan, Vrishali S Salian, Lushan Wang, Geoffry L Curran, Hoon-Ki Min, Val J Lowe, Karunya K Kandimall. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Molecular pharmaceutics. 2024-04-16. PMID:38625027. |
thus, we investigated the impact of insulin-like growth factor and insulin receptor (igf1r and ir) signaling on aβ and insulin trafficking at the bbb. |
2024-04-16 |
2024-04-18 |
mouse |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
igf1r stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating atg7. |
2024-01-23 |
2024-01-26 |
mouse |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
this article investigated the correlations between serum igf1r and atg7 with insulin resistance (ir) in gdm patients. |
2024-01-23 |
2024-01-26 |
mouse |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
the levels of serum igf1, igf1r, and atg7 and their correlations with the insulin resistance index homeostasis model assessment of insulin resistance (homa-ir) were measured and analyzed by elisa and pearson. |
2024-01-23 |
2024-01-26 |
mouse |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
additionally, in mouse pancreatic β cells, igf1r, atg7, beclin-1, and lc3-ii/lc3-i levels, cell viability/apoptosis, and insulin level were assessed by western blot, cck-8, flow cytometry, and elisa. |
2024-01-23 |
2024-01-26 |
mouse |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
collectively, igf1r stimulated cell viability, suppressed apoptosis, amplified insulin secretion, and increased atg7 expression to induce cell autophagy, which could be partially averted by atg7 silencing. |
2024-01-23 |
2024-01-26 |
mouse |
| Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco, Veronica Vell. IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance? Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672737. |
dysregulation of the expression and function of igf2 receptors, insulin receptor isoform a (ir-a), insulin growth factor receptor 1 (igf1r), and their downstream signaling effectors drive cancer initiation and progression. |
2023-01-21 |
2023-08-14 |
Not clear |
| Hirofumi Nagao, Weikang Cai, Bruna Brasil Brandão, Nicolai J Wewer Albrechtsen, Martin Steger, Arijeet K Gattu, Hui Pan, Jonathan M Dreyfuss, F Thomas Wunderlich, Matthias Mann, C Ronald Kah. Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. The Journal of clinical investigation. 2022-12-22. PMID:36548088. |
insulin and igf-1 receptors (ir/igf1r) are highly homologous and share similar signaling systems, but each has a unique physiological role, with ir primarily regulating metabolic homeostasis and igf1r regulating mitogenic control and growth. |
2022-12-22 |
2023-08-14 |
mouse |
| Francois Moreau, Nicholas S Kirk, Fa Zhang, Vasily Gelfanov, Edward O List, Martina Chrudinová, Hari Venugopal, Michael C Lawrence, Veronica Jimenez, Fatima Bosch, John J Kopchick, Richard D DiMarchi, Emrah Altindis, C Ronald Kah. Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nature communications. vol 13. issue 1. 2022-11-06. PMID:36335114. |
here we show that while single-chain (sc) and double-chain (dc) lcdv1-vilps have very low affinity for the insulin receptor, sclcdv1-vilp has high affinity for igf1r where it can antagonize human igf-1 signaling, without altering insulin signaling. |
2022-11-06 |
2023-08-14 |
mouse |
| Brandao Bruna Brasil, Sakaguchi Masaji, Batista Thiago Martins, Hu Jiang, Nie Song, Schepmoes Athena A, BonDurant Lucas, Moreau François, Qian Wei-Jun, Kulkarni Rohit, Kahn C Ronal. Apolipoprotein C3 and Circulating Mediators of Preadipocyte Proliferation in States of Lipodystrophy. Molecular metabolism. 2022-08-14. PMID:35964946. |
here we show that insulin and igf-1 receptors are essential for mature adipocyte survival and that deletion of both ir and igf1r specifically in fat using a tamoxifen inducible-adipoq-cre (ai-dko) leads to rapid and severe loss of adipocytes in all depots, associated with a metabolic syndrome characterized by hypertriglyceridemia, hyperglycemia, hyperinsulinemia, fatty liver, and pancreatic beta cell proliferation. |
2022-08-14 |
2023-08-14 |
mouse |
| Zhixin Ye, Songzi Wang, Xiaoqing Huang, Peisong Chen, Langhui Deng, Shiqi Li, Suiwen Lin, Zilian Wang, Bin Li. Plasma exosomal microRNAs Associated with Metabolism as Early Predictor of Gestational Diabetes Mellitus. Diabetes. 2022-08-04. PMID:35926094. |
igf1r and gys1 as target genes of mir-423-5p, and g6pc3 and fdft1 as target genes of mir-122-5p, were associated with insulin and ampk signaling pathways and may participate in the regulation of metabolism in gdm. |
2022-08-04 |
2023-08-14 |
Not clear |
| Aaron M Taylor, Jiayi M Sun, Alexander Yu, Horatiu Voicu, Jianhe Shen, Donald A Barkauskas, Timothy J Triche, Julie M Gastier-Foster, Tsz-Kwong Man, Ching C La. Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887382. |
insulin growth factor receptor 1 (igf1r) is a receptor tyrosine kinase which binds igf1 and igf2 to activate downstream pathways involved in cell apoptosis and proliferation. |
2022-07-27 |
2023-08-14 |
Not clear |
| Thi Ngoc Quynh Nguyen, Samil Jung, Hai Anh Nguyen, BeomSuk Lee, Son Hai Vu, Davaajargal Myagmarjav, Hye Hyeon Eum, Hae-Ock Lee, Taeyeon Jo, Yeongseon Choi, Myeong-Sok Le. The regulation of insulin receptor/insulin-like growth factor 1 receptor ratio, an important factor for breast cancer prognosis, by TRIP-Br1. Journal of hematology & oncology. vol 15. issue 1. 2022-06-16. PMID:35710446. |
here, we propose a novel mechanism that oncogenic protein trip-br1 renders breast cancer cells and insulin deficient mice to have higher ir/igf1r ratio by positively and negatively regulating ir and igf1r expression at the protein level, respectively. |
2022-06-16 |
2023-08-14 |
mouse |
| Xi Zhang, Tianzi Wei, Cang Wu, Junyi Jiang, Shengming Chen, Yinqing Hu, Yi Lu, Dayong Sun, Liting Zhai, Jian Zhang, Chuang Li. Cryo-EM structure reveals polymorphic ligand-bound states of IGF1R. Journal of molecular biology. 2022-03-18. PMID:35300993. |
here, we report 10 distinct structures (7.9-3.6 Å) of igf1r bound to igf1 or insulin to reveal the polymorphic conformations of ligand-bound igf1r. |
2022-03-18 |
2023-08-13 |
Not clear |
| Gourav Bhardwaj, Christie M Penniman, Katherine Klaus, Eric T Weatherford, Hui Pan, Jonathan M Dreyfuss, K Sreekumaran Nair, C Ronald Kahn, Brian T O'Neil. Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors. Frontiers in physiology. vol 12. 2022-02-21. PMID:35185597. |
insulin and igf-1, acting through the insulin receptor (ir) and igf-1 receptor (igf1r), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. |
2022-02-21 |
2023-08-13 |
mouse |
| Sandra Sánchez-Sarasúa, María Meseguer-Beltrán, Cristina García-Díaz, Maria Teresa Beltrán-Bretones, Nisrin ElMlili, Ana María Sánchez-Pére. IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis. Molecular and cellular neurosciences. 2021-12-23. PMID:34942345. |
in this work, we performed a comparative study of irs1 and irs2, together with the igf1 (igf1r) and insulin (ir) receptor expression in the hippocampus and prefrontal cortex during development. |
2021-12-23 |
2023-08-13 |
rat |
| Gourav Bhardwaj, Christie M Penniman, Jayashree Jena, Pablo A Suarez Beltran, Collin Foster, Kennedy Poro, Taylor L Junck, Antentor O Hinton, Rhonda Souvenir, Jordan D Fuqua, Pablo E Morales, Roberto Bravo-Sagua, William I Sivitz, Vitor A Lira, E Dale Abel, Brian T O'Neil. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. The Journal of clinical investigation. vol 131. issue 18. 2021-11-15. PMID:34343133. |
the actions of insulin and igf-1 through the insulin receptor (ir) and igf-1 receptor (igf1r) maintain muscle mass via suppression of forkhead box o (foxo) transcription factors, but whether foxo activation coordinates atrophy in concert with mitochondrial dysfunction is unknown. |
2021-11-15 |
2023-08-13 |
mouse |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
the objective of this study was to investigate the relationship between cort, insulin, prolactin, growth hormone, and insulin-like growth factor-1 in milk as well as the effect of cort on the expression of receptors of insulin (insr), prolactin (prlr), growth hormone (ghr); we also studied the insulin-like growth factor-1 (igf1r), glucocorticoid (nr3c1), mineralocorticoid (nr3c2), b-cell lymphoma 2 (bcl2), bcl-2-like protein x (bax) genes, and the apoptosis rate of mammary epithelial cells of lactating saanen goats in vivo and in vitro. |
2021-11-10 |
2023-08-13 |
Not clear |
| Leonardo Luís Artico, Angelo Brunelli Albertoni Laranjeira, Livia Weijenborg Campos, Juliana Ronchi Corrêa, Priscila Pini Zenatti, José Barreto Campello Carvalheira, Sandra Regina Brambilla, Alexandre Eduardo Nowill, Silvia Regina Brandalise, José Andrés Yune. Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia. Blood advances. vol 5. issue 18. 2021-11-01. PMID:34438446. |
igfbp7 is an igfbp-related protein (igfbp-rp) that in contrast to other igfbps/igfbp-rps features higher affinity for insulin than igfs and was shown to bind the igf1 receptor (igf1r) as well. |
2021-11-01 |
2023-08-13 |
Not clear |
| Leonardo Luís Artico, Angelo Brunelli Albertoni Laranjeira, Livia Weijenborg Campos, Juliana Ronchi Corrêa, Priscila Pini Zenatti, José Barreto Campello Carvalheira, Sandra Regina Brambilla, Alexandre Eduardo Nowill, Silvia Regina Brandalise, José Andrés Yune. Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia. Blood advances. vol 5. issue 18. 2021-11-01. PMID:34438446. |
the affinity of homodimeric igf1r for insulin is reportedly >100 times lower than for igf1. |
2021-11-01 |
2023-08-13 |
Not clear |