| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew L Zhou, Suresh K Swaminathan, Vrishali S Salian, Lushan Wang, Geoffry L Curran, Hoon-Ki Min, Val J Lowe, Karunya K Kandimall. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Molecular pharmaceutics. 2024-04-16. PMID:38625027. |
thus, we investigated the impact of insulin-like growth factor and insulin receptor (igf1r and ir) signaling on aβ and insulin trafficking at the bbb. |
2024-04-16 |
2024-04-18 |
mouse |
| Yaroslav V Bershatsky, Andrey S Kuznetsov, Aisha R Idiatullina, Olga V Bocharova, Sofya M Dolotova, Alina A Gavrilenkova, Oxana V Serova, Igor E Deyev, Tatiana V Rakitina, Olga T Zangieva, Konstantin V Pavlov, Oleg V Batishchev, Vladimir V Britikov, Sergey A Usanov, Alexander S Arseniev, Roman G Efremov, Eduard V Bocharo. Diversity of Structural, Dynamic, and Environmental Effects Explain a Distinctive Functional Role of Transmembrane Domains in the Insulin Receptor Subfamily. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835322. |
human insr, igf1r, and irr receptor tyrosine kinases (rtk) of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes and are directly associated with many pathologies, including neurodegenerative diseases. |
2023-02-25 |
2023-08-14 |
human |
| Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco, Veronica Vell. IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance? Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672737. |
dysregulation of the expression and function of igf2 receptors, insulin receptor isoform a (ir-a), insulin growth factor receptor 1 (igf1r), and their downstream signaling effectors drive cancer initiation and progression. |
2023-01-21 |
2023-08-14 |
Not clear |
| Francois Moreau, Nicholas S Kirk, Fa Zhang, Vasily Gelfanov, Edward O List, Martina Chrudinová, Hari Venugopal, Michael C Lawrence, Veronica Jimenez, Fatima Bosch, John J Kopchick, Richard D DiMarchi, Emrah Altindis, C Ronald Kah. Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nature communications. vol 13. issue 1. 2022-11-06. PMID:36335114. |
here we show that while single-chain (sc) and double-chain (dc) lcdv1-vilps have very low affinity for the insulin receptor, sclcdv1-vilp has high affinity for igf1r where it can antagonize human igf-1 signaling, without altering insulin signaling. |
2022-11-06 |
2023-08-14 |
mouse |
| Gourav Bhardwaj, Christie M Penniman, Katherine Klaus, Eric T Weatherford, Hui Pan, Jonathan M Dreyfuss, K Sreekumaran Nair, C Ronald Kahn, Brian T O'Neil. Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors. Frontiers in physiology. vol 12. 2022-02-21. PMID:35185597. |
insulin and igf-1, acting through the insulin receptor (ir) and igf-1 receptor (igf1r), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. |
2022-02-21 |
2023-08-13 |
mouse |
| Priyanka Sengupta, Debashis Mukhopadhya. Insulin dysregulation as a prominent driver of cell cycle re-entry in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108922. |
the ccr markers were monitored and correlated functionally with upregulation of insulin receptor (insr) and insulin like growth factor 1 receptor (igf1r) in alzheimer's disease (ad) cell model and mouse brain tissue. |
2022-02-03 |
2023-08-13 |
mouse |
| Gourav Bhardwaj, Christie M Penniman, Jayashree Jena, Pablo A Suarez Beltran, Collin Foster, Kennedy Poro, Taylor L Junck, Antentor O Hinton, Rhonda Souvenir, Jordan D Fuqua, Pablo E Morales, Roberto Bravo-Sagua, William I Sivitz, Vitor A Lira, E Dale Abel, Brian T O'Neil. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. The Journal of clinical investigation. vol 131. issue 18. 2021-11-15. PMID:34343133. |
the actions of insulin and igf-1 through the insulin receptor (ir) and igf-1 receptor (igf1r) maintain muscle mass via suppression of forkhead box o (foxo) transcription factors, but whether foxo activation coordinates atrophy in concert with mitochondrial dysfunction is unknown. |
2021-11-15 |
2023-08-13 |
mouse |
| Margarita González-Beltrán, Claudio Gómez-Alegrí. Molecular Modeling and Bioinformatics Analysis of Drug-Receptor Interactions in the System Formed by Glargine, Its Metabolite M1, the Insulin Receptor, and the IGF1 Receptor. Bioinformatics and biology insights. vol 15. 2021-10-02. PMID:34594103. |
insulin and insulin-like growth factor type 1 (igf1) regulate multiple physiological functions by acting on the insulin receptor (ir) and insulin-like growth factor type 1 receptor (igf1r). |
2021-10-02 |
2023-08-13 |
Not clear |
| Lijuan Hu, Xiaoqing Xu, Qiuju Li, Xijuan Chen, Xiangfei Yuan, Shuai Qiu, Chuanshan Yao, Dapeng Zhang, Feng Wan. Caveolin-1 increases glycolysis in pancreatic cancer cells and triggers cachectic states. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 8. 2021-08-10. PMID:34320244. |
in pancreatic cancer, autocrine insulin-like growth factor-1 (igf-1) and paracrine insulin stimulate both igf-1 receptor (igf1r) and insulin receptor (ir) to increase tumor growth and glycolysis. |
2021-08-10 |
2023-08-13 |
mouse |
| Amber R Hackett, Amy Strickland, Jeffrey Milbrand. Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy. Glia. vol 68. issue 5. 2021-06-10. PMID:31758725. |
here, we created an insulin resistant sc by deleting both insulin receptor (insr) and insulin-like growth factor receptor 1 (igf1r), to determine the role of this signaling pathway in development and response to injury in order to understand sc defects in dn. |
2021-06-10 |
2023-08-13 |
mouse |
| Nirupama Devanathan, Ann C Kimble-Hil. Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer. Indiana University journal of undergraduate research. vol 4. issue 1. 2020-09-29. PMID:30906876. |
epidemiological studies have proposed a link between type ii diabetes and cancer via the igf/insulin signaling pathway, which includes insulin-like peptides (igf1, igf2, and insulin), insulin receptors (ir-a, ir-b, igf1r, and hybrids), and insulin substrate proteins (irs1-6). |
2020-09-29 |
2023-08-13 |
Not clear |
| Takayoshi Sasako, Kohjiro Uek. Insulin/IGF-1 signaling and aging. Nihon rinsho. Japanese journal of clinical medicine. vol 74. issue 9. 2019-05-06. PMID:30557473. |
insulin is bound to insulin receptor on cell surface, whereas igf-1 is bound to igf1r, but the molecules to transduce intracellular signals are almost identical, including akt and foxo. |
2019-05-06 |
2023-08-13 |
mouse |
| Smriti Gupta, Kamalendra Yadav, Shrikant S Mantri, Nitin K Singhal, Subramaniam Ganesh, Rajat Sandhi. Evidence for Compromised Insulin Signaling and Neuronal Vulnerability in Experimental Model of Sporadic Alzheimer's Disease. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29611103. |
increased amyloidogenesis was accompanied by decreased expression of mediators in insulin signaling pathway that included insulin receptor (ir), insulin receptor substrate 2 (irs2), insulin-like growth factor 2 (igf2), insulin-like growth factor 1 receptor (igf1r), total-glycogen synthase kinase 3β (t-gsk3β), and phosphorylated-gsk3β |
2019-01-18 |
2023-08-13 |
Not clear |
| Heleen K Bronsveld, Marie L De Bruin, Jelle Wesseling, Joyce Sanders, Ingrid Hofland, Vibeke Jensen, Marloes T Bazelier, Bas Ter Braak, Anthonius de Boer, Peter Vestergaard, Marjanka K Schmid. The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors. BMC cancer. vol 18. issue 1. 2018-10-02. PMID:29486734. |
the insulin receptor (insr) and the insulin growth factor 1 receptor (igf1r) play important roles in the etiology of both diabetes mellitus and breast cancer. |
2018-10-02 |
2023-08-13 |
Not clear |
| Jie Ying Chan, Benjamin J Hackel, Douglas Ye. Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds. Molecular cancer therapeutics. vol 16. issue 7. 2018-03-28. PMID:28468775. |
insulin receptor (insr) and the type i insulin-like growth factor (igf1r) are homologous receptors necessary for signal transduction by their cognate ligands insulin, igf-i and igf-ii. |
2018-03-28 |
2023-08-13 |
Not clear |
| Lijun Li, Marcus Byrd, Kwame Doh, Patrice D Dixon, Hwal Lee, Swasti Tiwari, Carolyn M Ecelbarge. Absence of renal enlargement in fructose-fed proximal-tubule-select insulin receptor (IR), insulin-like-growth factor receptor (IGF1R) double knockout mice. Physiological reports. vol 4. issue 23. 2018-02-01. PMID:27923977. |
to test whether insulin and/or igf1 signaling in the pt is involved in renal structural/functional responses to dietary fructose, we bred mice with dual knockout (ko) of the insulin receptor (ir) and the igf1 receptor (igf1r) in pt by cre-lox recombination, using a γ-glutamyl transferase promoter. |
2018-02-01 |
2023-08-13 |
mouse |
| Jeremie Boucher, Samir Softic, Abdelfattah El Ouaamari, Megan T Krumpoch, Andre Kleinridders, Rohit N Kulkarni, Brian T O'Neill, C Ronald Kah. Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Diabetes. vol 65. issue 8. 2017-06-05. PMID:27207537. |
to determine the roles of insulin and insulin-like growth factor 1 (igf-1) action in adipose tissue, we created mice lacking the insulin receptor (ir), igf-1 receptor (igf1r), or both using cre-recombinase driven by the adiponectin promoter. |
2017-06-05 |
2023-08-13 |
mouse |
| B ter Braak, C L E Siezen, N Kannegieter, E Koedoot, B van de Water, J W van der Laa. Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel. Archives of toxicology. vol 88. issue 4. 2016-05-06. PMID:24464500. |
modifications on the insulin molecular structure can affect the affinity and activation towards two closely related receptor tyrosine kinases: the insulin receptor (insr) and the insulin-like growth factor 1 receptor (igf1r). |
2016-05-06 |
2023-08-12 |
human |
| M Agostina Santoro, R Eric Blue, Sarah F Andres, Amanda T Mah, Laurianne Van Landeghem, P Kay Lun. Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. American journal of physiology. Gastrointestinal and liver physiology. vol 309. issue 7. 2016-01-15. PMID:26251471. |
we hypothesized that hyperinsulinemia associated with obesity would lead to reduced colon epithelial cell (cec) apoptosis after radiation and that this effect would be altered by deletion of the insulin-like growth factor (igf) 1 receptor (igf1r) or the insulin receptor (ir). |
2016-01-15 |
2023-08-13 |
mouse |
| Maciej Tarnowski, Marta Tkacz, Michał Czerewaty, Agata Poniewierska-Baran, Katarzyna Grymuła, Mariusz Z Ratajcza. 5‑Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin‑like growth factor 2 expression and reactivating the H19 gene product miR‑675, which negatively affects insulin‑like growth factors and insulin signaling. International journal of oncology. vol 46. issue 5. 2015-12-29. PMID:25707431. |
insulin-like growth factor 2 (igf2) and 1 (igf1) and insulin (ins) promote proliferation of rhabdomyosarcoma (rms) cells by interacting with the insulin-like growth factor 1 receptor (igf1r) and the insulin receptor (insr). |
2015-12-29 |
2023-08-13 |
human |