| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boyu Li, Limin Ye, Cheng Zhang, Ruofan Liu, Chi Wang, Xiaotian Zhang, Hong Ji, Haibo Y. Effects of glycerol monolaurate on estradiol and follicle-stimulating hormones, offspring quality, and mRNA expression of reproductive-related genes of zebrafish (Danio rerio) females. Fish physiology and biochemistry. 2024-04-16. PMID:38625478. |
these results suggest that gml may stimulate the expression of gnrh2 and gnrh3 by increasing the expression level of kiss1 and kiss2 genes in the hypothalamus, thus promoting the synthesis of fsh and e2. |
2024-04-16 |
2024-04-18 |
zebrafish |
| Adiba Aasif, Roshan Alam, Haseeb Ahsan, Mohammad Mustufa Khan, Arshiya Khan, Saba Kha. The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome. Endocrine regulations. vol 57. issue 1. 2023-12-21. PMID:38127687. |
kisspeptin, a neuropeptide produced by the kiss1 gene, plays a vital role in the regulation of hpg axis by binding with its receptors kiss1r/gpr54, and stimulates gonadotropin secretion from the hypothalamus into pituitary to release luteinizing hormone (lh) and follicle stimulating hormone (fsh). |
2023-12-21 |
2023-12-24 |
Not clear |
| Marilou Poitras, Alexandre Morin, George E Bentley, Hélène Plamondo. Global Cerebral Ischemia in Adult Female Rats Interrupts Estrous Cyclicity and Induces Lasting Changes in Hypothalamic-Pituitary-Gonadal Axis Signaling Peptides. Neuroscience letters. 2023-12-04. PMID:38048875. |
a second objective aimed to assess persistent alterations of hpg axis activation through determination of the expression of estrogen receptor alpha (erα), kisspeptin (kiss1), and gonadotropin-inhibitory hormone (gnih/rfamide-related peptide; rfrp3) in the medial preoptic area (poa), arcuate nucleus (arc), dorsomedial nucleus (dmh) of the hypothalamus, and ca1 of the hippocampus 25 days post ischemia. |
2023-12-04 |
2023-12-10 |
rat |
| Stephen Manchishi, Malwina Prater, William Henry Colledg. Transcriptional profiling of Kiss1 neurons from arcuate and rostral periventricular hypothalamic regions in female mice. Reproduction (Cambridge, England). 2023-11-07. PMID:37934722. |
the two main populations of kiss1 neurons are located in the arcuate (arc) and the rostral periventricular area of the third ventricle (rp3v) of the hypothalamus. |
2023-11-07 |
2023-11-20 |
mouse |
| Siva Prasad Panda, Adarsh Kesharwani, Gaurav Deep Singh, Dsnbk Prasanth, Bhaskara Raju Vatchavai, P V Kamala Kumari, Sunil Kumar Panda, Sarada Prasanna Mallic. Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer's disease: StAR actions in prevention of neuroendocrine dysfunction. Ageing research reviews. 2023-10-11. PMID:37821047. |
the kisspeptin1 (kiss1)/neurokinin b (nkb)/dynorphin (dyn) [kndy] neurons in the hypothalamus regulate the reproduction stage in human beings and rodents. |
2023-10-11 |
2023-10-15 |
human |
| Naira da Silva Mansano, Henrique Rodrigues Vieira, Roberta Araujo-Lopes, Raphael Escorsim Szawka, Jose Donato, Renata Fraza. Fasting modulates GABAergic synaptic transmission to arcuate kisspeptin neurons in female mice. Endocrinology. 2023-10-04. PMID:37793082. |
by measuring genes related to lh pulse generation in micropunches obtained from the arcuate nucleus of the hypothalamus (arh), we observed that fasting reduced kiss1 mrna levels in female and male mice. |
2023-10-04 |
2023-10-07 |
mouse |
| Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. |
we hypothesize that the maternal cafeteria (caf) diet has adverse effects on the offspring's hormonal, metabolic and reproductive functions due to sex-specific alterations in the expression of kiss1, gpr54, pdyn, tac2, and sirt1 in the hypothalamus, and kiss1, gpr54, sirt1 in the liver. |
2023-09-04 |
2023-09-07 |
rat |
| Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. |
mrna for kiss1, gpr54, pdyn, tac2 and sirt1 were measured by real-time pcr in the hypothalamus and/or livers. |
2023-09-04 |
2023-09-07 |
rat |
| Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. |
we found that caf offspring had: lower weight and altered body composition; increased cholesterol and triglycerides levels, sex-specific changes in glucose and insulin levels; sex-dependent changes in sirt1/kiss1 mrna ratio in the hypothalamus, sex-specific alterations in kiss1 and sirt1 mrna in the liver with more diversity in males; a delayed puberty onset in females. |
2023-09-04 |
2023-09-07 |
rat |
| Chan Jin Park, Shiori Minabe, Rex A Hess, Po-Ching Patrick Lin, Sherry Zhou, Shah Tauseef Bashir, Radwa Barakat, Arnon Gal, CheMyong Jay K. Single neonatal estrogen implant sterilizes female animals by decreasing hypothalamic KISS1 expression. Scientific reports. vol 13. issue 1. 2023-06-14. PMID:37316510. |
in neonatal female beagle dogs, implantation of an eb-containing silicone capsule also reduced ovarian follicle development and significantly inhibited kiss1 expression in the hypothalamus. |
2023-06-14 |
2023-08-14 |
rat |
| Cornelia Voigt, Manfred Gahr, Nigel C Bennet. Differential regulation of Kiss1 gene expression by oestradiol in the hypothalamus of the female Damaraland mole-rat, an induced ovulator. General and comparative endocrinology. 2023-06-11. PMID:37302764. |
differential regulation of kiss1 gene expression by oestradiol in the hypothalamus of the female damaraland mole-rat, an induced ovulator. |
2023-06-11 |
2023-08-14 |
rat |
| Jessica Cassin, Maria I Stamou, Kimberly W Keefe, Kaitlin Sung, Celine Bojo, Karen J Tonsfeldt, Rebecca A Rojas, Vanessa Ferreira Lopes, Lacey Plummer, Kathryn B Salnikov, David L Keefe, Metin Ozata, Myron Genel, Neoklis A Georgopoulos, Janet E Hall, William F Crowley, Stephanie B Seminara, Pamela L Mellon, Ravikumar Balasubramania. Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI insight. 2023-01-05. PMID:36602867. |
we found that sox2 is highly expressed in the hypothalamus of adult mice and colocalizes with kiss1 expression in the anteroventral periventricular nucleus of adult female mice. |
2023-01-05 |
2023-08-14 |
mouse |
| Hira Zubair, Muhammad Saqib, Muhammad Noman Khan, Shazia Shamas, Shahzad Irfan, Muhammad Shaha. Variation in Hypothalamic GnIH Expression and Its Association with Animals : an open access journal from MDPI. vol 12. issue 24. 2022-12-23. PMID:36552453. |
this study was aimed at examining the variation in gnih immunoreactivity (-ir) and associated changes among gnih, gnrh, and kiss1 mrna expression in the hypothalamus of infant, juvenile, prepubertal, and adult male rhesus monkeys. |
2022-12-23 |
2023-08-14 |
monkey |
| Ruoxi Dai, Wen Xu, Wei Chen, Liyuan Cui, Lisha Li, Jing Zhou, Xueling Jin, Yan Wang, Ling Wang, Yan Su. Epigenetic modification of Kiss1 gene expression in the AVPV is essential for female reproductive aging. Bioscience trends. 2022-10-23. PMID:36273897. |
female reproductive senescence is heralded by hypothalamus region-specific changes in the transcription of genes such as kiss1 under estradiol (e2) positive feedback, associated with luteinizing hormone (lh) surge dysfunction and reproductive decline. |
2022-10-23 |
2023-08-14 |
rat |
| Stephanie A Roberts, Lydie Naulé, Soukayna Chouman, Tatyana Johnson, Marciana Johnson, Rona S Carroll, Victor M Navarro, Ursula B Kaise. Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice. Endocrinology. 2022-08-17. PMID:35974456. |
kiss1, tac2, and pdyn mrna levels were increased in the mediobasal hypothalamus in females at postnatal day 28, whereas kisspeptin and neurokinin b protein levels in the arcuate nucleus were decreased, following mkrn3 overexpression, compared to controls. |
2022-08-17 |
2023-08-14 |
mouse |
| Yan-Yu Zhang, Xian Zhang, Shao-Yang Bu, Wei-Wei Zhang, Tian-Xiu Li, De-Cai Zheng, Ze-Xiang Huang, Qian Wan. Sexually dimorphic distribution of kiss1 and kiss2 in the brain of yellowtail clownfish, Amphiprion clarkii. Endocrine connections. 2022-07-29. PMID:35904230. |
the coronal planes of brain showed that the kiss1 signal was mainly present in dorsal habenular nucleus (nhd) and kiss2 mrna was widely expressed in telencephalon, midbrain, and hypothalamus, especially in dorsal part of the nucleus of the lateral recess (nrld). |
2022-07-29 |
2023-08-14 |
Not clear |
| Yan-Yu Zhang, Xian Zhang, Shao-Yang Bu, Wei-Wei Zhang, Tian-Xiu Li, De-Cai Zheng, Ze-Xiang Huang, Qian Wan. Sexually dimorphic distribution of kiss1 and kiss2 in the brain of yellowtail clownfish, Amphiprion clarkii. Endocrine connections. 2022-07-29. PMID:35904230. |
the distribution of kiss1 and kiss2 neurons in nhd of habenula and nrld of hypothalamus may suggest that kiss genes associate environmental signaling and reproductive function in yellowtail clownfish. |
2022-07-29 |
2023-08-14 |
Not clear |
| Ling Cui, Chunlu Tan, Lili Huang, Weihao Wang, Zhengxiang Huang, Fang Geng, Mengjun Wu, Xiaolin Chen, Michael Cowley, Ferdinand Roelfsema, Chen Che. Dapagliflozin partially restores reproductive function in MC4R KO obese female mice. The Journal of endocrinology. 2022-05-25. PMID:35612570. |
estrous cycle was partially normalized; number of cl was significantly increased; and the expression of kiss1 and gnrh1 in hypothalamus and lh in pituitary was markedly increased by the dapagliflozin treatment. |
2022-05-25 |
2023-08-13 |
mouse |
| Melissa S Lamm, April D Lamb, Brandon P Klapheke, William A Tyler, John R Godwi. Characterization and Distribution of Kisspeptins, Kisspeptin Receptors, GnIH, and GnRH1 in the Brain of the Protogynous Bluehead Wrasse (Thalassoma bifasciatum). Journal of chemical neuroanatomy. 2022-03-14. PMID:35283253. |
expression of kiss1 was detected in the habenula, lateral hypothalamic nucleus (lhn), and preoptic area (poa), while kiss2 was expressed in the dorsal hypothalamus, with sporadic signal in the poa. |
2022-03-14 |
2023-08-13 |
Not clear |
| Shaoqi Xu, Mei Wang, Ya Li, Ni Tang, Xin Zhang, Hu Chen, Shupeng Zhang, Yanling Liu, Jun Wang, Defang Chen, Zhiqiong L. Cloning and expression of kiss genes and regulation of feeding in Siberian sturgeon (Acipenser baerii). Fish physiology and biochemistry. 2022-02-20. PMID:35184249. |
both kiss1 and kiss2 showed the highest expression level in the hypothalamus. |
2022-02-20 |
2023-08-13 |
Not clear |