| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dinesh Edem, Jhansi Maradana, Priyanka Majety, Mc Anto Antony, Lakshmi Meno. Persistent Insulin Autoimmune Syndrome in a Caucasian Male in the Absence of Triggers. Cureus. vol 16. issue 4. 2024-04-16. PMID:38623323. |
at an outside facility, he had initial labs that showed elevated insulin levels (141 µu/ml) with normal glucose, c-peptide, and proinsulin levels, but there was no availability of an iaa lab assay. |
2024-04-16 |
2024-04-18 |
Not clear |
| Kanwarpal K Dhaliwal, Gaurav Bector, Saurabh Arora, Amanpreet Singh, Sanjay Kalr. An Uncommon Case of Recurrent Hypoglycemic Episodes in a Healthy Non-diabetic Male: Insulin Autoimmune Syndrome. Cureus. vol 15. issue 6. 2023-08-01. PMID:37525774. |
the lab tests showed insulin of 1000 μiu/ml and c-peptide of 4.99 ng/ml. |
2023-08-01 |
2023-08-14 |
Not clear |
| Maryam Jafari, Ahmedyar Hasan, Jessie Joseph, Manal Mustafa, Samar AlMuntase. Painless Footdrop in a Child with Newly Diagnosed Type 1 Diabetes Mellitus: Case Report. Journal of clinical research in pediatric endocrinology. 2022-12-13. PMID:36511459. |
lab results confirmed a diagnosis of diabetes mellitus type 1 and the patient was started on subcutaneous insulin injections. |
2022-12-13 |
2023-08-14 |
Not clear |
| Reyaj Mikrani, Ian K Styles, Thu A Hoang, Mohammad Abdallah, Danielle Senyschyn, Christopher Jh Porter, Enyuan Cao, Natalie L Trevaski. Obesity-associated mesenteric lymph leakage impairs the trafficking of lipids, lipophilic drugs and antigens from the intestine to mesenteric lymph nodes. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2022-10-25. PMID:36283633. |
recently our lab reported that the mesenteric lymphatic vessels become highly branched and leak lymph to the surrounding mesenteric adipose tissue (mat) in mice and humans with obesity, promoting insulin resistance. |
2022-10-25 |
2023-08-14 |
mouse |
| Yue Liao, Susan M Schembre, Grace E Brannon, Zui Pan, Jing Wang, Sadia Ali, M Shaalan Beg, Karen M Basen-Engquis. Using wearable biological sensors to provide personalized feedback to motivate behavioral changes: Study protocol for a randomized controlled physical activity intervention in cancer survivors (Project KNOWN). PloS one. vol 17. issue 9. 2022-09-13. PMID:36099282. |
continuous glucose monitors (cgms) have been used to demonstrate the acute beneficial effects of physical activity on insulin sensitivity and glucose metabolisms in controlled lab settings. |
2022-09-13 |
2023-08-14 |
human |
| Emily M Makhlou. Presentation of Severe Diabetic Ketoacidosis in New-Onset Type One Diabetes Mellitus: The Importance of a Broad Differential in an Otherwise Healthy Population in the Operational Environment. Military medicine. 2022-09-09. PMID:36082965. |
the need for a high index of suspicion for dka in patients with these symptoms is required due to the lack of life-saving insulin and intensive lab monitoring required. |
2022-09-09 |
2023-08-14 |
Not clear |
| Janet M Wenzlau, James E DiLisio, Gene Barbour, Mylinh Dang, Anita C Hohenstein, Maki Nakayama, Thomas Delong, Rocky L Baker, Kathryn Haskin. Insulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes. Frontiers in immunology. vol 13. 2022-08-29. PMID:36032090. |
our lab previously discovered that hybrid insulin peptides (hips), comprised of insulin c-peptide fragments fused to other β-cell granule peptides, are ligands for several pathogenic cd4 t cell clones derived from nod mice and for autoreactive cd4 t cells from t1d patients. |
2022-08-29 |
2023-08-14 |
mouse |
| Jennifer R Stapel, Joshua S Speed, John S Clemme. Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension. Canadian journal of physiology and pharmacology. 2022-06-06. PMID:35658576. |
our lab recently reported that blockade of endothelin-1 (et-1) receptors attenuates insulin resistance in obese mice; therefore, we hypothesized that patients taking et-1 receptor antagonists (era) will have improved glycemic control. |
2022-06-06 |
2023-08-14 |
mouse |
| Jennifer Stapel, Joshua S Speed, John S Clemme. Endothelin-1 receptor antagonists reduce HbA1c in obese patients with pulmonary hypertension. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555706. |
our lab has recently shown that blockade of endothelin-1 (et-1) receptors attenuates insulin resistance in a mouse model of diet induced obesity. |
2022-05-13 |
2023-08-13 |
mouse |
| Arik Davidyan, Matthew P Bubak, Lauren G Koch, Tommy L Lewis, Benjamin F Mille. Intrinsic Mitochondrial Function Impacts the Outcomes of Metformin Treatment on Skeletal Muscle Mitochondrial Morphology in Aged Rat. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560636. |
previous data from our lab suggest that metformin is beneficial to individuals that are relatively insulin resistant and may be detrimental to those who are insulin sensitive. |
2022-05-13 |
2023-08-13 |
rat |
| A Sima, A R Vlad, B Timar, L Cotoi, L Sima, M Vlad, R Tima. INSULIN AUTOIMMUNE SYNDROME IN A YOUNG CAUCASIAN WOMAN. Acta endocrinologica (Bucharest, Romania : 2005). vol 17. issue 2. 2021-12-20. PMID:34925575. |
fasting lab tests revealed: glycemia 28 mg/dl, insulinemia 143.3 µu/ml, insulin antibodies above 100 u/ml, leading to the diagnosis of insulin autoimmune syndrome. |
2021-12-20 |
2023-08-13 |
Not clear |
| Manju Bala, Prachi Gupta, Sanjeev Gupta, Anita Dua, Elisha Injeti, Ashwani Mitta. Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes. Journal of pharmacological and toxicological methods. vol 109. 2021-11-25. PMID:33892108. |
our lab standardized protocols were observed to be effective in studying insulin resistance condition induced by diverse stresses (oxidative & inflammation) in myotubes. |
2021-11-25 |
2023-08-13 |
Not clear |
| Hilaree N Frazier, Adam O Ghoweri, Katie L Anderson, Ruei-Lung Lin, Gabriel J Popa, Michael D Mendenhall, Lawrence P Reagan, Rolf J Craven, Olivier Thibaul. Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Frontiers in neuroscience. vol 14. 2021-08-12. PMID:32733189. |
previously, our lab used a molecular approach to characterize the impact of insulin signaling on voltage-gated calcium channels and has also shown that acute insulin administration reduces calcium-induced calcium release in hippocampal neurons. |
2021-08-12 |
2023-08-13 |
human |
| Shoko Niida, Fumihiro Ogawa, Kento Nakajima, Kazuya Sakai, Munehito Uchiyama, Takeru Abe, Ichiro Takeuch. A Case of Central Pontine Myelinolysis Occurred During Treatment of Hyperosmolar Hyperglycemic Syndrome. International medical case reports journal. vol 14. 2021-06-29. PMID:34177275. |
then, we started therapeutic interventions for them based on the guideline with severe control for blood sugar (bs; primary 1635 mg/dl) under insulin therapy and hypernatremia (primary 153 meq/l) under crystal infusion control in advanced care unit, apparently on routine lab data. |
2021-06-29 |
2023-08-13 |
Not clear |
| Katie Vines, Rongzi Li, Thangiah Geetha, Tom L Broderick, Chad C Carroll, Jeganathan Ramesh Bab. Nerve growth factor receptor TrkA signaling in streptozotocin-induced type 1 diabetes rat brain. Biochemical and biophysical research communications. vol 514. issue 4. 2020-07-20. PMID:31113619. |
previous work from our lab demonstrated a new role of trka in the insulin signaling pathway. |
2020-07-20 |
2023-08-13 |
rat |
| Ruifeng Mao, Yingying Chen, Qian Wu, Tong Zhang, Enjie Diao, Dongli Wu, Man Wang, Yu Liu, Lu Lu, Xin Chang, Ying Zheng, Yefu Wan. Oral delivery of single-chain insulin (SCI-59) analog by bacterium-like particles (BLPs) induces oral tolerance and prevents autoimmune diabetes in NOD mice. Immunology letters. vol 214. 2020-04-15. PMID:31473255. |
based on our previous study, a single-chain insulin (sci-59) analog, bound to the surface of lactic acid bacteria (lab) bacterium-like particles (blps), was more stable in the simulated gastric fluid, compared to free sci-59 and insulin. |
2020-04-15 |
2023-08-13 |
mouse |
| Priya Pathak, Jitendra S Kanshana, BabuNageswar Kanuri, Sanjay C Rebello, Hobby Aggarwal, Kumaravelu Jagavelu, Madhu Dikshi. Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice. European journal of pharmacology. vol 855. 2019-12-20. PMID:31063772. |
recent study from this lab indicated enhanced susceptibility of inos ko mice for diet induced obesity (dio) and systemic insulin resistance (ir) as compared to c57bl/6 (wt) mice. |
2019-12-20 |
2023-08-13 |
mouse |
| Karel Erion, Barbara E Corke. β-Cell Failure or β-Cell Abuse? Frontiers in endocrinology. vol 9. 2019-11-20. PMID:30271382. |
data from our lab and others document that several nutrients and environmental toxins can stimulate insulin secretion at non-stimulatory glucose in the absence of insulin resistance. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jianping Y. Role of adipose hypoxia in endocrine alterations: a possible new anti-inflammatory therapeutic target in obesity? Expert review of endocrinology & metabolism. vol 3. issue 1. 2019-11-20. PMID:30743779. |
recent work from his lab reported that adipose hypoxia may contribute to chronic inflammation and insulin resistance in obesity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jingying Liu, Ulrich Werner, Mario Funke, Melissa Besenius, Lasse Saaby, Mathias Fanø, Huiling Mu, Anette Müllert. SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats. International journal of pharmaceutics. vol 560. 2019-06-12. PMID:30790612. |
to face the challenges of oral delivery of peptide and protein (p/p) drugs, self-emulsifying drug delivery systems (seddss) containing monoacyl phosphatidylcholine (mapc), labrasol (lab) and medium-chain (mc) monoglycerides as permeation enhancers (pes) were evaluated for their effect on intestinal absorption of insulin. |
2019-06-12 |
2023-08-13 |
rat |